JP2011500077A - 方法及び組成物 - Google Patents
方法及び組成物 Download PDFInfo
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- JP2011500077A JP2011500077A JP2010530545A JP2010530545A JP2011500077A JP 2011500077 A JP2011500077 A JP 2011500077A JP 2010530545 A JP2010530545 A JP 2010530545A JP 2010530545 A JP2010530545 A JP 2010530545A JP 2011500077 A JP2011500077 A JP 2011500077A
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- trna synthetase
- trna
- polypeptide
- lysine
- acetyl lysine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- Chemical & Material Sciences (AREA)
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- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0721291.3A GB0721291D0 (en) | 2007-10-30 | 2007-10-30 | Methods and compositions |
| PCT/GB2008/003611 WO2009056803A1 (en) | 2007-10-30 | 2008-10-27 | Methods and compositions |
Publications (2)
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| JP2011500077A true JP2011500077A (ja) | 2011-01-06 |
| JP2011500077A5 JP2011500077A5 (enExample) | 2011-12-01 |
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| JP2010530545A Pending JP2011500077A (ja) | 2007-10-30 | 2008-10-27 | 方法及び組成物 |
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| EP (1) | EP2212422A1 (enExample) |
| JP (1) | JP2011500077A (enExample) |
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| CA (1) | CA2703847A1 (enExample) |
| GB (1) | GB0721291D0 (enExample) |
| WO (1) | WO2009056803A1 (enExample) |
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| GB2470770A (en) * | 2009-06-04 | 2010-12-08 | Medical Res Council | Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs |
| GB0917240D0 (en) | 2009-10-01 | 2009-11-18 | Medical Res Council | Incorporation of methyl lysine into poiypeptide |
| GB0917242D0 (en) | 2009-10-01 | 2009-11-18 | Medical Res Council | Acetyl lysine incorporation with tRNA synthetase |
| CN102939302A (zh) * | 2010-03-24 | 2013-02-20 | 医药研究委员会 | 方法 |
| JP6343604B2 (ja) * | 2012-05-18 | 2018-06-13 | メディカル リサーチ カウンシル | ＢＣＮ基を含むアミノ酸をコードする直交性コドンと、直交性ＰｙｌＲＳ合成酵素とを使用して、ＢＣＮ基を含むアミノ酸をポリペプチドに取り込む方法 |
| GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
| CN105294475A (zh) * | 2015-11-14 | 2016-02-03 | 复旦大学 | 广谱的去乙酰化酶抑制剂乙酰化赖氨酸及其应用 |
| CN117286182A (zh) * | 2017-06-02 | 2023-12-26 | Ambrx公司 | 促进含非天然氨基酸的蛋白质产生的方法和组合物 |
| EP3818072A1 (en) * | 2018-07-03 | 2021-05-12 | Technische Universität München | Means and methods for site-specific protein modification using transpeptidases |
| GB201817444D0 (en) | 2018-10-26 | 2018-12-12 | Res & Innovation Uk | Methods and compositions |
| CN111718920B (zh) * | 2019-03-19 | 2021-05-07 | 宁波鲲鹏生物科技有限公司 | 在蛋白中高效引入赖氨酸衍生物的氨酰基-tRNA合成酶 |
| EP4328308A1 (en) | 2022-08-22 | 2024-02-28 | Technische Universität Berlin | Modified trna-synthetase for the incorporation of non-canonical amino acids |
| GB202307998D0 (en) | 2023-05-29 | 2023-07-12 | Res & Innovation Uk | Aminoacyl-irna synthetase sets |
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| WO2007099854A1 (ja) * | 2006-02-22 | 2007-09-07 | Riken | サプレッサーｔＲＮＡの合成方法、ＤＮＡ構築物及びそれを用いた非天然型アミノ酸組み込みタンパク質の製造 |
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2007
- 2007-10-30 GB GBGB0721291.3A patent/GB0721291D0/en not_active Ceased
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2008
- 2008-10-27 US US12/739,247 patent/US20110027829A1/en not_active Abandoned
- 2008-10-27 CA CA2703847A patent/CA2703847A1/en not_active Abandoned
- 2008-10-27 EP EP08844006A patent/EP2212422A1/en not_active Withdrawn
- 2008-10-27 CN CN2008801232954A patent/CN101910403B/zh not_active Expired - Fee Related
- 2008-10-27 JP JP2010530545A patent/JP2011500077A/ja active Pending
- 2008-10-27 WO PCT/GB2008/003611 patent/WO2009056803A1/en not_active Ceased
Non-Patent Citations (3)
| Title |
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| JPN6013034546; Ｓｈｏｇｒｅｎ-Ｋｎａａｋ ｅｔ ａｌ: Ｓｃｉｅｎｃｅ Ｖｏｌ．３１１, ｐ．８４４-８４７ * |
| JPN6013034547; Ｘｉｅ Ｊ ａｎｄ Ｓｃｈｕｌｔｚ Ｐ Ｇ: Ｃｕｒｒｅｎｔ Ｏｐｉｎｉｏｎ ｉｎ Ｃｈｅｍｉｃａｌ Ｂｉｏｌｏｇｙ Ｖｏｌ．９, ｐ．５４８-５５４，２００５ * |
| JPN6013034548; Ｐｏｌｙｃａｒｐｏ Ｃ ｅｔ ａｌ: ＰＮＡＳ Ｖｏｌ．１０１，Ｎｏ．３４, ｐ．１２４５０-１２４５４ * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009056803A1 (en) | 2009-05-07 |
| US20110027829A1 (en) | 2011-02-03 |
| CN101910403B (zh) | 2013-08-07 |
| EP2212422A1 (en) | 2010-08-04 |
| GB0721291D0 (en) | 2007-12-12 |
| CA2703847A1 (en) | 2009-05-07 |
| CN101910403A (zh) | 2010-12-08 |
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