JP2010531687A5 - - Google Patents
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- Publication number
- JP2010531687A5 JP2010531687A5 JP2010513732A JP2010513732A JP2010531687A5 JP 2010531687 A5 JP2010531687 A5 JP 2010531687A5 JP 2010513732 A JP2010513732 A JP 2010513732A JP 2010513732 A JP2010513732 A JP 2010513732A JP 2010531687 A5 JP2010531687 A5 JP 2010531687A5
- Authority
- JP
- Japan
- Prior art keywords
- adhesive system
- isocyanate
- group
- component
- prepolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000853 adhesive Substances 0.000 claims description 25
- 230000001070 adhesive effect Effects 0.000 claims description 25
- -1 aliphatic isocyanate Chemical class 0.000 claims description 10
- IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 6
- 239000007795 chemical reaction product Substances 0.000 claims description 6
- 229940009098 aspartate Drugs 0.000 claims description 5
- 239000012948 isocyanate Substances 0.000 claims description 5
- VHRGRCVQAFMJIZ-UHFFFAOYSA-N cadaverine Chemical compound NCCCCCN VHRGRCVQAFMJIZ-UHFFFAOYSA-N 0.000 claims description 4
- 230000001413 cellular effect Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 125000000962 organic group Chemical group 0.000 claims description 4
- 229920005862 polyol Polymers 0.000 claims description 4
- 150000003077 polyols Chemical class 0.000 claims description 4
- 235000003704 aspartic acid Nutrition 0.000 claims description 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 3
- 150000002513 isocyanates Chemical class 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims description 3
- 229920000570 polyether Polymers 0.000 claims description 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 2
- JZUHIOJYCPIVLQ-UHFFFAOYSA-N 2-methylpentane-1,5-diamine Chemical compound NCC(C)CCCN JZUHIOJYCPIVLQ-UHFFFAOYSA-N 0.000 claims description 2
- HUXPKQXHDPXCMM-UHFFFAOYSA-N 5,6-dimethylheptane-1,6-diamine Chemical compound CC(N)(C)C(C)CCCCN HUXPKQXHDPXCMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- NAQMVNRVTILPCV-UHFFFAOYSA-N hexane-1,6-diamine Chemical compound NCCCCCCN NAQMVNRVTILPCV-UHFFFAOYSA-N 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000002313 adhesive film Substances 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000003106 tissue adhesive Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07012984 | 2007-07-03 | ||
| EP07012984.6 | 2007-07-03 | ||
| EP07021764A EP2011808A1 (de) | 2007-07-03 | 2007-11-09 | Medizinische Klebstoffe für die Chirurgie |
| EP07021764.1 | 2007-11-09 | ||
| PCT/EP2008/004980 WO2009003596A1 (de) | 2007-07-03 | 2008-06-20 | Medizinische klebstoffe für die chirurgie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010531687A JP2010531687A (ja) | 2010-09-30 |
| JP2010531687A5 true JP2010531687A5 (https=) | 2011-08-04 |
| JP5425767B2 JP5425767B2 (ja) | 2014-02-26 |
Family
ID=38786985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010513732A Expired - Fee Related JP5425767B2 (ja) | 2007-07-03 | 2008-06-20 | 手術のための医療用接着剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7754782B2 (https=) |
| EP (3) | EP2011808A1 (https=) |
| JP (1) | JP5425767B2 (https=) |
| KR (1) | KR20100028580A (https=) |
| CN (1) | CN101687969B (https=) |
| AT (2) | ATE534683T1 (https=) |
| CA (1) | CA2691911A1 (https=) |
| DE (1) | DE502008002492D1 (https=) |
| DK (1) | DK2173782T3 (https=) |
| ES (2) | ES2375689T3 (https=) |
| TW (1) | TW200918568A (https=) |
| WO (1) | WO2009003596A1 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2083025A1 (de) * | 2008-01-24 | 2009-07-29 | Bayer MaterialScience AG | Medizinische Klebstoffe für die Chirurgie |
| EP2095832A1 (de) * | 2008-02-28 | 2009-09-02 | Bayer MaterialScience AG | Polyharnstoff-Systeme und deren Anwendung als postoperative Adhäsionsbarrieren, Filme und Verbundteile. |
| EP2145634A1 (de) | 2008-07-17 | 2010-01-20 | Bayer MaterialScience AG | Medizinische Klebstoffe zur Stillung schwerwiegender Blutungen und Abdichtung von Leckagen |
| EP2275466A1 (de) | 2009-07-16 | 2011-01-19 | Bayer MaterialScience AG | Polyharnstoff-basierter Gewebekleber |
| CN102711738A (zh) | 2009-11-13 | 2012-10-03 | 百时美施贵宝公司 | 质量得以减小的二甲双胍制剂 |
| JP5784623B2 (ja) | 2009-11-13 | 2015-09-24 | アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ | 速放性錠剤製剤 |
| EP3315124B1 (en) | 2009-11-13 | 2021-01-06 | Astrazeneca AB | Bilayer tablet formulations |
| EP2336212B1 (de) | 2009-12-12 | 2012-03-07 | Bayer MaterialScience AG | Klebstoffverbundsystem zum Abdecken, Verschliessen oder Verkleben von Zellgewebe |
| DE102009054749A1 (de) * | 2009-12-16 | 2011-06-22 | Evonik Degussa GmbH, 45128 | Zusammensetzung aus (cyclo)aliphatischen Diisocyanaten und aromatischen Säurehalogeniden |
| CN103370064A (zh) | 2010-09-03 | 2013-10-23 | 百时美施贵宝公司 | 使用水溶性抗氧化剂的药物制剂 |
| US11058796B2 (en) | 2010-10-20 | 2021-07-13 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US11207109B2 (en) | 2010-10-20 | 2021-12-28 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US10525169B2 (en) | 2010-10-20 | 2020-01-07 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US20120101593A1 (en) | 2010-10-20 | 2012-04-26 | BIOS2 Medical, Inc. | Implantable polymer for bone and vascular lesions |
| US11484627B2 (en) | 2010-10-20 | 2022-11-01 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US10525168B2 (en) | 2010-10-20 | 2020-01-07 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| US11291483B2 (en) | 2010-10-20 | 2022-04-05 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants |
| CA2826391C (en) | 2011-02-01 | 2017-01-24 | Bristol-Myers Squibb Company | Pharmaceutical formulations including an amine compound |
| WO2012107376A1 (de) * | 2011-02-09 | 2012-08-16 | Bayer Materialscience Ag | Gewebekleber auf basis aminosubstituierter triacetale |
| WO2012107375A1 (de) * | 2011-02-09 | 2012-08-16 | Bayer Materialscience Ag | Gewebekleber auf basis stickstoffmodifizierter aspartate |
| PL2673311T3 (pl) * | 2011-02-09 | 2015-02-27 | Bayer Materialscience Ag | Kleje tkankowe na bazie trójfunkcjonalnych asparginianów |
| EP2699615B1 (de) | 2011-04-19 | 2015-06-17 | Medical Adhesive Revolution GmbH | Medizinischer klebstoff zur stillung von blutungen |
| WO2012143358A1 (de) * | 2011-04-19 | 2012-10-26 | Bayer Materialscience Ag | Gewebekleber mit beschleunigter aushärtung |
| CN103030773A (zh) * | 2011-10-10 | 2013-04-10 | 珠海飞扬化工有限公司 | 一种聚合型改性聚天门冬氨酸酯化合物及其制备方法 |
| TW201325933A (zh) * | 2011-12-19 | 2013-07-01 | Compal Electronics Inc | 具有立體圖紋的工件 |
| ES2694826T3 (es) | 2011-12-20 | 2018-12-27 | Adhesys Medical Gmbh | Prepolímero con funcionalidad isocianato para un adhesivo de tejidos biodegradable |
| ES2576702T3 (es) * | 2012-01-09 | 2016-07-08 | Adhesys Medical Gmbh | Agentes de curado (a base de aspartato) modificados por ésteres de beta-aminoácido y su uso en adhesivos de tejido de poliurea |
| EP2817346B1 (en) | 2012-02-21 | 2017-04-26 | Dow Global Technologies LLC | Compositions containing aromatic isocyanate functional components and aliphatic aromatic isocyanate functional components having improved cure speed |
| EP2819620A4 (en) | 2012-02-29 | 2015-11-04 | 206 Ortho Inc | METHOD AND APPARATUS FOR TREATING BONE FRACTURES, INCLUDING THE USE OF COMPOSITE IMPLANTS |
| CN102806809A (zh) * | 2012-08-28 | 2012-12-05 | 深圳市飞扬骏研技术开发有限公司 | 天冬聚脲表面装饰层及施工方法 |
| CN103072423A (zh) * | 2012-11-23 | 2013-05-01 | 牛智勇 | 具有多彩自然花纹型饰面层的一体板制作工艺 |
| CN103072422A (zh) * | 2012-11-23 | 2013-05-01 | 牛智勇 | 具有浮雕花纹型饰面层的一体板制作工艺 |
| EP2999747B1 (en) | 2013-05-23 | 2020-08-12 | 206 ORTHO, Inc. | Apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone |
| JP6137471B2 (ja) * | 2013-05-30 | 2017-05-31 | 日立工機株式会社 | コードレス丸のこ |
| CN103627361B (zh) * | 2013-11-29 | 2015-08-26 | 深圳市百安百科技有限公司 | 一种用于油面粘接的修补剂 |
| EP3154444B1 (en) | 2014-05-08 | 2022-02-23 | 206 Ortho, Inc. | Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications |
| DE102018202050A1 (de) * | 2018-02-09 | 2019-08-14 | Glue Tec Industrieklebstoffe Gmbh & Co. Kg | Zweikomponenten-strukturklebstoffe |
| EP3698723A1 (de) | 2019-02-20 | 2020-08-26 | Adhesys Medical GmbH | Applikator für einen zwei-komponenten gewebekleber |
| EP3756705A1 (de) | 2019-06-27 | 2020-12-30 | Adhesys Medical GmbH | Applikator für einen zwei-komponenten gewebekleber |
| US20210040362A1 (en) | 2019-08-08 | 2021-02-11 | Covestro Llc | Flexible polyureas for flexible packaging adhesive without aromatic amine migration |
| US20210039359A1 (en) | 2019-08-08 | 2021-02-11 | Covestro Llc | Flexibilized polyurethanes for flexible packaging adhesive without aromatic amine migration |
| US20210179903A1 (en) * | 2019-12-11 | 2021-06-17 | Covestro Llc | Adhesive produced using aspartate-terminated prepolymers |
| KR102619234B1 (ko) * | 2021-11-29 | 2024-01-02 | 한국생산기술연구원 | 극저온용 2액형 반응성 접착제 조성물 |
| CN114773562B (zh) * | 2022-04-27 | 2023-07-25 | 广东粤港澳大湾区黄埔材料研究院 | 生物功能型单组分医用胶粘剂及其制备方法、应用 |
| CN115970043B (zh) * | 2022-09-09 | 2024-08-23 | 吉林大学 | 一种用于修复组织的黏合剂及其制备方法和应用 |
| CN116899007A (zh) * | 2023-06-29 | 2023-10-20 | 华南理工大学 | 一种基于聚氨酯的软组织生物粘合剂制备方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1155871A (en) * | 1980-10-16 | 1983-10-25 | Gencorp Inc. | Method for treating polypropylene ether and poly-1,2- butylene ether polyols |
| US4740534A (en) | 1985-08-30 | 1988-04-26 | Sanyo Chemical Industries, Ltd. | Surgical adhesive |
| US5236741A (en) * | 1989-06-23 | 1993-08-17 | Bayer Aktiengesellschaft | Process for the production of polyurethane coatings |
| JPH04150866A (ja) | 1990-10-15 | 1992-05-25 | Nisshinbo Ind Inc | 外科用接着剤 |
| JP2928892B2 (ja) | 1990-11-27 | 1999-08-03 | 三洋化成工業株式会社 | 外科用接着剤 |
| US5156613A (en) | 1991-02-13 | 1992-10-20 | Interface Biomedical Laboratories Corp. | Collagen welding rod material for use in tissue welding |
| US5243012A (en) | 1992-06-10 | 1993-09-07 | Miles Inc. | Polyurea coating compositions having improved pot lives |
| US6017577A (en) | 1995-02-01 | 2000-01-25 | Schneider (Usa) Inc. | Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices |
| US5506327A (en) * | 1995-05-23 | 1996-04-09 | Bayer Corporation | Blocked polyisocyanates with improved thermal stability |
| US5591807A (en) * | 1995-05-23 | 1997-01-07 | The Sherwin-Williams Company | Polyimine/polyisocyanate coating composition containing polymeric anhydride |
| DE19542119C1 (de) * | 1995-11-11 | 1997-02-13 | Herberts Gmbh | Überzugsmittel und Verfahren zur Herstellung von Mehrschichtüberzügen |
| US6123667A (en) | 1997-03-20 | 2000-09-26 | Focal, Inc. | Retracting tissue using photoadhering adhesive |
| US6355829B2 (en) | 1999-09-02 | 2002-03-12 | Bayer Corporation | Aspartate-terminated urea/urethane prepolymers and their use in coating compositions |
| JP4383859B2 (ja) | 2001-07-18 | 2009-12-16 | エヌイーシー ショット コンポーネンツ株式会社 | 温度ヒューズ |
| DE10135316A1 (de) * | 2001-07-19 | 2003-01-30 | Bayer Ag | Verwendung spezieller Härter in 2-Komponenten PU-Systemen zum Beschichten flexibler Substrate |
| US6630555B2 (en) * | 2001-11-06 | 2003-10-07 | Lord Corporation | Internally blocked organoborate initiators and adhesives therefrom |
| US8501165B2 (en) * | 2001-12-12 | 2013-08-06 | Promethean Surgical Devices Llc | In situ bonds |
| US6897281B2 (en) * | 2002-04-05 | 2005-05-24 | Noveon Ip Holdings Corp. | Breathable polyurethanes, blends, and articles |
| DE10216945A1 (de) * | 2002-04-17 | 2003-11-06 | Bayer Ag | Selbstvernetzende PUR-Dispersionen |
| DE10246708A1 (de) * | 2002-10-07 | 2004-04-15 | Bayer Ag | Zweikomponenten-Systeme für die Herstellung elastischer Beschichtungen |
| DE10260270A1 (de) * | 2002-12-20 | 2004-07-01 | Bayer Ag | Hydrophile Polyurethan-Polyharnstoff-Dispersion |
| US20050129733A1 (en) | 2003-12-09 | 2005-06-16 | Milbocker Michael T. | Surgical adhesive and uses therefore |
| US8313809B2 (en) * | 2007-12-11 | 2012-11-20 | Patrick Ilfrey | Same-day coatings and processes |
| EP2083025A1 (de) * | 2008-01-24 | 2009-07-29 | Bayer MaterialScience AG | Medizinische Klebstoffe für die Chirurgie |
| EP2095832A1 (de) * | 2008-02-28 | 2009-09-02 | Bayer MaterialScience AG | Polyharnstoff-Systeme und deren Anwendung als postoperative Adhäsionsbarrieren, Filme und Verbundteile. |
-
2007
- 2007-11-09 EP EP07021764A patent/EP2011808A1/de not_active Withdrawn
-
2008
- 2008-06-20 KR KR1020097027263A patent/KR20100028580A/ko not_active Withdrawn
- 2008-06-20 ES ES09015098T patent/ES2375689T3/es active Active
- 2008-06-20 JP JP2010513732A patent/JP5425767B2/ja not_active Expired - Fee Related
- 2008-06-20 WO PCT/EP2008/004980 patent/WO2009003596A1/de not_active Ceased
- 2008-06-20 EP EP09015098A patent/EP2182018B1/de not_active Not-in-force
- 2008-06-20 AT AT09015098T patent/ATE534683T1/de active
- 2008-06-20 DK DK08773541.1T patent/DK2173782T3/da active
- 2008-06-20 EP EP08773541A patent/EP2173782B1/de not_active Not-in-force
- 2008-06-20 DE DE502008002492T patent/DE502008002492D1/de active Active
- 2008-06-20 AT AT08773541T patent/ATE496952T1/de active
- 2008-06-20 CA CA002691911A patent/CA2691911A1/en not_active Abandoned
- 2008-06-20 CN CN2008800230256A patent/CN101687969B/zh not_active Expired - Fee Related
- 2008-06-20 ES ES08773541T patent/ES2358079T3/es active Active
- 2008-06-30 US US12/164,278 patent/US7754782B2/en not_active Expired - Fee Related
- 2008-07-02 TW TW097124821A patent/TW200918568A/zh unknown
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