JP2016145229A5 - - Google Patents
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- Publication number
- JP2016145229A5 JP2016145229A5 JP2016041446A JP2016041446A JP2016145229A5 JP 2016145229 A5 JP2016145229 A5 JP 2016145229A5 JP 2016041446 A JP2016041446 A JP 2016041446A JP 2016041446 A JP2016041446 A JP 2016041446A JP 2016145229 A5 JP2016145229 A5 JP 2016145229A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen atom
- formula
- monovalent
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 22
- -1 bicyclic aromatic compound Chemical class 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000006828 (C2-C7) alkoxycarbonyl group Chemical group 0.000 claims 6
- 125000003368 amide group Chemical group 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 4
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 4
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical group FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 3
- 238000001668 nucleic acid synthesis Methods 0.000 claims 3
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims 3
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 3
- 125000002103 4,4'-dimethoxytriphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 1
- 239000004971 Cross linker Substances 0.000 claims 1
- 238000006482 condensation reaction Methods 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 230000018044 dehydration Effects 0.000 claims 1
- 238000006297 dehydration reaction Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013070381 | 2013-03-28 | ||
| JP2013070381 | 2013-03-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015508725A Division JP5925383B2 (ja) | 2013-03-28 | 2014-03-27 | 光クロスリンク能を有する光応答性ヌクレオチドアナログ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016145229A JP2016145229A (ja) | 2016-08-12 |
| JP2016145229A5 true JP2016145229A5 (enExample) | 2017-04-27 |
| JP6312729B2 JP6312729B2 (ja) | 2018-04-18 |
Family
ID=51624521
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015508725A Active JP5925383B2 (ja) | 2013-03-28 | 2014-03-27 | 光クロスリンク能を有する光応答性ヌクレオチドアナログ |
| JP2016041446A Active JP6312729B2 (ja) | 2013-03-28 | 2016-03-03 | 光クロスリンク能を有する光応答性ヌクレオチドアナログ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015508725A Active JP5925383B2 (ja) | 2013-03-28 | 2014-03-27 | 光クロスリンク能を有する光応答性ヌクレオチドアナログ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10450334B2 (enExample) |
| EP (1) | EP2980073B1 (enExample) |
| JP (2) | JP5925383B2 (enExample) |
| CN (1) | CN105579437B (enExample) |
| CA (1) | CA2908379C (enExample) |
| WO (1) | WO2014157565A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2908379C (en) * | 2013-03-28 | 2021-03-30 | Japan Advanced Institute Of Science And Technology | Photoresponsive nucleotide analogue having photocrosslinking ability |
| CN105899525B (zh) * | 2013-10-30 | 2021-03-12 | 国立研究开发法人科学技术振兴机构 | 光交联的形成抑制方法、及自交联体形成抑制型光响应性核酸 |
| WO2018013999A1 (en) | 2016-07-15 | 2018-01-18 | Am Chemicals Llc | Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis |
| JP6920689B2 (ja) * | 2017-07-26 | 2021-08-18 | 日華化学株式会社 | 可視光域で光架橋可能な光応答性ヌクレオチドアナログ |
| US11214590B2 (en) | 2017-07-26 | 2022-01-04 | Japan Advanced Institute Of Science And Technology | Photoresponsive nucleotide analog capable of photocrosslinking in visible light region |
| JP7104399B2 (ja) * | 2018-04-04 | 2022-07-21 | 国立大学法人北陸先端科学技術大学院大学 | 光反応性人工アミノ酸、及び光架橋性人工ポリペプチド |
| CN115803462A (zh) | 2020-04-22 | 2023-03-14 | 日华化学株式会社 | 核酸的检测方法及寡核苷酸探针 |
| CN117105996B (zh) * | 2023-10-24 | 2024-02-06 | 北京瑞博奥医药科技有限公司 | 一种脱氧核糖衍生物的制备的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ239250A (en) * | 1990-08-09 | 1993-12-23 | Genta Inc | Chirally pure non-nucleotide reagents for use in preparing |
| JP3753942B2 (ja) | 2000-03-10 | 2006-03-08 | 独立行政法人科学技術振興機構 | ５−ピリミジン含有核酸、それを用いた可逆的連結方法 |
| JP3753938B2 (ja) | 2000-12-15 | 2006-03-08 | 独立行政法人科学技術振興機構 | 光連結性ヌクレオシド含有ｄｎａを用いて塩基を点変異する方法 |
| TW200528467A (en) * | 2004-02-27 | 2005-09-01 | Japan Science & Tech Agency | DNA enzyme and method of controlling the activity thereof |
| US8481714B2 (en) * | 2007-11-19 | 2013-07-09 | Japan Advanced Institute Of Science And Technology | Light-responsive artificial nucleotide having photo-crosslinking ability |
| JP4814904B2 (ja) | 2008-04-16 | 2011-11-16 | 国立大学法人北陸先端科学技術大学院大学 | 核酸類の配列選択的な精製方法 |
| CN102171234A (zh) * | 2008-08-05 | 2011-08-31 | 康奈尔大学 | 光交联核酸水凝胶 |
| WO2010147673A2 (en) * | 2009-06-19 | 2010-12-23 | University Of Florida Research Foundation, Inc. | Single-dna molecule nanomotor regulated by photons |
| CA2908379C (en) * | 2013-03-28 | 2021-03-30 | Japan Advanced Institute Of Science And Technology | Photoresponsive nucleotide analogue having photocrosslinking ability |
| CN105899525B (zh) * | 2013-10-30 | 2021-03-12 | 国立研究开发法人科学技术振兴机构 | 光交联的形成抑制方法、及自交联体形成抑制型光响应性核酸 |
-
2014
- 2014-03-27 CA CA2908379A patent/CA2908379C/en active Active
- 2014-03-27 WO PCT/JP2014/058988 patent/WO2014157565A1/ja not_active Ceased
- 2014-03-27 JP JP2015508725A patent/JP5925383B2/ja active Active
- 2014-03-27 US US14/780,187 patent/US10450334B2/en active Active
- 2014-03-27 CN CN201480030704.1A patent/CN105579437B/zh active Active
- 2014-03-27 EP EP14773781.1A patent/EP2980073B1/en active Active
-
2016
- 2016-03-03 JP JP2016041446A patent/JP6312729B2/ja active Active