JP2010540412A5 - - Google Patents
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- Publication number
- JP2010540412A5 JP2010540412A5 JP2010512025A JP2010512025A JP2010540412A5 JP 2010540412 A5 JP2010540412 A5 JP 2010540412A5 JP 2010512025 A JP2010512025 A JP 2010512025A JP 2010512025 A JP2010512025 A JP 2010512025A JP 2010540412 A5 JP2010540412 A5 JP 2010540412A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- water
- added
- brs
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- GYHMKJMKSFLHOF-UHFFFAOYSA-N (2-fluoro-3-methylphenyl)hydrazine Chemical compound CC1=CC=CC(NN)=C1F GYHMKJMKSFLHOF-UHFFFAOYSA-N 0.000 description 1
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- WFZUBZAEFXETBF-UHFFFAOYSA-N 2-fluoro-3-methylaniline Chemical compound CC1=CC=CC(N)=C1F WFZUBZAEFXETBF-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010512025A JP5345140B2 (ja) | 2007-09-28 | 2008-09-24 | プロトンポンプ阻害剤としての５員複素環化合物 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007256274 | 2007-09-28 | ||
| JP2007256274 | 2007-09-28 | ||
| JP2008218076 | 2008-08-27 | ||
| JP2008218076 | 2008-08-27 | ||
| JP2010512025A JP5345140B2 (ja) | 2007-09-28 | 2008-09-24 | プロトンポンプ阻害剤としての５員複素環化合物 |
| PCT/JP2008/067784 WO2009041705A2 (en) | 2007-09-28 | 2008-09-24 | 5-membered heterocyclic compounds as proton pump inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540412A JP2010540412A (ja) | 2010-12-24 |
| JP2010540412A5 true JP2010540412A5 (enExample) | 2011-07-21 |
| JP5345140B2 JP5345140B2 (ja) | 2013-11-20 |
Family
ID=40512007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010512025A Active JP5345140B2 (ja) | 2007-09-28 | 2008-09-24 | プロトンポンプ阻害剤としての５員複素環化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090156642A1 (enExample) |
| EP (1) | EP2190822B1 (enExample) |
| JP (1) | JP5345140B2 (enExample) |
| KR (1) | KR101558011B1 (enExample) |
| AR (1) | AR068538A1 (enExample) |
| CL (1) | CL2008002834A1 (enExample) |
| PE (1) | PE20090709A1 (enExample) |
| TW (1) | TW200920366A (enExample) |
| WO (1) | WO2009041705A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2196459B1 (en) * | 2007-09-28 | 2016-11-02 | Takeda Pharmaceutical Company Limited | 5-membered heterocyclic compound |
| WO2010013823A2 (en) | 2008-07-28 | 2010-02-04 | Takeda Pharmaceutical Company Limited | Pharmaceutical composition |
| PE20110300A1 (es) | 2008-08-27 | 2011-06-16 | Takeda Pharmaceutical | Compuestos de pirrol como inhibidores de la bomba de protones |
| US8895588B2 (en) * | 2009-03-26 | 2014-11-25 | Takeda Pharmaceutical Company Limited | Pyrazole compound |
| US8648080B2 (en) | 2009-07-09 | 2014-02-11 | Raqualia Pharma Inc. | Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility |
| US8481549B2 (en) | 2010-01-19 | 2013-07-09 | Theravance, Inc. | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents |
| US10039813B2 (en) | 2012-02-07 | 2018-08-07 | Massachusetts Institute Of Technology | Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness |
| JP6216338B2 (ja) | 2012-06-27 | 2017-10-18 | 武田薬品工業株式会社 | 塩により安定化されたアミンおよび有機酸の液状製剤 |
| US9724396B2 (en) | 2013-03-15 | 2017-08-08 | Massachusetts Institute Of Technology | Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness |
| WO2014144878A2 (en) * | 2013-03-15 | 2014-09-18 | The Scripps Research Institute | Novel thiol & amino modifying reagents for protein chemistry and methods of use thereof |
| US10317418B2 (en) | 2015-02-24 | 2019-06-11 | Massachusetts Institute Of Technology | Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness |
| CN106146466A (zh) * | 2016-06-30 | 2016-11-23 | 珠海赛隆药业股份有限公司（长沙）医药研发中心 | 富马酸沃诺拉赞中间体、其制备方法和制备富马酸沃诺拉赞的方法 |
| CN108203430A (zh) * | 2016-12-16 | 2018-06-26 | 天地人和生物科技有限公司 | 一种新型可逆性质子泵抑制剂及其制备方法和用途 |
| US20200128830A1 (en) | 2017-04-24 | 2020-04-30 | Bayer Aktiengesellschaft | Fused bicyclic heterocycle derivatives as pesticides |
| WO2021104256A1 (zh) * | 2019-11-25 | 2021-06-03 | 杭州华东医药集团新药研究院有限公司 | 一种杂环衍生物、其药物组合物及用途 |
| GB201919212D0 (en) | 2019-12-23 | 2020-02-05 | Ucb Biopharma Sprl | Dihydro-cyclopenta-isoquinoline sulfonamides derivatives |
| GB201919213D0 (en) | 2019-12-23 | 2020-02-05 | Ucb Biopharma Sprl | Dihydrocyclopenta-Isoquinoline-Sulfanamide derivatives compounds |
| CN111943932B (zh) * | 2020-08-06 | 2023-07-14 | 四川国康药业有限公司 | 一种可以治疗消化性溃疡的3-吡啶磺酰-1-n-杂吡咯衍生物及其制备方法和用途 |
| CN113620930B (zh) * | 2021-07-12 | 2022-08-16 | 南京烁慧医药科技有限公司 | 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用 |
| CN121358483A (zh) * | 2023-03-17 | 2026-01-16 | 嘉兴佰美济华医药科技有限公司 | σ-1受体配体及其应用 |
| CN120208865A (zh) * | 2025-03-11 | 2025-06-27 | 宿迁海德医药化工有限公司 | 一种2-氯-3-肼基吡啶的合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3285991A (en) * | 1963-03-26 | 1966-11-15 | Union Carbide Corp | Polyepoxides cured with the reaction product of a dihydroxydiphenylsul-fone, an amine, and an aldehyde |
| DE69532245T2 (de) * | 1994-09-26 | 2004-09-16 | Shionogi & Co., Ltd. | Imidazolderivat |
| AU2003254282A1 (en) * | 2002-08-01 | 2004-02-23 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
| WO2004103968A1 (en) * | 2003-05-26 | 2004-12-02 | Aponetics Ag | Sulfopyrroles |
| EP2336107B1 (en) * | 2004-09-30 | 2015-09-23 | Takeda Pharmaceutical Company Limited | Proton pump inhibitors |
| FR2881744B1 (fr) * | 2005-02-09 | 2007-04-27 | Sanofi Aventis Sa | Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique |
| EP2327692B9 (en) * | 2005-08-30 | 2014-06-04 | Takeda Pharmaceutical Company Limited | 1-heterocyclylsulfonyl, 2-aminomethyl, 5-(hetero-)aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors |
| FR2894578B1 (fr) * | 2005-12-12 | 2008-02-01 | Sanofi Aventis Sa | Derives heterocycliques, leur preparation et leur application en therapeutique. |
| EP2005957B1 (en) * | 2006-03-31 | 2012-05-30 | Takeda Pharmaceutical Company Limited | Acid secretion inhibitor |
| EP2196459B1 (en) * | 2007-09-28 | 2016-11-02 | Takeda Pharmaceutical Company Limited | 5-membered heterocyclic compound |
-
2008
- 2008-09-24 PE PE2008001664A patent/PE20090709A1/es not_active Application Discontinuation
- 2008-09-24 TW TW097136593A patent/TW200920366A/zh unknown
- 2008-09-24 CL CL2008002834A patent/CL2008002834A1/es unknown
- 2008-09-24 EP EP08834057.5A patent/EP2190822B1/en active Active
- 2008-09-24 AR ARP080104134A patent/AR068538A1/es unknown
- 2008-09-24 KR KR1020107009249A patent/KR101558011B1/ko active Active
- 2008-09-24 US US12/284,636 patent/US20090156642A1/en not_active Abandoned
- 2008-09-24 WO PCT/JP2008/067784 patent/WO2009041705A2/en not_active Ceased
- 2008-09-24 JP JP2010512025A patent/JP5345140B2/ja active Active
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