JP2011504375A5 - - Google Patents

Download PDF

Info

Publication number
JP2011504375A5
JP2011504375A5 JP2010535876A JP2010535876A JP2011504375A5 JP 2011504375 A5 JP2011504375 A5 JP 2011504375A5 JP 2010535876 A JP2010535876 A JP 2010535876A JP 2010535876 A JP2010535876 A JP 2010535876A JP 2011504375 A5 JP2011504375 A5 JP 2011504375A5
Authority
JP
Japan
Prior art keywords
nucleic acid
seq
complex
spacer
conjugate according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010535876A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011504375A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/KR2008/006962 external-priority patent/WO2009069935A2/en
Publication of JP2011504375A publication Critical patent/JP2011504375A/ja
Publication of JP2011504375A5 publication Critical patent/JP2011504375A5/ja
Pending legal-status Critical Current

Links

JP2010535876A 2007-11-26 2008-11-26 細胞の中に核酸を導入する医薬組成物及びその方法 Pending JP2011504375A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99012407P 2007-11-26 2007-11-26
PCT/KR2008/006962 WO2009069935A2 (en) 2007-11-26 2008-11-26 Pharmaceutical compositions and methods for delivering nucleic acids into cells

Publications (2)

Publication Number Publication Date
JP2011504375A JP2011504375A (ja) 2011-02-10
JP2011504375A5 true JP2011504375A5 (https=) 2012-01-05

Family

ID=40679127

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010535876A Pending JP2011504375A (ja) 2007-11-26 2008-11-26 細胞の中に核酸を導入する医薬組成物及びその方法

Country Status (5)

Country Link
US (1) US7981446B2 (https=)
EP (1) EP2220228A4 (https=)
JP (1) JP2011504375A (https=)
KR (1) KR20100109912A (https=)
WO (1) WO2009069935A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080084937A (ko) * 2005-11-04 2008-09-22 포휴먼텍(주) 융합 폴리펩타이드를 세포로 전달하는 방법
WO2011133112A1 (en) * 2010-04-20 2011-10-27 National University Of Singapore Cell penetrating peptide derived from the premembrane protein of flavivirus
US9801948B2 (en) 2011-09-21 2017-10-31 Yale University Antimicrobial compositions and methods of use thereof
CN103088065B (zh) * 2013-01-25 2014-12-10 北京银杏德济生物技术有限公司 一种能够大规模并快速高纯度地诱导间充质干细胞转决定成造血干细胞的方法
CN109414414A (zh) 2016-03-16 2019-03-01 戴维·格拉德斯通研究所 用于治疗肥胖症和/或糖尿病以及用于鉴定候选治疗剂的方法和组合物
GR1010063B (el) * 2019-11-11 2021-08-20 Αριστοτελειο Πανεπιστημιο Θεσσαλονικης-Ειδικος Λογαριασμος Κονδυλιων Ερευνας Μεθοδος για την αναπτυξη μιας πλατφορμας για την παραγωγη δυναμενων για μεταφορα μεσω πεπτιδιου μεταγωγης (ptd), in vitro μεταγραφομενων (ivt) mrna θεραπευτικων
CN114644686B (zh) * 2022-03-24 2023-09-05 中国人民解放军陆军军医大学 一种用于dna疫苗递送系统及其应用和dna疫苗

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000469A1 (en) * 1992-06-26 1994-01-06 Immunex Corporation Novel tyrosine kinase
US6103521A (en) * 1995-02-06 2000-08-15 Cell Genesys, Inc. Multispecific chimeric receptors
US6051429A (en) * 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
EP0920508A1 (en) 1996-08-23 1999-06-09 Chiron Corporation HUMAN POLYHOMEOTIC 1 ($i(hph1)) ACTS AS AN ONCOGENE
AU741546B2 (en) * 1997-07-24 2001-12-06 Perseptive Biosystems, Inc. Conjugates of transporter peptides and nucleic acid analogs, and their use
AU761027B2 (en) * 1998-08-25 2003-05-29 Merck Patent Gmbh Expression and export of angiostatin and endostatin as immunofusis
US6251599B1 (en) * 1998-11-06 2001-06-26 Selective Genetics, Inc. Stabilized nucleic acid compositions and methods of preparation and use thereof
US6903077B1 (en) * 1999-01-04 2005-06-07 University Of Vermont And State Agricultural College Methods and products for delivering nucleic acids
US20030104622A1 (en) * 1999-09-01 2003-06-05 Robbins Paul D. Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses
EP1235914A2 (en) * 1999-11-24 2002-09-04 Joseph Rosenecker Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells
IL154589A0 (en) * 2000-08-25 2003-09-17 Aventis Pharma Inc Membrane penetrating peptides and uses thereof
GB0103110D0 (en) * 2000-08-25 2001-03-28 Aventis Pharma Inc A membrane penetrating peptide encoded by a nuclear localization sequence from human period 1
US7332474B2 (en) * 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
KR20030062788A (ko) 2002-01-19 2003-07-28 포휴먼텍(주) 생체분자 전달 펩타이드 mph1-btm 및 이것을포함하는 생명공학제품
KR20030062789A (ko) * 2002-01-19 2003-07-28 포휴먼텍(주) 생체분자 전달 펩타이드 sim2-btm 및 이것을포함하는 생명공학제품
KR100591936B1 (ko) * 2002-11-12 2006-06-22 포휴먼텍(주) 세포내 dna/rna 전달 방법, 및 이것의 기초 및임상학적 응용
US7166692B2 (en) 2003-03-04 2007-01-23 Canbrex Bio Science Walkersville, Inc. Intracellular delivery of small molecules, proteins, and nucleic acids
PL2604286T3 (pl) * 2003-05-01 2015-03-31 Cornell Res Foundation Inc Sposoby i kompleksy nośnikowe do transportu cząsteczek do komórek
US7339042B2 (en) * 2003-06-09 2008-03-04 University Of Florida Research Foundation, Inc. Gene delivery to tumors
CA2526506A1 (en) * 2003-06-09 2004-12-16 Boehringer Ingelheim International Gmbh Inhibitors of papilloma virus
US7754500B2 (en) * 2003-11-21 2010-07-13 Anp Technologies, Inc. Asymmetrically branched polymer conjugates and microarray assays
US20060035815A1 (en) * 2004-05-04 2006-02-16 Nastech Pharmaceutical Company Inc. Pharmaceutical compositions for delivery of ribonucleic acid to a cell
US20060024331A1 (en) * 2004-08-02 2006-02-02 Ester Fernandez-Salas Toxin compounds with enhanced membrane translocation characteristics
KR20080084937A (ko) * 2005-11-04 2008-09-22 포휴먼텍(주) 융합 폴리펩타이드를 세포로 전달하는 방법
EP1797901A1 (en) * 2005-12-16 2007-06-20 Diatos Cell penetrating peptide conjugates for delivering nucleic acids into cells
CN101490080A (zh) * 2006-07-24 2009-07-22 为人技术株式会社 用于缓解和治疗缺血性病症的药物组合物及其输送方法
CN101511872A (zh) * 2006-08-29 2009-08-19 为人技术株式会社 用于抑制凋亡的药物组合物及其递送方法
KR20080076622A (ko) * 2007-02-16 2008-08-20 포항공과대학교 산학협력단 올리고머화된 단백질 전달체와 이를 이용한 세포내바이러스 벡터 전달 방법

Similar Documents

Publication Publication Date Title
Dong et al. DNA functional materials assembled from branched DNA: design, synthesis, and applications
JP2011504375A5 (https=)
CN110291198B (zh) 经修饰的指导rna
CN103403189B (zh) 用于稳定的多价RNA纳米颗粒中的pRNA多价连接域
Stewart et al. Programmable RNA microstructures for coordinated delivery of siRNAs
JP7749201B6 (ja) 分岐オリゴヌクレオチド
JP2022545385A5 (https=)
CA3218778A1 (en) Modified mrna, modified non-coding rna, and uses thereof
JP2012502657A5 (https=)
CA2860527C (en) High-efficiency nanoparticle-type double-helical oligo-rna structure and method for preparing same
WO2018082126A1 (zh) 一种TDNs-AS1411-核酸药物复合纳米材料载药系统及其制备方法
WO2007127219A3 (en) Targeted delivery to leukocytes using protein carriers
JP2014504150A5 (https=)
KR20100089796A (ko) 세포 내 전달능이 증가된 작은 간섭 rna 복합체
CN113166750A (zh) 可编程的条件性sirna及其用途
WO2015048429A1 (en) Engineering dna assembly in vivo and methods of making and using the reverse transcriptase technology
JP2011520424A5 (https=)
CN111218443B (zh) 合成核酸药物偶联物的方法
Snead et al. Biogenesis and function of endogenous and exogenous siRNAs
Bian et al. Xeno nucleic acids as functional materials: from biophysical properties to application
Yu et al. Enzymatically Synthesized DNA Polymer as Co-carrier for Enhanced RNA Interference
Patutina et al. Opening new frontiers with catalytic nucleic acids in miRNA inhibition
CN120476212A (zh) 自环化rna的制备方法
Ahmadvand et al. Biological targeting and innovative therapeutic interventions with phage-displayed peptides and structured nucleic acids (aptamers)
Kuwahara Progress in chemically modified nucleic acid aptamers