JP2011504890A5 - - Google Patents
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- Publication number
- JP2011504890A5 JP2011504890A5 JP2010535281A JP2010535281A JP2011504890A5 JP 2011504890 A5 JP2011504890 A5 JP 2011504890A5 JP 2010535281 A JP2010535281 A JP 2010535281A JP 2010535281 A JP2010535281 A JP 2010535281A JP 2011504890 A5 JP2011504890 A5 JP 2011504890A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- salt
- genitourinary disorders
- azabicyclo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 206010020853 Hypertonic bladder Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 claims 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 206010046694 Urogenital disease Diseases 0.000 claims 1
- UXZDMXYRRQJIBJ-IBGZPJMESA-N [(3R)-1-azabicyclo[2.2.2]octan-3-yl] N-(3-fluorophenyl)-N-[(3,4,5-trifluorophenyl)methyl]carbamate Chemical compound FC1=CC=CC(N(CC=2C=C(F)C(F)=C(F)C=2)C(=O)O[C@@H]2C3CCN(CC3)C2)=C1 UXZDMXYRRQJIBJ-IBGZPJMESA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
Claims (7)
- 化合物Ｉと、Ｄ−酒石酸との化学量論比が実質的に１：１であり、図１に示される°２θにピークを有するＸ線粉末回折図を特徴とする結晶性多型Ｉの形態である、下記構造式の化合物Ｉ（（Ｒ）−３−フルオロフェニル−３，４，５−トリフルオロベンジルカルバミン酸１−アザビシクロ［２．２．２］オクト−３−イルエステル）のＤ−酒石酸塩：
- 実質的に無水結晶性塩である、請求項１に記載の塩。
- 請求項１および２のいずれか一項に記載の塩を含んでなる、医薬組成物。
- 少なくとも一種類の薬学上許容される担体または賦形剤を更に含んでなる、請求項３に記載の医薬組成物。
- 尿生殖器障害を伴う疾患または症状の治療のための、請求項３または４に記載の医薬組成物。
- 前記尿生殖器障害を伴う疾患が尿失禁である、請求項５に記載の医薬組成物。
- 前記尿生殖器障害を伴う疾患が過活動膀胱である、請求項５に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07384038A EP2065385A1 (en) | 2007-11-28 | 2007-11-28 | Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester |
| EP07384038.1 | 2007-11-28 | ||
| PCT/EP2008/010012 WO2009068253A2 (en) | 2007-11-28 | 2008-11-26 | Stable crystalline salt of (r)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabicyclo [2.2.2]oct-yl ester |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011504890A JP2011504890A (ja) | 2011-02-17 |
| JP2011504890A5 true JP2011504890A5 (ja) | 2011-09-01 |
| JP5336509B2 JP5336509B2 (ja) | 2013-11-06 |
Family
ID=39401152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010535281A Expired - Fee Related JP5336509B2 (ja) | 2007-11-28 | 2008-11-26 | （ｒ）−３−フルオロフェニル−３，４，５−トリフルオロベンジルカルバミン酸１−アザビシクロ［２．２．２］オクト−３−イルエステルの安定な結晶性塩 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8492402B2 (ja) |
| EP (2) | EP2065385A1 (ja) |
| JP (1) | JP5336509B2 (ja) |
| KR (1) | KR101557832B1 (ja) |
| CN (1) | CN101925600B (ja) |
| AU (1) | AU2008329181B2 (ja) |
| BR (1) | BRPI0819607A2 (ja) |
| CA (1) | CA2706565C (ja) |
| DK (1) | DK2220082T3 (ja) |
| EA (1) | EA017483B1 (ja) |
| ES (1) | ES2498819T3 (ja) |
| HK (1) | HK1144192A1 (ja) |
| IL (1) | IL206032A (ja) |
| MX (1) | MX2010005850A (ja) |
| NZ (1) | NZ585833A (ja) |
| PL (1) | PL2220082T3 (ja) |
| UA (1) | UA102083C2 (ja) |
| WO (1) | WO2009068253A2 (ja) |
| ZA (1) | ZA201003718B (ja) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1345937T3 (da) | 2000-12-22 | 2006-01-16 | Almirall Prodesfarma Ag | Quinuclidincarbamatderivater og deres anvendelse som M3-antagonister |
| PT3150610T (pt) | 2010-02-12 | 2019-11-11 | Pfizer | Sais e polrmorfos de 8-fluor0-2-{4- [(metilamino}metil]fenil}-1,3,4,5-tetrahidr0-6hazepin0[ 5,4,3-cd]indol-6-0na |
| KR101978364B1 (ko) | 2017-06-15 | 2019-05-14 | 크리스탈지노믹스(주) | 알킬카바모일 나프탈렌일옥시 옥테노일 하이드록시아마이드 또는 그 유도체의 약학적으로 허용 가능한 염 및 그 제조방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE510305C2 (sv) * | 1997-05-30 | 1999-05-10 | Astra Ab | Nytt salt |
| PT1300407E (pt) * | 2000-06-27 | 2004-05-31 | S A L V A T Lab Sa | Compostos carbamatos derivados de arilalquilaminas |
| DK1345937T3 (da) * | 2000-12-22 | 2006-01-16 | Almirall Prodesfarma Ag | Quinuclidincarbamatderivater og deres anvendelse som M3-antagonister |
| US7452904B2 (en) | 2001-12-20 | 2008-11-18 | Chiesi Farmaceutici S.P.A. | 1-alkyl-1-azoniabicyclo' 2.2.2 octane carbamate derivatives and their use as muscarinic receptor antagonists |
| ES2203327B1 (es) * | 2002-06-21 | 2005-06-16 | Almirall Prodesfarma, S.A. | Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen. |
| ES2246170B1 (es) * | 2004-07-29 | 2007-04-01 | Almirall Prodesfarma, S.A. | Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio. |
-
2007
- 2007-11-28 EP EP07384038A patent/EP2065385A1/en not_active Withdrawn
-
2008
- 2008-11-26 PL PL08854867T patent/PL2220082T3/pl unknown
- 2008-11-26 CA CA2706565A patent/CA2706565C/en not_active Expired - Fee Related
- 2008-11-26 CN CN2008801254506A patent/CN101925600B/zh not_active Expired - Fee Related
- 2008-11-26 AU AU2008329181A patent/AU2008329181B2/en not_active Ceased
- 2008-11-26 UA UAA201007997A patent/UA102083C2/uk unknown
- 2008-11-26 EA EA201070651A patent/EA017483B1/ru not_active IP Right Cessation
- 2008-11-26 WO PCT/EP2008/010012 patent/WO2009068253A2/en active Application Filing
- 2008-11-26 NZ NZ585833A patent/NZ585833A/en not_active IP Right Cessation
- 2008-11-26 JP JP2010535281A patent/JP5336509B2/ja not_active Expired - Fee Related
- 2008-11-26 ES ES08854867.2T patent/ES2498819T3/es active Active
- 2008-11-26 MX MX2010005850A patent/MX2010005850A/es active IP Right Grant
- 2008-11-26 US US12/744,493 patent/US8492402B2/en not_active Expired - Fee Related
- 2008-11-26 DK DK08854867.2T patent/DK2220082T3/da active
- 2008-11-26 BR BRPI0819607A patent/BRPI0819607A2/pt not_active IP Right Cessation
- 2008-11-26 EP EP08854867.2A patent/EP2220082B1/en not_active Not-in-force
- 2008-11-28 KR KR1020107013939A patent/KR101557832B1/ko not_active IP Right Cessation
-
2010
- 2010-05-25 ZA ZA2010/03718A patent/ZA201003718B/en unknown
- 2010-05-27 IL IL206032A patent/IL206032A/en not_active IP Right Cessation
- 2010-11-04 HK HK10110355.6A patent/HK1144192A1/xx not_active IP Right Cessation
-
2013
- 2013-02-08 US US13/763,063 patent/US8871787B2/en not_active Expired - Fee Related
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