JP2010539187A5 - - Google Patents
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- Publication number
- JP2010539187A5 JP2010539187A5 JP2010525103A JP2010525103A JP2010539187A5 JP 2010539187 A5 JP2010539187 A5 JP 2010539187A5 JP 2010525103 A JP2010525103 A JP 2010525103A JP 2010525103 A JP2010525103 A JP 2010525103A JP 2010539187 A5 JP2010539187 A5 JP 2010539187A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- dioxo
- dihydropyrimidin
- tert
- butyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims 47
- 150000001875 compounds Chemical class 0.000 claims 45
- -1 hydroxy, methyl Chemical group 0.000 claims 39
- 150000003839 salts Chemical class 0.000 claims 39
- 125000000217 alkyl group Chemical group 0.000 claims 32
- 239000003814 drug Substances 0.000 claims 32
- 125000003342 alkenyl group Chemical group 0.000 claims 30
- 125000000304 alkynyl group Chemical group 0.000 claims 27
- 125000005843 halogen group Chemical group 0.000 claims 23
- 241000711549 Hepacivirus C Species 0.000 claims 22
- 229940124597 therapeutic agent Drugs 0.000 claims 22
- 125000000623 heterocyclic group Chemical group 0.000 claims 20
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 20
- 125000003545 alkoxy group Chemical group 0.000 claims 19
- 125000004452 carbocyclyl group Chemical group 0.000 claims 18
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 16
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 239000003112 inhibitor Substances 0.000 claims 13
- 125000004043 oxo group Chemical group O=* 0.000 claims 13
- 125000003302 alkenyloxy group Chemical group 0.000 claims 12
- 125000005133 alkynyloxy group Chemical group 0.000 claims 12
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 11
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 9
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 9
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 229960000329 ribavirin Drugs 0.000 claims 9
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 9
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 8
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 102000014150 Interferons Human genes 0.000 claims 6
- 108010050904 Interferons Proteins 0.000 claims 6
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 229940079322 interferon Drugs 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 229920002477 rna polymer Polymers 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 125000005092 alkenyloxycarbonyl group Chemical group 0.000 claims 5
- 125000005137 alkenylsulfonyl group Chemical group 0.000 claims 5
- 125000005198 alkynylcarbonyloxy group Chemical group 0.000 claims 5
- 125000005225 alkynyloxycarbonyl group Chemical group 0.000 claims 5
- 125000005139 alkynylsulfonyl group Chemical group 0.000 claims 5
- 229940124411 anti-hiv antiviral agent Drugs 0.000 claims 5
- 125000005884 carbocyclylalkyl group Chemical group 0.000 claims 5
- NBRBXGKOEOGLOI-UHFFFAOYSA-N dasabuvir Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C=C1N1C=CC(=O)NC1=O NBRBXGKOEOGLOI-UHFFFAOYSA-N 0.000 claims 5
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- DYMRYCZRMAHYKE-UHFFFAOYSA-N n-diazonitramide Chemical compound [O-][N+](=O)N=[N+]=[N-] DYMRYCZRMAHYKE-UHFFFAOYSA-N 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 208000005176 Hepatitis C Diseases 0.000 claims 4
- 125000005090 alkenylcarbonyl group Chemical group 0.000 claims 4
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 4
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 4
- KWEDUNSJJZVRKR-UHFFFAOYSA-N carbononitridic azide Chemical compound [N-]=[N+]=NC#N KWEDUNSJJZVRKR-UHFFFAOYSA-N 0.000 claims 4
- 125000001624 naphthyl group Chemical group 0.000 claims 4
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 3
- 125000005087 alkynylcarbonyl group Chemical group 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- 125000005097 aminocarbonylalkyl group Chemical group 0.000 claims 3
- CREXVNNSNOKDHW-UHFFFAOYSA-N azaniumylideneazanide Chemical group N[N] CREXVNNSNOKDHW-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 3
- 241001493065 dsRNA viruses Species 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 2
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 2
- AQFWJMYYGAZRTL-UHFFFAOYSA-N 1-[3-(2-amino-1,3-benzothiazol-6-yl)-5-tert-butyl-4-methoxyphenyl]pyrimidine-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3SC(N)=NC3=CC=2)C=C1N1C=CC(=O)NC1=O AQFWJMYYGAZRTL-UHFFFAOYSA-N 0.000 claims 2
- VMQMZMRVKUZKQL-UHFFFAOYSA-N Cu+ Chemical class [Cu+] VMQMZMRVKUZKQL-UHFFFAOYSA-N 0.000 claims 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 2
- 125000005193 alkenylcarbonyloxy group Chemical group 0.000 claims 2
- 125000005197 alkyl carbonyloxy alkyl group Chemical group 0.000 claims 2
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims 2
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 239000010949 copper Substances 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 159000000000 sodium salts Chemical class 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000000845 uracil-1-yl group Chemical group [*]N1C(=O)N([H])C(=O)C([H])=C1[H] 0.000 claims 2
- 230000029812 viral genome replication Effects 0.000 claims 2
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims 1
- YXRGAZPCDALZSP-UHFFFAOYSA-N 1-(3-tert-butyl-4-methoxy-5-naphthalen-2-ylphenyl)pyrimidine-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3C=CC=CC3=CC=2)C=C1N1C=CC(=O)NC1=O YXRGAZPCDALZSP-UHFFFAOYSA-N 0.000 claims 1
- XZXYGRARNRNIPW-UHFFFAOYSA-N 1-[3-(1,3-benzothiazol-2-yl)-5-tert-butyl-4-methoxyphenyl]-1,3-diazinane-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2SC3=CC=CC=C3N=2)C=C1N1CCC(=O)NC1=O XZXYGRARNRNIPW-UHFFFAOYSA-N 0.000 claims 1
- PVIVCOLZLYNGPB-UHFFFAOYSA-N 1-[3-(1,3-benzothiazol-6-yl)-5-tert-butyl-4-methoxyphenyl]pyrimidine-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3SC=NC3=CC=2)C=C1N1C=CC(=O)NC1=O PVIVCOLZLYNGPB-UHFFFAOYSA-N 0.000 claims 1
- JAESXJLAMBRTBM-UHFFFAOYSA-N 1-[3-tert-butyl-4-methoxy-5-(1-methylsulfonyl-2,3-dihydroindol-5-yl)phenyl]pyrimidine-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CCN(C3=CC=2)S(C)(=O)=O)C=C1N1C=CC(=O)NC1=O JAESXJLAMBRTBM-UHFFFAOYSA-N 0.000 claims 1
- HHBKKXLZBBILEV-UHFFFAOYSA-N 1-[3-tert-butyl-4-methoxy-5-(1-oxo-2,3-dihydroinden-5-yl)phenyl]pyrimidine-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CCC(=O)C3=CC=2)C=C1N1C=CC(=O)NC1=O HHBKKXLZBBILEV-UHFFFAOYSA-N 0.000 claims 1
- RWPKQMZFXORKQF-UHFFFAOYSA-N 1-[3-tert-butyl-4-methoxy-5-(1-oxo-2,3-dihydroisoindol-5-yl)phenyl]pyrimidine-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CNC(=O)C3=CC=2)C=C1N1C=CC(=O)NC1=O RWPKQMZFXORKQF-UHFFFAOYSA-N 0.000 claims 1
- ZFRHKNRVKQELLK-UHFFFAOYSA-N 1-[3-tert-butyl-4-methoxy-5-(3-methyl-1-benzofuran-6-yl)phenyl]pyrimidine-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3OC=C(C)C3=CC=2)C=C1N1C=CC(=O)NC1=O ZFRHKNRVKQELLK-UHFFFAOYSA-N 0.000 claims 1
- XNJMOOOQQDDAAE-UHFFFAOYSA-N 1-[3-tert-butyl-4-methoxy-5-(5-nitro-1,3-benzoxazol-2-yl)phenyl]-1,3-diazinane-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2OC3=CC=C(C=C3N=2)[N+]([O-])=O)C=C1N1CCC(=O)NC1=O XNJMOOOQQDDAAE-UHFFFAOYSA-N 0.000 claims 1
- DHOPGXUASGTCKU-UHFFFAOYSA-N 1-[3-tert-butyl-4-methoxy-5-(6-methoxynaphthalen-2-yl)phenyl]pyrimidine-2,4-dione Chemical compound C1=CC2=CC(OC)=CC=C2C=C1C(C(=C(C=1)C(C)(C)C)OC)=CC=1N1C=CC(=O)NC1=O DHOPGXUASGTCKU-UHFFFAOYSA-N 0.000 claims 1
- SAGLGVMHVLWDRP-UHFFFAOYSA-N 1-[3-tert-butyl-4-methoxy-5-(6-nitro-1,3-benzoxazol-2-yl)phenyl]-1,3-diazinane-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2OC3=CC(=CC=C3N=2)[N+]([O-])=O)C=C1N1CCC(=O)NC1=O SAGLGVMHVLWDRP-UHFFFAOYSA-N 0.000 claims 1
- NWHSVWGQIUBZQT-UHFFFAOYSA-N 1-[3-tert-butyl-4-methoxy-5-[2-(propylamino)-1,3-benzothiazol-6-yl]phenyl]pyrimidine-2,4-dione Chemical compound C1=C2SC(NCCC)=NC2=CC=C1C(C(=C(C=1)C(C)(C)C)OC)=CC=1N1C=CC(=O)NC1=O NWHSVWGQIUBZQT-UHFFFAOYSA-N 0.000 claims 1
- FBNXRQIJHASXJZ-UHFFFAOYSA-N 1-[3-tert-butyl-5-(1-hydroxy-2,3-dihydro-1h-inden-5-yl)-4-methoxyphenyl]pyrimidine-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CCC(O)C3=CC=2)C=C1N1C=CC(=O)NC1=O FBNXRQIJHASXJZ-UHFFFAOYSA-N 0.000 claims 1
- WWCQVRQPZOUFOP-UHFFFAOYSA-N 1-[3-tert-butyl-5-(2-chloro-1,3-benzothiazol-6-yl)-4-methoxyphenyl]pyrimidine-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3SC(Cl)=NC3=CC=2)C=C1N1C=CC(=O)NC1=O WWCQVRQPZOUFOP-UHFFFAOYSA-N 0.000 claims 1
- DGTXGWLRWHJWAO-UHFFFAOYSA-N 1-[3-tert-butyl-5-[2-(2,5-dimethylpyrrol-1-yl)-1,3-benzothiazol-6-yl]-4-methoxyphenyl]pyrimidine-2,4-dione Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3SC(=NC3=CC=2)N2C(=CC=C2C)C)C=C1N1C=CC(=O)NC1=O DGTXGWLRWHJWAO-UHFFFAOYSA-N 0.000 claims 1
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 claims 1
- MTNFZAKOJUMHNX-UHFFFAOYSA-N 2-[5-(2,4-dioxopyrimidin-1-yl)-3-[6-(methanesulfonamido)naphthalen-2-yl]-2-methoxyphenyl]-2-methylpropanoic acid Chemical compound C1=C(C(C)(C)C(O)=O)C(OC)=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C=C1N1C=CC(=O)NC1=O MTNFZAKOJUMHNX-UHFFFAOYSA-N 0.000 claims 1
- YNFBMDWHEHETJW-UHFFFAOYSA-N 2-pyridin-2-yl-1h-benzimidazole Chemical compound N1=CC=CC=C1C1=NC2=CC=CC=C2N1 YNFBMDWHEHETJW-UHFFFAOYSA-N 0.000 claims 1
- PCJMVHPWWFMSSS-UHFFFAOYSA-N 5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-n-methylsulfonyl-2,3-dihydro-1h-indene-1-carboxamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CCC(C3=CC=2)C(=O)NS(C)(=O)=O)C=C1N1C=CC(=O)NC1=O PCJMVHPWWFMSSS-UHFFFAOYSA-N 0.000 claims 1
- 239000005725 8-Hydroxyquinoline Substances 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 229910021589 Copper(I) bromide Inorganic materials 0.000 claims 1
- 229910021591 Copper(I) chloride Inorganic materials 0.000 claims 1
- 229910021595 Copper(I) iodide Inorganic materials 0.000 claims 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 125000005091 alkenylcarbonylamino group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 1
- 125000005088 alkynylcarbonylamino group Chemical group 0.000 claims 1
- 125000006598 aminocarbonylamino group Chemical group 0.000 claims 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical class [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 claims 1
- CREMABGTGYGIQB-UHFFFAOYSA-N carbon carbon Chemical compound C.C CREMABGTGYGIQB-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 claims 1
- YZDBZOOCRDOXFK-UHFFFAOYSA-N cyano-(diazidoamino)carbamic acid Chemical compound C(=O)(O)N(N(N=[N+]=[N-])N=[N+]=[N-])C#N YZDBZOOCRDOXFK-UHFFFAOYSA-N 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000005508 decahydronaphthalenyl group Chemical group 0.000 claims 1
- 125000004639 dihydroindenyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 125000005280 halo alkyl sulfonyloxy group Chemical group 0.000 claims 1
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 1
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- UHMIQMCYZFEWKI-UHFFFAOYSA-N methyl 2-[5-(2,4-dioxopyrimidin-1-yl)-3-[6-(methanesulfonamido)naphthalen-2-yl]-2-methoxyphenyl]-2-methylpropanoate Chemical compound C=1C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)=C(OC)C(C(C)(C)C(=O)OC)=CC=1N1C=CC(=O)NC1=O UHMIQMCYZFEWKI-UHFFFAOYSA-N 0.000 claims 1
- LWUPFIBYTKEWJQ-UHFFFAOYSA-N n'-[5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-2,3-dihydro-1h-inden-1-yl]methanesulfonohydrazide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CCC(C3=CC=2)NNS(C)(=O)=O)C=C1N1C=CC(=O)NC1=O LWUPFIBYTKEWJQ-UHFFFAOYSA-N 0.000 claims 1
- CMOBXBANKIGTSJ-UHFFFAOYSA-N n-(2-cyanophenyl)pyridine-2-carboxamide Chemical compound C=1C=CC=NC=1C(=O)NC1=CC=CC=C1C#N CMOBXBANKIGTSJ-UHFFFAOYSA-N 0.000 claims 1
- WUYINQBOZASLCM-UHFFFAOYSA-N n-(4-cyanophenyl)pyridine-2-carboxamide Chemical compound C=1C=CC=NC=1C(=O)NC1=CC=C(C#N)C=C1 WUYINQBOZASLCM-UHFFFAOYSA-N 0.000 claims 1
- BSGREXYSTRLYNX-SZXQPVLSSA-N n-[(e)-[5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-2,3-dihydroinden-1-ylidene]amino]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CCC(/C3=CC=2)=N\NS(C)(=O)=O)C=C1N1C=CC(=O)NC1=O BSGREXYSTRLYNX-SZXQPVLSSA-N 0.000 claims 1
- WZXVXZFFDOBSBD-YYADALCUSA-N n-[(e)-[5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)phenyl]-2,3-dihydroinden-1-ylidene]amino]methanesulfonamide Chemical compound C=1C(C(C)(C)C)=CC(C=2C=C3CCC(/C3=CC=2)=N\NS(C)(=O)=O)=CC=1N1C=CC(=O)NC1=O WZXVXZFFDOBSBD-YYADALCUSA-N 0.000 claims 1
- WTLGVHMLSDGNGC-SZXQPVLSSA-N n-[(e)-[6-[5-(2,4-dioxopyrimidin-1-yl)-2-methoxy-3-thiophen-2-ylphenyl]-2,3-dihydroinden-1-ylidene]amino]methanesulfonamide Chemical compound C1=C(C=2C=C3C(=N/NS(C)(=O)=O)/CCC3=CC=2)C(OC)=C(C=2SC=CC=2)C=C1N1C=CC(=O)NC1=O WTLGVHMLSDGNGC-SZXQPVLSSA-N 0.000 claims 1
- UZAAZICNWHJGFD-SZXQPVLSSA-N n-[(e)-[6-[5-(2,4-dioxopyrimidin-1-yl)-3-(furan-2-yl)-2-methoxyphenyl]-2,3-dihydroinden-1-ylidene]amino]methanesulfonamide Chemical compound C1=C(C=2C=C3C(=N/NS(C)(=O)=O)/CCC3=CC=2)C(OC)=C(C=2OC=CC=2)C=C1N1C=CC(=O)NC1=O UZAAZICNWHJGFD-SZXQPVLSSA-N 0.000 claims 1
- OIOOUZKXUXQCIF-JOCHJYFZSA-N n-[2-[(1r)-5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-2,3-dihydro-1h-inden-1-yl]propan-2-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CC[C@H](C3=CC=2)C(C)(C)NS(C)(=O)=O)C=C1N1C=CC(=O)NC1=O OIOOUZKXUXQCIF-JOCHJYFZSA-N 0.000 claims 1
- OIOOUZKXUXQCIF-QFIPXVFZSA-N n-[2-[(1s)-5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-2,3-dihydro-1h-inden-1-yl]propan-2-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CC[C@@H](C3=CC=2)C(C)(C)NS(C)(=O)=O)C=C1N1C=CC(=O)NC1=O OIOOUZKXUXQCIF-QFIPXVFZSA-N 0.000 claims 1
- FJGZPBUBGDMIEQ-UHFFFAOYSA-N n-[2-[3-tert-butyl-5-(2,4-dioxo-1,3-diazinan-1-yl)-2-methoxyphenyl]-1,3-benzothiazol-5-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2SC3=CC=C(NS(C)(=O)=O)C=C3N=2)C=C1N1CCC(=O)NC1=O FJGZPBUBGDMIEQ-UHFFFAOYSA-N 0.000 claims 1
- DOARMVDILKEQDJ-UHFFFAOYSA-N n-[2-[3-tert-butyl-5-(2,4-dioxo-1,3-diazinan-1-yl)-2-methoxyphenyl]-1,3-benzothiazol-6-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2SC3=CC(NS(C)(=O)=O)=CC=C3N=2)C=C1N1CCC(=O)NC1=O DOARMVDILKEQDJ-UHFFFAOYSA-N 0.000 claims 1
- GQSANLVBMNPJMC-UHFFFAOYSA-N n-[2-[3-tert-butyl-5-(2,4-dioxo-1,3-diazinan-1-yl)-2-methoxyphenyl]-1,3-benzoxazol-5-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2OC3=CC=C(NS(C)(=O)=O)C=C3N=2)C=C1N1CCC(=O)NC1=O GQSANLVBMNPJMC-UHFFFAOYSA-N 0.000 claims 1
- MEZSDRNJRNOHMP-UHFFFAOYSA-N n-[2-[3-tert-butyl-5-(2,4-dioxo-1,3-diazinan-1-yl)-2-methoxyphenyl]-1,3-benzoxazol-6-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2OC3=CC(NS(C)(=O)=O)=CC=C3N=2)C=C1N1CCC(=O)NC1=O MEZSDRNJRNOHMP-UHFFFAOYSA-N 0.000 claims 1
- KZJUZGIPMPKLQT-UHFFFAOYSA-N n-[2-[3-tert-butyl-5-(2,4-dioxo-1,3-diazinan-1-yl)-2-methoxyphenyl]-3h-benzimidazol-5-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2NC3=CC=C(NS(C)(=O)=O)C=C3N=2)C=C1N1CCC(=O)NC1=O KZJUZGIPMPKLQT-UHFFFAOYSA-N 0.000 claims 1
- WXGACALVDQEAAO-UHFFFAOYSA-N n-[2-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-1,3-benzoxazol-5-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2OC3=CC=C(NS(C)(=O)=O)C=C3N=2)C=C1N1C=CC(=O)NC1=O WXGACALVDQEAAO-UHFFFAOYSA-N 0.000 claims 1
- YVFJERSHMIZROV-UHFFFAOYSA-N n-[2-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-3,4-dihydro-1h-isoquinolin-6-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(N2CC3=CC=C(NS(C)(=O)=O)C=C3CC2)C=C1N1C=CC(=O)NC1=O YVFJERSHMIZROV-UHFFFAOYSA-N 0.000 claims 1
- XITJLAONOGOXPU-UHFFFAOYSA-N n-[2-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]quinolin-6-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2N=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C=C1N1C=CC(=O)NC1=O XITJLAONOGOXPU-UHFFFAOYSA-N 0.000 claims 1
- OIOOUZKXUXQCIF-UHFFFAOYSA-N n-[2-[5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-2,3-dihydro-1h-inden-1-yl]propan-2-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CCC(C3=CC=2)C(C)(C)NS(C)(=O)=O)C=C1N1C=CC(=O)NC1=O OIOOUZKXUXQCIF-UHFFFAOYSA-N 0.000 claims 1
- SZESPTRIDHGUMG-UHFFFAOYSA-N n-[2-[5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-3h-inden-1-yl]propan-2-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CC=C(C3=CC=2)C(C)(C)NS(C)(=O)=O)C=C1N1C=CC(=O)NC1=O SZESPTRIDHGUMG-UHFFFAOYSA-N 0.000 claims 1
- QFNWRWSMBBUABM-UHFFFAOYSA-N n-[5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-2,3-dihydro-1h-inden-1-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CCC(C3=CC=2)NS(C)(=O)=O)C=C1N1C=CC(=O)NC1=O QFNWRWSMBBUABM-UHFFFAOYSA-N 0.000 claims 1
- ORZIFRIOPKCERB-UHFFFAOYSA-N n-[6-[3-(3-chlorophenyl)-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C(OC)=C(C=2C=C(Cl)C=CC=2)C=C1N1C=CC(=O)NC1=O ORZIFRIOPKCERB-UHFFFAOYSA-N 0.000 claims 1
- DONIOQPZCANINF-UHFFFAOYSA-N n-[6-[3-bromo-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C(OC)=C(Br)C=C1N1C=CC(=O)NC1=O DONIOQPZCANINF-UHFFFAOYSA-N 0.000 claims 1
- DHPZPQJFXMGFMT-UHFFFAOYSA-N n-[6-[3-tert-butyl-2-chloro-5-(2,4-dioxopyrimidin-1-yl)phenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C=1C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)=C(Cl)C(C(C)(C)C)=CC=1N1C=CC(=O)NC1=O DHPZPQJFXMGFMT-UHFFFAOYSA-N 0.000 claims 1
- VTZYWEBKMIPMOK-UHFFFAOYSA-N n-[6-[3-tert-butyl-5-(2,4-dioxo-1,3-diazinan-1-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C=C1N1CCC(=O)NC1=O VTZYWEBKMIPMOK-UHFFFAOYSA-N 0.000 claims 1
- YZNCUYVHKAAFNE-UHFFFAOYSA-N n-[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-ethoxyphenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OCC)=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C=C1N1C=CC(=O)NC1=O YZNCUYVHKAAFNE-UHFFFAOYSA-N 0.000 claims 1
- VQTJHVDHKTWBNP-UHFFFAOYSA-N n-[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-1,3-benzothiazol-2-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3SC(NS(C)(=O)=O)=NC3=CC=2)C=C1N1C=CC(=O)NC1=O VQTJHVDHKTWBNP-UHFFFAOYSA-N 0.000 claims 1
- GQYTVPPMADGMEG-UHFFFAOYSA-N n-[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-3,4-dihydro-1h-isoquinolin-2-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CCN(CC3=CC=2)NS(C)(=O)=O)C=C1N1C=CC(=O)NC1=O GQYTVPPMADGMEG-UHFFFAOYSA-N 0.000 claims 1
- VHAQVZZQZQBPFL-UHFFFAOYSA-N n-[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]quinolin-2-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3C=CC(NS(C)(=O)=O)=NC3=CC=2)C=C1N1C=CC(=O)NC1=O VHAQVZZQZQBPFL-UHFFFAOYSA-N 0.000 claims 1
- QIPZQFYINUXBFX-UHFFFAOYSA-N n-[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]quinoxalin-2-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3N=CC(NS(C)(=O)=O)=NC3=CC=2)C=C1N1C=CC(=O)NC1=O QIPZQFYINUXBFX-UHFFFAOYSA-N 0.000 claims 1
- JAQQZCHPFDGGCY-UHFFFAOYSA-N n-[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)phenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C=1C(C(C)(C)C)=CC(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)=CC=1N1C=CC(=O)NC1=O JAQQZCHPFDGGCY-UHFFFAOYSA-N 0.000 claims 1
- RQFNDCIXKAIMTO-UHFFFAOYSA-N n-[6-[5-(2,4-dioxopyrimidin-1-yl)-2-methoxy-3-(1-methoxy-2-methylpropan-2-yl)phenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C=1C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)=C(OC)C(C(C)(C)COC)=CC=1N1C=CC(=O)NC1=O RQFNDCIXKAIMTO-UHFFFAOYSA-N 0.000 claims 1
- BFSOPAVRUAFZES-UHFFFAOYSA-N n-[6-[5-(2,4-dioxopyrimidin-1-yl)-2-methoxy-3-(2-trimethylsilylethynyl)phenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C(OC)=C(C#C[Si](C)(C)C)C=C1N1C=CC(=O)NC1=O BFSOPAVRUAFZES-UHFFFAOYSA-N 0.000 claims 1
- JUEYZKZXMUYVJK-UHFFFAOYSA-N n-[6-[5-(2,4-dioxopyrimidin-1-yl)-2-methoxy-3-(5-methylfuran-2-yl)phenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C(OC)=C(C=2OC(C)=CC=2)C=C1N1C=CC(=O)NC1=O JUEYZKZXMUYVJK-UHFFFAOYSA-N 0.000 claims 1
- OHJVMZMYTGBOFZ-UHFFFAOYSA-N n-[6-[5-(2,4-dioxopyrimidin-1-yl)-2-methoxy-3-(trifluoromethyl)phenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C(F)(F)F)C(OC)=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C=C1N1C=CC(=O)NC1=O OHJVMZMYTGBOFZ-UHFFFAOYSA-N 0.000 claims 1
- MOXQSCXVOXWDML-UHFFFAOYSA-N n-[6-[5-(2,4-dioxopyrimidin-1-yl)-2-methoxy-3-phenylphenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C(OC)=C(C=2C=CC=CC=2)C=C1N1C=CC(=O)NC1=O MOXQSCXVOXWDML-UHFFFAOYSA-N 0.000 claims 1
- PZUHHFOWCAQSSK-UHFFFAOYSA-N n-[6-[5-(2,4-dioxopyrimidin-1-yl)-2-methoxy-3-thiophen-2-ylphenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C(OC)=C(C=2SC=CC=2)C=C1N1C=CC(=O)NC1=O PZUHHFOWCAQSSK-UHFFFAOYSA-N 0.000 claims 1
- HSWQYCLLXRZTNO-UHFFFAOYSA-N n-[6-[5-(2,4-dioxopyrimidin-1-yl)-2-methoxy-3-thiophen-3-ylphenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C(OC)=C(C2=CSC=C2)C=C1N1C=CC(=O)NC1=O HSWQYCLLXRZTNO-UHFFFAOYSA-N 0.000 claims 1
- QNBYHXKNWCQTLS-UHFFFAOYSA-N n-[6-[5-(2,4-dioxopyrimidin-1-yl)-3-(1-hydroxy-2-methylpropan-2-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C(C)(C)CO)C(OC)=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C=C1N1C=CC(=O)NC1=O QNBYHXKNWCQTLS-UHFFFAOYSA-N 0.000 claims 1
- MVWTZSAJNXJGAW-UHFFFAOYSA-N n-[6-[5-(2,4-dioxopyrimidin-1-yl)-3-(furan-2-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C(OC)=C(C=2OC=CC=2)C=C1N1C=CC(=O)NC1=O MVWTZSAJNXJGAW-UHFFFAOYSA-N 0.000 claims 1
- IWCJOVAPXCYCKX-UHFFFAOYSA-N n-[6-[5-(2,4-dioxopyrimidin-1-yl)-3-(furan-3-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C(OC)=C(C2=COC=C2)C=C1N1C=CC(=O)NC1=O IWCJOVAPXCYCKX-UHFFFAOYSA-N 0.000 claims 1
- WTXZYCQMXHDUAC-UHFFFAOYSA-N n-[6-[5-(2,4-dioxopyrimidin-1-yl)-3-(methanesulfonamido)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C(OC)=C(NS(C)(=O)=O)C=C1N1C=CC(=O)NC1=O WTXZYCQMXHDUAC-UHFFFAOYSA-N 0.000 claims 1
- IWENBQYSPNHRJN-UHFFFAOYSA-N n-[6-[5-(2,4-dioxopyrimidin-1-yl)-3-iodo-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide Chemical compound C1=C(C=2C=C3C=CC(NS(C)(=O)=O)=CC3=CC=2)C(OC)=C(I)C=C1N1C=CC(=O)NC1=O IWENBQYSPNHRJN-UHFFFAOYSA-N 0.000 claims 1
- DDQAGIWEIQNYDV-SANMLTNESA-N n-[[(1r)-5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-1-fluoro-2,3-dihydroinden-1-yl]methyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3C([C@@](CC3)(F)CNS(C)(=O)=O)=CC=2)C=C1N1C=CC(=O)NC1=O DDQAGIWEIQNYDV-SANMLTNESA-N 0.000 claims 1
- IYTYOXLXXMKIMX-SFHVURJKSA-N n-[[(1r)-5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-2,3-dihydro-1h-inden-1-yl]methyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CC[C@@H](CNS(C)(=O)=O)C3=CC=2)C=C1N1C=CC(=O)NC1=O IYTYOXLXXMKIMX-SFHVURJKSA-N 0.000 claims 1
- DDQAGIWEIQNYDV-AREMUKBSSA-N n-[[(1s)-5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-1-fluoro-2,3-dihydroinden-1-yl]methyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3C([C@](CC3)(F)CNS(C)(=O)=O)=CC=2)C=C1N1C=CC(=O)NC1=O DDQAGIWEIQNYDV-AREMUKBSSA-N 0.000 claims 1
- IYTYOXLXXMKIMX-GOSISDBHSA-N n-[[(1s)-5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-2,3-dihydro-1h-inden-1-yl]methyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CC[C@H](CNS(C)(=O)=O)C3=CC=2)C=C1N1C=CC(=O)NC1=O IYTYOXLXXMKIMX-GOSISDBHSA-N 0.000 claims 1
- DDQAGIWEIQNYDV-UHFFFAOYSA-N n-[[5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-1-fluoro-2,3-dihydroinden-1-yl]methyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3C(C(CC3)(F)CNS(C)(=O)=O)=CC=2)C=C1N1C=CC(=O)NC1=O DDQAGIWEIQNYDV-UHFFFAOYSA-N 0.000 claims 1
- SNZYDZSZLNFANX-UHFFFAOYSA-N n-[[5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-1-methyl-2,3-dihydroinden-1-yl]methyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3C(C(CC3)(C)CNS(C)(=O)=O)=CC=2)C=C1N1C=CC(=O)NC1=O SNZYDZSZLNFANX-UHFFFAOYSA-N 0.000 claims 1
- IYTYOXLXXMKIMX-UHFFFAOYSA-N n-[[5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-2,3-dihydro-1h-inden-1-yl]methyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CCC(CNS(C)(=O)=O)C3=CC=2)C=C1N1C=CC(=O)NC1=O IYTYOXLXXMKIMX-UHFFFAOYSA-N 0.000 claims 1
- MNFQFJFIUOVKFY-UHFFFAOYSA-N n-[[5-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-3h-inden-1-yl]methyl]-n-methylmethanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3CC=C(CN(C)S(C)(=O)=O)C3=CC=2)C=C1N1C=CC(=O)NC1=O MNFQFJFIUOVKFY-UHFFFAOYSA-N 0.000 claims 1
- QEQINMWJWJSCMD-UHFFFAOYSA-N n-[[5-[5-(2,4-dioxopyrimidin-1-yl)-2-methoxy-3-thiophen-2-ylphenyl]-3h-inden-1-yl]methyl]methanesulfonamide Chemical compound C1=C(C=2C=C3CC=C(CNS(C)(=O)=O)C3=CC=2)C(OC)=C(C=2SC=CC=2)C=C1N1C=CC(=O)NC1=O QEQINMWJWJSCMD-UHFFFAOYSA-N 0.000 claims 1
- DLRBINTUAXJWPN-UHFFFAOYSA-N n-[[5-[5-(2,4-dioxopyrimidin-1-yl)-2-methoxy-3-thiophen-3-ylphenyl]-3h-inden-1-yl]methyl]methanesulfonamide Chemical compound C1=C(C=2C=C3CC=C(CNS(C)(=O)=O)C3=CC=2)C(OC)=C(C2=CSC=C2)C=C1N1C=CC(=O)NC1=O DLRBINTUAXJWPN-UHFFFAOYSA-N 0.000 claims 1
- JKMROEKFKNRCQC-UHFFFAOYSA-N n-[[5-[5-(2,4-dioxopyrimidin-1-yl)-3-(furan-2-yl)-2-methoxyphenyl]-3h-inden-1-yl]methyl]methanesulfonamide Chemical compound C1=C(C=2C=C3CC=C(CNS(C)(=O)=O)C3=CC=2)C(OC)=C(C=2OC=CC=2)C=C1N1C=CC(=O)NC1=O JKMROEKFKNRCQC-UHFFFAOYSA-N 0.000 claims 1
- KSLSIEFZPSLNIF-UHFFFAOYSA-N n-[[5-[5-(2,4-dioxopyrimidin-1-yl)-3-(furan-3-yl)-2-methoxyphenyl]-3h-inden-1-yl]methyl]methanesulfonamide Chemical compound C1=C(C=2C=C3CC=C(CNS(C)(=O)=O)C3=CC=2)C(OC)=C(C2=COC=C2)C=C1N1C=CC(=O)NC1=O KSLSIEFZPSLNIF-UHFFFAOYSA-N 0.000 claims 1
- OHYYUFSMPNNOPR-UHFFFAOYSA-N n-[[6-[3-tert-butyl-2-chloro-5-(2,4-dioxopyrimidin-1-yl)phenyl]-1-benzothiophen-3-yl]methyl]methanesulfonamide Chemical compound C=1C(C=2C=C3SC=C(CNS(C)(=O)=O)C3=CC=2)=C(Cl)C(C(C)(C)C)=CC=1N1C=CC(=O)NC1=O OHYYUFSMPNNOPR-UHFFFAOYSA-N 0.000 claims 1
- AGGBXQKHIOJSOM-UHFFFAOYSA-N n-[[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-1,2-benzoxazol-3-yl]methyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3ON=C(CNS(C)(=O)=O)C3=CC=2)C=C1N1C=CC(=O)NC1=O AGGBXQKHIOJSOM-UHFFFAOYSA-N 0.000 claims 1
- DSBZMFBIBUTQAU-UHFFFAOYSA-N n-[[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-1-benzofuran-3-yl]methyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3OC=C(CNS(C)(=O)=O)C3=CC=2)C=C1N1C=CC(=O)NC1=O DSBZMFBIBUTQAU-UHFFFAOYSA-N 0.000 claims 1
- NWDQPWDUNFAXND-UHFFFAOYSA-N n-[[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-1-benzothiophen-2-yl]methyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3SC(CNS(C)(=O)=O)=CC3=CC=2)C=C1N1C=CC(=O)NC1=O NWDQPWDUNFAXND-UHFFFAOYSA-N 0.000 claims 1
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- CNFBZBKPLGSFTC-UHFFFAOYSA-N n-[[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]-1-benzothiophen-3-yl]methyl]methanesulfonamide Chemical compound C1=C(C(C)(C)C)C(OC)=C(C=2C=C3SC=C(CNS(C)(=O)=O)C3=CC=2)C=C1N1C=CC(=O)NC1=O CNFBZBKPLGSFTC-UHFFFAOYSA-N 0.000 claims 1
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- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 229960003540 oxyquinoline Drugs 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
- MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 claims 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 1
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| PL2203431T3 (pl) | 2007-09-17 | 2012-01-31 | Abbvie Bahamas Ltd | Pirymidyny o działaniu przeciw zakaźnym oraz ich zastosowania |
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| PL2203431T3 (pl) * | 2007-09-17 | 2012-01-31 | Abbvie Bahamas Ltd | Pirymidyny o działaniu przeciw zakaźnym oraz ich zastosowania |
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