JP2011148777A - 液剤組成物 - Google Patents
液剤組成物 Download PDFInfo
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- JP2011148777A JP2011148777A JP2010283968A JP2010283968A JP2011148777A JP 2011148777 A JP2011148777 A JP 2011148777A JP 2010283968 A JP2010283968 A JP 2010283968A JP 2010283968 A JP2010283968 A JP 2010283968A JP 2011148777 A JP2011148777 A JP 2011148777A
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- bitterness
- hop extract
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- Prior art date
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- 239000007788 liquid Substances 0.000 title claims abstract description 22
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 239000000284 extract Substances 0.000 claims abstract description 17
- -1 acetal diethyl aminoacetate Chemical class 0.000 claims abstract description 12
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229920002554 vinyl polymer Polymers 0.000 claims abstract description 11
- 235000019658 bitter taste Nutrition 0.000 abstract description 21
- 238000013329 compounding Methods 0.000 abstract description 2
- 241000218228 Humulus Species 0.000 description 17
- 238000011156 evaluation Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 244000025221 Humulus lupulus Species 0.000 description 4
- 235000008694 Humulus lupulus Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- AKYHKWQPZHDOBW-UHFFFAOYSA-N (5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol Chemical compound OS(O)(=O)=O.C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 AKYHKWQPZHDOBW-UHFFFAOYSA-N 0.000 description 2
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
- 239000001576 FEMA 2977 Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 206010039897 Sedation Diseases 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- UAHWPYUMFXYFJY-UHFFFAOYSA-N beta-myrcene Chemical compound CC(C)=CCCC(=C)C=C UAHWPYUMFXYFJY-UHFFFAOYSA-N 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 229960003110 quinine sulfate Drugs 0.000 description 2
- 230000036280 sedation Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- DRSITEVYZGOOQG-UHFFFAOYSA-N Cohumulone Chemical compound CC(C)C(=O)C1=C(O)C(CC=C(C)C)=C(O)C(O)(CC=C(C)C)C1=O DRSITEVYZGOOQG-UHFFFAOYSA-N 0.000 description 1
- DRSITEVYZGOOQG-HXUWFJFHSA-N Cohumulone Natural products CC(C)C(=O)C1=C(O)C(CC=C(C)C)=C(O)[C@](O)(CC=C(C)C)C1=O DRSITEVYZGOOQG-HXUWFJFHSA-N 0.000 description 1
- RMFGNMMNUZWCRZ-UHFFFAOYSA-N Humulone Natural products CC(C)CC(=O)C1=C(O)C(O)(CC=C(C)C)C(O)=C(CC=C(C)C)C1=O RMFGNMMNUZWCRZ-UHFFFAOYSA-N 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 108010000817 Leuprolide Proteins 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- YPIGGYHFMKJNKV-UHFFFAOYSA-N N-ethylglycine Chemical compound CC[NH2+]CC([O-])=O YPIGGYHFMKJNKV-UHFFFAOYSA-N 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- LUJAXSNNYBCFEE-UHFFFAOYSA-N Quercetin 3,7-dimethyl ether Natural products C=1C(OC)=CC(O)=C(C(C=2OC)=O)C=1OC=2C1=CC=C(O)C(O)=C1 LUJAXSNNYBCFEE-UHFFFAOYSA-N 0.000 description 1
- PUTDIROJWHRSJW-UHFFFAOYSA-N Quercitrin Natural products CC1OC(Oc2cc(cc(O)c2O)C3=CC(=O)c4c(O)cc(O)cc4O3)C(O)C(O)C1O PUTDIROJWHRSJW-UHFFFAOYSA-N 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- OXGUCUVFOIWWQJ-XIMSSLRFSA-N acanthophorin B Natural products O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-XIMSSLRFSA-N 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- VYBREYKSZAROCT-UHFFFAOYSA-N alpha-myrcene Natural products CC(=C)CCCC(=C)C=C VYBREYKSZAROCT-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- HAVYZKHVTLAPDZ-RCHZWEEESA-N beta-Humulene Natural products C\C1=C\CC(C)(C)\C=C\CC(=C)CCC1 HAVYZKHVTLAPDZ-RCHZWEEESA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- VMSLCPKYRPDHLN-NRFANRHFSA-N humulone Chemical compound CC(C)CC(=O)C1=C(O)C(CC=C(C)C)=C(O)[C@@](O)(CC=C(C)C)C1=O VMSLCPKYRPDHLN-NRFANRHFSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 206010021654 increased appetite Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- RGLRXNKKBLIBQS-XNHQSDQCSA-N leuprolide acetate Chemical compound CC(O)=O.CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 RGLRXNKKBLIBQS-XNHQSDQCSA-N 0.000 description 1
- 229940087857 lupron Drugs 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- OEKUVLQNKPXSOY-UHFFFAOYSA-N quercetin 3-O-beta-D-glucopyranosyl(1->3)-alpha-L-rhamnopyranosyl(1->6)-beta-d-galactopyranoside Natural products OC1C(O)C(C(O)C)OC1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OEKUVLQNKPXSOY-UHFFFAOYSA-N 0.000 description 1
- QPHXPNUXTNHJOF-UHFFFAOYSA-N quercetin-7-O-beta-L-rhamnopyranoside Natural products OC1C(O)C(O)C(C)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 QPHXPNUXTNHJOF-UHFFFAOYSA-N 0.000 description 1
- OXGUCUVFOIWWQJ-HQBVPOQASA-N quercitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-HQBVPOQASA-N 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000011496 sports drink Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- HAVYZKHVTLAPDZ-PRUKLFJYSA-N β-humulene Chemical compound C\C1=C\CC(C)(C)\C=C/CC(=C)CCC1 HAVYZKHVTLAPDZ-PRUKLFJYSA-N 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Seasonings (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
【解決手段】ホップエキス及びポリビニルアセタールジエチルアミノアセテートを配合することを特徴とする液剤組成物。
【選択図】なし
Description
(1)ホップエキス及びポリビニルアセタールジエチルアミノアセテートを含有することを特徴とする液剤組成物、又は
(2)ホップエキス1質量部に対して、ポリビニルアセタールジエチルアミノアセテートを0.01質量部以上配合することを特徴とする、(1)に記載の液剤組成物である。
<実施例>
(1)苦味の評価
精製水にホップエキス(松浦薬業(株))200mg又は400mgを溶かし、その溶液に表1〜3に示す配合量のポリビニルアセタールジエチルアミノアセテート又はポピドンを添加・溶解させた。さらに精製水を加えて全量100mLとし、塩酸及び水酸化ナトリウムでpH3〜4.5に調整した。各試験液をガラスビンに充填後殺菌し、表1〜3に示す実施例1〜8及び比較例1〜6の液剤組成物を得た。
各液剤組成物約10mLを5秒間口に含んだ時に感じる苦味の最大値について、成人男女からなるパネルにより評価した。評価方法は、以下のスタンダードに対する相対評価とした。
Claims (2)
- ホップエキス及びポリビニルアセタールジエチルアミノアセテートを配合することを特徴とする液剤組成物。
- ホップエキス1質量部に対して、ポリビニルアセタールジエチルアミノアセテートを0.01質量部以上配合することを特徴とする、請求項1に記載の液剤組成物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010283968A JP5830855B2 (ja) | 2009-12-22 | 2010-12-21 | 液剤組成物 |
Applications Claiming Priority (3)
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---|---|---|---|
JP2009290880 | 2009-12-22 | ||
JP2009290880 | 2009-12-22 | ||
JP2010283968A JP5830855B2 (ja) | 2009-12-22 | 2010-12-21 | 液剤組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011148777A true JP2011148777A (ja) | 2011-08-04 |
JP5830855B2 JP5830855B2 (ja) | 2015-12-09 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2010283968A Active JP5830855B2 (ja) | 2009-12-22 | 2010-12-21 | 液剤組成物 |
Country Status (1)
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JP (1) | JP5830855B2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108524793A (zh) * | 2018-02-08 | 2018-09-14 | 芜湖市诺康生物科技有限公司 | 一种消肿利尿保健品及其制备方法 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6213326B2 (ja) * | 1978-07-14 | 1987-03-25 | Fujisawa Pharmaceutical Co | |
JP2879905B2 (ja) * | 1989-08-28 | 1999-04-05 | 武田薬品工業株式会社 | イブプロフェン含有経口投与用組成物 |
JP2001019639A (ja) * | 1999-07-07 | 2001-01-23 | Nitto Yakuhin Kogyo Kk | 感冒固形製剤 |
JP2002060339A (ja) * | 2000-08-17 | 2002-02-26 | Takeda Chem Ind Ltd | 高甘味度甘味料含有組成物およびその利用 |
JP2005272401A (ja) * | 2004-03-25 | 2005-10-06 | Tendou Seiyaku Kk | チュアブル錠 |
JP2006055074A (ja) * | 2004-08-20 | 2006-03-02 | Takeda-Kirin Foods Corp | ホップ抽出物含有組成物 |
JP2007269716A (ja) * | 2006-03-31 | 2007-10-18 | Sato Pharmaceutical Co Ltd | 塩酸セチリジン含有粒子 |
JP2008231008A (ja) * | 2007-03-19 | 2008-10-02 | Kobayashi Pharmaceut Co Ltd | 抗酸化作用を有する組成物 |
-
2010
- 2010-12-21 JP JP2010283968A patent/JP5830855B2/ja active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6213326B2 (ja) * | 1978-07-14 | 1987-03-25 | Fujisawa Pharmaceutical Co | |
JP2879905B2 (ja) * | 1989-08-28 | 1999-04-05 | 武田薬品工業株式会社 | イブプロフェン含有経口投与用組成物 |
JP2001019639A (ja) * | 1999-07-07 | 2001-01-23 | Nitto Yakuhin Kogyo Kk | 感冒固形製剤 |
JP2002060339A (ja) * | 2000-08-17 | 2002-02-26 | Takeda Chem Ind Ltd | 高甘味度甘味料含有組成物およびその利用 |
JP2005272401A (ja) * | 2004-03-25 | 2005-10-06 | Tendou Seiyaku Kk | チュアブル錠 |
JP2006055074A (ja) * | 2004-08-20 | 2006-03-02 | Takeda-Kirin Foods Corp | ホップ抽出物含有組成物 |
JP2007269716A (ja) * | 2006-03-31 | 2007-10-18 | Sato Pharmaceutical Co Ltd | 塩酸セチリジン含有粒子 |
JP2008231008A (ja) * | 2007-03-19 | 2008-10-02 | Kobayashi Pharmaceut Co Ltd | 抗酸化作用を有する組成物 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108524793A (zh) * | 2018-02-08 | 2018-09-14 | 芜湖市诺康生物科技有限公司 | 一种消肿利尿保健品及其制备方法 |
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