JP2010532665A5 - - Google Patents
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- JP2010532665A5 JP2010532665A5 JP2010515331A JP2010515331A JP2010532665A5 JP 2010532665 A5 JP2010532665 A5 JP 2010532665A5 JP 2010515331 A JP2010515331 A JP 2010515331A JP 2010515331 A JP2010515331 A JP 2010515331A JP 2010532665 A5 JP2010532665 A5 JP 2010532665A5
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- JP
- Japan
- Prior art keywords
- seq
- deletions
- nucleic acid
- oligonucleotide
- nucleotide additions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000012217 deletion Methods 0.000 claims 73
- 230000037430 deletion Effects 0.000 claims 73
- 150000007523 nucleic acids Chemical class 0.000 claims 64
- 108020004707 nucleic acids Proteins 0.000 claims 63
- 102000039446 nucleic acids Human genes 0.000 claims 63
- 230000005257 nucleotidylation Effects 0.000 claims 59
- 108091034117 Oligonucleotide Proteins 0.000 claims 54
- 239000002773 nucleotide Substances 0.000 claims 27
- 125000003729 nucleotide group Chemical group 0.000 claims 27
- 244000052769 pathogen Species 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- 230000001717 pathogenic effect Effects 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 239000000523 sample Substances 0.000 claims 8
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 7
- 230000003321 amplification Effects 0.000 claims 7
- 238000003199 nucleic acid amplification method Methods 0.000 claims 7
- 230000000295 complement effect Effects 0.000 claims 6
- 241000588923 Citrobacter Species 0.000 claims 4
- 241000588914 Enterobacter Species 0.000 claims 4
- 244000052616 bacterial pathogen Species 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- 241000894007 species Species 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 241000194017 Streptococcus Species 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 241000588697 Enterobacter cloacae Species 0.000 claims 2
- 241000588748 Klebsiella Species 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 241000607734 Yersinia <bacteria> Species 0.000 claims 2
- 208000037815 bloodstream infection Diseases 0.000 claims 2
- 241000589291 Acinetobacter Species 0.000 claims 1
- 241000588626 Acinetobacter baumannii Species 0.000 claims 1
- 208000020154 Acnes Diseases 0.000 claims 1
- 241000607516 Aeromonas caviae Species 0.000 claims 1
- 241000607528 Aeromonas hydrophila Species 0.000 claims 1
- 241000228212 Aspergillus Species 0.000 claims 1
- 241000228197 Aspergillus flavus Species 0.000 claims 1
- 241001225321 Aspergillus fumigatus Species 0.000 claims 1
- 241000228245 Aspergillus niger Species 0.000 claims 1
- 241001465318 Aspergillus terreus Species 0.000 claims 1
- 241000193755 Bacillus cereus Species 0.000 claims 1
- 244000063299 Bacillus subtilis Species 0.000 claims 1
- 235000014469 Bacillus subtilis Nutrition 0.000 claims 1
- 241000606124 Bacteroides fragilis Species 0.000 claims 1
- 241000589513 Burkholderia cepacia Species 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 241000222122 Candida albicans Species 0.000 claims 1
- 241000222173 Candida parapsilosis Species 0.000 claims 1
- 241000222178 Candida tropicalis Species 0.000 claims 1
- 206010008631 Cholera Diseases 0.000 claims 1
- 241000588917 Citrobacter koseri Species 0.000 claims 1
- 241000193468 Clostridium perfringens Species 0.000 claims 1
- 241001478240 Coccus Species 0.000 claims 1
- 241000595586 Coryne Species 0.000 claims 1
- 208000004232 Enteritis Diseases 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000589014 Kingella kingae Species 0.000 claims 1
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 1
- 240000008415 Lactuca sativa Species 0.000 claims 1
- 235000003228 Lactuca sativa Nutrition 0.000 claims 1
- 241000186779 Listeria monocytogenes Species 0.000 claims 1
- 241000588772 Morganella morganii Species 0.000 claims 1
- 241000588653 Neisseria Species 0.000 claims 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims 1
- 241000588650 Neisseria meningitidis Species 0.000 claims 1
- 241000606860 Pasteurella Species 0.000 claims 1
- 241000606856 Pasteurella multocida Species 0.000 claims 1
- 241000224016 Plasmodium Species 0.000 claims 1
- 241000588770 Proteus mirabilis Species 0.000 claims 1
- 241000588768 Providencia Species 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 241000607720 Serratia Species 0.000 claims 1
- 241000607715 Serratia marcescens Species 0.000 claims 1
- 241000607768 Shigella Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 241000191984 Staphylococcus haemolyticus Species 0.000 claims 1
- 241000192087 Staphylococcus hominis Species 0.000 claims 1
- 241001464905 Staphylococcus saccharolyticus Species 0.000 claims 1
- 241001147691 Staphylococcus saprophyticus Species 0.000 claims 1
- 241000194049 Streptococcus equinus Species 0.000 claims 1
- 241000194019 Streptococcus mutans Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- 241000194023 Streptococcus sanguinis Species 0.000 claims 1
- 241000607598 Vibrio Species 0.000 claims 1
- 208000025087 Yersinia pseudotuberculosis infectious disease Diseases 0.000 claims 1
- 241000222126 [Candida] glabrata Species 0.000 claims 1
- 238000007792 addition Methods 0.000 claims 1
- 229940091771 aspergillus fumigatus Drugs 0.000 claims 1
- 229940095731 candida albicans Drugs 0.000 claims 1
- 208000032343 candida glabrata infection Diseases 0.000 claims 1
- 229940055022 candida parapsilosis Drugs 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 229940076266 morganella morganii Drugs 0.000 claims 1
- 229940051027 pasteurella multocida Drugs 0.000 claims 1
- 229940037649 staphylococcus haemolyticus Drugs 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92974907P | 2007-07-11 | 2007-07-11 | |
| PCT/CA2008/001298 WO2009006743A1 (en) | 2007-07-11 | 2008-07-11 | Nucleic acid sequences and combination thereof for sensitive amplification and detection of bacterial and fungal sepsis pathogens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010532665A JP2010532665A (ja) | 2010-10-14 |
| JP2010532665A5 true JP2010532665A5 (enExample) | 2011-09-01 |
Family
ID=40228145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010515331A Pending JP2010532665A (ja) | 2007-07-11 | 2008-07-11 | 細菌性および真菌性敗血症の病原菌の高感度な増幅および検出用の核酸配列およびその組合せ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110151453A1 (enExample) |
| EP (1) | EP2176281A4 (enExample) |
| JP (1) | JP2010532665A (enExample) |
| AU (1) | AU2008274856A1 (enExample) |
| CA (1) | CA2693438A1 (enExample) |
| WO (1) | WO2009006743A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102031297B (zh) * | 2010-08-18 | 2013-01-30 | 李国辉 | 一种检测乳酒念珠菌的dna探针、基因芯片及其应用 |
| CN102230015B (zh) * | 2011-06-21 | 2013-05-01 | 北京出入境检验检疫局检验检疫技术中心 | 检测洋葱腐烂病菌的核苷酸序列和试剂盒 |
| RU2510856C2 (ru) * | 2012-02-24 | 2014-04-10 | Закрытое акционерное общество "Научно-производственная фирма ДНК-Технология" | НАБОР СИНТЕТИЧЕСКИХ ОЛИГОНУКЛЕОТИДОВ ДЛЯ ВЫЯВЛЕНИЯ ДНК ПАРОДОНТОПАТОГЕННОГО МИКРООРГАНИЗМА Candida albicans МЕТОДОМ ПОЛИМЕРАЗНОЙ ЦЕПНОЙ РЕАКЦИИ |
| EP3968023B1 (en) | 2013-08-19 | 2025-10-08 | Invitae Corporation | Assays for single molecule detection and use thereof |
| US10253376B2 (en) * | 2013-10-16 | 2019-04-09 | Wisconsin Alumni Research Foundation | DNA-based detection and identification of eight mastitis pathogens |
| US10260111B1 (en) * | 2014-01-20 | 2019-04-16 | Brett Eric Etchebarne | Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample |
| CN113528623A (zh) | 2015-02-18 | 2021-10-22 | 卓异生物公司 | 用于单分子检测的测定及其应用 |
| JP6834164B2 (ja) * | 2016-03-29 | 2021-02-24 | 東洋紡株式会社 | Ｐｃｒ反応溶液の検出感度を維持する方法 |
| CN111073987B (zh) * | 2016-08-30 | 2022-09-20 | 上海市生物医药技术研究院 | 小肠结肠炎耶尔森氏菌的快速恒温检测方法、引物组及试剂盒 |
| CN106701994A (zh) * | 2017-02-20 | 2017-05-24 | 中国水产科学研究院淡水渔业研究中心 | 同步检测肺炎克雷伯氏菌和豚鼠气单胞菌的双重pcr引物及其检测方法 |
| EP4549590A3 (en) | 2017-08-24 | 2025-08-06 | Roche Diagnostics GmbH | Electrochemical detection of bacterial and/or fungal infections |
| US20190062809A1 (en) | 2017-08-24 | 2019-02-28 | Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) | Electrochemical detection of bacterial and/or fungal infections |
| JP2021502825A (ja) * | 2017-11-13 | 2021-02-04 | ライフ テクノロジーズ コーポレイション | 尿路微生物検出のための組成物、方法、およびキット |
| CN108913792A (zh) * | 2018-08-03 | 2018-11-30 | 暨南大学 | 基于数字pcr技术检测猪链球菌的引物和探针及其试剂盒与方法 |
| WO2020106158A1 (en) * | 2018-11-20 | 2020-05-28 | Acd Pharmaceuticals As | Serratia liquefaciens variant |
| TWI716083B (zh) * | 2018-12-28 | 2021-01-11 | 國立成功大學 | 敗血症的菌種預測系統與方法 |
| CN114269944A (zh) * | 2019-07-19 | 2022-04-01 | 保障生物系统控股有限公司 | 使用探针、探针分子以及包含探针的阵列组合检测基因组序列用于对生物体特异性检测 |
| FR3106834B1 (fr) * | 2020-01-30 | 2024-11-29 | Ocean Diagnostics | Nouveau procédé de PCR multiplexe et utilisation |
| CN112626263B (zh) * | 2021-01-20 | 2022-08-05 | 中国人民解放军总医院 | 酶切探针恒温检测呼吸道感染真菌病原体的试剂盒 |
| WO2022157672A1 (en) * | 2021-01-20 | 2022-07-28 | Safeguard Biosystems Holdings Ltd | Improved detection of genomic sequences and probe molecules therefor |
| TW202246525A (zh) * | 2021-01-20 | 2022-12-01 | 英商安全保護生技系統公司 | 基因體序列之改善之偵測及用於其之探針分子 |
| CN114182029A (zh) * | 2021-11-30 | 2022-03-15 | 石家庄君乐宝乳业有限公司 | 一种引物组合及其在检测乳制品中阪崎克罗诺杆菌的应用 |
| CN116516038B (zh) * | 2023-06-28 | 2023-09-15 | 圣湘生物科技股份有限公司 | 血流感染病原体联检并区分的组合物、试剂盒及用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2283458A1 (en) * | 1999-09-28 | 2001-03-28 | Michel G. Bergeron | Highly conserved genes and their use to generate species-specific, genus-specific, family-specific, group-specific and universal nucleic acid probes and amplification primers to rapidly detect and identify bacterial, fungal and parasitical pathogens from clinical specimens for diagnosis |
| CA2388461C (en) * | 1999-09-28 | 2013-06-11 | Infectio Diagnostic (I.D.I.) Inc. | Highly conserved genes and their use to generate probes and primers for the detection of microorganisms |
| US20070154903A1 (en) * | 2005-06-23 | 2007-07-05 | Nanosphere, Inc. | Selective isolation and concentration of nucleic acids from complex samples |
| EP1924700A4 (en) * | 2005-07-27 | 2010-09-01 | Diagnostic Array Systems Pty L | METHOD FOR DETECTION AND / OR IDENTIFICATION OF A MICROORGANISM |
-
2008
- 2008-07-11 AU AU2008274856A patent/AU2008274856A1/en not_active Abandoned
- 2008-07-11 JP JP2010515331A patent/JP2010532665A/ja active Pending
- 2008-07-11 EP EP08783216A patent/EP2176281A4/en not_active Withdrawn
- 2008-07-11 US US12/668,622 patent/US20110151453A1/en not_active Abandoned
- 2008-07-11 WO PCT/CA2008/001298 patent/WO2009006743A1/en not_active Ceased
- 2008-07-11 CA CA2693438A patent/CA2693438A1/en not_active Abandoned
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