JP2011042668A5 - - Google Patents
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- Publication number
- JP2011042668A5 JP2011042668A5 JP2010232760A JP2010232760A JP2011042668A5 JP 2011042668 A5 JP2011042668 A5 JP 2011042668A5 JP 2010232760 A JP2010232760 A JP 2010232760A JP 2010232760 A JP2010232760 A JP 2010232760A JP 2011042668 A5 JP2011042668 A5 JP 2011042668A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- adrenergic receptor
- receptor agonist
- composition according
- intravitreal administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 10
- 208000017442 Retinal disease Diseases 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- XYLJNLCSTIOKRM-UHFFFAOYSA-N Alphagan Chemical group C1=CC2=NC=CN=C2C(Br)=C1NC1=NCCN1 XYLJNLCSTIOKRM-UHFFFAOYSA-N 0.000 claims 4
- 229960003679 brimonidine Drugs 0.000 claims 4
- 239000007909 solid dosage form Substances 0.000 claims 4
- -1 2-imidazolin-2-ylamino group Chemical group 0.000 claims 3
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- 208000022873 Ocular disease Diseases 0.000 claims 2
- 208000030533 eye disease Diseases 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000008297 liquid dosage form Substances 0.000 claims 1
- 210000001328 optic nerve Anatomy 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 0 C*1C=NC(I(C)(*)=C*(/C=C/C2(C)*)NC(C)=NCCCN)=C2N=C1 Chemical compound C*1C=NC(I(C)(*)=C*(/C=C/C2(C)*)NC(C)=NCCCN)=C2N=C1 0.000 description 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/496,262 US5856329A (en) | 1995-06-28 | 1995-06-28 | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006000809A Division JP2006241138A (ja) | 1995-06-28 | 2006-01-05 | 網膜障害を処置するための医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011042668A JP2011042668A (ja) | 2011-03-03 |
| JP2011042668A5 true JP2011042668A5 (https=) | 2012-03-01 |
Family
ID=23971914
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50445497A Expired - Lifetime JP4621306B2 (ja) | 1995-06-28 | 1996-06-17 | 眼の神経損傷の処置に（２−イミダゾリン−２−イルアミノ）キノキサリンを使用する方法 |
| JP2006000809A Withdrawn JP2006241138A (ja) | 1995-06-28 | 2006-01-05 | 網膜障害を処置するための医薬組成物 |
| JP2010232760A Pending JP2011042668A (ja) | 1995-06-28 | 2010-10-15 | 網膜障害を処置するための医薬組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50445497A Expired - Lifetime JP4621306B2 (ja) | 1995-06-28 | 1996-06-17 | 眼の神経損傷の処置に（２−イミダゾリン−２−イルアミノ）キノキサリンを使用する方法 |
| JP2006000809A Withdrawn JP2006241138A (ja) | 1995-06-28 | 2006-01-05 | 網膜障害を処置するための医薬組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5856329A (https=) |
| EP (3) | EP1611891B1 (https=) |
| JP (3) | JP4621306B2 (https=) |
| KR (1) | KR19990028403A (https=) |
| CN (3) | CN1197391A (https=) |
| AT (2) | ATE447956T1 (https=) |
| AU (1) | AU715742B2 (https=) |
| BR (1) | BR9609219A (https=) |
| CA (1) | CA2225626C (https=) |
| DE (2) | DE69638072D1 (https=) |
| DK (1) | DK0835110T4 (https=) |
| ES (2) | ES2262157T5 (https=) |
| PT (1) | PT835110E (https=) |
| WO (1) | WO1997001339A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6294563B1 (en) | 1994-10-27 | 2001-09-25 | Allergan Sales, Inc. | Combinations of prostaglandins and brimonidine or derivatives thereof |
| US5856329A (en) * | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
| US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| WO1999025350A1 (en) * | 1997-11-14 | 1999-05-27 | Alcon Laboratories, Inc. | Treatment of diabetic retinopathy |
| US6242442B1 (en) | 1998-12-17 | 2001-06-05 | Alcon Laboratories, Inc. | Brinzolamide and brimonidine for treating ocular conditions |
| US6247473B1 (en) | 1999-02-18 | 2001-06-19 | Third Millenium Trust | System and method for testing the neuroprotective or neuroregenerative effects of drugs |
| HK1046108B (en) * | 1999-11-12 | 2007-01-05 | Alcon, Inc. | Neurophilin ligands for treating ocular conditions |
| US6294553B1 (en) * | 2000-02-15 | 2001-09-25 | Allergan Sales, Inc. | Method for treating ocular pain |
| DE10013318A1 (de) * | 2000-03-17 | 2001-09-20 | Merck Patent Gmbh | Formulierung enthaltend Chinoxalinderivate |
| PL360707A1 (en) * | 2000-07-14 | 2004-09-20 | Allergan Inc. | Compositions containing alpha-2-adrenergic agonist components |
| DE10035620B4 (de) * | 2000-07-21 | 2005-07-14 | *Acri.Tec Gesellschaft für ophthalmologische Produkte mbH | Verwendung von Taurin als neuroprotektives Agens in der Ophthalmologie |
| US20030082183A1 (en) * | 2000-11-01 | 2003-05-01 | Wheeler Larry A. | Methods and compositions for treatment of ocular neovascularization and neural injury |
| AU2002248284A1 (en) * | 2000-11-01 | 2002-08-06 | Allergan, Inc. | Compositions for treatment of ocular neovascularization |
| US7030149B2 (en) * | 2002-04-19 | 2006-04-18 | Allergan, Inc. | Combination of brimonidine timolol for topical ophthalmic use |
| US7642258B2 (en) * | 2002-04-19 | 2010-01-05 | Allergan, Inc. | Combination of brimonidine and timolol for topical ophthalmic use |
| US8529927B2 (en) * | 2004-04-30 | 2013-09-10 | Allergan, Inc. | Alpha-2 agonist polymeric drug delivery systems |
| US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
| US8425929B2 (en) * | 2004-04-30 | 2013-04-23 | Allergan, Inc. | Sustained release intraocular implants and methods for preventing retinal dysfunction |
| JP2008501343A (ja) * | 2004-06-04 | 2008-01-24 | ワシントン・ユニバーシティ | 神経障害を治療するための方法および組成物 |
| US7534795B2 (en) * | 2005-10-25 | 2009-05-19 | Allergan, Inc. | Compounds and their use related to compositions for treating disease |
| WO2007056457A2 (en) | 2005-11-09 | 2007-05-18 | Combinatorx, Incorporated | Methods, compositions, and kits for the treatment of medical conditions |
| JP2009525970A (ja) * | 2006-02-06 | 2009-07-16 | ニコックス エス エイ | α２−アドレナリン受容体アゴニストとしてのアプラクロニジンおよびブリモドニジンのニトロオキシ含有誘導体 |
| US8969415B2 (en) | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| CN101821254B (zh) * | 2007-08-15 | 2013-10-09 | 阿勒根公司 | 肾上腺素能化合物 |
| US9095506B2 (en) | 2008-11-17 | 2015-08-04 | Allergan, Inc. | Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof |
| PH12012500928A1 (en) | 2009-11-09 | 2012-11-26 | Allergan Inc | Compositions and methods for stimulating hair growth |
| US9522153B2 (en) | 2009-12-22 | 2016-12-20 | Allergan, Inc. | Compositions and methods for lowering intraocular pressure |
| CN109602691A (zh) | 2013-02-15 | 2019-04-12 | 阿勒根公司 | 持续药物递送植入物 |
| JP6628252B2 (ja) * | 2014-02-28 | 2020-01-08 | 国立大学法人京都大学 | 虚血性眼疾患の処置用の医薬組成物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4029792A (en) * | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
| US4587257A (en) * | 1984-12-14 | 1986-05-06 | Alcon Laboratories, Inc. | Control of ocular bleeding using clonidine derivatives |
| US5021410A (en) * | 1989-05-22 | 1991-06-04 | Allergan, Inc. | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure |
| US5180721A (en) * | 1989-05-22 | 1993-01-19 | Allergan, Inc. | Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure |
| US5077292A (en) * | 1989-10-12 | 1991-12-31 | Allergan, Inc. | (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same |
| US5021416A (en) * | 1989-10-31 | 1991-06-04 | Allergan, Inc. | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
| US5215991A (en) * | 1990-01-26 | 1993-06-01 | Allergan, Inc. | Combination of selective alpha-adrenergic agonists and Na+ /H+ ex |
| SK77396A3 (en) † | 1993-12-17 | 1997-01-08 | Procter & Gamble | 6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists |
| WO1996013267A2 (en) * | 1994-10-27 | 1996-05-09 | Allergan | Combinations of prostaglandins and brimonidine or derivatives thereof for the treatment of glaucoma |
| US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US5856329A (en) * | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
-
1995
- 1995-06-28 US US08/496,262 patent/US5856329A/en not_active Expired - Lifetime
-
1996
- 1996-06-17 CN CN96196328A patent/CN1197391A/zh active Pending
- 1996-06-17 KR KR1019970709719A patent/KR19990028403A/ko not_active Ceased
- 1996-06-17 ES ES96923317T patent/ES2262157T5/es not_active Expired - Lifetime
- 1996-06-17 EP EP05076936A patent/EP1611891B1/en not_active Expired - Lifetime
- 1996-06-17 PT PT96923317T patent/PT835110E/pt unknown
- 1996-06-17 AU AU63864/96A patent/AU715742B2/en not_active Expired
- 1996-06-17 CN CN2006101011051A patent/CN1943577B/zh not_active Expired - Lifetime
- 1996-06-17 EP EP05028359A patent/EP1642581B1/en not_active Expired - Lifetime
- 1996-06-17 DK DK96923317.0T patent/DK0835110T4/da active
- 1996-06-17 BR BR9609219A patent/BR9609219A/pt not_active Application Discontinuation
- 1996-06-17 ES ES05028359T patent/ES2333339T3/es not_active Expired - Lifetime
- 1996-06-17 DE DE69638072T patent/DE69638072D1/de not_active Expired - Lifetime
- 1996-06-17 DE DE69636012T patent/DE69636012T3/de not_active Expired - Lifetime
- 1996-06-17 CA CA002225626A patent/CA2225626C/en not_active Expired - Lifetime
- 1996-06-17 EP EP96923317A patent/EP0835110B2/en not_active Expired - Lifetime
- 1996-06-17 JP JP50445497A patent/JP4621306B2/ja not_active Expired - Lifetime
- 1996-06-17 WO PCT/US1996/010468 patent/WO1997001339A1/en not_active Ceased
- 1996-06-17 CN CN200910178530A patent/CN101683343A/zh active Pending
- 1996-06-17 AT AT05028359T patent/ATE447956T1/de not_active IP Right Cessation
- 1996-06-17 AT AT96923317T patent/ATE322267T1/de active
-
2006
- 2006-01-05 JP JP2006000809A patent/JP2006241138A/ja not_active Withdrawn
-
2010
- 2010-10-15 JP JP2010232760A patent/JP2011042668A/ja active Pending
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