JP2011503057A5 - - Google Patents
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- Publication number
- JP2011503057A5 JP2011503057A5 JP2010533028A JP2010533028A JP2011503057A5 JP 2011503057 A5 JP2011503057 A5 JP 2011503057A5 JP 2010533028 A JP2010533028 A JP 2010533028A JP 2010533028 A JP2010533028 A JP 2010533028A JP 2011503057 A5 JP2011503057 A5 JP 2011503057A5
- Authority
- JP
- Japan
- Prior art keywords
- lipid compound
- compound according
- lipid
- pharmaceutical composition
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 phosphate ester Chemical class 0.000 claims 53
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 150000002632 lipids Chemical class 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 6
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 3
- 102000004877 Insulin Human genes 0.000 claims 3
- 108090001061 Insulin Proteins 0.000 claims 3
- 206010022489 Insulin Resistance Diseases 0.000 claims 3
- 238000008214 LDL Cholesterol Methods 0.000 claims 3
- 108010069201 VLDL Cholesterol Proteins 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 206010012601 diabetes mellitus Diseases 0.000 claims 3
- 239000008103 glucose Substances 0.000 claims 3
- 229940125396 insulin Drugs 0.000 claims 3
- 230000002093 peripheral effect Effects 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 150000003626 triacylglycerols Chemical class 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 206010014486 Elevated triglycerides Diseases 0.000 claims 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 229960003194 meglumine Drugs 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 235000021281 monounsaturated fatty acids Nutrition 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 150000004671 saturated fatty acids Chemical class 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 125000002640 tocopherol group Chemical group 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98669807P | 2007-11-09 | 2007-11-09 | |
| US60/986,698 | 2007-11-09 | ||
| PCT/NO2008/000391 WO2009061208A1 (en) | 2007-11-09 | 2008-11-06 | Lipid compounds for use in cosmetic products, as food supplement or as a medicament |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011503057A JP2011503057A (ja) | 2011-01-27 |
| JP2011503057A5 true JP2011503057A5 (enExample) | 2011-12-22 |
| JP5620272B2 JP5620272B2 (ja) | 2014-11-05 |
Family
ID=40625964
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010533028A Active JP5620272B2 (ja) | 2007-11-09 | 2008-11-06 | 化粧品において，食品サプリメントとして，または医薬品として用いるための脂質化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8741966B2 (enExample) |
| EP (1) | EP2217224B1 (enExample) |
| JP (1) | JP5620272B2 (enExample) |
| ES (1) | ES2733353T3 (enExample) |
| WO (1) | WO2009061208A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8741966B2 (en) | 2007-11-09 | 2014-06-03 | Pronova Biopharma Norge As | Lipid compounds for use in cosmetic products, as food supplement or as a medicament |
| EP2147910A1 (en) * | 2008-07-15 | 2010-01-27 | Pronova BioPharma Norge AS | Novel lipid compounds |
| JP5843755B2 (ja) | 2009-05-08 | 2016-01-13 | プロノヴァ・バイオファーマ・ノルゲ・アーエスＰｒｏｎｏｖａ ＢｉｏＰｈａｒｍａ Ｎｏｒｇｅ ＡＳ | 心血管性、代謝性および炎症性疾患領域に関する疾患の処置のための多価不飽和脂肪酸 |
| GB0909643D0 (en) * | 2009-06-04 | 2009-07-22 | Avexxin As | Glomerulonephritis treatment |
| GB201014633D0 (en) | 2010-09-02 | 2010-10-13 | Avexxin As | Rheumatoid arthritis treatment |
| NZ610705A (en) * | 2010-11-05 | 2014-10-31 | Pronova Biopharma Norge As | Methods of treatment using lipid compounds |
| AU2014222389B2 (en) | 2013-02-28 | 2018-11-29 | Pronova Biopharma Norge As | A composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same |
| US20180104201A1 (en) | 2015-04-28 | 2018-04-19 | Pronova Biopharma Norge As | Use of structurally enhanced fatty acids containing sulphur for preventing and or treating non alcoholic steatohepatitis |
| GB201604316D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
| CN109789111B (zh) | 2016-09-21 | 2021-11-16 | 埃维克辛公司 | 药物组合物 |
| PT3720431T (pt) | 2017-12-06 | 2024-12-05 | Basf As | Derivados de ácidos gordos para o tratamento da esteato-hepatite não alcoólica |
| CN112351775A (zh) | 2018-05-23 | 2021-02-09 | 北海医疗私人有限公司 | 用于改善血糖控制和治疗炎性肠病的结构修饰的脂肪酸 |
| CN116829139A (zh) | 2020-12-22 | 2023-09-29 | 北海医疗私人有限公司 | 用于治疗非酒精性脂肪性肝炎的包含含氧的结构增强的脂肪酸的联合治疗剂 |
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| CN101225064A (zh) | 2007-01-19 | 2008-07-23 | 上海汇瑞生物科技有限公司 | 一种制备β-硫杂-α-烷基脂肪酸的新方法 |
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| US8741966B2 (en) | 2007-11-09 | 2014-06-03 | Pronova Biopharma Norge As | Lipid compounds for use in cosmetic products, as food supplement or as a medicament |
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| SI2315740T1 (en) | 2008-07-08 | 2018-03-30 | Catabasis Pharmaceuticals, Inc. | Fatty acids acetylated salicylates and their uses |
| EP2147910A1 (en) | 2008-07-15 | 2010-01-27 | Pronova BioPharma Norge AS | Novel lipid compounds |
| JP5843755B2 (ja) | 2009-05-08 | 2016-01-13 | プロノヴァ・バイオファーマ・ノルゲ・アーエスＰｒｏｎｏｖａ ＢｉｏＰｈａｒｍａ Ｎｏｒｇｅ ＡＳ | 心血管性、代謝性および炎症性疾患領域に関する疾患の処置のための多価不飽和脂肪酸 |
| RU2569063C2 (ru) | 2009-09-01 | 2015-11-20 | Катабэйсис Фармасьютикалз, Инк. | Конъюгаты жирных кислот и ниацина и их применение |
| US20130046013A1 (en) | 2010-01-20 | 2013-02-21 | Ragnar Hovland | Salicylate fatty acid derivatives |
| NZ610705A (en) | 2010-11-05 | 2014-10-31 | Pronova Biopharma Norge As | Methods of treatment using lipid compounds |
| WO2012115695A1 (en) | 2011-02-25 | 2012-08-30 | Catabasis Pharmaceuticals, Inc. | Bis-fatty acid conjugates and their uses |
| WO2013016531A2 (en) | 2011-07-26 | 2013-01-31 | Purdue Research Foundation | Compounds and methods for use in treating neoplasia and cancer |
-
2008
- 2008-11-06 US US12/741,890 patent/US8741966B2/en active Active
- 2008-11-06 JP JP2010533028A patent/JP5620272B2/ja active Active
- 2008-11-06 WO PCT/NO2008/000391 patent/WO2009061208A1/en not_active Ceased
- 2008-11-06 EP EP08846228.8A patent/EP2217224B1/en active Active
- 2008-11-06 ES ES08846228T patent/ES2733353T3/es active Active
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