JP2011500077A5 - - Google Patents
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- Publication number
- JP2011500077A5 JP2011500077A5 JP2010530545A JP2010530545A JP2011500077A5 JP 2011500077 A5 JP2011500077 A5 JP 2011500077A5 JP 2010530545 A JP2010530545 A JP 2010530545A JP 2010530545 A JP2010530545 A JP 2010530545A JP 2011500077 A5 JP2011500077 A5 JP 2011500077A5
- Authority
- JP
- Japan
- Prior art keywords
- trna synthetase
- polypeptide
- trna
- nucleic acid
- acetyl lysine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000052866 Amino Acyl-tRNA Synthetases Human genes 0.000 claims 17
- 108700028939 Amino Acyl-tRNA Synthetases Proteins 0.000 claims 17
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- DTERQYGMUDWYAZ-ZETCQYMHSA-N N(6)-acetyl-L-lysine Chemical compound CC(=O)NCCCC[C@H]([NH3+])C([O-])=O DTERQYGMUDWYAZ-ZETCQYMHSA-N 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 108020005038 Terminator Codon Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229960003966 nicotinamide Drugs 0.000 claims 3
- 235000005152 nicotinamide Nutrition 0.000 claims 3
- 239000011570 nicotinamide Substances 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 108020004705 Codon Proteins 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 239000011436 cob Substances 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000006196 deacetylation Effects 0.000 claims 1
- 238000003381 deacetylation reaction Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0721291.3A GB0721291D0 (en) | 2007-10-30 | 2007-10-30 | Methods and compositions |
| PCT/GB2008/003611 WO2009056803A1 (en) | 2007-10-30 | 2008-10-27 | Methods and compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011500077A JP2011500077A (ja) | 2011-01-06 |
| JP2011500077A5 true JP2011500077A5 (enExample) | 2011-12-01 |
Family
ID=38834528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010530545A Pending JP2011500077A (ja) | 2007-10-30 | 2008-10-27 | 方法及び組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110027829A1 (enExample) |
| EP (1) | EP2212422A1 (enExample) |
| JP (1) | JP2011500077A (enExample) |
| CN (1) | CN101910403B (enExample) |
| CA (1) | CA2703847A1 (enExample) |
| GB (1) | GB0721291D0 (enExample) |
| WO (1) | WO2009056803A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2470770A (en) * | 2009-06-04 | 2010-12-08 | Medical Res Council | Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs |
| GB0917240D0 (en) | 2009-10-01 | 2009-11-18 | Medical Res Council | Incorporation of methyl lysine into poiypeptide |
| GB0917242D0 (en) | 2009-10-01 | 2009-11-18 | Medical Res Council | Acetyl lysine incorporation with tRNA synthetase |
| CN102939302A (zh) * | 2010-03-24 | 2013-02-20 | 医药研究委员会 | 方法 |
| JP6343604B2 (ja) * | 2012-05-18 | 2018-06-13 | メディカル リサーチ カウンシル | ＢＣＮ基を含むアミノ酸をコードする直交性コドンと、直交性ＰｙｌＲＳ合成酵素とを使用して、ＢＣＮ基を含むアミノ酸をポリペプチドに取り込む方法 |
| GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| CN105294475A (zh) * | 2015-11-14 | 2016-02-03 | 复旦大学 | 广谱的去乙酰化酶抑制剂乙酰化赖氨酸及其应用 |
| CN117286182A (zh) * | 2017-06-02 | 2023-12-26 | Ambrx公司 | 促进含非天然氨基酸的蛋白质产生的方法和组合物 |
| EP3818072A1 (en) * | 2018-07-03 | 2021-05-12 | Technische Universität München | Means and methods for site-specific protein modification using transpeptidases |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| CN111718920B (zh) * | 2019-03-19 | 2021-05-07 | 宁波鲲鹏生物科技有限公司 | 在蛋白中高效引入赖氨酸衍生物的氨酰基-tRNA合成酶 |
| EP4328308A1 (en) | 2022-08-22 | 2024-02-28 | Technische Universität Berlin | Modified trna-synthetase for the incorporation of non-canonical amino acids |
| GB202307998D0 (en) | 2023-05-29 | 2023-07-12 | Res & Innovation Uk | Aminoacyl-irna synthetase sets |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007099854A1 (ja) * | 2006-02-22 | 2007-09-07 | Riken | サプレッサーｔＲＮＡの合成方法、ＤＮＡ構築物及びそれを用いた非天然型アミノ酸組み込みタンパク質の製造 |
-
2007
- 2007-10-30 GB GBGB0721291.3A patent/GB0721291D0/en not_active Ceased
-
2008
- 2008-10-27 US US12/739,247 patent/US20110027829A1/en not_active Abandoned
- 2008-10-27 CA CA2703847A patent/CA2703847A1/en not_active Abandoned
- 2008-10-27 EP EP08844006A patent/EP2212422A1/en not_active Withdrawn
- 2008-10-27 CN CN2008801232954A patent/CN101910403B/zh not_active Expired - Fee Related
- 2008-10-27 JP JP2010530545A patent/JP2011500077A/ja active Pending
- 2008-10-27 WO PCT/GB2008/003611 patent/WO2009056803A1/en not_active Ceased
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