JP2011200233A5 - - Google Patents
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- JP2011200233A5 JP2011200233A5 JP2011095100A JP2011095100A JP2011200233A5 JP 2011200233 A5 JP2011200233 A5 JP 2011200233A5 JP 2011095100 A JP2011095100 A JP 2011095100A JP 2011095100 A JP2011095100 A JP 2011095100A JP 2011200233 A5 JP2011200233 A5 JP 2011200233A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- cytotoxic agent
- protein
- seq
- agent conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108090000623 proteins and genes Proteins 0.000 claims description 69
- 102000004169 proteins and genes Human genes 0.000 claims description 64
- 238000000034 method Methods 0.000 claims description 43
- 210000004027 cell Anatomy 0.000 claims description 38
- 239000000203 mixture Substances 0.000 claims description 31
- 229940127089 cytotoxic agent Drugs 0.000 claims description 28
- 239000002254 cytotoxic agent Substances 0.000 claims description 26
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 25
- 239000012634 fragment Substances 0.000 claims description 19
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 12
- 230000012010 growth Effects 0.000 claims description 12
- 201000000849 skin cancer Diseases 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 8
- 102000036639 antigens Human genes 0.000 claims description 8
- 108091007433 antigens Proteins 0.000 claims description 8
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 claims description 4
- 108010066676 Abrin Proteins 0.000 claims description 4
- 101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 210000004408 hybridoma Anatomy 0.000 claims description 3
- FBUTXZSKZCQABC-UHFFFAOYSA-N 2-amino-1-methyl-7h-purine-6-thione Chemical compound S=C1N(C)C(N)=NC2=C1NC=N2 FBUTXZSKZCQABC-UHFFFAOYSA-N 0.000 claims description 2
- 101001123514 Arabidopsis thaliana Pectinesterase 40 Proteins 0.000 claims description 2
- 108010092160 Dactinomycin Proteins 0.000 claims description 2
- 102000016607 Diphtheria Toxin Human genes 0.000 claims description 2
- 108010053187 Diphtheria Toxin Proteins 0.000 claims description 2
- 108700004714 Gelonium multiflorum GEL Proteins 0.000 claims description 2
- 229930192392 Mitomycin Natural products 0.000 claims description 2
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 2
- 229930012538 Paclitaxel Natural products 0.000 claims description 2
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims description 2
- 229930183665 actinomycin Natural products 0.000 claims description 2
- 108010001818 alpha-sarcin Proteins 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims description 2
- 229930195731 calicheamicin Natural products 0.000 claims description 2
- 229960001338 colchicine Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 108010028531 enomycin Proteins 0.000 claims description 2
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims description 2
- 229960005420 etoposide Drugs 0.000 claims description 2
- 229960004857 mitomycin Drugs 0.000 claims description 2
- 108010010621 modeccin Proteins 0.000 claims description 2
- 229960001592 paclitaxel Drugs 0.000 claims description 2
- 108010076042 phenomycin Proteins 0.000 claims description 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 2
- NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 claims description 2
- 229960001278 teniposide Drugs 0.000 claims description 2
- 229960003048 vinblastine Drugs 0.000 claims description 2
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims description 2
- 229960004528 vincristine Drugs 0.000 claims description 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims description 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 description 31
- 125000003729 nucleotide group Chemical group 0.000 description 31
- 108090000765 processed proteins & peptides Proteins 0.000 description 23
- 108091033319 polynucleotide Proteins 0.000 description 19
- 102000040430 polynucleotide Human genes 0.000 description 19
- 239000002157 polynucleotide Substances 0.000 description 19
- 239000000523 sample Substances 0.000 description 18
- 206010028980 Neoplasm Diseases 0.000 description 17
- 201000011510 cancer Diseases 0.000 description 17
- 102000004196 processed proteins & peptides Human genes 0.000 description 15
- 229920001184 polypeptide Polymers 0.000 description 11
- 210000001744 T-lymphocyte Anatomy 0.000 description 8
- 230000000295 complement effect Effects 0.000 description 8
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 7
- 108020004999 messenger RNA Proteins 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 150000007523 nucleic acids Chemical class 0.000 description 7
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 6
- 108091026890 Coding region Proteins 0.000 description 6
- 108020004459 Small interfering RNA Proteins 0.000 description 6
- 210000003719 b-lymphocyte Anatomy 0.000 description 6
- 230000010076 replication Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 230000035899 viability Effects 0.000 description 6
- 239000002299 complementary DNA Substances 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 210000000987 immune system Anatomy 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 3
- 102000053642 Catalytic RNA Human genes 0.000 description 3
- 108090000994 Catalytic RNA Proteins 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 210000002443 helper t lymphocyte Anatomy 0.000 description 3
- 108091092562 ribozyme Proteins 0.000 description 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44663303P | 2003-02-10 | 2003-02-10 | |
| US60/446,633 | 2003-02-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503486A Division JP2007524361A (ja) | 2003-02-10 | 2004-02-10 | 膀胱癌及びその他の癌の治療及び検出に有用な名称１５８ｐ１ｄ７の核酸及び対応タンパク質 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014246948A Division JP2015057068A (ja) | 2003-02-10 | 2014-12-05 | 膀胱癌及びその他の癌の治療及び検出に有用な名称１５８ｐ１ｄ７の核酸及び対応タンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011200233A JP2011200233A (ja) | 2011-10-13 |
| JP2011200233A5 true JP2011200233A5 (enExample) | 2012-09-06 |
Family
ID=32869540
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503486A Pending JP2007524361A (ja) | 2003-02-10 | 2004-02-10 | 膀胱癌及びその他の癌の治療及び検出に有用な名称１５８ｐ１ｄ７の核酸及び対応タンパク質 |
| JP2011095100A Pending JP2011200233A (ja) | 2003-02-10 | 2011-04-21 | 膀胱癌及びその他の癌の治療及び検出に有用な名称１５８ｐ１ｄ７の核酸及び対応タンパク質 |
| JP2014246948A Pending JP2015057068A (ja) | 2003-02-10 | 2014-12-05 | 膀胱癌及びその他の癌の治療及び検出に有用な名称１５８ｐ１ｄ７の核酸及び対応タンパク質 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503486A Pending JP2007524361A (ja) | 2003-02-10 | 2004-02-10 | 膀胱癌及びその他の癌の治療及び検出に有用な名称１５８ｐ１ｄ７の核酸及び対応タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014246948A Pending JP2015057068A (ja) | 2003-02-10 | 2014-12-05 | 膀胱癌及びその他の癌の治療及び検出に有用な名称１５８ｐ１ｄ７の核酸及び対応タンパク質 |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP2343315A3 (enExample) |
| JP (3) | JP2007524361A (enExample) |
| AU (3) | AU2004210975B2 (enExample) |
| CA (2) | CA2515699C (enExample) |
| IL (1) | IL170080A (enExample) |
| WO (1) | WO2004072263A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0501741D0 (en) * | 2005-01-27 | 2005-03-02 | Binding Site The Ltd | Antibody |
| EP1840133A1 (en) * | 2006-03-29 | 2007-10-03 | Global Biotech Development Corp. Ltd. | New immunomodulating oligopeptides |
| CA2647728C (en) * | 2006-03-31 | 2014-12-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of eg5 gene |
| JP2013179911A (ja) * | 2012-03-02 | 2013-09-12 | Dainippon Printing Co Ltd | 電極付き細胞試験具の接続装置、及びそれを用いた細胞試験装置 |
| SG11201501286PA (en) | 2012-08-23 | 2015-05-28 | Agensys Inc | Antibody drug conjugates (adc) that bind to 158p1d7 proteins |
| EP3579872A1 (en) * | 2017-02-10 | 2019-12-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway |
| JPWO2023105976A1 (enExample) * | 2021-12-08 | 2023-06-15 |
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| AU2001285210A1 (en) * | 2000-08-22 | 2002-03-04 | Agensys, Inc. | Nucleic acid and corresponding protein named 158p1d7 useful in the treatment and detection of bladder and other cancers |
| EP2298789B1 (en) * | 2000-09-08 | 2012-03-14 | Schering Corporation | Mammalian genes; related reagents and methods |
| WO2002026826A2 (en) * | 2000-09-27 | 2002-04-04 | Curagen Corporation | Proteins and nucleic acids encoding same |
| AU2002245317A1 (en) * | 2001-01-24 | 2002-08-06 | Protein Design Labs | Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer |
| WO2003102155A2 (en) * | 2002-06-03 | 2003-12-11 | Curagen Corporation | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| CN104010774B (zh) | 2011-09-15 | 2017-10-13 | 康富真信息技术股份有限公司 | 用于自动生成机器人程序的系统和方法 |
-
2004
- 2004-02-10 CA CA2515699A patent/CA2515699C/en not_active Expired - Lifetime
- 2004-02-10 EP EP10075689A patent/EP2343315A3/en not_active Withdrawn
- 2004-02-10 JP JP2006503486A patent/JP2007524361A/ja active Pending
- 2004-02-10 WO PCT/US2004/003984 patent/WO2004072263A2/en not_active Ceased
- 2004-02-10 EP EP04709923A patent/EP1594892A2/en not_active Withdrawn
- 2004-02-10 CA CA2860151A patent/CA2860151A1/en not_active Abandoned
- 2004-02-10 AU AU2004210975A patent/AU2004210975B2/en not_active Expired
-
2005
- 2005-08-04 IL IL170080A patent/IL170080A/en active IP Right Grant
-
2008
- 2008-07-10 AU AU2008203053A patent/AU2008203053B2/en not_active Expired
-
2010
- 2010-04-22 AU AU2010201615A patent/AU2010201615B2/en not_active Expired
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2011
- 2011-04-21 JP JP2011095100A patent/JP2011200233A/ja active Pending
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2014
- 2014-12-05 JP JP2014246948A patent/JP2015057068A/ja active Pending
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