ES2562081T3 - Forma cristalina 2 de 2-((R)-2-metilpirrolidin-2-il)-1H-bencimidazol-4-carboxamida - Google Patents
Forma cristalina 2 de 2-((R)-2-metilpirrolidin-2-il)-1H-bencimidazol-4-carboxamida Download PDFInfo
- Publication number
- ES2562081T3 ES2562081T3 ES08837011.9T ES08837011T ES2562081T3 ES 2562081 T3 ES2562081 T3 ES 2562081T3 ES 08837011 T ES08837011 T ES 08837011T ES 2562081 T3 ES2562081 T3 ES 2562081T3
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- Prior art keywords
- abt
- methylpyrrolidin
- carboxamide
- benzimidazol
- crystalline form
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97965407P | 2007-10-12 | 2007-10-12 | |
| US979654P | 2007-10-12 | ||
| PCT/US2008/079439 WO2009049109A1 (en) | 2007-10-12 | 2008-10-10 | 2-((r)-2-methylpyrrolidin-2-yl)-1h-benzimidazole-4-carboxamide crystalline form 2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2562081T3 true ES2562081T3 (es) | 2016-03-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08837011.9T Active ES2562081T3 (es) | 2007-10-12 | 2008-10-10 | Forma cristalina 2 de 2-((R)-2-metilpirrolidin-2-il)-1H-bencimidazol-4-carboxamida |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8013168B2 (enExample) |
| EP (2) | EP2727921B1 (enExample) |
| JP (3) | JP2011500588A (enExample) |
| CN (2) | CN101821269B (enExample) |
| CA (1) | CA2696423A1 (enExample) |
| ES (1) | ES2562081T3 (enExample) |
| MX (1) | MX2010003771A (enExample) |
| WO (1) | WO2009049109A1 (enExample) |
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| KR20100090769A (ko) * | 2007-10-12 | 2010-08-17 | 아보트 러보러터리즈 | 2-((ｒ)-2-메틸피롤리딘-2-일)-1ｈ-벤즈이미다졸-4-카복스아미드 결정형 1 |
| AU2012243132A1 (en) * | 2011-04-11 | 2013-10-24 | Abbvie Inc. | PARP inhibitors for the treatment of CIPN |
| CN105130961B (zh) * | 2015-08-06 | 2018-02-16 | 苏州晶云药物科技有限公司 | Abt‑888的晶型b及其制备方法和应用 |
| CN106995436A (zh) * | 2016-01-25 | 2017-08-01 | 重庆医药工业研究院有限责任公司 | 一种维利帕尼晶型a及其制备方法 |
| US20190092756A1 (en) * | 2016-03-09 | 2019-03-28 | Crystal Pharmatech Co., Ltd. | Crystalline form a of 2-[(2r)-2-methyl-2-pyrrolidyl]-1h-benzimidazole-7-carboxamide dihydrochloride and preparation method thereof |
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| CN1184208C (zh) * | 1998-11-27 | 2005-01-12 | 巴斯福股份公司 | 取代的苯并咪唑及其制备和用途 |
| SK9742002A3 (en) * | 2000-01-07 | 2003-02-04 | Transform Pharmaceuticals Inc | High-throughput formation, identification, and analysis of diverse solid-forms |
| DE10021468A1 (de) * | 2000-05-04 | 2001-11-08 | Basf Ag | Verwendung von PARP-Inhibitoren in kosmetischen Zubereitungen |
| CN1926127A (zh) * | 2003-12-29 | 2007-03-07 | 万有制药株式会社 | 新的2－杂芳基取代苯并咪唑衍生物 |
| TWI375673B (en) * | 2005-04-11 | 2012-11-01 | Abbott Lab | 1h-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent parp inhibitors |
| KR20100090769A (ko) | 2007-10-12 | 2010-08-17 | 아보트 러보러터리즈 | 2-((ｒ)-2-메틸피롤리딘-2-일)-1ｈ-벤즈이미다졸-4-카복스아미드 결정형 1 |
-
2008
- 2008-10-10 CA CA2696423A patent/CA2696423A1/en not_active Abandoned
- 2008-10-10 JP JP2010529062A patent/JP2011500588A/ja active Pending
- 2008-10-10 MX MX2010003771A patent/MX2010003771A/es active IP Right Grant
- 2008-10-10 US US12/248,988 patent/US8013168B2/en active Active
- 2008-10-10 EP EP14153258.0A patent/EP2727921B1/en active Active
- 2008-10-10 CN CN200880111585.7A patent/CN101821269B/zh not_active Expired - Fee Related
- 2008-10-10 ES ES08837011.9T patent/ES2562081T3/es active Active
- 2008-10-10 CN CN201410190297.2A patent/CN104230893A/zh active Pending
- 2008-10-10 WO PCT/US2008/079439 patent/WO2009049109A1/en not_active Ceased
- 2008-10-10 EP EP08837011.9A patent/EP2217603B1/en active Active
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2014
- 2014-07-10 JP JP2014142419A patent/JP2014237660A/ja active Pending
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2016
- 2016-11-11 JP JP2016220205A patent/JP2017071617A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN104230893A (zh) | 2014-12-24 |
| JP2014237660A (ja) | 2014-12-18 |
| JP2017071617A (ja) | 2017-04-13 |
| EP2217603A1 (en) | 2010-08-18 |
| WO2009049109A1 (en) | 2009-04-16 |
| CN101821269A (zh) | 2010-09-01 |
| US8013168B2 (en) | 2011-09-06 |
| CN101821269B (zh) | 2014-05-28 |
| US20090099246A1 (en) | 2009-04-16 |
| JP2011500588A (ja) | 2011-01-06 |
| EP2727921A1 (en) | 2014-05-07 |
| EP2727921B1 (en) | 2017-04-19 |
| CA2696423A1 (en) | 2009-04-16 |
| EP2217603B1 (en) | 2015-11-18 |
| MX2010003771A (es) | 2010-04-21 |
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