JP2011163986A - マイクロ流路デバイス - Google Patents
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Abstract
【解決手段】液を流通させる流路が設けられたマイクロ流路デバイスであって、本流路と、前記本流路を挟んで該本流路にそれぞれ接続する一対の分流路と、を備え、前記本流路は、第1の区間と、第2の区間と、前記第1の区間と前記第2の区間とを連結する連結区間と、を含み、前記第2の区間は、前記第1の区間に比べて、底面と天井面との間隔が小さく、前記連結区間は、前記第1の区間から前記第2の区間に向けて、底面と天井面との間隔が次第に小さくなっており、前記本流路における前記一対の分流路との接続区間と、前記連結区間とは、重なりを有し、前記一対の分流路は、少なくとも前記接続区間と前記連結区間とが重なる区間において、前記本流路の底面及び天井面を跨いで該本流路に接続している。
【選択図】図3
Description
分流路5の流路厚T3は、導入区間20における本流路4の流路厚T1と同じとなっており、接続区間24のうち導入区間20と重なる区間24bにおいて、基板2の表面を基準に、分流路5の底面32と本流路4の底面30とは同じ深さに位置し、よって、分流路5の天井面33と本流路4の天井面31とは同じ深さに位置している。即ち、区間24bにおいて、分流路5の底面32は、本流路4の底面30と面一であり、分流路5の天井面33は、本流路4の天井面31と面一である。なお、接続区間24のうち連結区間22と重なる区間24aにおいては、分流路5は、本流路4の底面30及び天井面31を跨いで本流路4に接続している。
2 基板
3 流路
4 本流路
5 分流路
10 基板部材
11 基板部材
12 溝
13 溝
14 導入孔
15 排出孔
20 導入区間
21 検出区間
22 連結区間
23 排出区間
24 接続区間
25 接続口
30 底面
31 天井面
32 底面
33 天井面
Claims (8)
- 液を流通させる流路が設けられたマイクロ流路デバイスであって、
前記流路は、本流路と、前記本流路を挟んで該本流路にそれぞれ接続する一対の分流路と、を備え、
前記本流路は、第1の区間と、第2の区間と、前記第1の区間と前記第2の区間とを連結する連結区間と、を含み、
前記第2の区間は、前記第1の区間に比べて、底面と天井面との間隔が小さく、
前記連結区間は、前記第1の区間から前記第2の区間に向けて、底面と天井面との間隔が次第に小さくなっており、
前記本流路における前記一対の分流路との接続区間と、前記連結区間とは、重なりを有し、
前記一対の分流路は、少なくとも前記接続区間と前記連結区間とが重なる区間において、前記本流路の底面及び天井面を跨いで該本流路に接続しているマイクロ流路デバイス。 - 請求項1記載のマイクロ流路デバイスであって、
前記接続区間は、前記第1の区間に及んでおり、
前記一対の分流路の各々の底面は、前記本流路の前記第1の区間における底面と面一であり、
前記一対の分流路の各々の天井面は、前記本流路の前記第1の区間における天井面と面一であるマイクロ流路デバイス。 - 請求項1又は請求項2に記載のマイクロ流路デバイスであって、
前記接続区間は、前記連結区間における前記第2の区間側の端に達しているか、又は前記第2の区間に及んでいるマイクロ流路デバイス。 - 請求項1から3のいずれか一項記載のマイクロ流路デバイスであって、
複数の基板部材が積層されてなる基板を備え、
前記本流路及び前記一対の分流路は、隣り合う二枚の前記基板部材の間に形成されており、前記一対の分流路は、これら二枚の基板部材に跨っているマイクロ流路デバイス。 - 請求項1から4のいずれか一項記載のマイクロ流路デバイスであって、
前記第2の区間は、毛細管力で液体が浸潤するマイクロ流路デバイス。 - 請求項1から4のいずれか一項記載のマイクロ流路デバイスであって、
前記第2の区間における底面と天井面との間隔は、0.2mm以下であるマイクロ流路デバイス。 - 請求項1から6のいずれか一項に記載のマイクロ流路デバイスであって、
前記第2の区間は、該第2の区間を流れる液に含まれる検出対象物質を検出する検出手段が設けられているマイクロ流路デバイス。 - 請求項7に記載のマイクロ流路デバイスであって、
前記検出対象物質は、抗原であり、
前記検出手段は、前記抗原を特異的に吸着する抗体であるマイクロ流路デバイス。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010028265A JP5250574B2 (ja) | 2010-02-10 | 2010-02-10 | マイクロ流路デバイス |
US13/024,079 US8470262B2 (en) | 2010-02-10 | 2011-02-09 | Microfluidic device |
EP11153981.3A EP2353721B1 (en) | 2010-02-10 | 2011-02-10 | Microfluidic device |
CN201110037570.4A CN102192977B (zh) | 2010-02-10 | 2011-02-10 | 微流体器件 |
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JP2010028265A JP5250574B2 (ja) | 2010-02-10 | 2010-02-10 | マイクロ流路デバイス |
Publications (2)
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JP2011163986A true JP2011163986A (ja) | 2011-08-25 |
JP5250574B2 JP5250574B2 (ja) | 2013-07-31 |
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US (1) | US8470262B2 (ja) |
EP (1) | EP2353721B1 (ja) |
JP (1) | JP5250574B2 (ja) |
CN (1) | CN102192977B (ja) |
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CA2872177A1 (en) | 2012-05-08 | 2013-11-14 | Quidel Corporation | Device for isolating an analyte from a sample, and methods of use |
WO2014031786A1 (en) * | 2012-08-23 | 2014-02-27 | Northwestern University | Device with controlled fluid dynamics, for isolation of an analyte from a sample |
EP3347691B1 (de) * | 2015-09-11 | 2022-01-12 | Leibniz-Institut für Photonische Technologien e.V. | Anordnung für die individualisierte patientenblutanalyse und verwendung |
JP6339274B1 (ja) * | 2017-06-19 | 2018-06-06 | 積水化学工業株式会社 | マイクロ流体デバイス |
WO2019007958A1 (en) * | 2017-07-05 | 2019-01-10 | miDiagnostics NV | DEVICE FOR DISSOLVING A REAGENT IN A FLUID IN A MICROFLUIDIC SYSTEM WITH CAPILLARY CONTROL |
Citations (3)
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JP2005181295A (ja) * | 2003-10-23 | 2005-07-07 | F Hoffmann La Roche Ag | 流動トリガー装置 |
JP2006337221A (ja) * | 2005-06-03 | 2006-12-14 | Sharp Corp | 電気化学検出装置 |
WO2009130976A1 (ja) * | 2008-04-25 | 2009-10-29 | アークレイ株式会社 | 微細流路および分析用具 |
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DE2934691C2 (de) * | 1979-08-28 | 1988-06-16 | Fresenius AG, 6380 Bad Homburg | Verfahren zur Durchführung von Analysen im Durchflußverfahren und Meßvorrichtung hierfür |
US6561208B1 (en) * | 2000-04-14 | 2003-05-13 | Nanostream, Inc. | Fluidic impedances in microfluidic system |
DE10302721A1 (de) * | 2003-01-23 | 2004-08-05 | Steag Microparts Gmbh | Mikrofluidische Anordnung zum Dosieren von Flüssigkeiten |
DE10345817A1 (de) * | 2003-09-30 | 2005-05-25 | Boehringer Ingelheim Microparts Gmbh | Verfahren und Vorrichtung zum Koppeln von Hohlfasern an ein mikrofluidisches Netzwerk |
WO2006022495A1 (en) * | 2004-08-21 | 2006-03-02 | Lg Chem, Ltd. | A capillary flow control module and lab-on-a-chip equipped with the same |
US20070280857A1 (en) * | 2006-06-02 | 2007-12-06 | Applera Corporation | Devices and Methods for Positioning Dried Reagent In Microfluidic Devices |
GB2446204A (en) * | 2007-01-12 | 2008-08-06 | Univ Brunel | A Microfluidic device |
CN101382538B (zh) * | 2007-09-04 | 2013-06-05 | 财团法人工业技术研究院 | 自动分流的微流体装置 |
CN101533005B (zh) * | 2009-04-14 | 2012-10-10 | 北京大学 | 微流分配装置、其制备方法及用途 |
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- 2011-02-09 US US13/024,079 patent/US8470262B2/en active Active
- 2011-02-10 CN CN201110037570.4A patent/CN102192977B/zh active Active
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JP2005181295A (ja) * | 2003-10-23 | 2005-07-07 | F Hoffmann La Roche Ag | 流動トリガー装置 |
JP2006337221A (ja) * | 2005-06-03 | 2006-12-14 | Sharp Corp | 電気化学検出装置 |
WO2009130976A1 (ja) * | 2008-04-25 | 2009-10-29 | アークレイ株式会社 | 微細流路および分析用具 |
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Publication number | Publication date |
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EP2353721B1 (en) | 2019-11-06 |
EP2353721A3 (en) | 2014-01-08 |
EP2353721A2 (en) | 2011-08-10 |
JP5250574B2 (ja) | 2013-07-31 |
CN102192977B (zh) | 2014-10-29 |
CN102192977A (zh) | 2011-09-21 |
US8470262B2 (en) | 2013-06-25 |
US20110194978A1 (en) | 2011-08-11 |
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