JP2010531878A5 - - Google Patents
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- JP2010531878A5 JP2010531878A5 JP2010514839A JP2010514839A JP2010531878A5 JP 2010531878 A5 JP2010531878 A5 JP 2010531878A5 JP 2010514839 A JP2010514839 A JP 2010514839A JP 2010514839 A JP2010514839 A JP 2010514839A JP 2010531878 A5 JP2010531878 A5 JP 2010531878A5
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- cancer cells
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- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 101001003140 Homo sapiens Interleukin-15 receptor subunit alpha Proteins 0.000 claims 16
- 206010028980 Neoplasm Diseases 0.000 claims 15
- 201000011510 cancer Diseases 0.000 claims 15
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 claims 12
- 102000056003 human IL15 Human genes 0.000 claims 12
- 102000003812 Interleukin-15 Human genes 0.000 claims 10
- 108090000172 Interleukin-15 Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 2
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000036737 immune function Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93747107P | 2007-06-27 | 2007-06-27 | |
| PCT/US2008/008084 WO2009002562A2 (en) | 2007-06-27 | 2008-06-27 | Complexes of il-15 and il-15ralpha and uses thereof |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014001373A Division JP2014114294A (ja) | 2007-06-27 | 2014-01-08 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2015115431A Division JP2015212270A (ja) | 2007-06-27 | 2015-06-08 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010531878A JP2010531878A (ja) | 2010-09-30 |
| JP2010531878A5 true JP2010531878A5 (cg-RX-API-DMAC7.html) | 2011-08-11 |
Family
ID=40186225
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010514839A Pending JP2010531878A (ja) | 2007-06-27 | 2008-06-27 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2014001373A Pending JP2014114294A (ja) | 2007-06-27 | 2014-01-08 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2015115431A Pending JP2015212270A (ja) | 2007-06-27 | 2015-06-08 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2016226503A Withdrawn JP2017079745A (ja) | 2007-06-27 | 2016-11-22 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2018245439A Withdrawn JP2019088288A (ja) | 2007-06-27 | 2018-12-27 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2021086283A Pending JP2021152017A (ja) | 2007-06-27 | 2021-05-21 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2022172896A Pending JP2023015158A (ja) | 2007-06-27 | 2022-10-28 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014001373A Pending JP2014114294A (ja) | 2007-06-27 | 2014-01-08 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2015115431A Pending JP2015212270A (ja) | 2007-06-27 | 2015-06-08 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2016226503A Withdrawn JP2017079745A (ja) | 2007-06-27 | 2016-11-22 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2018245439A Withdrawn JP2019088288A (ja) | 2007-06-27 | 2018-12-27 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2021086283A Pending JP2021152017A (ja) | 2007-06-27 | 2021-05-21 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
| JP2022172896A Pending JP2023015158A (ja) | 2007-06-27 | 2022-10-28 | ＩＬ‐１５とＩＬ‐１５Ｒαとの複合体及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9931377B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2173378B1 (cg-RX-API-DMAC7.html) |
| JP (7) | JP2010531878A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008269032B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2691785C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2173378T3 (cg-RX-API-DMAC7.html) |
| ES (2) | ES2466916T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1198421A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL202997A (cg-RX-API-DMAC7.html) |
| NZ (4) | NZ703668A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009002562A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (116)
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| EP3805245A1 (en) | 2005-05-17 | 2021-04-14 | University of Connecticut | Compositions and methods for immunomodulation in an organism |
| EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| NZ595736A (en) | 2005-12-02 | 2013-05-31 | Sinai School Medicine | Chimeric viruses presenting non-native surface proteins and uses thereof |
| BRPI0707106B1 (pt) | 2006-01-13 | 2022-06-07 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Polinucleotídeo interleucina-15, vetor de expressão, e, composição farmacêutica |
| JP5501222B2 (ja) | 2007-05-11 | 2014-05-21 | アルター・バイオサイエンス・コーポレーション | 融合分子及びｉｌ−１５変異体 |
| US9931377B2 (en) | 2007-06-27 | 2018-04-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cell expressing complexes of IL-15 and IL-15Ralpha |
| US8871191B2 (en) | 2009-08-14 | 2014-10-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of IL-15 preparations to treat lymphopenia |
| KR20120093163A (ko) * | 2009-09-14 | 2012-08-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Ｉｌ-15 수용체 알파 및/또는 이를 인코딩하는 핵산 분자를 포함하는 백신 및 면역 치료제, 및 이를 이용하는 방법 |
| CN101837123B (zh) * | 2010-05-27 | 2016-05-25 | 四川大学 | 肿瘤细胞疫苗及其制备方法 |
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| US20170335281A1 (en) | 2014-03-15 | 2017-11-23 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
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