JP2011168603A5 - - Google Patents

Download PDF

Info

Publication number
JP2011168603A5
JP2011168603A5 JP2011087496A JP2011087496A JP2011168603A5 JP 2011168603 A5 JP2011168603 A5 JP 2011168603A5 JP 2011087496 A JP2011087496 A JP 2011087496A JP 2011087496 A JP2011087496 A JP 2011087496A JP 2011168603 A5 JP2011168603 A5 JP 2011168603A5
Authority
JP
Japan
Prior art keywords
phe
lys
arg
composition
peptide represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011087496A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011168603A (ja
JP5650040B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2011168603A publication Critical patent/JP2011168603A/ja
Publication of JP2011168603A5 publication Critical patent/JP2011168603A5/ja
Application granted granted Critical
Publication of JP5650040B2 publication Critical patent/JP5650040B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2011087496A 2003-05-01 2011-04-11 細胞に分子を送達する方法及び担体複合体 Expired - Lifetime JP5650040B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46751603P 2003-05-01 2003-05-01
US60/467,516 2003-05-01

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006532552A Division JP4879020B2 (ja) 2003-05-01 2004-05-03 細胞に分子を送達する方法及び担体複合体

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014178031A Division JP5995930B2 (ja) 2003-05-01 2014-09-02 細胞に分子を送達する方法及び担体複合体

Publications (3)

Publication Number Publication Date
JP2011168603A JP2011168603A (ja) 2011-09-01
JP2011168603A5 true JP2011168603A5 (US07585860-20090908-C00112.png) 2012-07-12
JP5650040B2 JP5650040B2 (ja) 2015-01-07

Family

ID=33551404

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2006532552A Expired - Lifetime JP4879020B2 (ja) 2003-05-01 2004-05-03 細胞に分子を送達する方法及び担体複合体
JP2011087496A Expired - Lifetime JP5650040B2 (ja) 2003-05-01 2011-04-11 細胞に分子を送達する方法及び担体複合体
JP2014178031A Expired - Lifetime JP5995930B2 (ja) 2003-05-01 2014-09-02 細胞に分子を送達する方法及び担体複合体
JP2016050272A Expired - Lifetime JP6395749B2 (ja) 2003-05-01 2016-03-14 細胞に分子を送達する方法及び担体複合体
JP2018133252A Expired - Lifetime JP6698756B2 (ja) 2003-05-01 2018-07-13 細胞に分子を送達する方法及び担体複合体
JP2020032792A Pending JP2020105184A (ja) 2003-05-01 2020-02-28 細胞に分子を送達する方法及び担体複合体

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2006532552A Expired - Lifetime JP4879020B2 (ja) 2003-05-01 2004-05-03 細胞に分子を送達する方法及び担体複合体

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2014178031A Expired - Lifetime JP5995930B2 (ja) 2003-05-01 2014-09-02 細胞に分子を送達する方法及び担体複合体
JP2016050272A Expired - Lifetime JP6395749B2 (ja) 2003-05-01 2016-03-14 細胞に分子を送達する方法及び担体複合体
JP2018133252A Expired - Lifetime JP6698756B2 (ja) 2003-05-01 2018-07-13 細胞に分子を送達する方法及び担体複合体
JP2020032792A Pending JP2020105184A (ja) 2003-05-01 2020-02-28 細胞に分子を送達する方法及び担体複合体

Country Status (18)

Country Link
US (6) US7704954B2 (US07585860-20090908-C00112.png)
EP (7) EP2604285B1 (US07585860-20090908-C00112.png)
JP (6) JP4879020B2 (US07585860-20090908-C00112.png)
KR (1) KR101161823B1 (US07585860-20090908-C00112.png)
CN (2) CN101214380A (US07585860-20090908-C00112.png)
AU (1) AU2004252419B2 (US07585860-20090908-C00112.png)
BR (1) BRPI0409911A (US07585860-20090908-C00112.png)
CA (1) CA2524258C (US07585860-20090908-C00112.png)
DK (4) DK2604621T3 (US07585860-20090908-C00112.png)
ES (3) ES2520815T3 (US07585860-20090908-C00112.png)
HK (6) HK1089450A1 (US07585860-20090908-C00112.png)
MX (1) MXPA05011773A (US07585860-20090908-C00112.png)
NZ (1) NZ543410A (US07585860-20090908-C00112.png)
PL (2) PL2604286T3 (US07585860-20090908-C00112.png)
PT (2) PT2604286E (US07585860-20090908-C00112.png)
SI (1) SI2604285T1 (US07585860-20090908-C00112.png)
WO (1) WO2005001023A2 (US07585860-20090908-C00112.png)
ZA (1) ZA200509229B (US07585860-20090908-C00112.png)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030062788A (ko) * 2002-01-19 2003-07-28 포휴먼텍(주) 생체분자 전달 펩타이드 mph1-btm 및 이것을포함하는 생명공학제품
ES2436011T3 (es) 2003-02-04 2013-12-26 Cornell Research Foundation, Inc. Métodos para prevenir la transición de la permeabilidad mitocondrial
KR101161823B1 (ko) * 2003-05-01 2012-07-03 코넬 리서치 화운데이션,인크. 세포로 분자를 전달하는 방법 및 이것을 위한 캐리어 복합체
RU2376028C2 (ru) 2004-01-23 2009-12-20 Корнелл Рисеч Фаундейшн, Инк. Способ уменьшения окислительного повреждения (варианты)
US7534819B2 (en) * 2005-06-10 2009-05-19 University Of Washington Compositions and methods for intracellular delivery of biotinylated cargo
KR20140106761A (ko) * 2005-09-16 2014-09-03 코넬 리서치 화운데이션,인크. Cd36 발현을 감소시키는 방법
KR20080084937A (ko) * 2005-11-04 2008-09-22 포휴먼텍(주) 융합 폴리펩타이드를 세포로 전달하는 방법
EP2044108A4 (en) * 2006-07-24 2010-06-30 Forhumantech Co Ltd PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND TREATMENT OF ISCHEMIC SUDIDS AND METHOD FOR THEIR ADMINISTRATION
CN101511872A (zh) * 2006-08-29 2009-08-19 为人技术株式会社 用于抑制凋亡的药物组合物及其递送方法
PL2118123T3 (pl) 2007-01-31 2016-06-30 Dana Farber Cancer Inst Inc Stabilizowane peptydy p53 i ich zastosowania
CA2682174C (en) 2007-03-28 2021-04-06 President And Fellows Of Harvard College Stitched polypeptides
US7981446B2 (en) * 2007-11-26 2011-07-19 Forhumantech. Co., Ltd. Pharmaceutical compositions and methods for delivering nucleic acids into cells
SI2252312T1 (sl) 2008-02-07 2014-08-29 Cornell University, Postopki za preprečevanje ali zdravljenje insulinske rezistence
DK2262520T3 (en) 2008-02-26 2017-08-07 Univ Cornell COMPOSITIONS FOR PREVENTION AND TREATMENT OF Kidney Injury
ES2666458T3 (es) * 2008-09-22 2018-05-04 Aileron Therapeutics, Inc. Macrociclos peptidomiméticos
BRPI0920899A2 (pt) 2008-11-24 2016-04-26 Aileron Therapeutics Inc macrociclos peptidomiméticos com propriedades melhoradas
DE102008061044A1 (de) * 2008-12-11 2010-06-17 Henkel Ag & Co. Kgaa Zusammensetzung mit antioxidativ wirksamen Peptiden
US20100331265A1 (en) * 2009-03-20 2010-12-30 Tompkins Ronald G Methods for the prevention and treatment of burn injuries and secondary complications
HUE029550T2 (en) * 2009-08-12 2017-03-28 Univ Cornell Methods of preventing or treating metabolic syndrome
EP3318264A1 (en) 2009-08-24 2018-05-09 Stealth Peptides International, Inc. Methods ans compositions for preventing or treating opthalmic conditions
EP2944317A1 (en) 2009-10-05 2015-11-18 Cornell University Methods for the prevention or treatment of heart failure
US20110245183A1 (en) * 2010-04-06 2011-10-06 Perricone Nicholas V Topical Uses of Szeto-Schiller Peptides
US20110245182A1 (en) * 2010-04-06 2011-10-06 Perricone Nicholas V Topical Uses of Szeto-Schiller Peptides
EP3290433A1 (en) * 2010-05-03 2018-03-07 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
CN102010461B (zh) * 2010-10-11 2014-02-12 华南理工大学 一种alpha螺旋状阳离子多肽分子及其制法和应用
GB201018125D0 (en) * 2010-10-26 2010-12-08 Marealis As Peptide
CN107219358A (zh) * 2011-03-24 2017-09-29 康奈尔大学 芳香族阳离子肽及其用途
AU2012271691A1 (en) * 2011-06-14 2014-01-16 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
JP6025311B2 (ja) 2011-08-01 2016-11-16 キヤノン株式会社 眼科診断支援装置および方法
AU2012315586B2 (en) 2011-09-29 2017-07-20 Mayo Foundation For Medical Education And Research Aromatic-cationic peptides and methods for using same
AU2012326496B2 (en) * 2011-10-17 2017-08-24 Cornell University Aromatic-cationic peptides and uses of same
CN108929375A (zh) 2011-10-18 2018-12-04 爱勒让治疗公司 拟肽大环化合物
CN107312066A (zh) * 2011-12-09 2017-11-03 康德生物医疗技术公司 芳香族阳离子肽及其用途
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
ES2817877T3 (es) 2012-02-15 2021-04-08 Aileron Therapeutics Inc Macrociclos peptidomiméticos
CN104334181A (zh) * 2012-04-12 2015-02-04 康肽德生物医药技术有限公司 芳香族阳离子肽及其用途
AU2013296494B2 (en) * 2012-08-02 2018-04-26 Stealth Biotherapeutics Inc. Methods for treatment of atherosclerosis
WO2014138429A2 (en) 2013-03-06 2014-09-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and use thereof in regulating hif1alpha
US9850278B2 (en) 2013-04-25 2017-12-26 Carmel-Haifa University Economic Corp. Synthetic anti-inflammatory peptides and use thereof
WO2015134096A1 (en) * 2014-03-03 2015-09-11 Stealth Peptides International, Inc. Pharmaceutically relevant aromatic-cationic peptides
CA2950410A1 (en) * 2014-05-28 2015-12-03 D. Travis Wilson Therapeutic compositions including therapeutic small molecules and uses thereof
US10576124B2 (en) 2014-05-28 2020-03-03 Stealth Biotherapeutics Corp Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
HUE054626T2 (hu) * 2014-06-25 2021-09-28 Flamma Spa Eljárás D-arginil-2,6-dimetil-L-tirozil-L-lizil-L-fenilalaninamid elõállítására
ES2890676T3 (es) * 2014-06-30 2022-01-21 Flamma Spa Procedimiento para la producción de D-arginil-2,6-dimetil-L-tirosil-L-lisil-L-fenilalaninamida
WO2016004093A2 (en) * 2014-07-01 2016-01-07 Stealth Biotherapeutics Corp Therapeutic compositions including galectin-3 inhibitors and uses thereof
JP2017533889A (ja) 2014-09-24 2017-11-16 エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. ペプチド模倣大環状分子およびその使用
US20160228491A1 (en) * 2015-02-09 2016-08-11 Stealth Biotherapeutics Corp Therapeutic compositions including phenazine-3-one and phenothiazine-3-one derivatives and uses thereof
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2016209261A1 (en) * 2015-06-26 2016-12-29 Stealth Biotherapeutics Corp Therapeutic compositions including gramicidin s peptidyl conjugates or imidazole-substituted fatty acids, variants thereof, and uses thereof
EP3347372A4 (en) 2015-09-10 2019-09-04 Aileron Therapeutics, Inc. PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1
CN113876600B (zh) * 2015-10-21 2024-05-17 密歇根大学董事会 用纳米粒检测和治疗龋和微腔
US20200308220A1 (en) * 2015-11-30 2020-10-01 Peter Schiller Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome
EP3542822A4 (en) 2016-11-16 2020-08-19 Luca Science Inc. PROCESS FOR THE PRODUCTION OF MYOCARDIAL STEM CELL USED FOR THE TREATMENT AND / OR PREVENTION OF HEART ARREST
EP3563833B1 (en) * 2016-12-28 2024-06-26 Chugai Seiyaku Kabushiki Kaisha Self-emulsifying drug formulation for improving membrane permeability of compound
CN107230021B (zh) * 2017-06-08 2020-05-26 桂林理工大学 筛选供水管网泄漏区域的方法
EP3813883A1 (en) * 2018-06-29 2021-05-05 Glykos Biomedical Oy Conjugates
WO2021132735A2 (en) 2019-12-27 2021-07-01 Luca Science Inc. Isolated mitochondria with smaller size and lipid membrane-based vesicles encapsulating isolated mitochondria
WO2021216499A1 (en) * 2020-04-23 2021-10-28 North Carolina State University Cell-penetrating peptide-microrna conjugates for intracellular cell delivery
KR20240073137A (ko) 2020-09-09 2024-05-24 소셜 프로핏 네트워크 미토콘드리아에 비오틴의 전달을 위한 방법 및 조성물

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55500053A (US07585860-20090908-C00112.png) * 1978-01-16 1980-01-31
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
ATE136905T1 (de) * 1988-06-30 1996-05-15 Astra Ab Dermorphin-analoge, deren herstellungsverfahren, pharmazeutische zusammensetzungen und methode zur therapeutischen behandlung unter verwendung der analoge
US5602100A (en) * 1988-06-30 1997-02-11 Astra Ab Dermorphin analogs having pharmacological activity
US5652122A (en) * 1989-12-21 1997-07-29 Frankel; Alan Nucleic acids encoding and methods of making tat-derived transport polypeptides
US5169934A (en) * 1990-05-14 1992-12-08 Anergen, Inc. Intracellularly cleavable compounds
NL9001639A (nl) 1990-07-19 1992-02-17 Amc Amsterdam Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen.
US5714327A (en) 1990-07-19 1998-02-03 Kreatech Diagnostics Platinum-containing compounds, methods for their preparation and applications thereof
US5554728A (en) * 1991-07-23 1996-09-10 Nexstar Pharmaceuticals, Inc. Lipid conjugates of therapeutic peptides and protease inhibitors
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5674534A (en) 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
IS4261A (is) 1994-02-21 1995-08-22 Astra Aktiebolag Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra
EP0747092B1 (en) * 1995-06-09 2003-12-03 Hisamitsu Pharmaceutical Co., Inc. Matrix for iontophoresis
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US5885958A (en) * 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
CA2314267A1 (en) 1997-12-10 1999-06-17 Washington University Anti-pathogen system and methods of use thereof
WO1999055321A1 (en) * 1998-04-24 1999-11-04 Mitokor Compounds and methods for treating mitochondria-associated diseases
US7138103B2 (en) * 1998-06-22 2006-11-21 Immunomedics, Inc. Use of bi-specific antibodies for pre-targeting diagnosis and therapy
US6703381B1 (en) * 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
SE9900961D0 (sv) * 1999-03-16 1999-03-16 Astra Ab Novel compounds
US6669951B2 (en) * 1999-08-24 2003-12-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
EP1218544B1 (en) * 1999-10-04 2009-06-03 The University of Medicine and Dentistry of New Jersey TAR RNA binding peptides
US6759520B1 (en) * 1999-10-28 2004-07-06 The New England Medical Center Hospitals, Inc. Chimeric analgesic peptides
US20050192215A1 (en) * 2000-01-21 2005-09-01 Malabika Ghosh Methods and materials relating to novel polypeptides and polynucleotides
GB0005703D0 (en) * 2000-03-09 2000-05-03 Alpharma As Compounds
EP1303186B1 (en) * 2000-07-18 2011-01-26 Cornell Research Foundation, Inc. Medicinal uses of mu-opioid receptor agonists
US6900178B2 (en) * 2000-09-12 2005-05-31 University Of Kentucky Research Foundation Protection against ischemia and reperfusion injury
GB0026924D0 (en) * 2000-11-03 2000-12-20 Univ Cambridge Tech Antibacterial agents
CA2437983C (en) * 2001-02-16 2011-10-25 Cellgate, Inc. Transporters comprising spaced arginine moieties
DE10121982B4 (de) * 2001-05-05 2008-01-24 Lts Lohmann Therapie-Systeme Ag Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung
US20070015146A1 (en) * 2001-05-22 2007-01-18 Gene Logic, Inc. Molecular nephrotoxicology modeling
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
ES2436011T3 (es) * 2003-02-04 2013-12-26 Cornell Research Foundation, Inc. Métodos para prevenir la transición de la permeabilidad mitocondrial
KR101161823B1 (ko) * 2003-05-01 2012-07-03 코넬 리서치 화운데이션,인크. 세포로 분자를 전달하는 방법 및 이것을 위한 캐리어 복합체
WO2005032481A2 (en) * 2003-09-30 2005-04-14 Scios Inc. Quinazoline derivatives as medicaments
RU2376028C2 (ru) 2004-01-23 2009-12-20 Корнелл Рисеч Фаундейшн, Инк. Способ уменьшения окислительного повреждения (варианты)
US20050272101A1 (en) * 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
KR20140106761A (ko) * 2005-09-16 2014-09-03 코넬 리서치 화운데이션,인크. Cd36 발현을 감소시키는 방법
US20070259377A1 (en) * 2005-10-11 2007-11-08 Mickey Urdea Diabetes-associated markers and methods of use thereof
US20080027082A1 (en) * 2006-06-19 2008-01-31 Berthold Hocher Use of adenosine a1 antagonists in radiocontrast media induced nephropathy
SI2252312T1 (sl) * 2008-02-07 2014-08-29 Cornell University, Postopki za preprečevanje ali zdravljenje insulinske rezistence
DK2262520T3 (en) * 2008-02-26 2017-08-07 Univ Cornell COMPOSITIONS FOR PREVENTION AND TREATMENT OF Kidney Injury
CN112639591A (zh) 2018-06-29 2021-04-09 瑞尔D斯帕克有限责任公司 隐私显示的稳定化

Similar Documents

Publication Publication Date Title
JP2011168603A5 (US07585860-20090908-C00112.png)
FIC20240022I1 (fi) Retsafungiini tai sen farmaseuttisesti hyväksyttävä suola, erityisesti retsafungiiniasetaatti
JP2012081521A5 (US07585860-20090908-C00112.png)
JP2013525942A5 (US07585860-20090908-C00112.png)
JP2011170856A5 (US07585860-20090908-C00112.png)
MX2013012542A (es) Compuestos de amida y aplicacion farmaceutica para el mismo.
JP2011105738A5 (US07585860-20090908-C00112.png)
JP2015501646A5 (US07585860-20090908-C00112.png)
JP2013532130A5 (US07585860-20090908-C00112.png)
EA201490761A1 (ru) R(+)-n-формилпропаргиламиноиндан
JP2013543797A5 (US07585860-20090908-C00112.png)
ITAN20120150A1 (it) Servomeccanismo per l'apertura di una serratura.
EA201370149A1 (ru) Антагонисты рецептора
FI20116212A (fi) Polypeptidi
JP2012044147A5 (US07585860-20090908-C00112.png)
JP2011170857A5 (US07585860-20090908-C00112.png)
JP2011181497A5 (US07585860-20090908-C00112.png)
EP2668951A4 (en) 1,2,4-OXADIAZOL DERIVATIVES AS MODULATOR RECEPTOR MEDICINES FOR GLP-1 PEPTIDE
DK2785675T3 (da) 5,5-dimethyl-2-propyl-hexahydro-2,4a-methanonaphthalen-1-on som duftmiddel
ITMI20111829A1 (it) Procedimento per la preparazione di una composizione a base di equolo
CA2735430A1 (en) Straight-n-go
TH117776B (th) ชิ้นส่วนก่อสร้าง
TH122029B (th) ด้ามแปรงสีฟัน
TH120671B (th) ด้ามแปรงสีฟัน
TH117780B (th) ชิ้นส่วนก่อสร้าง