JP2011500035A5 - - Google Patents
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- Publication number
- JP2011500035A5 JP2011500035A5 JP2010529192A JP2010529192A JP2011500035A5 JP 2011500035 A5 JP2011500035 A5 JP 2011500035A5 JP 2010529192 A JP2010529192 A JP 2010529192A JP 2010529192 A JP2010529192 A JP 2010529192A JP 2011500035 A5 JP2011500035 A5 JP 2011500035A5
- Authority
- JP
- Japan
- Prior art keywords
- codon
- polynucleotide
- immune response
- synonymous
- construct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108091033319 polynucleotide Proteins 0.000 claims description 70
- 102000040430 polynucleotide Human genes 0.000 claims description 70
- 239000002157 polynucleotide Substances 0.000 claims description 70
- 108020004705 Codon Proteins 0.000 claims description 66
- 230000028993 immune response Effects 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 19
- 241000124008 Mammalia Species 0.000 claims description 17
- 239000000427 antigen Substances 0.000 claims description 16
- 108091007433 antigens Proteins 0.000 claims description 16
- 102000036639 antigens Human genes 0.000 claims description 16
- 229920001184 polypeptide Polymers 0.000 claims description 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 13
- 230000001105 regulatory effect Effects 0.000 claims description 8
- 150000007523 nucleic acids Chemical group 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 4
- 230000001747 exhibiting effect Effects 0.000 claims description 4
- 230000024932 T cell mediated immunity Effects 0.000 claims description 3
- 230000028996 humoral immune response Effects 0.000 claims description 3
- 230000002500 effect on skin Effects 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims 4
- 231100000765 toxin Toxicity 0.000 claims 4
- 108700012359 toxins Proteins 0.000 claims 4
- 230000000368 destabilizing effect Effects 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108010049048 Cholera Toxin Proteins 0.000 claims 1
- 102000009016 Cholera Toxin Human genes 0.000 claims 1
- 241000193163 Clostridioides difficile Species 0.000 claims 1
- 241000193155 Clostridium botulinum Species 0.000 claims 1
- 241000193468 Clostridium perfringens Species 0.000 claims 1
- 108091026890 Coding region Proteins 0.000 claims 1
- 108010053187 Diphtheria Toxin Proteins 0.000 claims 1
- 102000016607 Diphtheria Toxin Human genes 0.000 claims 1
- 101710146739 Enterotoxin Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108010081690 Pertussis Toxin Proteins 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 108090000848 Ubiquitin Proteins 0.000 claims 1
- 102000044159 Ubiquitin Human genes 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000147 enterotoxin Substances 0.000 claims 1
- 231100000655 enterotoxin Toxicity 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 1
- 210000000612 antigen-presenting cell Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98014507P | 2007-10-15 | 2007-10-15 | |
| US60/980,145 | 2007-10-15 | ||
| PCT/AU2008/001463 WO2009049350A1 (en) | 2007-10-15 | 2008-10-02 | Expression system for modulating an immune response |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014097256A Division JP6155223B2 (ja) | 2007-10-15 | 2014-05-09 | 免疫応答をモジュレートするための発現系 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500035A JP2011500035A (ja) | 2011-01-06 |
| JP2011500035A5 true JP2011500035A5 (https=) | 2012-02-02 |
| JP5543921B2 JP5543921B2 (ja) | 2014-07-09 |
Family
ID=40566909
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529193A Pending JP2011500036A (ja) | 2007-10-15 | 2008-10-02 | 構築物系およびその使用 |
| JP2010529192A Active JP5543921B2 (ja) | 2007-10-15 | 2008-10-02 | 免疫応答をモジュレートするための発現系 |
| JP2014097256A Active JP6155223B2 (ja) | 2007-10-15 | 2014-05-09 | 免疫応答をモジュレートするための発現系 |
| JP2014147453A Pending JP2014221068A (ja) | 2007-10-15 | 2014-07-18 | 構築物系およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529193A Pending JP2011500036A (ja) | 2007-10-15 | 2008-10-02 | 構築物系およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014097256A Active JP6155223B2 (ja) | 2007-10-15 | 2014-05-09 | 免疫応答をモジュレートするための発現系 |
| JP2014147453A Pending JP2014221068A (ja) | 2007-10-15 | 2014-07-18 | 構築物系およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9593340B2 (https=) |
| EP (2) | EP2215269B1 (https=) |
| JP (4) | JP2011500036A (https=) |
| AU (2) | AU2008314486B2 (https=) |
| DK (1) | DK2215269T3 (https=) |
| ES (1) | ES2662030T3 (https=) |
| WO (2) | WO2009049350A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101621100B1 (ko) | 2007-03-30 | 2016-05-13 | 더 리서치 파운데이션 오브 스테이트 유니버시티 오브 뉴욕 | 백신에 유용한 약독화 바이러스 |
| JP2011500036A (ja) | 2007-10-15 | 2011-01-06 | ザ ユニバーシティー オブ クイーンズランド | 構築物系およびその使用 |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| US9795658B2 (en) | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
| EP4015523A1 (en) | 2010-05-05 | 2022-06-22 | New York University | Staphylococcus aureus leukocidins, therapeutic compositions, and uses thereof |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| US9918724B2 (en) | 2012-12-27 | 2018-03-20 | Wright Medical Technology, Inc. | Ankle replacement system and method |
| WO2014150841A2 (en) * | 2013-03-15 | 2014-09-25 | Dow Corning Corporation | Powdered resin linear organopolysiloxane compositions |
| WO2015054639A1 (en) * | 2013-10-11 | 2015-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Epstein-barr virus vaccines |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| AU2015327767A1 (en) * | 2014-10-01 | 2017-04-20 | Jingang Medicine (Australia) Pty Ltd | Therapeutic compositions and methods for inducing an immune response to herpes simplex virus type 2 (HSV-2) |
| WO2016086988A1 (en) * | 2014-12-03 | 2016-06-09 | Wageningen Universiteit | Optimisation of coding sequence for functional protein expression |
| JP2018517708A (ja) | 2015-06-05 | 2018-07-05 | ニューヨーク・ユニバーシティ | 抗ブドウ球菌生物学的薬剤のための組成物及び方法 |
| US10724040B2 (en) | 2015-07-15 | 2020-07-28 | The Penn State Research Foundation | mRNA sequences to control co-translational folding of proteins |
| RU2744193C2 (ru) | 2015-10-16 | 2021-03-03 | Канзас Стейт Юниверсити Рисерч Фаундейшн | Иммуногенные композиции для иммунизации свиней против цирковируса типа 3 и способы их получения и применения |
| WO2017096432A1 (en) * | 2015-12-09 | 2017-06-15 | Admedus Vaccines Pty Ltd | Immunomodulating composition for treatment |
| US11197925B2 (en) | 2016-02-19 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Influenza B virus replication for vaccine development |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| MX2020014243A (es) | 2018-06-19 | 2021-05-12 | Biontech Us Inc | Neoantigenos y usos de los mismos. |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) * | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| CN114222579A (zh) | 2019-04-04 | 2022-03-22 | 勃林格殷格翰动物保健美国有限公司 | 猪圆环病毒3型（pcv3）疫苗及其生产和用途 |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
| CN111363008B (zh) * | 2020-03-18 | 2021-11-16 | 北京鼎成肽源生物技术有限公司 | 一种输卵管癌靶标抗原组合、输卵管癌靶标抗原组合刺激培养的ctl细胞及其应用 |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN115704012A (zh) * | 2021-08-12 | 2023-02-17 | 中国科学院深圳先进技术研究院 | 一种含有降解决定子的重组病毒及其制备方法和应用 |
| CN117448254B (zh) * | 2023-10-23 | 2024-04-09 | 广州梵之容化妆品有限公司 | 一种光果甘草干细胞的制备方法及用途 |
| CN120060262B (zh) * | 2025-04-25 | 2025-08-12 | 中国农业科学院茶叶研究所 | 茶树CsU3启动子及其应用 |
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| US9795658B2 (en) * | 2010-04-20 | 2017-10-24 | Admedus Vaccines Pty Ltd | Expression system for modulating an immune response |
-
2008
- 2008-10-02 JP JP2010529193A patent/JP2011500036A/ja active Pending
- 2008-10-02 EP EP08800100.3A patent/EP2215269B1/en active Active
- 2008-10-02 WO PCT/AU2008/001463 patent/WO2009049350A1/en not_active Ceased
- 2008-10-02 WO PCT/AU2008/001465 patent/WO2009049351A1/en not_active Ceased
- 2008-10-02 US US12/738,284 patent/US9593340B2/en active Active
- 2008-10-02 JP JP2010529192A patent/JP5543921B2/ja active Active
- 2008-10-02 EP EP08800098A patent/EP2215231A4/en not_active Withdrawn
- 2008-10-02 US US12/738,291 patent/US20120040367A1/en not_active Abandoned
- 2008-10-02 AU AU2008314486A patent/AU2008314486B2/en not_active Ceased
- 2008-10-02 ES ES08800100.3T patent/ES2662030T3/es active Active
- 2008-10-02 DK DK08800100.3T patent/DK2215269T3/en active
- 2008-10-02 AU AU2008314485A patent/AU2008314485B9/en not_active Ceased
-
2014
- 2014-05-09 JP JP2014097256A patent/JP6155223B2/ja active Active
- 2014-07-18 JP JP2014147453A patent/JP2014221068A/ja active Pending
-
2017
- 2017-01-17 US US15/408,201 patent/US20170218393A1/en not_active Abandoned
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