JP2010527244A5 - - Google Patents
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- Publication number
- JP2010527244A5 JP2010527244A5 JP2010508603A JP2010508603A JP2010527244A5 JP 2010527244 A5 JP2010527244 A5 JP 2010527244A5 JP 2010508603 A JP2010508603 A JP 2010508603A JP 2010508603 A JP2010508603 A JP 2010508603A JP 2010527244 A5 JP2010527244 A5 JP 2010527244A5
- Authority
- JP
- Japan
- Prior art keywords
- pks system
- pufa pks
- seq
- chimeric
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 167
- 150000007523 nucleic acids Chemical group 0.000 claims description 55
- 241000233671 Schizochytrium Species 0.000 claims description 38
- 108020004707 nucleic acids Proteins 0.000 claims description 29
- 102000039446 nucleic acids Human genes 0.000 claims description 29
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 26
- 241000233675 Thraustochytrium Species 0.000 claims description 24
- 108700010070 Codon Usage Proteins 0.000 claims description 20
- 244000005700 microbiome Species 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 19
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 108090000623 proteins and genes Proteins 0.000 claims description 16
- 108700016155 Acyl transferases Proteins 0.000 claims description 6
- 102000057234 Acyl transferases Human genes 0.000 claims description 6
- 101710130262 Probable Vpr-like protein Proteins 0.000 claims description 6
- 108010019608 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase Proteins 0.000 claims description 4
- 102000000157 3-oxoacyl-(acyl-carrier-protein) reductase Human genes 0.000 claims description 4
- 108010055468 3-oxoacyl-(acyl-carrier-protein) reductase Proteins 0.000 claims description 4
- 102100037149 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial Human genes 0.000 claims description 4
- 101710198510 Enoyl-[acyl-carrier-protein] reductase [NADH] Proteins 0.000 claims description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
- 150000001413 amino acids Chemical group 0.000 claims description 4
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 claims description 2
- 102000002508 Peptide Elongation Factors Human genes 0.000 claims description 2
- 108010068204 Peptide Elongation Factors Proteins 0.000 claims description 2
- 241001467333 Thraustochytriaceae Species 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/749,686 US8003772B2 (en) | 1999-01-14 | 2007-05-16 | Chimeric PUFA polyketide synthase systems and uses thereof |
| US11/749,686 | 2007-05-16 | ||
| PCT/US2008/063835 WO2008144473A2 (en) | 2007-05-16 | 2008-05-16 | Chimeric pufa polyketide synthase systems and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527244A JP2010527244A (ja) | 2010-08-12 |
| JP2010527244A5 true JP2010527244A5 (cg-RX-API-DMAC7.html) | 2011-06-30 |
| JP5551584B2 JP5551584B2 (ja) | 2014-07-16 |
Family
ID=40122412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010508603A Expired - Fee Related JP5551584B2 (ja) | 2007-05-16 | 2008-05-16 | キメラｐｕｆａポリケチドシンターゼシステムおよびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8003772B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2160470B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5551584B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101539470B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101849014B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008254837B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0810302A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2687523C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2467918T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL202131A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2009012395A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008144473A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566583B1 (en) * | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
| US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7211418B2 (en) | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US8003772B2 (en) * | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| TWI324181B (en) | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| ES2529572T3 (es) | 2004-04-22 | 2015-02-23 | Commonwealth Scientific And Industrial Research Organisation | Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes |
| EP2357243B1 (en) | 2004-04-22 | 2018-12-12 | Commonwealth Scientific and Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| US7759548B2 (en) * | 2006-03-15 | 2010-07-20 | Martek Biosciences Corporation | Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems |
| RU2009111266A (ru) | 2006-08-29 | 2010-10-10 | Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) | Синтез жирных кислот |
| SG190572A1 (en) | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| WO2010057246A1 (en) | 2008-11-18 | 2010-05-27 | Commonwealth Scientific Industrial Research Organisation | Enzymes and methods for producing omega-3 fatty acids |
| AU2010225930B2 (en) * | 2009-03-16 | 2017-01-12 | Dsm Ip Assets B.V. | Protein production in microorganisms of the phylum Labyrinthulomycota |
| US8940884B2 (en) | 2009-03-19 | 2015-01-27 | Dsm Ip Assets B.V. | Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| EP2966169A1 (en) | 2009-09-24 | 2016-01-13 | Kyushu University | Method for transforming stramenopiles |
| ES2651313T3 (es) * | 2009-12-28 | 2018-01-25 | Dsm Ip Assets B.V. | Traustoquítridos recombinantes que crecen en xilosa, y composiciones, métodos de preparación y usos de los mismos |
| WO2011082190A1 (en) | 2009-12-28 | 2011-07-07 | Martek Biosciences Corporation | Recombinant thraustochytrids that grow on sucrose, and compositions, methods of making, and uses thereof |
| CA3028175C (en) * | 2009-12-28 | 2022-05-24 | Sanofi Vaccine Technologies, S.A.S. | Methods of producing heterologous viral neuraminidase proteins in microalgae |
| EP3213766A1 (en) | 2009-12-28 | 2017-09-06 | Merial Ltd. | Recombinant ndv antigen and uses thereof |
| JP5838473B2 (ja) * | 2009-12-28 | 2016-01-06 | サノフィ ワクチン テクノロジーズ エス．エー．エス． | 微細藻類におけるヘマグルチニン−ノイラミニダーゼタンパク質の産生方法 |
| CN102884201B (zh) * | 2010-01-19 | 2016-04-13 | 帝斯曼知识产权资产管理有限公司 | 生产二十碳五烯酸的微生物、脂肪酸组成物及其制作方法与用途 |
| CN103492410A (zh) | 2010-03-12 | 2014-01-01 | 梅里亚有限公司 | 蓝舌病毒重组疫苗和其使用 |
| US11236351B2 (en) * | 2010-05-17 | 2022-02-01 | Dow Agrosciences Llc | Production of DHA and other LC PUFAs in plants |
| TW201144442A (en) | 2010-05-17 | 2011-12-16 | Dow Agrosciences Llc | Production of DHA and other LC-PUFAs in plants |
| UY33492A (es) | 2010-07-09 | 2012-01-31 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| CA2807014A1 (en) | 2010-08-03 | 2012-02-09 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| CA2823678A1 (en) * | 2010-10-01 | 2012-04-05 | Kyushu University, National University Corporation | Transformation of a stramenopile for production of a microbial oil |
| CA2829296C (en) * | 2011-03-07 | 2019-10-29 | ShuoCheng ZHANG | Engineering thraustochytrid microorganisms |
| CN103930104A (zh) | 2011-07-21 | 2014-07-16 | 帝斯曼知识产权资产管理有限公司 | 脂肪酸组合物 |
| TW201307553A (zh) * | 2011-07-26 | 2013-02-16 | Dow Agrosciences Llc | 在植物中生產二十二碳六烯酸（ｄｈａ）及其他長鏈多元不飽和脂肪酸（ｌｃ－ｐｕｆａ）之技術 |
| HUE033766T2 (en) | 2012-06-15 | 2018-01-29 | Commw Scient Ind Res Org | Production of long chain polyunsaturated fatty acids in plant cells |
| TW201525136A (zh) | 2013-11-26 | 2015-07-01 | Dow Agrosciences Llc | 利用破囊壺菌ＰＵＦＡ合成酶於油籽作物中生成ω－３長鏈多不飽和脂肪酸 |
| KR102386838B1 (ko) | 2013-12-18 | 2022-04-15 | 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 | 장쇄 다중불포화 지방산을 포함하는 지질 |
| KR102527795B1 (ko) | 2014-06-27 | 2023-05-02 | 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 | 도코사펜타에노산을 포함하는 지질 |
| CA2977271A1 (en) | 2015-03-02 | 2016-09-09 | Synthetic Genomics, Inc. | Regulatory elements from labyrinthulomycetes microorganisms |
| CA2978770A1 (en) * | 2015-03-12 | 2016-09-15 | Synthetic Genomics, Inc. | Microorganisms for fatty acid production using elongase and desaturase enzymes |
| EP3430035A4 (en) | 2016-03-16 | 2020-02-19 | Conagen Inc. | PRODUCTION OF PROTEINS IN LABYRINE THULOMYCETES |
| JP6966040B2 (ja) | 2016-05-12 | 2021-11-10 | ディーエスエム アイピー アセッツ ビー.ブイ.Dsm Ip Assets B.V. | 微細藻類中でのオメガ−３多価不飽和脂肪酸産生を増加させる方法 |
| CN109689856A (zh) | 2016-07-13 | 2019-04-26 | 帝斯曼知识产权资产管理有限公司 | 用于海藻宿主细胞的CRISPR-Cas系统 |
| US10633454B2 (en) | 2016-11-01 | 2020-04-28 | Conagen Inc. | Expression of modified glycoproteins and glycopeptides |
| CN106947706B (zh) * | 2017-05-10 | 2020-07-07 | 南京工业大学 | 一株裂殖壶菌菌株、其构建方法及应用 |
| WO2020032261A1 (ja) | 2018-08-10 | 2020-02-13 | 協和発酵バイオ株式会社 | エイコサペンタエン酸を生産する微生物及びエイコサペンタエン酸の製造法 |
| US12241101B2 (en) | 2018-08-10 | 2025-03-04 | Kyowa Hakko Bio Co., Ltd. | Microorganism producing polyunsaturated fatty acid and method for producing polyunsaturated fatty acid |
| WO2023144707A1 (en) | 2022-01-25 | 2023-08-03 | Dsm Ip Assets B.V. | Media refinement and nutrient feeding approaches to increase polyunsaturated fatty acid production |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5246841A (en) * | 1986-12-26 | 1993-09-21 | Sagami Chemical Research Center | Microbial process for production of eicosapentaenoic acid |
| US5340742A (en) * | 1988-09-07 | 1994-08-23 | Omegatech Inc. | Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids |
| US5130242A (en) * | 1988-09-07 | 1992-07-14 | Phycotech, Inc. | Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids |
| US5639790A (en) * | 1991-05-21 | 1997-06-17 | Calgene, Inc. | Plant medium-chain thioesterases |
| US5798259A (en) * | 1992-05-15 | 1998-08-25 | Sagami Chemical Research Center | Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid |
| CA2113557A1 (en) | 1992-05-15 | 1993-11-25 | Kazunaga Yazawa | Gene which codes for eicosapentaenoic acid synthetase group and process for producing eicosapentaenoic acid |
| US5683898A (en) * | 1992-05-15 | 1997-11-04 | Sagami Chemical Research Center | Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid |
| US5310242A (en) * | 1992-09-28 | 1994-05-10 | Golder Kimberly A | Portable infant seat |
| DE4323727A1 (de) * | 1993-07-15 | 1995-03-09 | Boehringer Mannheim Gmbh | Verfahren zur Identifizierung von menschlichen und tierischen Zellen mit der Fähigkeit zu unbegrenzter Proliferation oder zur Tumorbildung |
| US5672491A (en) * | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
| EP0831149A4 (en) | 1995-01-13 | 2000-12-06 | Sagami Chem Res | GENES CODING FOR THE GROUP OF ENZYMES FOR BIOSYNTHESIS OF EICOSAPENTIC ACID AND METHOD FOR PRODUCING EICOSAPENTIC ACID |
| DE69637953D1 (de) | 1995-04-17 | 2009-07-30 | Nat Inst Of Advanced Ind Scien | Hoch ungesättigte fettsäurenproduzierende mikroorganismen und verfahren zur herstellung von hoch ungesättigten fettsäuren durch verwendung dieser mikroorganismen |
| US6033883A (en) * | 1996-12-18 | 2000-03-07 | Kosan Biosciences, Inc. | Production of polyketides in bacteria and yeast |
| CN1660065A (zh) | 1997-03-27 | 2005-08-31 | 布里斯托尔-迈尔斯斯奎布公司 | 二十二碳六烯酸和花生四烯酸促进不足月婴儿生长的用途 |
| PL336077A1 (en) | 1997-04-11 | 2000-06-05 | Calgene Llc | Methods of and compositions for synthesising long-chain polyunsaturated fatty acids in plants |
| IN1998CH01219A (en) * | 1997-06-04 | 2005-03-04 | Calgene Llc | Production of polyunsaturated fatty acid by expression of polyketide-like synthesis genes in plants |
| US6566583B1 (en) | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| US6677145B2 (en) * | 1998-09-02 | 2004-01-13 | Abbott Laboratories | Elongase genes and uses thereof |
| US7271315B2 (en) * | 1999-01-14 | 2007-09-18 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7211418B2 (en) * | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
| US8003772B2 (en) * | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| DE60122719T2 (de) * | 2000-06-08 | 2008-04-17 | Miami University, Oxford | Fettsäure-elongase-3-ketoacyl-coa-synthase-polypeptide |
| US20040010817A1 (en) * | 2000-07-21 | 2004-01-15 | Washington State University Research Foundation | Plant acyl-CoA synthetases |
| CN100567483C (zh) * | 2000-09-28 | 2009-12-09 | 生物源食物及科学公司 | 脂肪酸去饱和酶家族成员fad4、fad5、fad5-2和fad6及它们的应用 |
| TWI426126B (zh) * | 2001-04-16 | 2014-02-11 | Dsm Ip Assets Bv | 多不飽和脂肪酸（ｐｕｆａ）聚乙醯合成酶系統及其用途（二） |
| TWI324181B (en) * | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| US20040005672A1 (en) * | 2002-02-22 | 2004-01-08 | Santi Daniel V. | Heterologous production of polyketides |
| GB2385852A (en) * | 2002-02-27 | 2003-09-03 | Rothamsted Ex Station | Delta 6-desaturases from Primulaceae |
| US7705202B2 (en) * | 2002-03-16 | 2010-04-27 | The University Of York | Transgenic plants expressing enzymes involved in fatty acid biosynthesis |
| US20040172682A1 (en) | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
| KR101234200B1 (ko) | 2003-03-26 | 2013-02-19 | 마텍 바이오싸이언스스 코포레이션 | Ｐｕｆａ 폴리케타이드 신타제 시스템 및 이의 용도 |
| ES2421138T3 (es) | 2003-03-31 | 2013-08-29 | University Of Bristol | Nuevas aciltransferasas vegetales específicas para ácidos grasos poliinsaturados de cadena larga |
| US7125672B2 (en) * | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| US7208590B2 (en) * | 2003-07-15 | 2007-04-24 | Abbott Laboratories | Genes involved in polyketide synthase pathways and uses thereof |
| DE102004017370A1 (de) | 2004-04-08 | 2005-10-27 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | PUFA-PKS Gene aus Ulkenia |
| DE102004060340A1 (de) | 2004-07-16 | 2006-02-09 | Basf Plant Science Gmbh | Verfahren zur Erhöhung des Gehalts an mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen |
| EP2339007A1 (en) | 2004-09-20 | 2011-06-29 | BASF Plant Science GmbH | Arabidopsis genes encoding proteins involved in sugar and lipid metabolism and methods of use |
| WO2006135866A2 (en) | 2005-06-10 | 2006-12-21 | Martek Biosciences Corporation | Pufa polyketide synthase systems and uses thereof |
| US7759548B2 (en) | 2006-03-15 | 2010-07-20 | Martek Biosciences Corporation | Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems |
| US8940884B2 (en) | 2009-03-19 | 2015-01-27 | Dsm Ip Assets B.V. | Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof |
-
2007
- 2007-05-16 US US11/749,686 patent/US8003772B2/en not_active Expired - Fee Related
-
2008
- 2008-05-16 MX MX2009012395A patent/MX2009012395A/es active IP Right Grant
- 2008-05-16 JP JP2010508603A patent/JP5551584B2/ja not_active Expired - Fee Related
- 2008-05-16 CN CN200880024785.9A patent/CN101849014B/zh not_active Expired - Fee Related
- 2008-05-16 ES ES08755645.2T patent/ES2467918T3/es active Active
- 2008-05-16 BR BRPI0810302-0A patent/BRPI0810302A2/pt not_active IP Right Cessation
- 2008-05-16 EP EP08755645.2A patent/EP2160470B1/en active Active
- 2008-05-16 AU AU2008254837A patent/AU2008254837B2/en not_active Ceased
- 2008-05-16 WO PCT/US2008/063835 patent/WO2008144473A2/en not_active Ceased
- 2008-05-16 KR KR1020097026099A patent/KR101539470B1/ko not_active Expired - Fee Related
- 2008-05-16 CA CA2687523A patent/CA2687523C/en active Active
-
2009
- 2009-11-15 IL IL202131A patent/IL202131A/en active IP Right Grant
-
2011
- 2011-06-27 US US13/170,011 patent/US8309796B2/en not_active Expired - Fee Related
-
2012
- 2012-10-02 US US13/633,770 patent/US8859855B2/en not_active Expired - Fee Related
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