JP2011500850A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011500850A5 JP2011500850A5 JP2010531298A JP2010531298A JP2011500850A5 JP 2011500850 A5 JP2011500850 A5 JP 2011500850A5 JP 2010531298 A JP2010531298 A JP 2010531298A JP 2010531298 A JP2010531298 A JP 2010531298A JP 2011500850 A5 JP2011500850 A5 JP 2011500850A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- glp
- composition according
- molecule
- dry powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98236807P | 2007-10-24 | 2007-10-24 | |
| US98562007P | 2007-11-05 | 2007-11-05 | |
| US3374008P | 2008-03-04 | 2008-03-04 | |
| US5212708P | 2008-05-09 | 2008-05-09 | |
| PCT/US2008/081218 WO2009055740A2 (en) | 2007-10-24 | 2008-10-24 | Method of preventing adverse effects by glp-1 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014190113A Division JP2015013892A (ja) | 2007-10-24 | 2014-09-18 | Glp−1による副作用を防止する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011500850A JP2011500850A (ja) | 2011-01-06 |
| JP2011500850A5 true JP2011500850A5 (enExample) | 2011-12-08 |
Family
ID=40546046
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010531298A Pending JP2011500850A (ja) | 2007-10-24 | 2008-10-24 | Glp−1による副作用を防止する方法 |
| JP2014190113A Pending JP2015013892A (ja) | 2007-10-24 | 2014-09-18 | Glp−1による副作用を防止する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014190113A Pending JP2015013892A (ja) | 2007-10-24 | 2014-09-18 | Glp−1による副作用を防止する方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US8377869B2 (enExample) |
| EP (2) | EP2954893A1 (enExample) |
| JP (2) | JP2011500850A (enExample) |
| KR (2) | KR101736535B1 (enExample) |
| CN (1) | CN101969927A (enExample) |
| AU (2) | AU2008316634B2 (enExample) |
| BR (1) | BRPI0818872A2 (enExample) |
| CA (1) | CA2703338A1 (enExample) |
| DK (1) | DK2211842T3 (enExample) |
| ES (1) | ES2547529T3 (enExample) |
| HU (1) | HUE025485T2 (enExample) |
| MX (1) | MX2010004510A (enExample) |
| PL (1) | PL2211842T3 (enExample) |
| RU (2) | RU2474415C2 (enExample) |
| WO (1) | WO2009055740A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| AU779986B2 (en) | 1999-06-29 | 2005-02-24 | Mannkind Corporation | Purification and stabilization of peptide and protein pharmaceutical agents |
| ATE385193T1 (de) | 2002-03-20 | 2008-02-15 | Mannkind Corp | Inhalationsgerät |
| US20080260838A1 (en) * | 2003-08-01 | 2008-10-23 | Mannkind Corporation | Glucagon-like peptide 1 (glp-1) pharmaceutical formulations |
| US8921311B2 (en) | 2003-08-01 | 2014-12-30 | Mannkind Corporation | Method for treating hyperglycemia |
| DK1786784T3 (da) | 2004-08-20 | 2011-02-14 | Mannkind Corp | Katalyse af diketopiperazinsyntese |
| BRPI0514293B1 (pt) | 2004-08-23 | 2022-07-19 | Mannkind Corporation | Sistema microparticulado para distribuição de droga |
| DK1928423T3 (en) | 2005-09-14 | 2016-02-29 | Mannkind Corp | A method for drug formulation based on increasing the affinity of the active substances to the crystalline microparticle surfaces |
| CA2643464C (en) | 2006-02-22 | 2018-09-04 | Mannkind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| EP2954893A1 (en) * | 2007-10-24 | 2015-12-16 | MannKind Corporation | An inhalable dry powder formulation comprising glp-1 for use in the treatment of hyperglycemia and diabetes |
| WO2011163272A1 (en) | 2010-06-21 | 2011-12-29 | Mannkind Corporation | Dry powder drug delivery system and methods |
| US8785396B2 (en) | 2007-10-24 | 2014-07-22 | Mannkind Corporation | Method and composition for treating migraines |
| SG192447A1 (en) * | 2008-03-27 | 2013-08-30 | Mannkind Corp | A dry powder inhalation system |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| CN106039494B (zh) | 2008-06-13 | 2019-12-24 | 曼金德公司 | 干粉吸入器和用于药物输送的系统 |
| BRPI0914308B8 (pt) | 2008-06-20 | 2021-06-22 | Mannkind Corp | sistema de inalação |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| EP2853268A1 (en) | 2009-01-08 | 2015-04-01 | Mannkind Corporation | Treatment of hyperglycemia with GLP-1 |
| JP5624063B2 (ja) * | 2009-03-04 | 2014-11-12 | マンカインドコーポレイション | 改善された乾燥粉末薬物送達システム |
| WO2010105094A1 (en) | 2009-03-11 | 2010-09-16 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
| US8227409B2 (en) * | 2009-06-12 | 2012-07-24 | Mannkind Corporation | Diketopiperazine microparticles with defined isomer contents |
| MY186975A (en) * | 2009-06-12 | 2021-08-26 | Mannkind Corp | Diketopiperazine microparticles with defined specific surface areas |
| WO2011017554A2 (en) * | 2009-08-07 | 2011-02-10 | Mannkind Corporation | Val (8) glp-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome |
| BR112012011603B8 (pt) | 2009-11-02 | 2021-07-27 | Mannkind Corp | sistema de criogranulação, conjunto de dispensador, método para criogranular uma composição farmacêutica e método para criopeletizar |
| SG10201406836SA (en) * | 2009-11-02 | 2014-12-30 | Mannkind Corp | Reactor For Producing Pharmaceutical Particles In A Precipitation Process |
| AU2015203301B2 (en) * | 2009-11-02 | 2017-05-25 | Mannkind Corporation | Reactor for producing pharmaceutical particles in a precipitation process |
| EP2496295A1 (en) | 2009-11-03 | 2012-09-12 | MannKind Corporation | An apparatus and method for simulating inhalation efforts |
| AU2011326529B2 (en) * | 2010-11-09 | 2015-07-30 | Mannkind Corporation | Composition comprising a serotonin receptor agonist and a diketopiperazine for treating migraines |
| MY180552A (en) | 2011-04-01 | 2020-12-02 | Mannkind Corp | Blister package for pharmaceutical cartridges |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| JP6018640B2 (ja) | 2011-10-24 | 2016-11-02 | マンカインド コーポレイション | 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム |
| DK2872205T3 (en) * | 2012-07-12 | 2017-02-27 | Mannkind Corp | DRY POWDER FORMAL ADMINISTRATION SYSTEM |
| EP2890391A4 (en) * | 2012-08-29 | 2016-03-09 | Mannkind Corp | METHOD AND COMPOSITION FOR TREATING HYPERGLYCEMIA |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
| LT2934567T (lt) | 2012-12-21 | 2018-09-10 | Sanofi | Eksendino-4 dariniai kaip dvigubi glp1/gip arba trigubi glp1/gip/gliukagono agonistai |
| KR102391750B1 (ko) | 2013-03-15 | 2022-04-28 | 맨카인드 코포레이션 | 미세결정성 디케토피페라진 조성물 및 방법 |
| EP3021834A1 (en) | 2013-07-18 | 2016-05-25 | MannKind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
| EP3080150B1 (en) | 2013-12-13 | 2018-08-01 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/升糖素受體促效劑 |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| WO2015148905A1 (en) | 2014-03-28 | 2015-10-01 | Mannkind Corporation | Use of ultrarapid acting insulin |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物 |
| KR20250152464A (ko) * | 2024-04-16 | 2025-10-23 | 한미약품 주식회사 | 흡입제 조성물 |
Family Cites Families (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5614492A (en) * | 1986-05-05 | 1997-03-25 | The General Hospital Corporation | Insulinotropic hormone GLP-1 (7-36) and uses thereof |
| US5120712A (en) * | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| US6849708B1 (en) * | 1986-05-05 | 2005-02-01 | The General Hospital Corporation | Insulinotropic hormone and uses thereof |
| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| US6645504B1 (en) * | 1987-06-24 | 2003-11-11 | Autoimmune Inc. | Bystander suppression of type I diabetes by oral administration of glucagon |
| US5545618A (en) * | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| US5693338A (en) * | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
| US6331318B1 (en) | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
| US5352461A (en) | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
| DK36392D0 (da) * | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Anvendelse af kemisk forbindelse |
| US6024090A (en) * | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| TW402506B (en) | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
| US6632456B1 (en) * | 1993-06-24 | 2003-10-14 | Astrazeneca Ab | Compositions for inhalation |
| US5705483A (en) * | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| US5574008A (en) * | 1994-08-30 | 1996-11-12 | Eli Lilly And Company | Biologically active fragments of glucagon-like insulinotropic peptide |
| FI972313L (fi) | 1994-12-01 | 1997-07-30 | Toyama Chemical Co Ltd | Uusia 2,3-diketopiperatsiinijohdannaisia ja niiden suoloja |
| US5990077A (en) * | 1995-04-14 | 1999-11-23 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
| US6428771B1 (en) | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
| JP3098401B2 (ja) | 1995-07-12 | 2000-10-16 | 株式会社エルティーティー研究所 | 経鼻投与用製剤 |
| US6852690B1 (en) * | 1995-08-22 | 2005-02-08 | Amylin Pharmaceuticals, Inc. | Method and composition for enhanced parenteral nutrition |
| US5766620A (en) * | 1995-10-23 | 1998-06-16 | Theratech, Inc. | Buccal delivery of glucagon-like insulinotropic peptides |
| AU722319B2 (en) * | 1996-02-27 | 2000-07-27 | Teijin Limited | Powdery composition for nasal administration |
| JPH1053765A (ja) * | 1996-06-04 | 1998-02-24 | Denso Corp | スメクチック液晶組成物及び液晶セル |
| US6006753A (en) * | 1996-08-30 | 1999-12-28 | Eli Lilly And Company | Use of GLP-1 or analogs to abolish catabolic changes after surgery |
| US6277819B1 (en) * | 1996-08-30 | 2001-08-21 | Eli Lilly And Company | Use of GLP-1 or analogs in treatment of myocardial infarction |
| JP3020141B2 (ja) * | 1996-10-07 | 2000-03-15 | 株式会社富士薬品 | 経鼻投与用製剤 |
| UA65549C2 (uk) * | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| ATE366584T1 (de) * | 1996-11-12 | 2007-08-15 | Novo Nordisk As | Verwendung von glp-1 peptiden |
| US5981488A (en) * | 1997-03-31 | 1999-11-09 | Eli Lillly And Company | Glucagon-like peptide-1 analogs |
| WO1999029336A1 (en) * | 1997-12-05 | 1999-06-17 | Eli Lilly And Company | Glp-1 formulations |
| US6380357B2 (en) * | 1997-12-16 | 2002-04-30 | Eli Lilly And Company | Glucagon-like peptide-1 crystals |
| US6998387B1 (en) * | 1998-03-19 | 2006-02-14 | Amylin Pharmaceuticals, Inc. | Human appetite control by glucagon-like peptide receptor binding compounds |
| FR2777283B1 (fr) * | 1998-04-10 | 2000-11-24 | Adir | Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| SE9802080D0 (sv) * | 1998-06-11 | 1998-06-11 | Hellstroem | Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein |
| US6087334A (en) * | 1998-08-21 | 2000-07-11 | Amylin Pharmaceuticals, Inc. | Anti-diabetic peptides |
| WO2000012136A1 (fr) * | 1998-08-26 | 2000-03-09 | Teijin Limited | Compositions en poudre s'administrant par voie nasale |
| US6720407B1 (en) * | 1998-08-28 | 2004-04-13 | Eli Lilly And Company | Method for administering insulinotropic peptides |
| TR200100600T2 (tr) * | 1998-08-28 | 2001-07-23 | Lilly And Company Eli | İnsülinotropik peptitlerin kullanımı. |
| US6375975B1 (en) * | 1998-12-21 | 2002-04-23 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary application |
| DE60026982T2 (de) | 1999-04-05 | 2006-11-16 | Mannkind Corp., Danbury | Verfahren zur bildung von feinem pulver |
| US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| PT1133312E (pt) * | 1999-06-21 | 2007-11-30 | Lilly Co Eli | Uso sinergístico de tiazolidinodionas com péptido 1 semelhante ao glucagon e os seus agonistas para tratar diabetes não insulino-dependente |
| AU779986B2 (en) | 1999-06-29 | 2005-02-24 | Mannkind Corporation | Purification and stabilization of peptide and protein pharmaceutical agents |
| US9006175B2 (en) * | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
| US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
| US7022674B2 (en) * | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
| WO2001051071A2 (en) * | 2000-01-11 | 2001-07-19 | Novo Nordisk A/S | Transepithelial delivery of glp-1 derivatives |
| US6540983B1 (en) * | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
| US6540982B1 (en) * | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
| US6608038B2 (en) * | 2000-03-15 | 2003-08-19 | Novartis Ag | Methods and compositions for treatment of diabetes and related conditions via gene therapy |
| US6468507B1 (en) * | 2000-05-01 | 2002-10-22 | Aeropharm Technology, Inc. | Non-aqueous aerosol formulation comprising rosiglitazone maleate, a non-aqueous carrier, and an amino acid stabilizer |
| US6447750B1 (en) * | 2000-05-01 | 2002-09-10 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| MXPA02012203A (es) * | 2000-06-16 | 2003-06-06 | Lilly Co Eli | Analogos de peptido 1 tipo glucagon. |
| US6562807B2 (en) * | 2000-06-23 | 2003-05-13 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| WO2002002560A2 (en) * | 2000-07-04 | 2002-01-10 | Novo Nordisk A/S | Purine-2,6-diones which are inhibitors of the enzyme dipeptidyl peptidase iv (dpp-iv) |
| US7259233B2 (en) * | 2000-12-13 | 2007-08-21 | Eli Lilly And Company | Chronic treatment regimen using glucagon-like insulinotropic peptides |
| WO2002083066A2 (en) * | 2001-04-11 | 2002-10-24 | Bristol-Myers Squibb Company | Amino acid complexes of c-aryl glucosides for treatment of diabetes and method |
| US7232897B2 (en) * | 2001-04-24 | 2007-06-19 | Harvard University, President And Fellows Of Harvard College | Compositions and methods for modulating NH2-terminal Jun Kinase activity |
| AU2002308706A1 (en) * | 2001-06-01 | 2002-12-16 | Eli Lilly And Company | Glp-1 formulations with protracted time action |
| KR100593348B1 (ko) * | 2001-08-23 | 2006-06-26 | 일라이 릴리 앤드 캄파니 | 글루카곤-유사 펩티드-1 유사체 |
| EP1432430A4 (en) * | 2001-08-28 | 2006-05-10 | Lilly Co Eli | PREMIXTURES OF GLP-1 AND BASALINSULIN |
| US7179788B2 (en) * | 2001-10-19 | 2007-02-20 | Eli Lilly And Company | Biphasic mixtures of GLP-1 and insulin |
| US20080260838A1 (en) | 2003-08-01 | 2008-10-23 | Mannkind Corporation | Glucagon-like peptide 1 (glp-1) pharmaceutical formulations |
| US20040038865A1 (en) | 2002-08-01 | 2004-02-26 | Mannkind Corporation | Cell transport compositions and uses thereof |
| US20040121964A1 (en) * | 2002-09-19 | 2004-06-24 | Madar David J. | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) |
| US20070077286A1 (en) * | 2003-12-24 | 2007-04-05 | Tsutomu Ishihara | Drug-containing nanoparticle, process for producing the same and parenterally administered preparation from the nanoparticle |
| AU2005240206B2 (en) * | 2004-05-06 | 2011-04-07 | Emisphere Technologies, Inc. | Solid dosage form of wetted heparin |
| DK1786784T3 (da) | 2004-08-20 | 2011-02-14 | Mannkind Corp | Katalyse af diketopiperazinsyntese |
| JP2008510825A (ja) | 2004-08-23 | 2008-04-10 | マンカインド コーポレイション | ホスホジエステラーゼ5型の阻害剤の肺送達 |
| BRPI0514293B1 (pt) | 2004-08-23 | 2022-07-19 | Mannkind Corporation | Sistema microparticulado para distribuição de droga |
| KR20070095927A (ko) * | 2004-12-03 | 2007-10-01 | 메데리오 에이지 | 폐 흡입을 위한 글루카곤-형 펩타이드 약제를 포함하는의약품 |
| SE0402976L (sv) * | 2004-12-03 | 2006-06-04 | Mederio Ag | Medicinsk produkt |
| CA2592776A1 (en) * | 2005-01-10 | 2006-08-17 | Mannkind Corporation | Methods and compositions for minimizing accrual of inhalable insulin in the lungs |
| US20100041612A1 (en) | 2005-09-08 | 2010-02-18 | Martin Beinborn | Fragments of the Glucagon-Like Peptide-1 and Uses Thereof |
| DK1928423T3 (en) | 2005-09-14 | 2016-02-29 | Mannkind Corp | A method for drug formulation based on increasing the affinity of the active substances to the crystalline microparticle surfaces |
| EP1968644B1 (en) * | 2005-12-16 | 2012-06-27 | Nektar Therapeutics | Polymer conjugates of glp-1 |
| CA2643464C (en) * | 2006-02-22 | 2018-09-04 | Mannkind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| KR20150042304A (ko) * | 2006-04-14 | 2015-04-20 | 맨카인드 코포레이션 | 글루카곤 유사 펩타이드 1 (glp-1) 약제학적 제제 |
| US8454971B2 (en) * | 2007-02-15 | 2013-06-04 | Indiana University Research And Technology Corporation | Glucagon/GLP-1 receptor co-agonists |
| MX2010004508A (es) | 2007-10-24 | 2010-07-02 | Mannkind Corp | Suministro de agentes activos. |
| EP2954893A1 (en) | 2007-10-24 | 2015-12-16 | MannKind Corporation | An inhalable dry powder formulation comprising glp-1 for use in the treatment of hyperglycemia and diabetes |
| EP2060268A1 (en) | 2007-11-15 | 2009-05-20 | Novo Nordisk A/S | Pharmaceutical compositions for pulmonary or nasal delivery of peptides |
| EP2853268A1 (en) * | 2009-01-08 | 2015-04-01 | Mannkind Corporation | Treatment of hyperglycemia with GLP-1 |
-
2008
- 2008-10-24 EP EP15178836.1A patent/EP2954893A1/en not_active Withdrawn
- 2008-10-24 JP JP2010531298A patent/JP2011500850A/ja active Pending
- 2008-10-24 US US12/258,340 patent/US8377869B2/en active Active
- 2008-10-24 DK DK08841194.7T patent/DK2211842T3/en active
- 2008-10-24 PL PL08841194T patent/PL2211842T3/pl unknown
- 2008-10-24 WO PCT/US2008/081218 patent/WO2009055740A2/en not_active Ceased
- 2008-10-24 KR KR1020137027725A patent/KR101736535B1/ko not_active Expired - Fee Related
- 2008-10-24 ES ES08841194.7T patent/ES2547529T3/es active Active
- 2008-10-24 CN CN2008801226703A patent/CN101969927A/zh active Pending
- 2008-10-24 RU RU2010120666/15A patent/RU2474415C2/ru not_active IP Right Cessation
- 2008-10-24 CA CA2703338A patent/CA2703338A1/en not_active Abandoned
- 2008-10-24 HU HUE08841194A patent/HUE025485T2/en unknown
- 2008-10-24 MX MX2010004510A patent/MX2010004510A/es active IP Right Grant
- 2008-10-24 BR BRPI0818872 patent/BRPI0818872A2/pt not_active IP Right Cessation
- 2008-10-24 AU AU2008316634A patent/AU2008316634B2/en not_active Ceased
- 2008-10-24 KR KR1020107011096A patent/KR101736502B1/ko not_active Expired - Fee Related
- 2008-10-24 EP EP08841194.7A patent/EP2211842B1/en not_active Not-in-force
-
2012
- 2012-10-30 RU RU2012146344/15A patent/RU2012146344A/ru not_active Application Discontinuation
-
2013
- 2013-01-02 US US13/732,911 patent/US20130125886A1/en not_active Abandoned
-
2014
- 2014-05-20 AU AU2014202731A patent/AU2014202731A1/en not_active Abandoned
- 2014-09-18 JP JP2014190113A patent/JP2015013892A/ja active Pending
-
2020
- 2020-01-14 US US16/742,193 patent/US20200147219A1/en not_active Abandoned
-
2022
- 2022-08-15 US US17/887,856 patent/US20220387593A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011500850A5 (enExample) | ||
| RU2012146344A (ru) | Способ предотвращения побочных эффектов glp-1 | |
| JP2011500851A5 (enExample) | ||
| JP5788374B2 (ja) | 糖尿病治療における優れた血糖コントロール | |
| Harsch | Inhaled insulins: their potential in the treatment of diabetes mellitus | |
| JP7362687B2 (ja) | 低血糖症の治療用経鼻粉末製剤 | |
| US8642548B2 (en) | Val (8) GLP-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome | |
| JP2008534622A5 (enExample) | ||
| RU2010120672A (ru) | Доставка активных веществ | |
| JP2012505852A5 (enExample) | ||
| JP2011503152A5 (enExample) | ||
| JP2003501361A5 (enExample) | ||
| WO2012104834A1 (en) | New oral dissolving films for insulin administration, for treating diabetes | |
| Uwaifo et al. | Novel pharmacologic agents for type 2 diabetes | |
| WO2009139362A1 (ja) | Dpp-iv阻害薬と他の糖尿病治療薬との併用又は組み合せからなる医薬 | |
| US20240342251A1 (en) | Method of treating hypoglycemia events in diabetes treatment | |
| JP2006515620A5 (enExample) | ||
| De Galan et al. | Efficacy and safety of inhaled insulin in the treatment of diabetes mellitus | |
| CN102655866B (zh) | 糖尿病的治疗或预防药 | |
| Arnolds et al. | Inhaled insulin | |
| Jani et al. | First approved inhaled insulin therapy for diabetes mellitus | |
| JP2012532852A (ja) | 2型糖尿病における食後高血糖の経頬粘膜治療の方法、および当該治療に用いられる医薬組成物 | |
| JPWO2006126673A1 (ja) | 組み合わせによる糖尿病治療薬 | |
| Kumbhar et al. | Novel route of inhaled insulin for diabetes treatment | |
| Davis | The role of inhaled insulin in the treatment of type 2 diabetes |