JP2010540593A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010540593A5 JP2010540593A5 JP2010527450A JP2010527450A JP2010540593A5 JP 2010540593 A5 JP2010540593 A5 JP 2010540593A5 JP 2010527450 A JP2010527450 A JP 2010527450A JP 2010527450 A JP2010527450 A JP 2010527450A JP 2010540593 A5 JP2010540593 A5 JP 2010540593A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- asthma
- dermatitis
- syndrome
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 Cc1ccccc1-c(cc1)c([C@@](*=O)[O-])cc1C1=NC(c(cccc2)c2OC)=*=CO1 Chemical compound Cc1ccccc1-c(cc1)c([C@@](*=O)[O-])cc1C1=NC(c(cccc2)c2OC)=*=CO1 0.000 description 11
- ZECNIOSRNLMLQL-UHFFFAOYSA-N CC(C(C=C1C2=[I]COC(c(cc3C)cnc3N3C(COC)CCC3)=N2)=CCC1OC)=C Chemical compound CC(C(C=C1C2=[I]COC(c(cc3C)cnc3N3C(COC)CCC3)=N2)=CCC1OC)=C ZECNIOSRNLMLQL-UHFFFAOYSA-N 0.000 description 1
- LMEIQOZLQFASPG-UHFFFAOYSA-N CC(C)Cc(cc1)ccc1C1=NC(c2ccccc2OC)=CCO1 Chemical compound CC(C)Cc(cc1)ccc1C1=NC(c2ccccc2OC)=CCO1 LMEIQOZLQFASPG-UHFFFAOYSA-N 0.000 description 1
- FJCWNYMWFMXWIG-UHFFFAOYSA-N CC(C1)C(OC)=CC(OC)=C1c(cc1)c(C)cc1-c1nc(-c(cccc2)c2OC)n[o]1 Chemical compound CC(C1)C(OC)=CC(OC)=C1c(cc1)c(C)cc1-c1nc(-c(cccc2)c2OC)n[o]1 FJCWNYMWFMXWIG-UHFFFAOYSA-N 0.000 description 1
- RDZNOCMUKDFOEB-UHFFFAOYSA-N CC(CCCC1)N1C(C=C1)=NCC=C1c1nc(-c(cc(cc2)F)c2OC)n[o]1 Chemical compound CC(CCCC1)N1C(C=C1)=NCC=C1c1nc(-c(cc(cc2)F)c2OC)n[o]1 RDZNOCMUKDFOEB-UHFFFAOYSA-N 0.000 description 1
- HBZMDATWKNBZOL-UHFFFAOYSA-N CN(CCOC1)C1I Chemical compound CN(CCOC1)C1I HBZMDATWKNBZOL-UHFFFAOYSA-N 0.000 description 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N CN1CCCCC1 Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 description 1
- GJSVCUHWEJFFMO-UHFFFAOYSA-N Cc(nccc1)c1I Chemical compound Cc(nccc1)c1I GJSVCUHWEJFFMO-UHFFFAOYSA-N 0.000 description 1
- YFSLWFVIZJXFTH-UHFFFAOYSA-N Cc1c(C)[o]nc1I Chemical compound Cc1c(C)[o]nc1I YFSLWFVIZJXFTH-UHFFFAOYSA-N 0.000 description 1
- MGGZZJQVRZTTSN-UHFFFAOYSA-N Cc1cc(-c2nc(-c(cccc3)c3OC(F)(F)F)n[o]2)ccc1-c1ccccc1OC Chemical compound Cc1cc(-c2nc(-c(cccc3)c3OC(F)(F)F)n[o]2)ccc1-c1ccccc1OC MGGZZJQVRZTTSN-UHFFFAOYSA-N 0.000 description 1
- XQPLNMPHXAMKKR-UHFFFAOYSA-N Cc1cc(-c2nc(-c(cccc3)c3OC)n[o]2)ccc1C1=CCCC=C1C Chemical compound Cc1cc(-c2nc(-c(cccc3)c3OC)n[o]2)ccc1C1=CCCC=C1C XQPLNMPHXAMKKR-UHFFFAOYSA-N 0.000 description 1
- FWIGHXDJQOUOMF-UHFFFAOYSA-N Cc1ccccc1-c(cc1)c(CN(C)C)cc1-c1nc(-c(cc(C=C)cc2)c2OC)n[o]1 Chemical compound Cc1ccccc1-c(cc1)c(CN(C)C)cc1-c1nc(-c(cc(C=C)cc2)c2OC)n[o]1 FWIGHXDJQOUOMF-UHFFFAOYSA-N 0.000 description 1
- PWMQGDXVGSGAHB-UHFFFAOYSA-N Cc1ccccc1-c(cc1)c(CN)cc1-c1nc(-c2cc(F)ccc2OC)n[o]1 Chemical compound Cc1ccccc1-c(cc1)c(CN)cc1-c1nc(-c2cc(F)ccc2OC)n[o]1 PWMQGDXVGSGAHB-UHFFFAOYSA-N 0.000 description 1
- MFQWILMXHRCFDY-UHFFFAOYSA-N Cc1ccccc1-c(ccc(-c1nc(-c2cc(F)ccc2OC)n[o]1)c1)c1C(O)=O Chemical compound Cc1ccccc1-c(ccc(-c1nc(-c2cc(F)ccc2OC)n[o]1)c1)c1C(O)=O MFQWILMXHRCFDY-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07117925.3 | 2007-10-04 | ||
| EP07117925 | 2007-10-04 | ||
| US99813607P | 2007-10-09 | 2007-10-09 | |
| US60/998,136 | 2007-10-09 | ||
| PCT/EP2008/063185 WO2009043890A1 (en) | 2007-10-04 | 2008-10-01 | Oxadiazole diaryl compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014197234A Division JP2015025001A (ja) | 2007-10-04 | 2014-09-26 | オキサジアゾール・ジアリール化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540593A JP2010540593A (ja) | 2010-12-24 |
| JP2010540593A5 true JP2010540593A5 (OSRAM) | 2013-10-24 |
| JP5727223B2 JP5727223B2 (ja) | 2015-06-03 |
Family
ID=38961274
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527450A Expired - Fee Related JP5727223B2 (ja) | 2007-10-04 | 2008-10-01 | オキサジアゾール・ジアリール化合物 |
| JP2014197234A Withdrawn JP2015025001A (ja) | 2007-10-04 | 2014-09-26 | オキサジアゾール・ジアリール化合物 |
| JP2016100693A Expired - Fee Related JP6224771B2 (ja) | 2007-10-04 | 2016-05-19 | オキサジアゾール・ジアリール化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014197234A Withdrawn JP2015025001A (ja) | 2007-10-04 | 2014-09-26 | オキサジアゾール・ジアリール化合物 |
| JP2016100693A Expired - Fee Related JP6224771B2 (ja) | 2007-10-04 | 2016-05-19 | オキサジアゾール・ジアリール化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8404676B2 (OSRAM) |
| EP (1) | EP2193126B1 (OSRAM) |
| JP (3) | JP5727223B2 (OSRAM) |
| KR (1) | KR20100083814A (OSRAM) |
| CN (2) | CN101815707B (OSRAM) |
| AR (1) | AR068730A1 (OSRAM) |
| AU (1) | AU2008306886B2 (OSRAM) |
| BR (1) | BRPI0817597A2 (OSRAM) |
| CA (1) | CA2696829C (OSRAM) |
| EA (1) | EA201070423A1 (OSRAM) |
| ES (1) | ES2547877T3 (OSRAM) |
| IL (1) | IL204520A (OSRAM) |
| MX (1) | MX2010003614A (OSRAM) |
| WO (1) | WO2009043890A1 (OSRAM) |
| ZA (1) | ZA201001217B (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2125797T3 (da) | 2007-03-16 | 2014-02-10 | Actelion Pharmaceuticals Ltd | Aminopyridinderivater som s1p1/edg1-receptoragonister |
| EP2193125B1 (en) | 2007-10-04 | 2017-01-11 | Merck Serono S.A. | Oxadiazole derivatives |
| MX2010003614A (es) * | 2007-10-04 | 2010-04-21 | Merck Serono Sa | Compuestos de diarilo oxadiazol. |
| US8551463B2 (en) | 2007-10-22 | 2013-10-08 | Living Proof, Inc. | Hair care compositions and methods of treating hair |
| KR20100110834A (ko) * | 2007-12-21 | 2010-10-13 | 메르크 세로노 에스. 에이. | 트리아졸 옥사다이아졸 유도체 |
| CA2714665A1 (en) * | 2008-03-06 | 2009-09-11 | Actelion Pharmaceuticals Ltd | Pyridine compounds |
| KR20100125380A (ko) | 2008-03-07 | 2010-11-30 | 액테리온 파마슈티칼 리미티드 | 신규한 아미노메틸 벤젠 유도체 |
| CN102361869A (zh) | 2009-01-23 | 2012-02-22 | 百时美施贵宝公司 | 在治疗自身免疫性疾病和炎性疾病中作为s1p激动剂的取代的噁二唑衍生物 |
| JP2012515789A (ja) | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | スフィンゴシン−１−リン酸アゴニストとしてのピラゾール−１，２，４−オキサジアゾール誘導体 |
| EP2382212B1 (en) | 2009-01-23 | 2014-07-16 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
| KR101409131B1 (ko) | 2009-07-16 | 2014-06-17 | 액테리온 파마슈티칼 리미티드 | 피리딘-4-일 유도체 |
| US8399451B2 (en) | 2009-08-07 | 2013-03-19 | Bristol-Myers Squibb Company | Heterocyclic compounds |
| WO2011133734A1 (en) | 2010-04-23 | 2011-10-27 | Bristol-Myers Squibb Company | 4 - (5 - isoxazolyl or 5 - pyrrazolyl -1,2,4- oxadiazol - 3 - yl) -mandelic acid amides as sphingosin- 1 - phosphate 1 rreceptor agonists |
| US8318783B2 (en) | 2010-04-27 | 2012-11-27 | Allergan, Inc. | 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-aryl-1,2,4-oxadiazole derivatives as sphingosine-1 phosphate receptors modulators |
| CN103237795B (zh) * | 2010-09-24 | 2015-10-21 | 百时美施贵宝公司 | 经取代的噁二唑化合物及其作为s1p1激动剂的用途 |
| WO2012098505A1 (en) | 2011-01-19 | 2012-07-26 | Actelion Pharmaceuticals Ltd | 2-methoxy-pyridin-4-yl derivatives |
| US9073881B2 (en) * | 2011-09-23 | 2015-07-07 | Hoffmann-La Roche Inc. | Benzoic acid derivatives |
| EP3298008B1 (en) | 2015-05-20 | 2019-11-20 | Idorsia Pharmaceuticals Ltd | Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol |
| EP4240350A4 (en) * | 2020-11-09 | 2024-09-18 | Arena Pharmaceuticals, Inc. | <sup2/>? <sub2/>?1?methods of treating conditions related to the s1preceptor |
| EP4050002A1 (en) * | 2021-02-26 | 2022-08-31 | First Health Pharmaceuticals B.V. | Anti-proliferative agents |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH623971B5 (de) | 1976-06-04 | 1982-01-15 | Hoechst Ag | Verfahren zur herstellung neuer benzofuranderivate und deren verwendung als optische aufheller. |
| US4135910A (en) * | 1977-05-12 | 1979-01-23 | Monsanto Company | Oxadiazol-3-yl-benzoates as plant growth regulants |
| DE4320801A1 (de) | 1993-06-23 | 1995-01-05 | Fahlberg List Pharma Gmbh | 2-Hydroxyphenylsubstituierte 1,2,4-Triazole und 1,2,4-Oxadiazole, ihre Verwendung als pharmazeutische Wirkstoffe und sie enthaltende Arzneimittel |
| DE19643037A1 (de) * | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| AUPP999799A0 (en) | 1999-04-27 | 1999-05-20 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| DK3549936T3 (da) | 2003-04-11 | 2021-07-12 | Ptc Therapeutics Inc | 1,2,4-oxadiazol-benzoesyreforbindelse og dens anvendelse til nonsense-undertrykkelse og behandlingen af sygdom |
| WO2004103279A2 (en) * | 2003-05-15 | 2004-12-02 | Merck & Co., Inc. | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists |
| EP1670463A2 (en) * | 2003-10-01 | 2006-06-21 | Merck & Co., Inc. | 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists |
| CN1894225A (zh) * | 2003-12-17 | 2007-01-10 | 默克公司 | 作为鞘氨醇1－磷酸(内皮分化基因)受体激动剂的(3,4－二取代)丙酸酯 |
| WO2005108370A1 (ja) * | 2004-04-16 | 2005-11-17 | Ajinomoto Co., Inc. | ベンゼン化合物 |
| EP2336113A1 (en) | 2004-05-29 | 2011-06-22 | 7TM Pharma A/S | CRTH2 Receptor Ligands for Medical Use |
| CN101043887A (zh) * | 2004-10-22 | 2007-09-26 | 默克公司 | 用作s1p受体激动剂的2－(芳基)氮杂环甲基羧酸酯、磺酸酯、膦酸酯、次膦酸酯和杂环化合物 |
| BRPI0612028A2 (pt) * | 2005-06-08 | 2010-10-13 | Novartis Ag | oxadiazóis ou isodiazóis policìclicos e uso dos mesmos como ligantes de receptor s1p |
| EP1932833B1 (en) * | 2005-10-07 | 2012-08-01 | Kissei Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same |
| TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
| JP2009269819A (ja) | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
| EP2081916A1 (en) | 2006-09-29 | 2009-07-29 | Novartis AG | Oxadiazole derivatives with anti-inflammatory and immunosuppressive properties |
| AU2007334436A1 (en) | 2006-12-15 | 2008-06-26 | Abbott Laboratories | Novel oxadiazole compounds |
| EP2014653A1 (en) | 2007-06-15 | 2009-01-14 | Bioprojet | Novel dicarboxylic acid derivatives as S1P1 receptor agonists |
| MX2010003614A (es) * | 2007-10-04 | 2010-04-21 | Merck Serono Sa | Compuestos de diarilo oxadiazol. |
| EP2193125B1 (en) | 2007-10-04 | 2017-01-11 | Merck Serono S.A. | Oxadiazole derivatives |
-
2008
- 2008-10-01 MX MX2010003614A patent/MX2010003614A/es not_active Application Discontinuation
- 2008-10-01 CN CN200880110507.5A patent/CN101815707B/zh not_active Expired - Fee Related
- 2008-10-01 US US12/675,254 patent/US8404676B2/en not_active Expired - Fee Related
- 2008-10-01 EA EA201070423A patent/EA201070423A1/ru unknown
- 2008-10-01 JP JP2010527450A patent/JP5727223B2/ja not_active Expired - Fee Related
- 2008-10-01 ES ES08804975.4T patent/ES2547877T3/es active Active
- 2008-10-01 WO PCT/EP2008/063185 patent/WO2009043890A1/en not_active Ceased
- 2008-10-01 CA CA2696829A patent/CA2696829C/en not_active Expired - Fee Related
- 2008-10-01 CN CN201410603560.6A patent/CN104478821B/zh not_active Expired - Fee Related
- 2008-10-01 KR KR1020107009974A patent/KR20100083814A/ko not_active Withdrawn
- 2008-10-01 AU AU2008306886A patent/AU2008306886B2/en not_active Ceased
- 2008-10-01 BR BRPI0817597 patent/BRPI0817597A2/pt not_active IP Right Cessation
- 2008-10-01 EP EP08804975.4A patent/EP2193126B1/en active Active
- 2008-10-03 AR ARP080104332A patent/AR068730A1/es not_active Application Discontinuation
-
2010
- 2010-02-19 ZA ZA2010/01217A patent/ZA201001217B/en unknown
- 2010-03-16 IL IL204520A patent/IL204520A/en not_active IP Right Cessation
-
2012
- 2012-12-12 US US13/711,934 patent/US8889668B2/en not_active Expired - Fee Related
-
2014
- 2014-09-26 JP JP2014197234A patent/JP2015025001A/ja not_active Withdrawn
-
2016
- 2016-05-19 JP JP2016100693A patent/JP6224771B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010540593A5 (OSRAM) | ||
| JP6506836B2 (ja) | Ｂ型肝炎ウイルス感染症の処置および予防のための新規ピリダゾンおよびトリアジノン | |
| JP2007515432A5 (OSRAM) | ||
| JP2006528980A5 (OSRAM) | ||
| JP2002528493A5 (OSRAM) | ||
| KR102212975B1 (ko) | 피리딘-４-일 유도체 | |
| JP2009534407A5 (OSRAM) | ||
| JP2009535307A5 (OSRAM) | ||
| JP2019533696A (ja) | Ｂ型肝炎ウイルス感染症の処置及び予防のための新規なテトラヒドロピリドピリミジン | |
| JP2019510787A5 (OSRAM) | ||
| JP2015535832A5 (OSRAM) | ||
| JP2013514980A5 (OSRAM) | ||
| JP2009532417A5 (OSRAM) | ||
| TW200806652A (en) | N-hydroxyacrylamide compounds | |
| JP2007522142A5 (OSRAM) | ||
| JP6781848B2 (ja) | 新規なピロロピリジン誘導体、その製造方法及び用途 | |
| HRP20211121T1 (hr) | Supstituirani biciklični spojevi | |
| WO2023169572A1 (zh) | 一种三嗪类化合物、其中间体、其制备方法及其用途 | |
| JP2007503432A5 (OSRAM) | ||
| JP2022526827A (ja) | （ｅ）－３－［２－（２－チエニル）ビニル］－１ｈ－ピラゾールの固体形態 | |
| JP3539926B2 (ja) | 抗ウイルス性ピリミジンジオン誘導体及びそれらの製造方法 | |
| JP2006507347A5 (OSRAM) | ||
| US9340539B2 (en) | Hepatitis C inhibitor compounds | |
| JP2007519685A5 (OSRAM) | ||
| JP2018510192A5 (OSRAM) |