JP2010535210A5 - - Google Patents
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- Publication number
- JP2010535210A5 JP2010535210A5 JP2010519922A JP2010519922A JP2010535210A5 JP 2010535210 A5 JP2010535210 A5 JP 2010535210A5 JP 2010519922 A JP2010519922 A JP 2010519922A JP 2010519922 A JP2010519922 A JP 2010519922A JP 2010535210 A5 JP2010535210 A5 JP 2010535210A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- ambrisentan
- glucuronidyl
- och
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 22
- OUJTZYPIHDYQMC-LJQANCHMSA-N ambrisentan Chemical compound O([C@@H](C(OC)(C=1C=CC=CC=1)C=1C=CC=CC=1)C(O)=O)C1=NC(C)=CC(C)=N1 OUJTZYPIHDYQMC-LJQANCHMSA-N 0.000 claims 8
- 229960002414 ambrisentan Drugs 0.000 claims 6
- 238000009472 formulation Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 150000004677 hydrates Chemical class 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 239000013543 active substance Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 229940118365 Endothelin receptor antagonist Drugs 0.000 claims 1
- 210000000941 bile Anatomy 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000002308 endothelin receptor antagonist Substances 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 0 *C(C(*)(c1ccccc1)c1ccccc1)Oc1nc(*)cc(*)n1 Chemical compound *C(C(*)(c1ccccc1)c1ccccc1)Oc1nc(*)cc(*)n1 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95305307P | 2007-07-31 | 2007-07-31 | |
| PCT/US2008/009236 WO2009017777A2 (en) | 2007-07-31 | 2008-07-31 | Metabolites and derivatives of ambrisentan |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010535210A JP2010535210A (ja) | 2010-11-18 |
| JP2010535210A5 true JP2010535210A5 (https=) | 2011-05-19 |
Family
ID=39924953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010519922A Pending JP2010535210A (ja) | 2007-07-31 | 2008-07-31 | アンブリセンタンの代謝産物および誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8217155B2 (https=) |
| EP (1) | EP2183223A2 (https=) |
| JP (1) | JP2010535210A (https=) |
| CN (1) | CN101801936B (https=) |
| AU (1) | AU2008282773B8 (https=) |
| CA (1) | CA2695259C (https=) |
| MX (1) | MX2010001255A (https=) |
| WO (1) | WO2009017777A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19533023B4 (de) | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| HUE025355T2 (en) | 2006-12-12 | 2016-02-29 | Gilead Sciences Inc | Composition for treating pulmonary hypertension |
| CA2695259C (en) | 2007-07-31 | 2016-05-24 | Gilead Colorado, Inc. | Metabolites and derivatives of ambrisentan |
| US9255931B2 (en) | 2010-06-24 | 2016-02-09 | Morehouse School Of Medicine | Method and compositions for the treatment and detection of endothelin-1 related kidney diseases |
| MX346730B (es) | 2010-10-15 | 2017-03-30 | Gilead Sciences Inc | Composiciones y metodos para el tratamiento de la hipertension pulmonar. |
| CN102276536B (zh) | 2011-06-10 | 2015-04-29 | 中国科学院化学研究所 | 一种光学纯的(+)-安倍生坦和光学纯的(+)-达芦生坦的制备方法 |
| CN103012281B (zh) * | 2011-09-22 | 2015-04-08 | 江苏康缘药业股份有限公司 | 一种手性2-[(4,6-二甲基嘧啶-2-基)氧基]-3-甲氧基-3,3-二苯基丙酸的消旋化方法 |
| CN104280480B (zh) * | 2013-07-02 | 2016-12-28 | 天津药物研究院有限公司 | 一种分离检测安立生坦及其有关物质的方法 |
| CN104515816B (zh) * | 2013-09-29 | 2016-04-20 | 天津药物研究院 | 一种安立生坦原料及制剂有关物质的检测方法 |
| CN104359993B (zh) * | 2014-12-09 | 2016-03-30 | 江苏康缘药业股份有限公司 | 一种安立生坦有关物质的检测方法 |
| EP3235496A1 (en) | 2016-04-19 | 2017-10-25 | Noorik Biopharmaceuticals AG | Treatment of acute renal failure |
| CA3161516A1 (en) | 2019-12-17 | 2021-06-24 | Philip Thomas FROHLICH | Methods of treating iga nephropathy with atrasentan |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19533023B4 (de) | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| DE19726146A1 (de) * | 1997-06-19 | 1998-12-24 | Basf Ag | Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten |
| DE19806438A1 (de) | 1998-02-17 | 1999-08-19 | Basf Ag | Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung |
| US6337328B1 (en) * | 1999-03-01 | 2002-01-08 | Sepracor, Inc. | Bupropion metabolites and methods of use |
| US7534766B2 (en) * | 2004-11-05 | 2009-05-19 | Wyeth | Glucuronide metabolites and epimers thereof of tigecycline |
| EP1844001B1 (en) * | 2005-01-25 | 2009-06-10 | DOMPE' pha.r.ma s.p.a. | Metabolites of 2-arylpropionic acid derivatives and pharmaceutical compositions containing them |
| KR101390563B1 (ko) * | 2005-01-31 | 2014-04-30 | 밀란 인크. | 글루쿠로니드화된 네비볼롤 |
| WO2006136945A1 (en) * | 2005-06-17 | 2006-12-28 | Pfizer Products Inc. | METABOLITES OF 1_ [_6- (1-ETHYL-l-HYDROXY-PROPYL) -PYRIDIN-3-YL] -3- [2- (4-METHYL-PIPERAZIN-I-YL) -BE NZYL] -PYRR0LIDIN-2-0NE AS SERATONIN RECEPTOR ANTAGONISTS |
| EP2091539A1 (en) | 2006-12-12 | 2009-08-26 | Gilead Colorado, Inc. | Ambrisentan combined with a renin inhibitor for hypertensive disorder |
| HUE025355T2 (en) | 2006-12-12 | 2016-02-29 | Gilead Sciences Inc | Composition for treating pulmonary hypertension |
| CA2695259C (en) | 2007-07-31 | 2016-05-24 | Gilead Colorado, Inc. | Metabolites and derivatives of ambrisentan |
| EP2545920A1 (en) * | 2007-08-22 | 2013-01-16 | Abbott GmbH & Co. KG | Therapy for complications of diabetes |
| WO2010062640A1 (en) | 2008-10-28 | 2010-06-03 | Gilead Colorado, Inc. | Methods for treating idiopathic pulmonary fibrosis and associated complications |
-
2008
- 2008-07-31 CA CA2695259A patent/CA2695259C/en active Active
- 2008-07-31 US US12/671,439 patent/US8217155B2/en active Active
- 2008-07-31 WO PCT/US2008/009236 patent/WO2009017777A2/en not_active Ceased
- 2008-07-31 MX MX2010001255A patent/MX2010001255A/es active IP Right Grant
- 2008-07-31 JP JP2010519922A patent/JP2010535210A/ja active Pending
- 2008-07-31 CN CN2008801071505A patent/CN101801936B/zh not_active Expired - Fee Related
- 2008-07-31 AU AU2008282773A patent/AU2008282773B8/en active Active
- 2008-07-31 EP EP08794904A patent/EP2183223A2/en not_active Withdrawn
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