JP2011500588A - ２−（（ｒ）−２−メチルピロリジン−２−イル）−１ｈ−ベンズイミダゾール−４−カルボキサミド結晶型２ - Google Patents

２−（（ｒ）−２−メチルピロリジン−２−イル）−１ｈ−ベンズイミダゾール−４−カルボキサミド結晶型２ Download PDF

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Publication number
JP2011500588A
JP2011500588A JP2010529062A JP2010529062A JP2011500588A JP 2011500588 A JP2011500588 A JP 2011500588A JP 2010529062 A JP2010529062 A JP 2010529062A JP 2010529062 A JP2010529062 A JP 2010529062A JP 2011500588 A JP2011500588 A JP 2011500588A
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JP
Japan
Prior art keywords
registered trademark
benzimidazole
methylpyrrolidin
abt
carboxamide
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Pending
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JP2010529062A
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English (en)
Japanese (ja)
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JP2011500588A5 (enExample
Inventor
チユー，クイトン
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Abbott Laboratories
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Abbott Laboratories
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Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of JP2011500588A publication Critical patent/JP2011500588A/ja
Publication of JP2011500588A5 publication Critical patent/JP2011500588A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2010529062A 2007-10-12 2008-10-10 ２−（（ｒ）−２−メチルピロリジン−２−イル）−１ｈ−ベンズイミダゾール−４−カルボキサミド結晶型２ Pending JP2011500588A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97965407P 2007-10-12 2007-10-12
PCT/US2008/079439 WO2009049109A1 (en) 2007-10-12 2008-10-10 2-((r)-2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide crystalline form 2

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014142419A Division JP2014237660A (ja) 2007-10-12 2014-07-10 ２−（（ｒ）−２−メチルピロリジン−２−イル）−１ｈ−ベンズイミダゾール−４−カルボキサミド結晶型２

Publications (2)

Publication Number Publication Date
JP2011500588A true JP2011500588A (ja) 2011-01-06
JP2011500588A5 JP2011500588A5 (enExample) 2014-03-27

Family

ID=40279000

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010529062A Pending JP2011500588A (ja) 2007-10-12 2008-10-10 ２−（（ｒ）−２−メチルピロリジン−２−イル）−１ｈ−ベンズイミダゾール−４−カルボキサミド結晶型２
JP2014142419A Pending JP2014237660A (ja) 2007-10-12 2014-07-10 ２−（（ｒ）−２−メチルピロリジン−２−イル）−１ｈ−ベンズイミダゾール−４−カルボキサミド結晶型２
JP2016220205A Pending JP2017071617A (ja) 2007-10-12 2016-11-11 ２−（（ｒ）−２−メチルピロリジン−２−イル）−１ｈ−ベンズイミダゾール−４−カルボキサミド結晶型２

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014142419A Pending JP2014237660A (ja) 2007-10-12 2014-07-10 ２−（（ｒ）−２−メチルピロリジン−２−イル）−１ｈ−ベンズイミダゾール−４−カルボキサミド結晶型２
JP2016220205A Pending JP2017071617A (ja) 2007-10-12 2016-11-11 ２−（（ｒ）−２−メチルピロリジン−２−イル）−１ｈ−ベンズイミダゾール−４−カルボキサミド結晶型２

Country Status (8)

Country Link
US (1) US8013168B2 (enExample)
EP (2) EP2727921B1 (enExample)
JP (3) JP2011500588A (enExample)
CN (2) CN101821269B (enExample)
CA (1) CA2696423A1 (enExample)
ES (1) ES2562081T3 (enExample)
MX (1) MX2010003771A (enExample)
WO (1) WO2009049109A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100090769A (ko) * 2007-10-12 2010-08-17 아보트 러보러터리즈 2-((ｒ)-2-메틸피롤리딘-2-일)-1ｈ-벤즈이미다졸-4-카복스아미드 결정형 1
AU2012243132A1 (en) * 2011-04-11 2013-10-24 Abbvie Inc. PARP inhibitors for the treatment of CIPN
CN105130961B (zh) * 2015-08-06 2018-02-16 苏州晶云药物科技有限公司 Abt‑888的晶型b及其制备方法和应用
CN106995436A (zh) * 2016-01-25 2017-08-01 重庆医药工业研究院有限责任公司 一种维利帕尼晶型a及其制备方法
US20190092756A1 (en) * 2016-03-09 2019-03-28 Crystal Pharmatech Co., Ltd. Crystalline form a of 2-[(2r)-2-methyl-2-pyrrolidyl]-1h-benzimidazole-7-carboxamide dihydrochloride and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110816A2 (en) * 2005-04-11 2006-10-19 Abbott Laboratories 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1184208C (zh) * 1998-11-27 2005-01-12 巴斯福股份公司 取代的苯并咪唑及其制备和用途
SK9742002A3 (en) * 2000-01-07 2003-02-04 Transform Pharmaceuticals Inc High-throughput formation, identification, and analysis of diverse solid-forms
DE10021468A1 (de) * 2000-05-04 2001-11-08 Basf Ag Verwendung von PARP-Inhibitoren in kosmetischen Zubereitungen
CN1926127A (zh) * 2003-12-29 2007-03-07 万有制药株式会社 新的2－杂芳基取代苯并咪唑衍生物
KR20100090769A (ko) 2007-10-12 2010-08-17 아보트 러보러터리즈 2-((ｒ)-2-메틸피롤리딘-2-일)-1ｈ-벤즈이미다졸-4-카복스아미드 결정형 1

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006110816A2 (en) * 2005-04-11 2006-10-19 Abbott Laboratories 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6013016606; 岡野定舗編著、新・薬剤学総論（改訂第３版）、株式会社南江堂、１９８７年４月１０日発行、ｐ．２６，１１１，２５６，２５７ *
JPN6013016607; Ｃ．Ｇ．ＷＥＲＭＵＴＨ編、最新　創薬化学　下巻、株式会社テクノミック、平成１１年９月２５日発行、ｐ．４５２-４５３ *

Also Published As

Publication number Publication date
CN104230893A (zh) 2014-12-24
JP2014237660A (ja) 2014-12-18
JP2017071617A (ja) 2017-04-13
EP2217603A1 (en) 2010-08-18
WO2009049109A1 (en) 2009-04-16
CN101821269A (zh) 2010-09-01
US8013168B2 (en) 2011-09-06
CN101821269B (zh) 2014-05-28
US20090099246A1 (en) 2009-04-16
EP2727921A1 (en) 2014-05-07
EP2727921B1 (en) 2017-04-19
CA2696423A1 (en) 2009-04-16
EP2217603B1 (en) 2015-11-18
ES2562081T3 (es) 2016-03-02
MX2010003771A (es) 2010-04-21

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