JP2010532366A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010532366A5 JP2010532366A5 JP2010515021A JP2010515021A JP2010532366A5 JP 2010532366 A5 JP2010532366 A5 JP 2010532366A5 JP 2010515021 A JP2010515021 A JP 2010515021A JP 2010515021 A JP2010515021 A JP 2010515021A JP 2010532366 A5 JP2010532366 A5 JP 2010532366A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methoxy
- pyrimidin
- chloro
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 claims 17
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 15
- DACXHHFKRWXMPE-UHFFFAOYSA-N 2-[3-(6-chloro-2-methoxypyrimidin-4-yl)phenyl]-2-methylpropanoic acid Chemical compound COC1=NC(Cl)=CC(C=2C=C(C=CC=2)C(C)(C)C(O)=O)=N1 DACXHHFKRWXMPE-UHFFFAOYSA-N 0.000 claims 11
- 238000005859 coupling reaction Methods 0.000 claims 7
- -1 6-chloro-2-methoxy-pyrimidin-4-yl Chemical group 0.000 claims 5
- 239000003054 catalyst Substances 0.000 claims 5
- 229910052763 palladium Inorganic materials 0.000 claims 5
- VHJKDOLGYMULOP-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)ethanamine Chemical compound NCCC1=CC=C(Cl)C=C1Cl VHJKDOLGYMULOP-UHFFFAOYSA-N 0.000 claims 4
- WDELVDLDINRUQF-UHFFFAOYSA-N 4,6-dichloro-2-methoxypyrimidine Chemical compound COC1=NC(Cl)=CC(Cl)=N1 WDELVDLDINRUQF-UHFFFAOYSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- FJKKCRCBBAXLQZ-UHFFFAOYSA-N 2-[3-[6-[2-(2,4-dichlorophenyl)ethylamino]-2-methoxypyrimidin-4-yl]phenyl]-2-methylpropanoic acid Chemical compound C=1C(C=2C=C(C=CC=2)C(C)(C)C(O)=O)=NC(OC)=NC=1NCCC1=CC=C(Cl)C=C1Cl FJKKCRCBBAXLQZ-UHFFFAOYSA-N 0.000 claims 3
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- VASYXSHADMRQTM-UHFFFAOYSA-N 2-(3-boronophenyl)-2-methylpropanoic acid Chemical compound OC(=O)C(C)(C)C1=CC=CC(B(O)O)=C1 VASYXSHADMRQTM-UHFFFAOYSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 claims 1
- 101150003085 Pdcl gene Proteins 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000005191 phase separation Methods 0.000 claims 1
- 238000001953 recrystallisation Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94725607P | 2007-06-29 | 2007-06-29 | |
| PCT/US2008/067963 WO2009006086A2 (en) | 2007-06-29 | 2008-06-24 | A new process for preparing 2-(3-{6-[2-(2,4-dichlorophenyl)-ethylamino]-2-methoxypyrimidin-4-yl}-phenyl)- 2-methylpropionic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010532366A JP2010532366A (ja) | 2010-10-07 |
| JP2010532366A5 true JP2010532366A5 (enExample) | 2011-07-21 |
Family
ID=40226759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010515021A Abandoned JP2010532366A (ja) | 2007-06-29 | 2008-06-24 | ２−（３−｛６−［２−（２，４−ジクロロフェニル）−エチルアミノ］−２−メトキシピリミジン−４−イル｝−フェニル）−２−メチルプロピオン酸を製造する新しい方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100184979A1 (enExample) |
| EP (1) | EP2170837B1 (enExample) |
| JP (1) | JP2010532366A (enExample) |
| AR (1) | AR067348A1 (enExample) |
| AT (1) | ATE531699T1 (enExample) |
| CL (1) | CL2008001913A1 (enExample) |
| PA (1) | PA8786301A1 (enExample) |
| PE (1) | PE20090428A1 (enExample) |
| TW (1) | TW200922927A (enExample) |
| UY (1) | UY31192A1 (enExample) |
| WO (1) | WO2009006086A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5833626B2 (ja) * | 2010-03-23 | 2015-12-16 | サイノファーム タイワン リミテッド | ラパチニブの調製プロセス及び中間体 |
| CN104592137B (zh) * | 2014-11-04 | 2016-09-14 | 江苏大学 | 2,2’,2”-[1,3,5-三嗪-2,4,6-三巯基]三丙酸及其合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN2005000795A (es) | 2004-10-15 | 2010-08-19 | Aventis Pharma Inc | Pirimidinas como antagonistas del receptor de prostaglandina d2 |
| GT200600457A (es) * | 2005-10-13 | 2007-04-27 | Aventis Pharma Inc | Sal de fosfato dihidrogeno como antagonistas del receptor de prostaglandina d2 |
| AR074776A1 (es) * | 2008-12-18 | 2011-02-09 | Sanofi Aventis | Metodo para tratar la degeneracion macular; modulando el sistema inmunitario del paciente |
-
2008
- 2008-06-24 JP JP2010515021A patent/JP2010532366A/ja not_active Abandoned
- 2008-06-24 WO PCT/US2008/067963 patent/WO2009006086A2/en not_active Ceased
- 2008-06-24 EP EP08771774A patent/EP2170837B1/en not_active Not-in-force
- 2008-06-24 AT AT08771774T patent/ATE531699T1/de active
- 2008-06-27 PE PE2008001109A patent/PE20090428A1/es not_active Application Discontinuation
- 2008-06-27 PA PA20088786301A patent/PA8786301A1/es unknown
- 2008-06-27 UY UY31192A patent/UY31192A1/es not_active Application Discontinuation
- 2008-06-27 AR ARP080102795A patent/AR067348A1/es not_active Application Discontinuation
- 2008-06-27 CL CL2008001913A patent/CL2008001913A1/es unknown
- 2008-06-27 TW TW097124002A patent/TW200922927A/zh unknown
-
2009
- 2009-12-16 US US12/639,507 patent/US20100184979A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101891649B (zh) | 一种制备3-氰基苯甲酸甲酯的生产方法 | |
| JP2010531876A5 (enExample) | ||
| US8252952B2 (en) | Optically active quaternary ammonium salt having axial asymmetry, and method for producing alpha-amino acid and derivative thereof by using the same | |
| CN102558020B (zh) | 一种3-芳巯基吲哚类化合物的合成方法 | |
| JP2004527577A5 (enExample) | ||
| CN102311394B (zh) | 一种5-乙基-5-苯基巴比妥酸的制备方法 | |
| JP2010532366A5 (enExample) | ||
| JP5689321B2 (ja) | ２−アミノ−４−トリフルオロメチルピリジン類の製造方法 | |
| KR20060020082A (ko) | 2-아미노피리딘 유도체의 제조방법 | |
| CN110452181A (zh) | 2-甲基-4-氨基-5-甲酰胺甲基嘧啶的合成方法 | |
| CN107001250B (zh) | 一种制备奥当卡替中间体的方法 | |
| CN102260236B (zh) | 一种香豆素类化合物的制备方法 | |
| JP4719446B2 (ja) | ｄｌ−１，２−ジフェニルエチレンジアミンの製造方法 | |
| CN101318919A (zh) | 6-乙硫基-3-庚烯-2-酮的合成方法 | |
| JP6709509B2 (ja) | 窒素含有ペンタフルオロスルファニルベンゼン化合物の製造方法 | |
| CN106496266B (zh) | 一种草铵膦的制备方法 | |
| RU2006143986A (ru) | Способ получения арилоксикарбоновых кислот | |
| WO2010024419A1 (ja) | α－ヒドロキシエステル化合物の製造方法 | |
| CN101863821B (zh) | 一种以手性脯氨酸酯为原料制备手性肼的方法 | |
| CN101490013B (zh) | 咪唑烷-2,4-二酮化合物的制备方法以及固体状4,5-二羟基-2-咪唑啉酮化合物的获取方法 | |
| TW200922927A (en) | A new process for preparing 2-(3-{6-[2-(2,4-dichlorophenyl)-ethylamino]-2-methoxypyrimidin-4-yl}-phenyl)-2-methylpropionic acid | |
| JPH0410450B2 (enExample) | ||
| JP4911528B2 (ja) | 光学活性ヒドロキシメチル化化合物の製法及びそのための触媒 | |
| KR101354175B1 (ko) | 2-(3,3-디메톡시)프로파노에이트기로부터 메틸 (ｅ)-2-(3-메톡시)아크릴레이트기의 제조방법 | |
| CN103450166A (zh) | 制备核苷化合物的方法 |