JP2010540555A5 - - Google Patents
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- Publication number
- JP2010540555A5 JP2010540555A5 JP2010527139A JP2010527139A JP2010540555A5 JP 2010540555 A5 JP2010540555 A5 JP 2010540555A5 JP 2010527139 A JP2010527139 A JP 2010527139A JP 2010527139 A JP2010527139 A JP 2010527139A JP 2010540555 A5 JP2010540555 A5 JP 2010540555A5
- Authority
- JP
- Japan
- Prior art keywords
- der
- pharmaceutical composition
- formula
- alkenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 125000003342 alkenyl group Chemical group 0.000 claims description 12
- 230000004968 inflammatory condition Effects 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 230000001613 neoplastic effect Effects 0.000 claims description 6
- 201000011510 cancer Diseases 0.000 claims description 5
- 210000004072 lung Anatomy 0.000 claims description 5
- 210000002808 connective tissue Anatomy 0.000 claims description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 3
- 210000005166 vasculature Anatomy 0.000 claims description 3
- 206010025323 Lymphomas Diseases 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000032839 leukemia Diseases 0.000 claims description 2
- 210000001672 ovary Anatomy 0.000 claims description 2
- 239000008024 pharmaceutical diluent Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims description 2
- 210000002307 prostate Anatomy 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 210000003932 urinary bladder Anatomy 0.000 claims description 2
- 201000005787 hematologic cancer Diseases 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000009149 molecular binding Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 13
- 230000007608 epigenetic mechanism Effects 0.000 description 2
- 230000002489 hematologic effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97543707P | 2007-09-26 | 2007-09-26 | |
| PCT/US2008/077669 WO2009042766A1 (en) | 2007-09-26 | 2008-09-25 | Azacytidine analogues and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010540555A JP2010540555A (ja) | 2010-12-24 |
| JP2010540555A5 true JP2010540555A5 (cg-RX-API-DMAC7.html) | 2011-08-25 |
Family
ID=40511851
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527139A Pending JP2010540555A (ja) | 2007-09-26 | 2008-09-25 | アザシチジン類似体およびその使用 |
| JP2010527140A Pending JP2010540556A (ja) | 2007-09-26 | 2008-09-25 | アザシチジン類似体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527140A Pending JP2010540556A (ja) | 2007-09-26 | 2008-09-25 | アザシチジン類似体およびその使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8399420B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2197274A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2010540555A (cg-RX-API-DMAC7.html) |
| KR (2) | KR20100072230A (cg-RX-API-DMAC7.html) |
| CN (2) | CN101815437A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2008304380A1 (cg-RX-API-DMAC7.html) |
| BR (2) | BRPI0817234A2 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2700207A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL204690A0 (cg-RX-API-DMAC7.html) |
| MX (2) | MX2010003261A (cg-RX-API-DMAC7.html) |
| NZ (2) | NZ583923A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2488591C2 (cg-RX-API-DMAC7.html) |
| UA (2) | UA99836C2 (cg-RX-API-DMAC7.html) |
| WO (2) | WO2009042767A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201001660B (cg-RX-API-DMAC7.html) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8497292B2 (en) | 2005-12-28 | 2013-07-30 | Translational Therapeutics, Inc. | Translational dysfunction based therapeutics |
| AU2008304380A1 (en) | 2007-09-26 | 2009-04-02 | Mount Sinai School Of Medicine | Azacytidine analogues and uses thereof |
| LT3692983T (lt) | 2008-05-15 | 2021-11-10 | Celgene Corporation | Citidino analogų peroralinės kompozicijos ir jų naudojimo būdai |
| EP2321302B1 (en) | 2008-08-01 | 2014-10-29 | Dr. Reddy's Laboratories Ltd. | Azacitidine process and polymorphs |
| AR076418A1 (es) * | 2009-04-27 | 2011-06-08 | Reddys Lab Inc Dr | Preparacion de decitabina |
| EP2670396A1 (en) | 2011-01-31 | 2013-12-11 | Celgene Corporation | Pharmaceutical compositions of cytidine analogs and methods of use thereof |
| WO2012142411A1 (en) * | 2011-04-15 | 2012-10-18 | Clavis Pharma Asa | Systems and methods for detecting hent1 expression in hematological disorders |
| AU2012318239B2 (en) | 2011-11-01 | 2015-07-09 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
| TWI615143B (zh) | 2012-02-24 | 2018-02-21 | 標誌製藥公司 | 使用ｔｏｒ激酶抑制劑組合療法以治療癌症之方法 |
| US9493500B2 (en) | 2012-07-19 | 2016-11-15 | Richard Daifuku | Fluorinated pyrimidine analogs and methods of use thereof |
| CN105392499B (zh) * | 2013-04-17 | 2018-07-24 | 西格诺药品有限公司 | 用于治疗癌症的包含tor激酶抑制剂和胞苷类似物的组合疗法 |
| WO2015195786A2 (en) | 2014-06-17 | 2015-12-23 | Celgene Corporation | Methods for treating cancers using oral formulations of cytidine analogs |
| CN107427529A (zh) * | 2014-12-26 | 2017-12-01 | 埃莫里大学 | N4‑羟基胞苷和衍生物及与其相关的抗病毒用途 |
| WO2017090264A1 (ja) | 2015-11-27 | 2017-06-01 | 大原薬品工業株式会社 | ５－アザシチジン又は其の２'－デオキシ体の５'位ジベンジル燐酸エステル |
| DK3383406T3 (da) | 2015-12-03 | 2022-01-10 | Epidestiny Inc | Sammensætninger indeholdende decitabin, 5-azacytidin og tetrahydrouridin og anvendelser deraf |
| US11572408B2 (en) | 2017-03-20 | 2023-02-07 | Vaccinex, Inc. | Treatment of cancer with a semaphorin-4D antibody in combination with an epigenetic modulating agent |
| EA202090103A1 (ru) | 2017-06-22 | 2020-04-24 | Селджин Корпорейшн | Лечение гепатоцеллюлярной карциномы, которая характеризуется вирусной инфекцией гепатита b |
| KR102810546B1 (ko) * | 2018-04-19 | 2025-05-20 | 써던 리서취 인스티튜트 | 암의 치료를 위한 4'-티오-뉴클레오타이드 및 -뉴클레오사이드 전구약물 |
| US20230416294A1 (en) * | 2020-08-10 | 2023-12-28 | The Johns Hopkins University | Decitabine analogs for immunological and oncological therapy |
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| BE612384A (fr) * | 1961-01-10 | 1962-05-02 | Spofa Vereinigte Pharma Werke | Procédé de préparation des 1-glycosyle-6-aza-uraciles |
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-
2008
- 2008-09-25 AU AU2008304380A patent/AU2008304380A1/en not_active Abandoned
- 2008-09-25 EP EP08834291A patent/EP2197274A4/en not_active Withdrawn
- 2008-09-25 US US12/238,054 patent/US8399420B2/en not_active Expired - Fee Related
- 2008-09-25 JP JP2010527139A patent/JP2010540555A/ja active Pending
- 2008-09-25 CA CA2700207A patent/CA2700207A1/en not_active Abandoned
- 2008-09-25 BR BRPI0817234-0A2A patent/BRPI0817234A2/pt not_active IP Right Cessation
- 2008-09-25 BR BRPI0817269-2A2A patent/BRPI0817269A2/pt not_active IP Right Cessation
- 2008-09-25 RU RU2010116274/04A patent/RU2488591C2/ru not_active IP Right Cessation
- 2008-09-25 UA UAA201004928A patent/UA99836C2/ru unknown
- 2008-09-25 MX MX2010003261A patent/MX2010003261A/es not_active Application Discontinuation
- 2008-09-25 NZ NZ583923A patent/NZ583923A/en not_active IP Right Cessation
- 2008-09-25 US US12/238,125 patent/US8158605B2/en not_active Expired - Fee Related
- 2008-09-25 NZ NZ583824A patent/NZ583824A/en not_active IP Right Cessation
- 2008-09-25 WO PCT/US2008/077673 patent/WO2009042767A1/en not_active Ceased
- 2008-09-25 KR KR1020107007252A patent/KR20100072230A/ko not_active Withdrawn
- 2008-09-25 CN CN200880108584A patent/CN101815437A/zh active Pending
- 2008-09-25 WO PCT/US2008/077669 patent/WO2009042766A1/en not_active Ceased
- 2008-09-25 AU AU2008304381A patent/AU2008304381A1/en not_active Abandoned
- 2008-09-25 CN CN2008801085550A patent/CN101877964A/zh active Pending
- 2008-09-25 CA CA2700267A patent/CA2700267A1/en not_active Abandoned
- 2008-09-25 JP JP2010527140A patent/JP2010540556A/ja active Pending
- 2008-09-25 KR KR1020107008902A patent/KR20100102092A/ko not_active Withdrawn
- 2008-09-25 UA UAA201004927A patent/UA99308C2/ru unknown
- 2008-09-25 MX MX2010003002A patent/MX2010003002A/es active IP Right Grant
- 2008-09-25 EP EP08832961A patent/EP2205073A4/en not_active Withdrawn
-
2010
- 2010-03-08 ZA ZA2010/01660A patent/ZA201001660B/en unknown
- 2010-03-23 IL IL204690A patent/IL204690A0/en unknown