JP2010540412A5 - - Google Patents
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- Publication number
- JP2010540412A5 JP2010540412A5 JP2010512025A JP2010512025A JP2010540412A5 JP 2010540412 A5 JP2010540412 A5 JP 2010540412A5 JP 2010512025 A JP2010512025 A JP 2010512025A JP 2010512025 A JP2010512025 A JP 2010512025A JP 2010540412 A5 JP2010540412 A5 JP 2010540412A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- water
- added
- brs
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- GYHMKJMKSFLHOF-UHFFFAOYSA-N (2-fluoro-3-methylphenyl)hydrazine Chemical compound CC1=CC=CC(NN)=C1F GYHMKJMKSFLHOF-UHFFFAOYSA-N 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- WFZUBZAEFXETBF-UHFFFAOYSA-N 2-fluoro-3-methylaniline Chemical compound CC1=CC=CC(N)=C1F WFZUBZAEFXETBF-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010512025A JP5345140B2 (ja) | 2007-09-28 | 2008-09-24 | プロトンポンプ阻害剤としての５員複素環化合物 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007256274 | 2007-09-28 | ||
| JP2007256274 | 2007-09-28 | ||
| JP2008218076 | 2008-08-27 | ||
| JP2008218076 | 2008-08-27 | ||
| JP2010512025A JP5345140B2 (ja) | 2007-09-28 | 2008-09-24 | プロトンポンプ阻害剤としての５員複素環化合物 |
| PCT/JP2008/067784 WO2009041705A2 (en) | 2007-09-28 | 2008-09-24 | 5-membered heterocyclic compounds as proton pump inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540412A JP2010540412A (ja) | 2010-12-24 |
| JP2010540412A5 true JP2010540412A5 (enExample) | 2011-07-21 |
| JP5345140B2 JP5345140B2 (ja) | 2013-11-20 |
Family
ID=40512007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512025A Active JP5345140B2 (ja) | 2007-09-28 | 2008-09-24 | プロトンポンプ阻害剤としての５員複素環化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090156642A1 (enExample) |
| EP (1) | EP2190822B1 (enExample) |
| JP (1) | JP5345140B2 (enExample) |
| KR (1) | KR101558011B1 (enExample) |
| AR (1) | AR068538A1 (enExample) |
| CL (1) | CL2008002834A1 (enExample) |
| PE (1) | PE20090709A1 (enExample) |
| TW (1) | TW200920366A (enExample) |
| WO (1) | WO2009041705A2 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101559597B1 (ko) * | 2007-09-28 | 2015-10-12 | 다케다 야쿠힌 고교 가부시키가이샤 | ５―원 헤테로시클릭 화합물 |
| EA201170272A1 (ru) | 2008-07-28 | 2011-10-31 | Такеда Фармасьютикал Компани Лимитед | Фармацевтическая композиция |
| HRP20130653T1 (en) | 2008-08-27 | 2013-08-31 | Takeda Pharmaceutical Company Limited | Pyrrole compounds |
| US8895588B2 (en) * | 2009-03-26 | 2014-11-25 | Takeda Pharmaceutical Company Limited | Pyrazole compound |
| CA2765529C (en) | 2009-07-09 | 2017-02-07 | Raqualia Pharma Inc. | Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility |
| EP2526095A1 (en) | 2010-01-19 | 2012-11-28 | Theravance, Inc. | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents |
| US10039813B2 (en) | 2012-02-07 | 2018-08-07 | Massachusetts Institute Of Technology | Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness |
| JP6216338B2 (ja) | 2012-06-27 | 2017-10-18 | 武田薬品工業株式会社 | 塩により安定化されたアミンおよび有機酸の液状製剤 |
| WO2014144878A2 (en) * | 2013-03-15 | 2014-09-18 | The Scripps Research Institute | Novel thiol & amino modifying reagents for protein chemistry and methods of use thereof |
| WO2014144231A1 (en) | 2013-03-15 | 2014-09-18 | Massachusetts Institute Of Technology | Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness |
| WO2016138099A1 (en) | 2015-02-24 | 2016-09-01 | Massachusetts Institute Of Technology | Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness |
| CN106146466A (zh) * | 2016-06-30 | 2016-11-23 | 珠海赛隆药业股份有限公司（长沙）医药研发中心 | 富马酸沃诺拉赞中间体、其制备方法和制备富马酸沃诺拉赞的方法 |
| CN108203430A (zh) * | 2016-12-16 | 2018-06-26 | 天地人和生物科技有限公司 | 一种新型可逆性质子泵抑制剂及其制备方法和用途 |
| KR102537983B1 (ko) | 2017-04-24 | 2023-05-31 | 바이엘 악티엔게젤샤프트 | 해충 방제제로서의 축합된 비시클릭 헤테로시클릭-화합물 유도체 |
| WO2021104256A1 (zh) * | 2019-11-25 | 2021-06-03 | 杭州华东医药集团新药研究院有限公司 | 一种杂环衍生物、其药物组合物及用途 |
| GB201919213D0 (en) * | 2019-12-23 | 2020-02-05 | Ucb Biopharma Sprl | Dihydrocyclopenta-Isoquinoline-Sulfanamide derivatives compounds |
| CN111943932B (zh) * | 2020-08-06 | 2023-07-14 | 四川国康药业有限公司 | 一种可以治疗消化性溃疡的3-吡啶磺酰-1-n-杂吡咯衍生物及其制备方法和用途 |
| CN113620930B (zh) * | 2021-07-12 | 2022-08-16 | 南京烁慧医药科技有限公司 | 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用 |
| WO2024196828A2 (en) * | 2023-03-17 | 2024-09-26 | Xibin Liao | Sigma-1 receptor ligands and use thereof |
| CN120208865A (zh) * | 2025-03-11 | 2025-06-27 | 宿迁海德医药化工有限公司 | 一种2-氯-3-肼基吡啶的合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3285991A (en) * | 1963-03-26 | 1966-11-15 | Union Carbide Corp | Polyepoxides cured with the reaction product of a dihydroxydiphenylsul-fone, an amine, and an aldehyde |
| BR9509024A (pt) * | 1994-09-26 | 1997-09-30 | Shionogi & Co | Derivados de imidazol |
| WO2004012659A2 (en) * | 2002-08-01 | 2004-02-12 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
| WO2004103968A1 (en) * | 2003-05-26 | 2004-12-02 | Aponetics Ag | Sulfopyrroles |
| KR101178747B1 (ko) * | 2004-09-30 | 2012-09-03 | 다케다 야쿠힌 고교 가부시키가이샤 | 프로톤 펌프 저해제 |
| FR2881744B1 (fr) * | 2005-02-09 | 2007-04-27 | Sanofi Aventis Sa | Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique |
| ME00610B (me) * | 2005-08-30 | 2011-12-20 | Takeda Pharmaceuticals Co | 1 –heterociklilsulfonil, 2 –aminometil, 5– (hetero–) aril supstituisan 1–h–pirol derivati kao inhibitori lučenja kiseline |
| FR2894578B1 (fr) * | 2005-12-12 | 2008-02-01 | Sanofi Aventis Sa | Derives heterocycliques, leur preparation et leur application en therapeutique. |
| JP5207964B2 (ja) * | 2006-03-31 | 2013-06-12 | 武田薬品工業株式会社 | 酸分泌抑制薬 |
| KR101559597B1 (ko) * | 2007-09-28 | 2015-10-12 | 다케다 야쿠힌 고교 가부시키가이샤 | ５―원 헤테로시클릭 화합물 |
-
2008
- 2008-09-24 PE PE2008001664A patent/PE20090709A1/es not_active Application Discontinuation
- 2008-09-24 TW TW097136593A patent/TW200920366A/zh unknown
- 2008-09-24 WO PCT/JP2008/067784 patent/WO2009041705A2/en not_active Ceased
- 2008-09-24 CL CL2008002834A patent/CL2008002834A1/es unknown
- 2008-09-24 AR ARP080104134A patent/AR068538A1/es unknown
- 2008-09-24 EP EP08834057.5A patent/EP2190822B1/en active Active
- 2008-09-24 US US12/284,636 patent/US20090156642A1/en not_active Abandoned
- 2008-09-24 KR KR1020107009249A patent/KR101558011B1/ko active Active
- 2008-09-24 JP JP2010512025A patent/JP5345140B2/ja active Active
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