JP2011148817A5 - - Google Patents

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Publication number
JP2011148817A5
JP2011148817A5 JP2011061926A JP2011061926A JP2011148817A5 JP 2011148817 A5 JP2011148817 A5 JP 2011148817A5 JP 2011061926 A JP2011061926 A JP 2011061926A JP 2011061926 A JP2011061926 A JP 2011061926A JP 2011148817 A5 JP2011148817 A5 JP 2011148817A5
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JP
Japan
Prior art keywords
boron
following formula
trifluoride
benzoyl
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011061926A
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English (en)
Japanese (ja)
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JP2011148817A (ja
JP5351919B2 (ja
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Publication of JP2011148817A publication Critical patent/JP2011148817A/ja
Publication of JP2011148817A5 publication Critical patent/JP2011148817A5/ja
Application granted granted Critical
Publication of JP5351919B2 publication Critical patent/JP5351919B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2011061926A 2004-07-21 2011-03-22 アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製 Expired - Lifetime JP5351919B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58986604P 2004-07-21 2004-07-21
US60/589,866 2004-07-21
US60823004P 2004-09-09 2004-09-09
US60/608,230 2004-09-09

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2007522763A Division JP5078612B2 (ja) 2004-07-21 2005-07-21 アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製

Publications (3)

Publication Number Publication Date
JP2011148817A JP2011148817A (ja) 2011-08-04
JP2011148817A5 true JP2011148817A5 (enExample) 2011-12-08
JP5351919B2 JP5351919B2 (ja) 2013-11-27

Family

ID=35786706

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007522763A Expired - Lifetime JP5078612B2 (ja) 2004-07-21 2005-07-21 アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製
JP2011061926A Expired - Lifetime JP5351919B2 (ja) 2004-07-21 2011-03-22 アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2007522763A Expired - Lifetime JP5078612B2 (ja) 2004-07-21 2005-07-21 アルキル置換された２−デオキシ−２−フルオロ−ｄ−リボフラノシルピリミジン類及びプリン類及びそれらの誘導体の調製

Country Status (16)

Country Link
EP (2) EP1773856B1 (enExample)
JP (2) JP5078612B2 (enExample)
KR (2) KR101236669B1 (enExample)
CN (1) CN102199181B (enExample)
AT (1) ATE543789T1 (enExample)
AU (2) AU2005267051B2 (enExample)
CA (2) CA2735079C (enExample)
DK (1) DK1773856T3 (enExample)
ES (1) ES2386005T3 (enExample)
IL (2) IL180832A (enExample)
MX (1) MX2007000803A (enExample)
NZ (1) NZ552927A (enExample)
PL (1) PL1773856T3 (enExample)
PT (1) PT1773856E (enExample)
RU (1) RU2407747C2 (enExample)
WO (1) WO2006012440A2 (enExample)

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US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
WO2004002422A2 (en) 2002-06-28 2004-01-08 Idenix (Cayman) Limited 2’-c-methyl-3’-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
CN101172993A (zh) 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
ES2624353T3 (es) 2002-11-15 2017-07-13 Idenix Pharmaceuticals Llc 2'-Metil nucleósidos en combinación con interferón y mutación de Flaviviridae
RU2005121904A (ru) 2002-12-12 2006-01-20 Айденикс (Кайман) Лимитед (Ky) Способ получения 2`-разветвленных нуклеозидов
EP4032897B1 (en) 2003-05-30 2025-01-29 Gilead Pharmasset LLC Modified fluorinated nucleoside analogues
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
WO2006031725A2 (en) 2004-09-14 2006-03-23 Pharmasset, Inc. Preparation of 2'­fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
WO2008045419A1 (en) 2006-10-10 2008-04-17 Pharmasset, Inc. Preparation of nucleosides ribofuranosyl pyrimidines
WO2008074693A2 (en) * 2006-12-18 2008-06-26 F. Hoffmann-La Roche Ag Process for preparing 3,5-di-omicron-acyl-2-fluoro-2-c-methyl-d-ribono-gamma-lactone
US7951789B2 (en) 2006-12-28 2011-05-31 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of viral infections
WO2008090046A1 (en) * 2007-01-23 2008-07-31 F. Hoffmann-La Roche Ag Alternate process for preparing 3,5-di-omicron-acyl-2-fluoro-2-c-methyl-d-ribono-gamma-lactone
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
SG172359A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Nucleoside phosphoramidates
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
NZ593647A (en) * 2008-12-23 2013-08-30 Gilead Pharmasset Llc Synthesis of purine nucleosides
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
JP2013527145A (ja) 2010-03-31 2013-06-27 ギリード・ファーマセット・エルエルシー リン含有活性化剤の立体選択的合成
JP5716500B2 (ja) 2010-06-03 2015-05-13 セントラル硝子株式会社 （２Ｒ）−２−フルオロ−２−Ｃ−メチル−Ｄ−リボノ−γ−ラクトン類前駆体の製造方法
PT3042910T (pt) 2010-11-30 2019-04-16 Gilead Pharmasset Llc 2'-espiro-nucleósidos para utilização na terapia da hepatite c
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
CN103476783A (zh) 2011-04-13 2013-12-25 吉里德科学公司 用于抗病毒治疗的1’-取代的嘧啶n-核苷类似物
CA2840242C (en) 2011-09-16 2019-03-26 Gilead Sciences, Inc. Methods for treating hcv
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
KR20200060782A (ko) 2013-01-31 2020-06-01 길리애드 파마셋 엘엘씨 두 항바이러스 화합물의 병용 제형물
WO2014132975A1 (ja) * 2013-02-28 2014-09-04 セントラル硝子株式会社 （２Ｒ）－２－フルオロ－２－Ｃ－メチル－Ｄ－リボノ－γ－ラクトンの製造方法
JP6476591B2 (ja) * 2013-06-05 2019-03-06 セントラル硝子株式会社 （２Ｒ）−２−フルオロ−２−Ｃ−メチル−Ｄ−リボノ−γ−ラクトン類の製造方法
EP3650014B1 (en) 2013-08-27 2021-10-06 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
US10100075B2 (en) * 2013-12-23 2018-10-16 Mylan Laboratories Limited Process for the preparation of sofosbuvir
WO2016035006A1 (en) * 2014-09-01 2016-03-10 Dr. Reddy’S Laboratories Limited Novel nucleotide analogs, process for the preparation of sofosbuvir and its analogs, novel forms of sofosbuvir and solid dispersion of sofosbuvir
WO2016042576A1 (en) 2014-09-16 2016-03-24 Cadila Healthcare Limited Co-crystal of sofosbuvir and amino acid and process for preparation thereof
CN104327138B (zh) * 2014-10-21 2017-05-10 齐鲁制药有限公司 Psi‑7977中间体化合物的制备方法
USD791845S1 (en) 2015-09-22 2017-07-11 Samsung Electronics Co., Ltd. Door guard for refrigerator
USD791200S1 (en) 2015-09-24 2017-07-04 Samsung Electronics Co., Ltd. Door guard for refrigerator
US10239910B2 (en) 2016-07-20 2019-03-26 Optimus Drugs (P) Limited Process for the preparation of sofosbuvir
CN109422710B (zh) * 2017-08-28 2022-06-21 常州制药厂有限公司 一种索非布韦氟内酯中间体的制备方法
CN111362989B (zh) * 2020-03-19 2022-03-08 江苏工程职业技术学院 一种索非布韦关键中间体的制备方法
WO2021202669A2 (en) 2020-04-01 2021-10-07 Reyoung Corporation Nucleoside and nucleotide conjugate compounds and uses thereof

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US5A (en) * 1836-08-10 Thomas Blanchard Machine for mortising solid wooden shells of ships' tackle-blocks
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
YU25500A (sh) * 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
US6462191B1 (en) * 2000-07-13 2002-10-08 Air Products And Chemicals, Inc. Synthesis of 2-deoxy-2-fluoro-arabinose derivatives
HUP0400726A3 (en) * 2001-01-22 2007-05-29 Merck & Co Inc Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
AU2003269902A1 (en) * 2002-07-16 2004-02-02 Isis Pharmaceuticals, Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
EP4032897B1 (en) * 2003-05-30 2025-01-29 Gilead Pharmasset LLC Modified fluorinated nucleoside analogues

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