JP4757632B2 - ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法 - Google Patents

２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法 Download PDF

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Publication number
JP4757632B2
JP4757632B2 JP2005501990A JP2005501990A JP4757632B2 JP 4757632 B2 JP4757632 B2 JP 4757632B2 JP 2005501990 A JP2005501990 A JP 2005501990A JP 2005501990 A JP2005501990 A JP 2005501990A JP 4757632 B2 JP4757632 B2 JP 4757632B2
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group
chloro
aryl
alkyl
sulfonyl
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Japanese (ja)
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JP2006508183A (ja
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ジェイ． ロビンス、モリス
ジャネバ、ズラトコ
フランカム、ポーラ
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Brigham Young University
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Brigham Young University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
JP2005501990A 2002-09-25 2003-09-25 ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法 Expired - Fee Related JP4757632B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41391502P 2002-09-25 2002-09-25
US60/413,915 2002-09-25
US41632902P 2002-10-04 2002-10-04
US60/416,329 2002-10-04
PCT/US2003/030386 WO2004028462A2 (en) 2002-09-25 2003-09-25 Method for the preparation of 2-halo-2'-deoxyadenosine compounds from 2'-deoxyguanosine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011051093A Division JP2011116782A (ja) 2002-09-25 2011-03-09 ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法

Publications (2)

Publication Number Publication Date
JP2006508183A JP2006508183A (ja) 2006-03-09
JP4757632B2 true JP4757632B2 (ja) 2011-08-24

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2005501990A Expired - Fee Related JP4757632B2 (ja) 2002-09-25 2003-09-25 ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法
JP2011051093A Pending JP2011116782A (ja) 2002-09-25 2011-03-09 ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法

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JP2011051093A Pending JP2011116782A (ja) 2002-09-25 2011-03-09 ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法

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Country Link
US (2) US7572909B2 (enExample)
EP (1) EP1556400B1 (enExample)
JP (2) JP4757632B2 (enExample)
AU (1) AU2003275267A1 (enExample)
CA (1) CA2540158C (enExample)
ES (1) ES2405825T3 (enExample)
WO (1) WO2004028462A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4757632B2 (ja) 2002-09-25 2011-08-24 ブリガム ヤング ユニバーシティー ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法
DK2805723T3 (da) 2004-12-22 2018-01-29 Merck Serono Sa Cladribin-regime til behandling af multipel sclerose
CA2649810A1 (en) 2006-05-24 2007-11-29 Laboratoires Serono S.A. Cladribine regimen for treating multiple sclerosis
SI1932918T1 (sl) 2006-12-15 2010-02-26 Explora Lab Sa Postopek izdelave kladribina
RU2324699C1 (ru) * 2007-02-05 2008-05-20 Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Россиийской Академии Наук СПОСОБ ПОЛУЧЕНИЯ 2,6-ДИХЛОР-9-(2,3,5-ТРИ-O-АЦЕТИЛ-β-D-РИБОФУРАНОЗИЛ)ПУРИНА
EP2343074A1 (en) 2009-12-23 2011-07-13 Merck Serono S.A. Use of purine analogues for treating airway diseases
RU2649828C1 (ru) * 2017-06-07 2018-04-04 Государственное бюджетное учреждение здравоохранения города Москвы Московский клинический научно-практический центр им. А.С. Логинова Департамента здравоохранения города Москвы Способ лечения волосатоклеточного лейкоза
KR20250005506A (ko) 2017-11-24 2025-01-09 메르크 파텐트 게엠베하 진행 형태의 다발성 경화증의 치료에서 사용을 위한 클라드리빈 용법
IL301246A (en) 2020-09-10 2023-05-01 Merck Patent Gmbh Cladribine treatment regimen
EP4302091A1 (en) 2021-03-03 2024-01-10 Ares Trading S.A. Improved treatment methods using dmds for the treatment of autoimmune diseases, and biomarker for predicting and/or optimising said treatment methods
WO2025125527A1 (en) 2023-12-14 2025-06-19 Ares Trading S.A. Cladribine regimen for treating myasthenia gravis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61106594A (ja) * 1984-08-06 1986-05-24 ブリガム　ヤング　ユニヴア−シテイ プリン誘導体およびその製造法
JPH05255378A (ja) * 1991-12-18 1993-10-05 Ortho Pharmaceut Corp ２−クロル−２′−デオキシアデノシンの製造法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760137A (en) 1984-08-06 1988-07-26 Brigham Young University Method for the production of 2'-deoxyadenosine compounds
DE3924424A1 (de) * 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
US5602246A (en) * 1992-11-25 1997-02-11 Schering Aktiengesellschaft Process for the preparation of fludarabine or fludarabine phosphate from guanosine
US6252061B1 (en) * 1998-03-23 2001-06-26 Reliable Biopharmaceutical, Inc. Process for the production of 2-halo-6-aminopurine derivatives
US6541626B2 (en) * 2001-04-17 2003-04-01 Isis Pharmaceuticals, Inc. Process for selective N-acylation of purine nucleosides
JP4757632B2 (ja) * 2002-09-25 2011-08-24 ブリガム ヤング ユニバーシティー ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61106594A (ja) * 1984-08-06 1986-05-24 ブリガム　ヤング　ユニヴア−シテイ プリン誘導体およびその製造法
JPH05255378A (ja) * 1991-12-18 1993-10-05 Ortho Pharmaceut Corp ２−クロル−２′−デオキシアデノシンの製造法

Also Published As

Publication number Publication date
EP1556400A4 (en) 2009-11-18
US8466275B2 (en) 2013-06-18
US20090270604A1 (en) 2009-10-29
US7572909B2 (en) 2009-08-11
US20070032645A1 (en) 2007-02-08
JP2011116782A (ja) 2011-06-16
AU2003275267A1 (en) 2004-04-19
WO2004028462A3 (en) 2004-06-10
CA2540158C (en) 2011-07-05
CA2540158A1 (en) 2004-04-08
EP1556400A2 (en) 2005-07-27
WO2004028462A2 (en) 2004-04-08
ES2405825T3 (es) 2013-06-03
EP1556400B1 (en) 2013-05-01
AU2003275267A8 (en) 2004-04-19
JP2006508183A (ja) 2006-03-09
WO2004028462A9 (en) 2010-08-26

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