JP2011116782A5 - - Google Patents
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- Publication number
- JP2011116782A5 JP2011116782A5 JP2011051093A JP2011051093A JP2011116782A5 JP 2011116782 A5 JP2011116782 A5 JP 2011116782A5 JP 2011051093 A JP2011051093 A JP 2011051093A JP 2011051093 A JP2011051093 A JP 2011051093A JP 2011116782 A5 JP2011116782 A5 JP 2011116782A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- chloro
- leaving
- oxo
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000005499 phosphonyl group Chemical group 0.000 claims 2
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 238000006193 diazotization reaction Methods 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41391502P | 2002-09-25 | 2002-09-25 | |
| US60/413,915 | 2002-09-25 | ||
| US41632902P | 2002-10-04 | 2002-10-04 | |
| US60/416,329 | 2002-10-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005501990A Division JP4757632B2 (ja) | 2002-09-25 | 2003-09-25 | ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011116782A JP2011116782A (ja) | 2011-06-16 |
| JP2011116782A5 true JP2011116782A5 (enExample) | 2012-09-06 |
Family
ID=32045263
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005501990A Expired - Fee Related JP4757632B2 (ja) | 2002-09-25 | 2003-09-25 | ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法 |
| JP2011051093A Pending JP2011116782A (ja) | 2002-09-25 | 2011-03-09 | ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005501990A Expired - Fee Related JP4757632B2 (ja) | 2002-09-25 | 2003-09-25 | ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7572909B2 (enExample) |
| EP (1) | EP1556400B1 (enExample) |
| JP (2) | JP4757632B2 (enExample) |
| AU (1) | AU2003275267A1 (enExample) |
| CA (1) | CA2540158C (enExample) |
| ES (1) | ES2405825T3 (enExample) |
| WO (1) | WO2004028462A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004028462A2 (en) | 2002-09-25 | 2004-04-08 | Brigham Young University, Technology Transfer Office | Method for the preparation of 2-halo-2'-deoxyadenosine compounds from 2'-deoxyguanosine |
| DK2805723T3 (da) | 2004-12-22 | 2018-01-29 | Merck Serono Sa | Cladribin-regime til behandling af multipel sclerose |
| MX2008014971A (es) | 2006-05-24 | 2008-12-05 | Serono Lab | Regimen de cladribine para tratar esclerosis multiple. |
| DE602006009282D1 (de) | 2006-12-15 | 2009-10-29 | Explora Lab Sa | Verfahren zur Herstellung von Cladribin |
| RU2324699C1 (ru) * | 2007-02-05 | 2008-05-20 | Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Россиийской Академии Наук | СПОСОБ ПОЛУЧЕНИЯ 2,6-ДИХЛОР-9-(2,3,5-ТРИ-O-АЦЕТИЛ-β-D-РИБОФУРАНОЗИЛ)ПУРИНА |
| EP2343074A1 (en) | 2009-12-23 | 2011-07-13 | Merck Serono S.A. | Use of purine analogues for treating airway diseases |
| RU2649828C1 (ru) * | 2017-06-07 | 2018-04-04 | Государственное бюджетное учреждение здравоохранения города Москвы Московский клинический научно-практический центр им. А.С. Логинова Департамента здравоохранения города Москвы | Способ лечения волосатоклеточного лейкоза |
| CN111356460A (zh) | 2017-11-24 | 2020-06-30 | 默克专利股份公司 | 用于治疗进展型形式的多发性硬化症的克拉屈滨疗法 |
| CA3194812A1 (en) | 2020-09-10 | 2022-03-17 | Merck Patent Gmbh | Novel treatment regimen for the treatment of autoimmune disorders |
| US20240077481A1 (en) | 2021-03-03 | 2024-03-07 | Ares Trading S.A. | Improved treatment methods using dmds for the treatment of autoimmune diseases, and biomarker for predicting and/or optimising said treatment methods |
| TW202541818A (zh) | 2023-12-14 | 2025-11-01 | 瑞士商亞利斯貿易公司 | 用於治療重症肌無力之克拉屈濱(cladribine)療程 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1269659A (en) * | 1984-08-06 | 1990-05-29 | Brigham Young University | Method for the production of 2'-deoxyadenosine compounds |
| US4760137A (en) | 1984-08-06 | 1988-07-26 | Brigham Young University | Method for the production of 2'-deoxyadenosine compounds |
| DE3924424A1 (de) * | 1989-07-24 | 1991-01-31 | Boehringer Mannheim Gmbh | Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung |
| US5208327A (en) * | 1991-12-18 | 1993-05-04 | Ortho Pharmaceutical Corporation | Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine |
| US5602246A (en) * | 1992-11-25 | 1997-02-11 | Schering Aktiengesellschaft | Process for the preparation of fludarabine or fludarabine phosphate from guanosine |
| US6252061B1 (en) | 1998-03-23 | 2001-06-26 | Reliable Biopharmaceutical, Inc. | Process for the production of 2-halo-6-aminopurine derivatives |
| US6541626B2 (en) * | 2001-04-17 | 2003-04-01 | Isis Pharmaceuticals, Inc. | Process for selective N-acylation of purine nucleosides |
| WO2004028462A2 (en) | 2002-09-25 | 2004-04-08 | Brigham Young University, Technology Transfer Office | Method for the preparation of 2-halo-2'-deoxyadenosine compounds from 2'-deoxyguanosine |
-
2003
- 2003-09-25 WO PCT/US2003/030386 patent/WO2004028462A2/en not_active Ceased
- 2003-09-25 EP EP03759541.0A patent/EP1556400B1/en not_active Expired - Lifetime
- 2003-09-25 ES ES03759541T patent/ES2405825T3/es not_active Expired - Lifetime
- 2003-09-25 CA CA2540158A patent/CA2540158C/en not_active Expired - Fee Related
- 2003-09-25 US US10/529,106 patent/US7572909B2/en not_active Expired - Lifetime
- 2003-09-25 AU AU2003275267A patent/AU2003275267A1/en not_active Abandoned
- 2003-09-25 JP JP2005501990A patent/JP4757632B2/ja not_active Expired - Fee Related
-
2009
- 2009-07-02 US US12/497,287 patent/US8466275B2/en not_active Expired - Fee Related
-
2011
- 2011-03-09 JP JP2011051093A patent/JP2011116782A/ja active Pending