JP2011500005A5 - - Google Patents
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- JP2011500005A5 JP2011500005A5 JP2010528256A JP2010528256A JP2011500005A5 JP 2011500005 A5 JP2011500005 A5 JP 2011500005A5 JP 2010528256 A JP2010528256 A JP 2010528256A JP 2010528256 A JP2010528256 A JP 2010528256A JP 2011500005 A5 JP2011500005 A5 JP 2011500005A5
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- JP
- Japan
- Prior art keywords
- polypeptide
- nod
- sirpα
- human
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims description 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 27
- 210000002540 macrophage Anatomy 0.000 claims description 24
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims description 19
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000044459 human CD47 Human genes 0.000 claims description 11
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 claims description 8
- 239000012634 fragment Substances 0.000 claims description 7
- 241000282412 Homo Species 0.000 claims description 4
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
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- 101000863873 Homo sapiens Tyrosine-protein phosphatase non-receptor type substrate 1 Proteins 0.000 description 37
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- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 1
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Images
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96072407P | 2007-10-11 | 2007-10-11 | |
| PCT/CA2008/001814 WO2009046541A1 (en) | 2007-10-11 | 2008-10-10 | MODULATION OF SIRPα - CD47 INTERACTION FOR INCREASING HUMAN HEMATOPOIETIC STEM CELL ENGRAFTMENT AND COMPOUNDS THEREFOR |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011500005A JP2011500005A (ja) | 2011-01-06 |
| JP2011500005A5 true JP2011500005A5 (enExample) | 2011-11-24 |
Family
ID=40548916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010528256A Pending JP2011500005A (ja) | 2007-10-11 | 2008-10-10 | ヒト造血幹細胞の生着を増加させるためのＳＩＲＰα−ＣＤ４７相互作用の調節およびそのための化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20100239578A1 (enExample) |
| EP (3) | EP2207797A4 (enExample) |
| JP (1) | JP2011500005A (enExample) |
| CN (2) | CN103242444A (enExample) |
| AU (1) | AU2008310263B2 (enExample) |
| CA (1) | CA2702217A1 (enExample) |
| WO (1) | WO2009046541A1 (enExample) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008017473A2 (en) | 2006-08-08 | 2008-02-14 | Gunther Hartmann | Structure and use of 5' phosphate oligonucleotides |
| ES2796085T3 (es) | 2008-01-15 | 2020-11-25 | Univ Leland Stanford Junior | Marcadores de células madre de leucemia mieloide aguda |
| JP5547656B2 (ja) * | 2008-01-15 | 2014-07-16 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| AU2016203572A1 (en) * | 2008-01-15 | 2016-06-16 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for manipulating phagocytosis mediated by CD47 |
| AU2014201010B2 (en) * | 2008-01-15 | 2016-03-03 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for manipulating phagocytosis mediated by CD47 |
| US11072655B2 (en) | 2008-01-15 | 2021-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
| US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| EP2379584A1 (en) * | 2008-12-19 | 2011-10-26 | Novartis AG | Soluble polypeptides for use in treating autoimmune and inflammatory disorders |
| DK2429574T3 (da) * | 2009-05-15 | 2015-06-22 | Univ Health Network | Sammensætninger og fremgangsmåder til behandling af hæmatologiske cancere der targeterer sirp-cd47-interaktionen |
| WO2011076781A1 (en) | 2009-12-22 | 2011-06-30 | Novartis Ag | Tetravalent cd47-antibody constant region fusion protein for use in therapy |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| BR112013031762A2 (pt) * | 2011-06-16 | 2016-09-13 | Novartis Ag | proteínas solúveis para utilização como terapêuticos |
| AU2013209736C1 (en) * | 2012-01-17 | 2017-12-14 | The Board Of Trustees Of The Leland Stanford Junior University | High affinity SIRP-alpha reagents |
| RU2642319C2 (ru) * | 2012-09-07 | 2018-01-24 | Йель Юниверсити | Генетически модифицированные, не принадлежащие к человеческому роду животные и способ их использования |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
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| WO2018140940A1 (en) | 2017-01-30 | 2018-08-02 | The Board Of Trustees Of The Leland Stanford Junior University | A non-genotoxic conditioning regimen for stem cell transplantation |
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| CN108484774B (zh) * | 2018-03-09 | 2021-11-05 | 上海高菲生物科技有限公司 | 一种SIRPα融合蛋白及其制备方法和用途 |
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| CN116472351A (zh) | 2021-08-17 | 2023-07-21 | 杭州九源基因工程有限公司 | 靶向SIRPα的单克隆抗体及其用途 |
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| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US6641809B1 (en) | 1990-03-26 | 2003-11-04 | Bristol-Myers Squibb Company | Method of regulating cellular processes mediated by B7 and CD28 |
| US5844095A (en) | 1991-06-27 | 1998-12-01 | Bristol-Myers Squibb Company | CTLA4 Ig fusion proteins |
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| US6541615B1 (en) * | 1996-11-15 | 2003-04-01 | Max-Planck-Gellschaft Zur Foderung Der Wissenschaften E.V. | SIRP proteins and uses thereof |
| CA2226962A1 (en) * | 1998-02-16 | 1999-08-16 | Marie Sarfati | Use of binding agents to cd47 and its ligands in the treatment or the prophylaxis of various inflammatory, autoimmune and allergic diseases and in the treatment of graft rejection |
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2008
- 2008-10-10 EP EP08838285A patent/EP2207797A4/en not_active Withdrawn
- 2008-10-10 EP EP11169933A patent/EP2388270A3/en not_active Withdrawn
- 2008-10-10 CN CN2013101029534A patent/CN103242444A/zh active Pending
- 2008-10-10 EP EP12189613A patent/EP2573112A1/en not_active Withdrawn
- 2008-10-10 US US12/682,307 patent/US20100239578A1/en not_active Abandoned
- 2008-10-10 CA CA2702217A patent/CA2702217A1/en not_active Abandoned
- 2008-10-10 WO PCT/CA2008/001814 patent/WO2009046541A1/en not_active Ceased
- 2008-10-10 JP JP2010528256A patent/JP2011500005A/ja active Pending
- 2008-10-10 CN CN2008801197876A patent/CN101970478A/zh active Pending
- 2008-10-10 AU AU2008310263A patent/AU2008310263B2/en not_active Expired - Fee Related
-
2012
- 2012-10-30 US US13/663,801 patent/US20130189253A1/en not_active Abandoned
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