AU2003275267A1 - Method for the preparation of 2-halo-2'-deoxyadenosine compounds from 2'-deoxyguanosine - Google Patents
Method for the preparation of 2-halo-2'-deoxyadenosine compounds from 2'-deoxyguanosineInfo
- Publication number
- AU2003275267A1 AU2003275267A1 AU2003275267A AU2003275267A AU2003275267A1 AU 2003275267 A1 AU2003275267 A1 AU 2003275267A1 AU 2003275267 A AU2003275267 A AU 2003275267A AU 2003275267 A AU2003275267 A AU 2003275267A AU 2003275267 A1 AU2003275267 A1 AU 2003275267A1
- Authority
- AU
- Australia
- Prior art keywords
- deoxyguanosine
- halo
- preparation
- deoxyadenosine
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- YKBGVTZYEHREMT-KVQBGUIXSA-N 2'-deoxyguanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 YKBGVTZYEHREMT-KVQBGUIXSA-N 0.000 title 1
- YKBGVTZYEHREMT-UHFFFAOYSA-N 2'-deoxyguanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1CC(O)C(CO)O1 YKBGVTZYEHREMT-UHFFFAOYSA-N 0.000 title 1
- VGONTNSXDCQUGY-UHFFFAOYSA-N desoxyinosine Natural products C1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 VGONTNSXDCQUGY-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41391502P | 2002-09-25 | 2002-09-25 | |
| US60/413,915 | 2002-09-25 | ||
| US41632902P | 2002-10-04 | 2002-10-04 | |
| US60/416,329 | 2002-10-04 | ||
| PCT/US2003/030386 WO2004028462A2 (en) | 2002-09-25 | 2003-09-25 | Method for the preparation of 2-halo-2'-deoxyadenosine compounds from 2'-deoxyguanosine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003275267A1 true AU2003275267A1 (en) | 2004-04-19 |
| AU2003275267A8 AU2003275267A8 (en) | 2004-04-19 |
Family
ID=32045263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003275267A Abandoned AU2003275267A1 (en) | 2002-09-25 | 2003-09-25 | Method for the preparation of 2-halo-2'-deoxyadenosine compounds from 2'-deoxyguanosine |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7572909B2 (enExample) |
| EP (1) | EP1556400B1 (enExample) |
| JP (2) | JP4757632B2 (enExample) |
| AU (1) | AU2003275267A1 (enExample) |
| CA (1) | CA2540158C (enExample) |
| ES (1) | ES2405825T3 (enExample) |
| WO (1) | WO2004028462A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4757632B2 (ja) | 2002-09-25 | 2011-08-24 | ブリガム ヤング ユニバーシティー | ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法 |
| DK2805723T3 (da) | 2004-12-22 | 2018-01-29 | Merck Serono Sa | Cladribin-regime til behandling af multipel sclerose |
| CA2649810A1 (en) | 2006-05-24 | 2007-11-29 | Laboratoires Serono S.A. | Cladribine regimen for treating multiple sclerosis |
| SI1932918T1 (sl) | 2006-12-15 | 2010-02-26 | Explora Lab Sa | Postopek izdelave kladribina |
| RU2324699C1 (ru) * | 2007-02-05 | 2008-05-20 | Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Россиийской Академии Наук | СПОСОБ ПОЛУЧЕНИЯ 2,6-ДИХЛОР-9-(2,3,5-ТРИ-O-АЦЕТИЛ-β-D-РИБОФУРАНОЗИЛ)ПУРИНА |
| EP2343074A1 (en) | 2009-12-23 | 2011-07-13 | Merck Serono S.A. | Use of purine analogues for treating airway diseases |
| RU2649828C1 (ru) * | 2017-06-07 | 2018-04-04 | Государственное бюджетное учреждение здравоохранения города Москвы Московский клинический научно-практический центр им. А.С. Логинова Департамента здравоохранения города Москвы | Способ лечения волосатоклеточного лейкоза |
| KR20250005506A (ko) | 2017-11-24 | 2025-01-09 | 메르크 파텐트 게엠베하 | 진행 형태의 다발성 경화증의 치료에서 사용을 위한 클라드리빈 용법 |
| IL301246A (en) | 2020-09-10 | 2023-05-01 | Merck Patent Gmbh | Cladribine treatment regimen |
| EP4302091A1 (en) | 2021-03-03 | 2024-01-10 | Ares Trading S.A. | Improved treatment methods using dmds for the treatment of autoimmune diseases, and biomarker for predicting and/or optimising said treatment methods |
| WO2025125527A1 (en) | 2023-12-14 | 2025-06-19 | Ares Trading S.A. | Cladribine regimen for treating myasthenia gravis |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1269659A (en) * | 1984-08-06 | 1990-05-29 | Brigham Young University | Method for the production of 2'-deoxyadenosine compounds |
| US4760137A (en) | 1984-08-06 | 1988-07-26 | Brigham Young University | Method for the production of 2'-deoxyadenosine compounds |
| DE3924424A1 (de) * | 1989-07-24 | 1991-01-31 | Boehringer Mannheim Gmbh | Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung |
| US5208327A (en) * | 1991-12-18 | 1993-05-04 | Ortho Pharmaceutical Corporation | Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine |
| US5602246A (en) * | 1992-11-25 | 1997-02-11 | Schering Aktiengesellschaft | Process for the preparation of fludarabine or fludarabine phosphate from guanosine |
| US6252061B1 (en) * | 1998-03-23 | 2001-06-26 | Reliable Biopharmaceutical, Inc. | Process for the production of 2-halo-6-aminopurine derivatives |
| US6541626B2 (en) * | 2001-04-17 | 2003-04-01 | Isis Pharmaceuticals, Inc. | Process for selective N-acylation of purine nucleosides |
| JP4757632B2 (ja) * | 2002-09-25 | 2011-08-24 | ブリガム ヤング ユニバーシティー | ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法 |
-
2003
- 2003-09-25 JP JP2005501990A patent/JP4757632B2/ja not_active Expired - Fee Related
- 2003-09-25 AU AU2003275267A patent/AU2003275267A1/en not_active Abandoned
- 2003-09-25 EP EP03759541.0A patent/EP1556400B1/en not_active Expired - Lifetime
- 2003-09-25 CA CA2540158A patent/CA2540158C/en not_active Expired - Fee Related
- 2003-09-25 US US10/529,106 patent/US7572909B2/en not_active Expired - Lifetime
- 2003-09-25 ES ES03759541T patent/ES2405825T3/es not_active Expired - Lifetime
- 2003-09-25 WO PCT/US2003/030386 patent/WO2004028462A2/en not_active Ceased
-
2009
- 2009-07-02 US US12/497,287 patent/US8466275B2/en not_active Expired - Fee Related
-
2011
- 2011-03-09 JP JP2011051093A patent/JP2011116782A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1556400A4 (en) | 2009-11-18 |
| US8466275B2 (en) | 2013-06-18 |
| US20090270604A1 (en) | 2009-10-29 |
| US7572909B2 (en) | 2009-08-11 |
| JP4757632B2 (ja) | 2011-08-24 |
| US20070032645A1 (en) | 2007-02-08 |
| JP2011116782A (ja) | 2011-06-16 |
| WO2004028462A3 (en) | 2004-06-10 |
| CA2540158C (en) | 2011-07-05 |
| CA2540158A1 (en) | 2004-04-08 |
| EP1556400A2 (en) | 2005-07-27 |
| WO2004028462A2 (en) | 2004-04-08 |
| ES2405825T3 (es) | 2013-06-03 |
| EP1556400B1 (en) | 2013-05-01 |
| AU2003275267A8 (en) | 2004-04-19 |
| JP2006508183A (ja) | 2006-03-09 |
| WO2004028462A9 (en) | 2010-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |