JP2010526106A5

JP2010526106A5 -

Download PDF

Info

Publication number: JP2010526106A5
Authority: JP; Japan
Prior art keywords: sulfonamido; dibenzo; furan; acid; methyl
Prior art date: 2008-05-05
Legal status : Withdrawn

Application number

JP2010506709A

Other languages

English (en)

Japanese (ja)

Other versions

JP2010526106A (ja

Filing date

2008-05-05

Publication date

2012-05-17

2008-05-05 Application filed filed Critical

2008-05-05 Priority claimed from PCT/US2008/062593 external-priority patent/WO2008137816A2/en

2010-07-29 Publication of JP2010526106A publication Critical patent/JP2010526106A/ja

2012-05-17 Publication of JP2010526106A5 publication Critical patent/JP2010526106A5/ja

Status Withdrawn legal-status Critical Current

Links

125000000217 alkyl group Chemical group 0.000 claims description 229
150000001875 compounds Chemical class 0.000 claims description 93
150000003839 salts Chemical class 0.000 claims description 90
150000002148 esters Chemical class 0.000 claims description 86
-1 N-isopropylcarbamimidoyl Chemical group 0.000 claims description 79
125000001072 heteroaryl group Chemical group 0.000 claims description 47
125000000753 cycloalkyl group Chemical group 0.000 claims description 42
125000000304 alkynyl group Chemical group 0.000 claims description 36
125000001188 haloalkyl group Chemical group 0.000 claims description 34
125000006374 C2-C10 alkenyl group Chemical group 0.000 claims description 28
125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 24
125000003118 aryl group Chemical group 0.000 claims description 21
239000002253 acid Substances 0.000 claims description 20
229910052739 hydrogen Inorganic materials 0.000 claims description 20
229910052736 halogen Inorganic materials 0.000 claims description 14
150000002367 halogens Chemical class 0.000 claims description 14
229910052717 sulfur Inorganic materials 0.000 claims description 10
241000124008 Mammalia Species 0.000 claims description 9
125000001424 substituent group Chemical group 0.000 claims description 9
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 8
125000003342 alkenyl group Chemical group 0.000 claims description 8
229910052799 carbon Inorganic materials 0.000 claims description 8
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
208000035475 disorder Diseases 0.000 claims description 8
230000001575 pathological effect Effects 0.000 claims description 8
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
102000005741 Metalloproteases Human genes 0.000 claims description 7
108010006035 Metalloproteases Proteins 0.000 claims description 7
239000011159 matrix material Substances 0.000 claims description 7
VCRAHYVYNXLHJB-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(4-methylthiophen-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CSC=C1C VCRAHYVYNXLHJB-NRFANRHFSA-N 0.000 claims description 6
125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 6
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 6
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
229940024606 amino acid Drugs 0.000 claims description 6
150000001413 amino acids Chemical class 0.000 claims description 6
150000001721 carbon Chemical group 0.000 claims description 6
125000000842 isoxazolyl group Chemical group 0.000 claims description 6
229910052760 oxygen Inorganic materials 0.000 claims description 6
125000003831 tetrazolyl group Chemical group 0.000 claims description 6
229960004295 valine Drugs 0.000 claims description 6
125000006708 (C5-C14) heteroaryl group Chemical group 0.000 claims description 5
125000002541 furyl group Chemical group 0.000 claims description 5
125000002883 imidazolyl group Chemical group 0.000 claims description 5
125000001715 oxadiazolyl group Chemical group 0.000 claims description 5
125000004076 pyridyl group Chemical group 0.000 claims description 5
125000000168 pyrrolyl group Chemical group 0.000 claims description 5
125000000335 thiazolyl group Chemical group 0.000 claims description 5
125000001544 thienyl group Chemical group 0.000 claims description 5
125000001425 triazolyl group Chemical group 0.000 claims description 5
MXFRFKFDNZFUHI-GOSISDBHSA-N (2r)-3-methyl-2-[[7-(1,3-thiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NC=CS1 MXFRFKFDNZFUHI-GOSISDBHSA-N 0.000 claims description 4
CHYPSOLFNUJOFQ-GOSISDBHSA-N (2r)-3-methyl-2-[[7-(1,3-thiazol-2-yl)dibenzothiophen-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3SC2=CC=1C1=NC=CS1 CHYPSOLFNUJOFQ-GOSISDBHSA-N 0.000 claims description 4
RVQOOWATMSVVAU-LJQANCHMSA-N (2r)-3-methyl-2-[[7-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(C(C)C)=N1 RVQOOWATMSVVAU-LJQANCHMSA-N 0.000 claims description 4
TVAGSALOYCVPAP-HSZRJFAPSA-N (2r)-3-methyl-2-[[7-[1-(2-methylpropyl)pyrazol-4-yl]dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CC(C)C)C=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 TVAGSALOYCVPAP-HSZRJFAPSA-N 0.000 claims description 4
JUURCPDGRPIPJW-JOCHJYFZSA-N (2r)-3-methyl-2-[[7-[4-(trifluoromethyl)phenyl]dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=C(C(F)(F)F)C=C1 JUURCPDGRPIPJW-JOCHJYFZSA-N 0.000 claims description 4
STDDMDWNCQOCLW-FQEVSTJZSA-N (2s)-2-[[7-(furan-2-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1SC2=CC=3C1=CC=CO1 STDDMDWNCQOCLW-FQEVSTJZSA-N 0.000 claims description 4
ZXWPYXYVPWIWTH-NRFANRHFSA-N (2s)-2-[[8-(3,5-dimethyl-1,2-oxazol-4-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C(C)=NOC=1C ZXWPYXYVPWIWTH-NRFANRHFSA-N 0.000 claims description 4
201000001320 Atherosclerosis Diseases 0.000 claims description 4
206010016654 Fibrosis Diseases 0.000 claims description 4
208000019693 Lung disease Diseases 0.000 claims description 4
206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
208000008589 Obesity Diseases 0.000 claims description 4
208000000453 Skin Neoplasms Diseases 0.000 claims description 4
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 4
208000006673 asthma Diseases 0.000 claims description 4
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
230000001684 chronic effect Effects 0.000 claims description 4
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 4
125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims description 4
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 4
206010012601 diabetes mellitus Diseases 0.000 claims description 4
230000004761 fibrosis Effects 0.000 claims description 4
239000001257 hydrogen Substances 0.000 claims description 4
GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims description 4
201000005202 lung cancer Diseases 0.000 claims description 4
208000020816 lung neoplasm Diseases 0.000 claims description 4
230000001404 mediated effect Effects 0.000 claims description 4
235000020824 obesity Nutrition 0.000 claims description 4
230000000414 obstructive effect Effects 0.000 claims description 4
201000008482 osteoarthritis Diseases 0.000 claims description 4
125000003226 pyrazolyl group Chemical group 0.000 claims description 4
206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
201000000849 skin cancer Diseases 0.000 claims description 4
208000020431 spinal cord injury Diseases 0.000 claims description 4
239000004474 valine Substances 0.000 claims description 4
125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 3
229910052757 nitrogen Inorganic materials 0.000 claims description 3
125000002971 oxazolyl group Chemical group 0.000 claims description 3
125000003373 pyrazinyl group Chemical group 0.000 claims description 3
125000000714 pyrimidinyl group Chemical group 0.000 claims description 3
125000001113 thiadiazolyl group Chemical group 0.000 claims description 3
DKYSMLNBMIZQJL-JOCHJYFZSA-N (2r)-2-[[7-(1,3-benzothiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1 DKYSMLNBMIZQJL-JOCHJYFZSA-N 0.000 claims description 2
UVFGMGODGHCWEB-JOCHJYFZSA-N (2r)-2-[[7-(1,3-benzothiazol-2-yl)dibenzothiophen-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C=3C=C4SC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1 UVFGMGODGHCWEB-JOCHJYFZSA-N 0.000 claims description 2
MKJSIHKQOWNHRU-JOCHJYFZSA-N (2r)-2-[[7-(1,3-benzoxazol-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2OC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1 MKJSIHKQOWNHRU-JOCHJYFZSA-N 0.000 claims description 2
PJUQYKFYQBYODS-XMMPIXPASA-N (2r)-2-[[7-(1-benzofuran-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2OC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC2=C1 PJUQYKFYQBYODS-XMMPIXPASA-N 0.000 claims description 2
AKJDDMBFNPUTEP-XMMPIXPASA-N (2r)-2-[[7-(1-benzothiophen-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC2=C1 AKJDDMBFNPUTEP-XMMPIXPASA-N 0.000 claims description 2
FLBLGWWWCFXJJC-AREMUKBSSA-N (2r)-2-[[7-(1-benzylpyrazol-4-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(=C1)C=NN1CC1=CC=CC=C1 FLBLGWWWCFXJJC-AREMUKBSSA-N 0.000 claims description 2
BWEOSIAMIQLVAL-HXUWFJFHSA-N (2r)-2-[[7-(2,4-dimethoxypyrimidin-5-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound COC1=NC(OC)=NC=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 BWEOSIAMIQLVAL-HXUWFJFHSA-N 0.000 claims description 2
DWISUBBEBFLNRS-HXUWFJFHSA-N (2r)-2-[[7-(2,4-dimethyl-1,3-thiazol-5-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C=1SC(C)=NC=1C DWISUBBEBFLNRS-HXUWFJFHSA-N 0.000 claims description 2
FLNYXJRIUHCEFH-HXUWFJFHSA-N (2r)-2-[[7-(2-methoxypyrimidin-5-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=NC(OC)=NC=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 FLNYXJRIUHCEFH-HXUWFJFHSA-N 0.000 claims description 2
AYCCKJBANOVGCC-OAQYLSRUSA-N (2r)-2-[[7-(3,5-dimethyl-1,2-oxazol-4-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C=1C(C)=NOC=1C AYCCKJBANOVGCC-OAQYLSRUSA-N 0.000 claims description 2
KRXKFJHIUJIOOE-HXUWFJFHSA-N (2r)-2-[[7-(3-methoxyprop-1-ynyl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC=C(C#CCOC)C=C3SC2=C1 KRXKFJHIUJIOOE-HXUWFJFHSA-N 0.000 claims description 2
HXDMHQRPIGGVQJ-OAQYLSRUSA-N (2r)-2-[[7-(4-fluoro-1,3-benzothiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1F HXDMHQRPIGGVQJ-OAQYLSRUSA-N 0.000 claims description 2
LUSXBDHEIQBWKO-HXUWFJFHSA-N (2r)-2-[[7-(5-bromothiophen-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=C(Br)S1 LUSXBDHEIQBWKO-HXUWFJFHSA-N 0.000 claims description 2
XCFOXFAYZNPHOE-HXUWFJFHSA-N (2r)-2-[[7-(5-chlorofuran-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=C(Cl)O1 XCFOXFAYZNPHOE-HXUWFJFHSA-N 0.000 claims description 2
MRWNMNBJFHVERG-HXUWFJFHSA-N (2r)-2-[[7-(5-chlorofuran-2-yl)dibenzothiophen-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3SC2=CC=1C1=CC=C(Cl)O1 MRWNMNBJFHVERG-HXUWFJFHSA-N 0.000 claims description 2
JIEVWFMIUJBLKA-HXUWFJFHSA-N (2r)-2-[[7-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(N=1)=NOC=1C1CCC1 JIEVWFMIUJBLKA-HXUWFJFHSA-N 0.000 claims description 2
RBPBPUGKGHLCIP-JOCHJYFZSA-N (2r)-2-[[7-(5-cyclohexyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(N=1)=NOC=1C1CCCCC1 RBPBPUGKGHLCIP-JOCHJYFZSA-N 0.000 claims description 2
SOJPLWOBVOZDMW-OAQYLSRUSA-N (2r)-2-[[7-(5-cyclopentyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(N=1)=NOC=1C1CCCC1 SOJPLWOBVOZDMW-OAQYLSRUSA-N 0.000 claims description 2
YZBILURNXZUFTN-LJQANCHMSA-N (2r)-2-[[7-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(N=1)=NOC=1C1CC1 YZBILURNXZUFTN-LJQANCHMSA-N 0.000 claims description 2
FAONYVNQBWVWQW-LJQANCHMSA-N (2r)-2-[[7-(5-ethyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound O1C(CC)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=2)=N1 FAONYVNQBWVWQW-LJQANCHMSA-N 0.000 claims description 2
UBKFOXZQDDUURB-JOCHJYFZSA-N (2r)-2-[[7-(5-ethylthiophen-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound S1C(CC)=CC=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 UBKFOXZQDDUURB-JOCHJYFZSA-N 0.000 claims description 2
DLFHTNBVSIENQW-XMMPIXPASA-N (2r)-2-[[7-(5-fluoro-1h-indol-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound FC1=CC=C2NC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC2=C1 DLFHTNBVSIENQW-XMMPIXPASA-N 0.000 claims description 2
DQBJMGHOWYXFJM-LJQANCHMSA-N (2r)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(C(C)(C)C)=N1 DQBJMGHOWYXFJM-LJQANCHMSA-N 0.000 claims description 2
UXYUAQNCMDVPCR-OAQYLSRUSA-N (2r)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-phenylpropanoic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)N[C@H](CC=3C=CC=CC=3)C(O)=O)=CC=2)=N1 UXYUAQNCMDVPCR-OAQYLSRUSA-N 0.000 claims description 2
ROWXCVNCYGOSEU-GOSISDBHSA-N (2r)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-4-methylpentanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](CC(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(C(C)(C)C)=N1 ROWXCVNCYGOSEU-GOSISDBHSA-N 0.000 claims description 2
YGRUDSYBWURNJC-HSZRJFAPSA-N (2r)-2-[[7-(5-tert-butylfuran-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=C(C(C)(C)C)O1 YGRUDSYBWURNJC-HSZRJFAPSA-N 0.000 claims description 2
AKBDDNKWXKZCAT-OAQYLSRUSA-N (2r)-2-[[7-(6-chloropyridin-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=C(Cl)N=C1 AKBDDNKWXKZCAT-OAQYLSRUSA-N 0.000 claims description 2
KRSVEDPTDZZKJQ-JOCHJYFZSA-N (2r)-2-[[7-(6-fluoro-1,3-benzothiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C(F)C=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1 KRSVEDPTDZZKJQ-JOCHJYFZSA-N 0.000 claims description 2
UQHQWCNASJELDN-HSZRJFAPSA-N (2r)-2-[[7-(6-methoxy-1,3-benzothiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C2OC3=CC=C(S(=O)(=O)N[C@H](C(C)C)C(O)=O)C=C3C2=CC=C1C1=NC2=CC=C(OC)C=C2S1 UQHQWCNASJELDN-HSZRJFAPSA-N 0.000 claims description 2
RZBHGWWIXZZDIE-JOCHJYFZSA-N (2r)-2-[[7-(6-methoxypyridin-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=NC(OC)=CC=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 RZBHGWWIXZZDIE-JOCHJYFZSA-N 0.000 claims description 2
QBZDEMPIXFGTOR-HXUWFJFHSA-N (2r)-2-[[7-(furan-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=CO1 QBZDEMPIXFGTOR-HXUWFJFHSA-N 0.000 claims description 2
YMEUKWAUTAFCQF-HXUWFJFHSA-N (2r)-2-[[7-(furan-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C=1C=COC=1 YMEUKWAUTAFCQF-HXUWFJFHSA-N 0.000 claims description 2
ZIFKIRZKPQSHGA-HCXLOTKHSA-N (2r)-2-[[7-[(e)-2-cyclohexylethenyl]dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1\C=C\C1CCCCC1 ZIFKIRZKPQSHGA-HCXLOTKHSA-N 0.000 claims description 2
UJQXNVUNVWNKPL-OAQYLSRUSA-N (2r)-2-[[7-[5-(2,2-dimethylpropyl)-1,2,4-oxadiazol-3-yl]dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(CC(C)(C)C)=N1 UJQXNVUNVWNKPL-OAQYLSRUSA-N 0.000 claims description 2
GJRHLVFJATZVDQ-HSZRJFAPSA-N (2r)-2-[[7-[5-(cyclopentylmethyl)-1,2,4-oxadiazol-3-yl]dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(N=1)=NOC=1CC1CCCC1 GJRHLVFJATZVDQ-HSZRJFAPSA-N 0.000 claims description 2
SHPFBVQYXBHTRS-MRXNPFEDSA-N (2r)-2-[[7-[5-chloro-4-(trifluoromethyl)-1,3-thiazol-2-yl]dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NC(C(F)(F)F)=C(Cl)S1 SHPFBVQYXBHTRS-MRXNPFEDSA-N 0.000 claims description 2
CLALSIAHDUVZJV-XMMPIXPASA-N (2r)-2-[[8-(4,4-dimethyl-2-oxo-1h-3,1-benzoxazin-6-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound N1C(=O)OC(C)(C)C2=CC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C21 CLALSIAHDUVZJV-XMMPIXPASA-N 0.000 claims description 2
FDXJBNPNRWLQES-HXUWFJFHSA-N (2r)-2-[[8-(5-chlorofuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(Cl)O1 FDXJBNPNRWLQES-HXUWFJFHSA-N 0.000 claims description 2
QODKHJZZECMWOS-JOCHJYFZSA-N (2r)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-2-phenylacetic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C4=CC=C(C=C4OC3=CC=2)S(=O)(=O)N[C@@H](C(O)=O)C=2C=CC=CC=2)=N1 QODKHJZZECMWOS-JOCHJYFZSA-N 0.000 claims description 2
XZGLXKXBYMBTRV-HSZRJFAPSA-N (2r)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-(1h-indol-3-yl)propanoic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C4=CC=C(C=C4OC3=CC=2)S(=O)(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(O)=O)=N1 XZGLXKXBYMBTRV-HSZRJFAPSA-N 0.000 claims description 2
NZQAAPJCTUNRMX-LJQANCHMSA-N (2r)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(C(C)(C)C)=N1 NZQAAPJCTUNRMX-LJQANCHMSA-N 0.000 claims description 2
NLXLWXGTVAEMII-GOSISDBHSA-N (2r)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-4-methylpentanoic acid Chemical compound C=1C(S(=O)(=O)N[C@H](CC(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(C(C)(C)C)=N1 NLXLWXGTVAEMII-GOSISDBHSA-N 0.000 claims description 2
OZJGHWHWUNCMFD-HXUWFJFHSA-N (2r)-3-methyl-2-[(7-pyrimidin-5-yldibenzofuran-2-yl)sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CN=CN=C1 OZJGHWHWUNCMFD-HXUWFJFHSA-N 0.000 claims description 2
MKUGBDHSVMEUDJ-HXUWFJFHSA-N (2r)-3-methyl-2-[(7-thiophen-2-yldibenzofuran-2-yl)sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=CS1 MKUGBDHSVMEUDJ-HXUWFJFHSA-N 0.000 claims description 2
ZMIQQVOEDLENOT-HXUWFJFHSA-N (2r)-3-methyl-2-[(7-thiophen-3-yldibenzofuran-2-yl)sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C=1C=CSC=1 ZMIQQVOEDLENOT-HXUWFJFHSA-N 0.000 claims description 2
GEHJYKSQSKVXEY-RUZDIDTESA-N (2r)-3-methyl-2-[[7-(1-methylindol-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C1=CC=C2N(C)C(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC2=C1 GEHJYKSQSKVXEY-RUZDIDTESA-N 0.000 claims description 2
KDQWONZILVAQAS-HXUWFJFHSA-N (2r)-3-methyl-2-[[7-(1-methylpyrazol-4-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C=1C=NN(C)C=1 KDQWONZILVAQAS-HXUWFJFHSA-N 0.000 claims description 2
RKJUJSCHEBSPPY-JOCHJYFZSA-N (2r)-3-methyl-2-[[7-(1-propylpyrazol-4-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CCC)C=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 RKJUJSCHEBSPPY-JOCHJYFZSA-N 0.000 claims description 2
VZSJLZLWFLWJJU-LJQANCHMSA-N (2r)-3-methyl-2-[[7-(1h-pyrazol-4-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C=1C=NNC=1 VZSJLZLWFLWJJU-LJQANCHMSA-N 0.000 claims description 2
ZTIBAZKSPAAWHI-HXUWFJFHSA-N (2r)-3-methyl-2-[[7-(1h-pyrrol-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=CN1 ZTIBAZKSPAAWHI-HXUWFJFHSA-N 0.000 claims description 2
SEMFDWYGUQJJMG-OAQYLSRUSA-N (2r)-3-methyl-2-[[7-(4,5,6-trifluoro-1,3-benzothiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound FC1=C(F)C=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1F SEMFDWYGUQJJMG-OAQYLSRUSA-N 0.000 claims description 2
GRPAOJQELOYHGJ-XMMPIXPASA-N (2r)-3-methyl-2-[[7-(4-methyl-2-phenyl-1,3-thiazol-5-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(=C(N=1)C)SC=1C1=CC=CC=C1 GRPAOJQELOYHGJ-XMMPIXPASA-N 0.000 claims description 2
KICOEUHSPRWFBO-OAQYLSRUSA-N (2r)-3-methyl-2-[[7-(4-methylthiophen-3-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CSC=C1C KICOEUHSPRWFBO-OAQYLSRUSA-N 0.000 claims description 2
PBXDHOYLSMWAAK-GOSISDBHSA-N (2r)-3-methyl-2-[[7-(5-methyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(C)=N1 PBXDHOYLSMWAAK-GOSISDBHSA-N 0.000 claims description 2
MFDHKVJJTDQSGJ-GOSISDBHSA-N (2r)-3-methyl-2-[[7-(5-methyl-1,3,4-thiadiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NN=C(C)S1 MFDHKVJJTDQSGJ-GOSISDBHSA-N 0.000 claims description 2
XRILZBPWMMUGAA-JOCHJYFZSA-N (2r)-3-methyl-2-[[7-(5-phenyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(N=1)=NOC=1C1=CC=CC=C1 XRILZBPWMMUGAA-JOCHJYFZSA-N 0.000 claims description 2
RZGHJCLQXWPAOF-AREMUKBSSA-N (2r)-3-methyl-2-[[7-(5-phenylthiophen-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(S1)=CC=C1C1=CC=CC=C1 RZGHJCLQXWPAOF-AREMUKBSSA-N 0.000 claims description 2
FRLIEOABZAZATR-HSZRJFAPSA-N (2r)-3-methyl-2-[[7-(5-propylthiophen-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound S1C(CCC)=CC=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 FRLIEOABZAZATR-HSZRJFAPSA-N 0.000 claims description 2
GVGQMSMAVJBAHP-HSZRJFAPSA-N (2r)-3-methyl-2-[[7-(6-methyl-1,3-benzothiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C1=C(C)C=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1 GVGQMSMAVJBAHP-HSZRJFAPSA-N 0.000 claims description 2
UNWPZQZOXCKGTP-OODIQHKMSA-N (2r)-3-methyl-2-[[7-[1-(2-methylbutyl)pyrazol-4-yl]dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CC(C)CC)C=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 UNWPZQZOXCKGTP-OODIQHKMSA-N 0.000 claims description 2
PJGWXFBIBIGDRJ-HSZRJFAPSA-N (2r)-3-methyl-2-[[7-[2-(2-methylpropyl)-1,3-thiazol-5-yl]dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound S1C(CC(C)C)=NC=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 PJGWXFBIBIGDRJ-HSZRJFAPSA-N 0.000 claims description 2
XKAJYASQFPOFFO-HSZRJFAPSA-N (2r)-3-methyl-2-[[7-[4-methyl-2-(2-methylpropyl)-1,3-thiazol-5-yl]dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound S1C(CC(C)C)=NC(C)=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 XKAJYASQFPOFFO-HSZRJFAPSA-N 0.000 claims description 2
AUFRHAGCCKGSIJ-OAQYLSRUSA-N (2r)-3-methyl-2-[[7-[5-(2-methylpropyl)-1,2,4-oxadiazol-3-yl]dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound O1C(CC(C)C)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=2)=N1 AUFRHAGCCKGSIJ-OAQYLSRUSA-N 0.000 claims description 2
IUYRAAWKZQFZLN-JOCHJYFZSA-N (2r)-3-methyl-2-[[7-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C1=C(OC(F)(F)F)C=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1 IUYRAAWKZQFZLN-JOCHJYFZSA-N 0.000 claims description 2
VNUZETQPGOVXGM-NRFANRHFSA-N (2s)-2-[(8-cyclopentyldibenzofuran-3-yl)sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1CCCC1 VNUZETQPGOVXGM-NRFANRHFSA-N 0.000 claims description 2
OIKVWJMIJQJPTM-SFHVURJKSA-N (2s)-2-[(8-ethynyldibenzofuran-3-yl)sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C(C#C)C=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 OIKVWJMIJQJPTM-SFHVURJKSA-N 0.000 claims description 2
MVGMLUHVHIOGIP-NDEPHWFRSA-N (2s)-2-[(9-dibenzofuran-1-yldibenzofuran-3-yl)sulfonylamino]-3-methylbutanoic acid Chemical compound O1C2=CC=CC=C2C2=C1C=CC=C2C1=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=CC=C1 MVGMLUHVHIOGIP-NDEPHWFRSA-N 0.000 claims description 2
PBWYHJCKZXXNOW-SFHVURJKSA-N (2s)-2-[[6-(2-chlorothiophen-3-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=C3)C=1SC2=C3C=1C=CSC=1Cl PBWYHJCKZXXNOW-SFHVURJKSA-N 0.000 claims description 2
WOVGSJCBVOSLER-QFIPXVFZSA-N (2s)-2-[[7-(1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C=3C=C4OC=5C(C4=CC=3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 WOVGSJCBVOSLER-QFIPXVFZSA-N 0.000 claims description 2
ONLUIZSXRZOWKA-QFIPXVFZSA-N (2s)-2-[[7-(1,3-benzoxazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2OC(C=3C=C4OC=5C(C4=CC=3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 ONLUIZSXRZOWKA-QFIPXVFZSA-N 0.000 claims description 2
WMKPFDBOJXFTPN-DEOSSOPVSA-N (2s)-2-[[7-(1-benzofuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2OC(C=3C=C4OC=5C(C4=CC=3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC2=C1 WMKPFDBOJXFTPN-DEOSSOPVSA-N 0.000 claims description 2
OJAOBEJFBWRHDW-DEOSSOPVSA-N (2s)-2-[[7-(1-benzothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C=3C=C4OC=5C(C4=CC=3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC2=C1 OJAOBEJFBWRHDW-DEOSSOPVSA-N 0.000 claims description 2
IALGPJQNDWBKSQ-FQEVSTJZSA-N (2s)-2-[[7-(2,4-dimethyl-1,3-thiazol-5-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C=1SC(C)=NC=1C IALGPJQNDWBKSQ-FQEVSTJZSA-N 0.000 claims description 2
QHHNGDOVRJRHNS-SFHVURJKSA-N (2s)-2-[[7-(2-chloro-1,3-thiazol-5-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CN=C(Cl)S1 QHHNGDOVRJRHNS-SFHVURJKSA-N 0.000 claims description 2
FCCHMTOYPPUUDK-IBGZPJMESA-N (2s)-2-[[7-(3,5-dichlorothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C=1SC(Cl)=CC=1Cl FCCHMTOYPPUUDK-IBGZPJMESA-N 0.000 claims description 2
KRXKFJHIUJIOOE-FQEVSTJZSA-N (2s)-2-[[7-(3-methoxyprop-1-ynyl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC=C(C#CCOC)C=C3SC2=C1 KRXKFJHIUJIOOE-FQEVSTJZSA-N 0.000 claims description 2
PILIUQSMALEBNG-QFIPXVFZSA-N (2s)-2-[[7-(4-bromo-5-ethylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound BrC1=C(CC)SC(C=2C=C3C(C4=CC=C(C=C4O3)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=2)=C1 PILIUQSMALEBNG-QFIPXVFZSA-N 0.000 claims description 2
IBBJNROSMMOOOA-NRFANRHFSA-N (2s)-2-[[7-(5,6-dihydro-4h-cyclopenta[d][1,3]thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=CC(C=2SC=3CCCC=3N=2)=C1 IBBJNROSMMOOOA-NRFANRHFSA-N 0.000 claims description 2
LHWRWIOMMDIVJW-FQEVSTJZSA-N (2s)-2-[[7-(5-chlorofuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=C(Cl)O1 LHWRWIOMMDIVJW-FQEVSTJZSA-N 0.000 claims description 2
BBNHLJVSBJWYFS-FQEVSTJZSA-N (2s)-2-[[7-(5-chlorofuran-2-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1SC2=CC=3C1=CC=C(Cl)O1 BBNHLJVSBJWYFS-FQEVSTJZSA-N 0.000 claims description 2
BNZYOSWYHWZZRX-FQEVSTJZSA-N (2s)-2-[[7-(5-chlorothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=C(Cl)S1 BNZYOSWYHWZZRX-FQEVSTJZSA-N 0.000 claims description 2
XGBAXQHABRASEY-FQEVSTJZSA-N (2s)-2-[[7-(5-chlorothiophen-2-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1SC2=CC=3C1=CC=C(Cl)S1 XGBAXQHABRASEY-FQEVSTJZSA-N 0.000 claims description 2
SDJMZIGZJRUSBB-IBGZPJMESA-N (2s)-2-[[7-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C(N=1)=NOC=1C1CC1 SDJMZIGZJRUSBB-IBGZPJMESA-N 0.000 claims description 2
UBKFOXZQDDUURB-QFIPXVFZSA-N (2s)-2-[[7-(5-ethylthiophen-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound S1C(CC)=CC=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C3OC2=C1 UBKFOXZQDDUURB-QFIPXVFZSA-N 0.000 claims description 2
HYEIHKRTMXDBJV-QFIPXVFZSA-N (2s)-2-[[7-(5-ethylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound S1C(CC)=CC=C1C1=CC=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 HYEIHKRTMXDBJV-QFIPXVFZSA-N 0.000 claims description 2
KCOHNRGUPUUTRS-DEOSSOPVSA-N (2s)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-2-(1h-indol-3-yl)acetic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)N[C@H](C(O)=O)C=3C4=CC=CC=C4NC=3)=CC=2)=N1 KCOHNRGUPUUTRS-DEOSSOPVSA-N 0.000 claims description 2
FMJDYTTZBKMCRA-QFIPXVFZSA-N (2s)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-2-phenylacetic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)N[C@H](C(O)=O)C=3C=CC=CC=3)=CC=2)=N1 FMJDYTTZBKMCRA-QFIPXVFZSA-N 0.000 claims description 2
DQBJMGHOWYXFJM-IBGZPJMESA-N (2s)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(C(C)(C)C)=N1 DQBJMGHOWYXFJM-IBGZPJMESA-N 0.000 claims description 2
ROWXCVNCYGOSEU-SFHVURJKSA-N (2s)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-4-methylpentanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@@H](CC(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(C(C)(C)C)=N1 ROWXCVNCYGOSEU-SFHVURJKSA-N 0.000 claims description 2
LSSPNSOFGKOJFU-IBGZPJMESA-N (2s)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NOC(C(C)(C)C)=N1 LSSPNSOFGKOJFU-IBGZPJMESA-N 0.000 claims description 2
YGRUDSYBWURNJC-QHCPKHFHSA-N (2s)-2-[[7-(5-tert-butylfuran-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=C(C(C)(C)C)O1 YGRUDSYBWURNJC-QHCPKHFHSA-N 0.000 claims description 2
VZADBEJFSRCFHF-QHCPKHFHSA-N (2s)-2-[[7-(5-tert-butylfuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=C(C(C)(C)C)O1 VZADBEJFSRCFHF-QHCPKHFHSA-N 0.000 claims description 2
XUFXYJYYGGYCJE-FQEVSTJZSA-N (2s)-2-[[7-(furan-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=CO1 XUFXYJYYGGYCJE-FQEVSTJZSA-N 0.000 claims description 2
DMRVVWUUWSUTPF-FQEVSTJZSA-N (2s)-2-[[7-(furan-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C=1C=COC=1 DMRVVWUUWSUTPF-FQEVSTJZSA-N 0.000 claims description 2
NDQORPRLFZIHQI-FQEVSTJZSA-N (2s)-2-[[7-(furan-3-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1SC2=CC=3C=1C=COC=1 NDQORPRLFZIHQI-FQEVSTJZSA-N 0.000 claims description 2
MIVHSZGGOLKIJA-INIZCTEOSA-N (2s)-2-[[7-(n'-hydroxycarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound ONC(=N)C1=CC=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 MIVHSZGGOLKIJA-INIZCTEOSA-N 0.000 claims description 2
HIKBWOJNMATYIY-INIZCTEOSA-N (2s)-2-[[7-[5-chloro-4-(trifluoromethyl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NC(C(F)(F)F)=C(Cl)S1 HIKBWOJNMATYIY-INIZCTEOSA-N 0.000 claims description 2
OJXHTCGCFFZMMJ-NDEPHWFRSA-N (2s)-2-[[7-[5-ethyl-4-(5-ethylthiophen-2-yl)thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound S1C(CC)=CC=C1C1=C(CC)SC(C=2C=C3C(C4=CC=C(C=C4O3)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=2)=C1 OJXHTCGCFFZMMJ-NDEPHWFRSA-N 0.000 claims description 2
MQYOBJHCSNBTGH-QHCPKHFHSA-N (2s)-2-[[8-(1,3-benzodioxol-5-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C2OCOC2=CC(C2=CC=C3OC=4C(C3=C2)=CC=C(C=4)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=C1 MQYOBJHCSNBTGH-QHCPKHFHSA-N 0.000 claims description 2
TYGUOZCIQMKNFS-QFIPXVFZSA-N (2s)-2-[[8-(1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 TYGUOZCIQMKNFS-QFIPXVFZSA-N 0.000 claims description 2
TXLLLKGIRPOVKR-QFIPXVFZSA-N (2s)-2-[[8-(1,3-benzoxazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2OC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 TXLLLKGIRPOVKR-QFIPXVFZSA-N 0.000 claims description 2
JOMUWLSAFJIALC-DEOSSOPVSA-N (2s)-2-[[8-(1-benzothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC2=C1 JOMUWLSAFJIALC-DEOSSOPVSA-N 0.000 claims description 2
HZFQLPLBPOFFSZ-DEOSSOPVSA-N (2s)-2-[[8-(1-benzothiophen-2-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C3=CC=C4SC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC2=C1 HZFQLPLBPOFFSZ-DEOSSOPVSA-N 0.000 claims description 2
UXSXLDRSHNYGME-DEOSSOPVSA-N (2s)-2-[[8-(1-benzothiophen-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2C(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CSC2=C1 UXSXLDRSHNYGME-DEOSSOPVSA-N 0.000 claims description 2
ZGGKMWOGTYCTRX-SANMLTNESA-N (2s)-2-[[8-(1-benzylpyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=C1)C=NN1CC1=CC=CC=C1 ZGGKMWOGTYCTRX-SANMLTNESA-N 0.000 claims description 2
SFQCDTKIHKVLDB-SANMLTNESA-N (2s)-2-[[8-(1-benzylpyrazol-4-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C(=C1)C=NN1CC1=CC=CC=C1 SFQCDTKIHKVLDB-SANMLTNESA-N 0.000 claims description 2
XCJBAALJKPVXHW-FQEVSTJZSA-N (2s)-2-[[8-(2,4-dimethyl-1,3-thiazol-5-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1SC(C)=NC=1C XCJBAALJKPVXHW-FQEVSTJZSA-N 0.000 claims description 2
WLAWRGNQJIIOBM-IBGZPJMESA-N (2s)-2-[[8-(2,5-dichlorofuran-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=C(Cl)OC=1Cl WLAWRGNQJIIOBM-IBGZPJMESA-N 0.000 claims description 2
BUDWSABESDDLQC-QFIPXVFZSA-N (2s)-2-[[8-(2,5-dimethylthiophen-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=C(C)SC=1C BUDWSABESDDLQC-QFIPXVFZSA-N 0.000 claims description 2
YLHPVVVVMXZTLV-SFHVURJKSA-N (2s)-2-[[8-(2-chloro-1,3-thiazol-4-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CSC(Cl)=N1 YLHPVVVVMXZTLV-SFHVURJKSA-N 0.000 claims description 2
WZUUKLCANAQARJ-SFHVURJKSA-N (2s)-2-[[8-(2-chloro-1,3-thiazol-5-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CN=C(Cl)S1 WZUUKLCANAQARJ-SFHVURJKSA-N 0.000 claims description 2
KLOPRDLMVVENMD-IBGZPJMESA-N (2s)-2-[[8-(2-chlorofuran-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=COC=1Cl KLOPRDLMVVENMD-IBGZPJMESA-N 0.000 claims description 2
XALYSICFKQWTFF-IBGZPJMESA-N (2s)-2-[[8-(2-chlorothiophen-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=CSC=1Cl XALYSICFKQWTFF-IBGZPJMESA-N 0.000 claims description 2
MLNLCCJLLRXNKW-IBGZPJMESA-N (2s)-2-[[8-(2-chlorothiophen-3-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C=CSC=1Cl MLNLCCJLLRXNKW-IBGZPJMESA-N 0.000 claims description 2
KDDIUYUBOHAVIC-IBGZPJMESA-N (2s)-2-[[8-(2-methoxyethynyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C#COC)=CC=C3OC2=C1 KDDIUYUBOHAVIC-IBGZPJMESA-N 0.000 claims description 2
ZKBWCHKYJOOXJS-FQEVSTJZSA-N (2s)-2-[[8-(2-methoxypyrimidin-5-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=NC(OC)=NC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 ZKBWCHKYJOOXJS-FQEVSTJZSA-N 0.000 claims description 2
AAOCOEXPVQOMFW-IBGZPJMESA-N (2s)-2-[[8-(3,5-dichlorofuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1OC(Cl)=CC=1Cl AAOCOEXPVQOMFW-IBGZPJMESA-N 0.000 claims description 2
XIRFRBMMYJUDLK-IBGZPJMESA-N (2s)-2-[[8-(3,5-dichlorothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1SC(Cl)=CC=1Cl XIRFRBMMYJUDLK-IBGZPJMESA-N 0.000 claims description 2
DOJXYCQGSYTEGR-NRFANRHFSA-N (2s)-2-[[8-(3,5-dimethyl-1,2-oxazol-4-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C(C)=NOC=1C DOJXYCQGSYTEGR-NRFANRHFSA-N 0.000 claims description 2
PUITVRKBXHHQIB-NRFANRHFSA-N (2s)-2-[[8-(3,5-dimethyl-1h-pyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C(C)=NNC=1C PUITVRKBXHHQIB-NRFANRHFSA-N 0.000 claims description 2
AVZAZXIJRWGXCY-NRFANRHFSA-N (2s)-2-[[8-(3,5-dimethyl-1h-pyrazol-4-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C(C)=NNC=1C AVZAZXIJRWGXCY-NRFANRHFSA-N 0.000 claims description 2
SDNRSJSFMMXKFU-FQEVSTJZSA-N (2s)-2-[[8-(3-formylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1SC=CC=1C=O SDNRSJSFMMXKFU-FQEVSTJZSA-N 0.000 claims description 2
CQMMTHJRTHXZSV-FQEVSTJZSA-N (2s)-2-[[8-(3-methoxy-3-oxoprop-1-ynyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C#CC(=O)OC)=CC=C3OC2=C1 CQMMTHJRTHXZSV-FQEVSTJZSA-N 0.000 claims description 2
CLALSIAHDUVZJV-DEOSSOPVSA-N (2s)-2-[[8-(4,4-dimethyl-2-oxo-1h-3,1-benzoxazin-6-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound N1C(=O)OC(C)(C)C2=CC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C21 CLALSIAHDUVZJV-DEOSSOPVSA-N 0.000 claims description 2
PHZLIBHAJXIHCW-SFHVURJKSA-N (2s)-2-[[8-(4,5-dihydro-1,3-oxazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NCCO1 PHZLIBHAJXIHCW-SFHVURJKSA-N 0.000 claims description 2
GYYAODRYWUYDQY-SFHVURJKSA-N (2s)-2-[[8-(4,5-dihydro-1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NCCS1 GYYAODRYWUYDQY-SFHVURJKSA-N 0.000 claims description 2
UHEVEGBMHFVIKN-SFHVURJKSA-N (2s)-2-[[8-(4,5-dihydro-1h-imidazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NCCN1 UHEVEGBMHFVIKN-SFHVURJKSA-N 0.000 claims description 2
UVNVIFGFMABDEH-FQEVSTJZSA-N (2s)-2-[[8-(4,5-dimethyl-1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC(C)=C(C)S1 UVNVIFGFMABDEH-FQEVSTJZSA-N 0.000 claims description 2
DATQMPZLPDEELU-SFHVURJKSA-N (2s)-2-[[8-(4-bromo-1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC(Br)=CS1 DATQMPZLPDEELU-SFHVURJKSA-N 0.000 claims description 2
ALCJHWBXIVQPRR-NRFANRHFSA-N (2s)-2-[[8-(4-fluoro-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1F ALCJHWBXIVQPRR-NRFANRHFSA-N 0.000 claims description 2
RYZLJYSVYRFCDD-QFIPXVFZSA-N (2s)-2-[[8-(4-methoxy-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C=4SC=5C=CC=C(C=5N=4)OC)=CC=C3OC2=C1 RYZLJYSVYRFCDD-QFIPXVFZSA-N 0.000 claims description 2
VHTZUQAPAIRDBJ-QHCPKHFHSA-N (2s)-2-[[8-(4-methoxyphenyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC(OC)=CC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 VHTZUQAPAIRDBJ-QHCPKHFHSA-N 0.000 claims description 2
NWRZZVFLHDOFGA-QFIPXVFZSA-N (2s)-2-[[8-(5,6-difluoro-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound FC1=C(F)C=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 NWRZZVFLHDOFGA-QFIPXVFZSA-N 0.000 claims description 2
NAMHJJLLTFDCNG-QFIPXVFZSA-N (2s)-2-[[8-(5-acetylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(C)=O)S1 NAMHJJLLTFDCNG-QFIPXVFZSA-N 0.000 claims description 2
YTGNAVJOYPJODX-QFIPXVFZSA-N (2s)-2-[[8-(5-acetylthiophen-2-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC=C(C(C)=O)S1 YTGNAVJOYPJODX-QFIPXVFZSA-N 0.000 claims description 2
IEZFHPMTZIBRIJ-DEOSSOPVSA-N (2s)-2-[[8-(5-benzyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1CC1=CC=CC=C1 IEZFHPMTZIBRIJ-DEOSSOPVSA-N 0.000 claims description 2
LDGFBRWCTQMLJI-FQEVSTJZSA-N (2s)-2-[[8-(5-carbamoylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(N)=O)S1 LDGFBRWCTQMLJI-FQEVSTJZSA-N 0.000 claims description 2
HJRSZDGUJSABSN-SFHVURJKSA-N (2s)-2-[[8-(5-chloro-1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC=C(Cl)S1 HJRSZDGUJSABSN-SFHVURJKSA-N 0.000 claims description 2
FDXJBNPNRWLQES-FQEVSTJZSA-N (2s)-2-[[8-(5-chlorofuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(Cl)O1 FDXJBNPNRWLQES-FQEVSTJZSA-N 0.000 claims description 2
VKWUUWBRHYYCCV-FQEVSTJZSA-N (2s)-2-[[8-(5-chlorothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(Cl)S1 VKWUUWBRHYYCCV-FQEVSTJZSA-N 0.000 claims description 2
WJMYDAMERKEXFF-FQEVSTJZSA-N (2s)-2-[[8-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1CCC1 WJMYDAMERKEXFF-FQEVSTJZSA-N 0.000 claims description 2
KGFSDLQCKJSBSH-NRFANRHFSA-N (2s)-2-[[8-(5-cyclopentyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1CCCC1 KGFSDLQCKJSBSH-NRFANRHFSA-N 0.000 claims description 2
HFOQNWMRADMEPV-IBGZPJMESA-N (2s)-2-[[8-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1CC1 HFOQNWMRADMEPV-IBGZPJMESA-N 0.000 claims description 2
YEALYCAODNUTLF-IBGZPJMESA-N (2s)-2-[[8-(5-ethyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound O1C(CC)=NC(C=2C=C3C4=CC=C(C=C4OC3=CC=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=N1 YEALYCAODNUTLF-IBGZPJMESA-N 0.000 claims description 2
CDLQIGGXSYPPQK-QFIPXVFZSA-N (2s)-2-[[8-(5-ethylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound S1C(CC)=CC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 CDLQIGGXSYPPQK-QFIPXVFZSA-N 0.000 claims description 2
ILBGGQDRKDWMEM-QFIPXVFZSA-N (2s)-2-[[8-(5-fluoro-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound FC1=CC=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 ILBGGQDRKDWMEM-QFIPXVFZSA-N 0.000 claims description 2
KWFTYLQUVUNSGF-FQEVSTJZSA-N (2s)-2-[[8-(5-fluorothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(F)S1 KWFTYLQUVUNSGF-FQEVSTJZSA-N 0.000 claims description 2
LAAHFEGDXUAJDE-QHCPKHFHSA-N (2s)-2-[[8-(5-methoxy-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C=4SC5=CC=C(C=C5N=4)OC)=CC=C3OC2=C1 LAAHFEGDXUAJDE-QHCPKHFHSA-N 0.000 claims description 2
QODKHJZZECMWOS-QFIPXVFZSA-N (2s)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-2-phenylacetic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C4=CC=C(C=C4OC3=CC=2)S(=O)(=O)N[C@H](C(O)=O)C=2C=CC=CC=2)=N1 QODKHJZZECMWOS-QFIPXVFZSA-N 0.000 claims description 2
NZQAAPJCTUNRMX-IBGZPJMESA-N (2s)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(C(C)(C)C)=N1 NZQAAPJCTUNRMX-IBGZPJMESA-N 0.000 claims description 2
NLXLWXGTVAEMII-SFHVURJKSA-N (2s)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-4-methylpentanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](CC(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(C(C)(C)C)=N1 NLXLWXGTVAEMII-SFHVURJKSA-N 0.000 claims description 2
UVPKGATURLQTFF-QHCPKHFHSA-N (2s)-2-[[8-(5-tert-butylfuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(C)(C)C)O1 UVPKGATURLQTFF-QHCPKHFHSA-N 0.000 claims description 2
KXKFCHFIAHCBBI-QFIPXVFZSA-N (2s)-2-[[8-(6-chloro-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C(Cl)C=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 KXKFCHFIAHCBBI-QFIPXVFZSA-N 0.000 claims description 2
VAFNGMYFSXTJRC-NRFANRHFSA-N (2s)-2-[[8-(6-chloropyridin-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(Cl)N=C1 VAFNGMYFSXTJRC-NRFANRHFSA-N 0.000 claims description 2
HZXKGDMQMNNCRD-NRFANRHFSA-N (2s)-2-[[8-(6-chloropyridin-3-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC=C(Cl)N=C1 HZXKGDMQMNNCRD-NRFANRHFSA-N 0.000 claims description 2
JELIUEOCFQOAQJ-QFIPXVFZSA-N (2s)-2-[[8-(6-fluoro-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C(F)C=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 JELIUEOCFQOAQJ-QFIPXVFZSA-N 0.000 claims description 2
GPWVHZYLSMEARM-QHCPKHFHSA-N (2s)-2-[[8-(6-methoxy-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C4=NC5=CC=C(C=C5S4)OC)=CC=C3OC2=C1 GPWVHZYLSMEARM-QHCPKHFHSA-N 0.000 claims description 2
YDQDFVSPQFLHIE-QFIPXVFZSA-N (2s)-2-[[8-(6-methoxypyridin-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=NC(OC)=CC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 YDQDFVSPQFLHIE-QFIPXVFZSA-N 0.000 claims description 2
SFFGSFGAFZZEKS-QFIPXVFZSA-N (2s)-2-[[8-(6-methoxypyridin-3-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=NC(OC)=CC=C1C1=CC=C(SC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 SFFGSFGAFZZEKS-QFIPXVFZSA-N 0.000 claims description 2
PPNPGGFZGVVPAB-FQEVSTJZSA-N (2s)-2-[[8-(furan-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=CO1 PPNPGGFZGVVPAB-FQEVSTJZSA-N 0.000 claims description 2
CCYLJGZXXCVFGH-FQEVSTJZSA-N (2s)-2-[[8-(furan-2-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC=CO1 CCYLJGZXXCVFGH-FQEVSTJZSA-N 0.000 claims description 2
JYGJKRYSCVUTOS-FQEVSTJZSA-N (2s)-2-[[8-(furan-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=COC=1 JYGJKRYSCVUTOS-FQEVSTJZSA-N 0.000 claims description 2
WYMLGTKWPSECSN-FQEVSTJZSA-N (2s)-2-[[8-(furan-3-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C=COC=1 WYMLGTKWPSECSN-FQEVSTJZSA-N 0.000 claims description 2
SBYYWMWJIOJBDA-QHCPKHFHSA-N (2s)-2-[[8-(n'-benzylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=N)NCC1=CC=CC=C1 SBYYWMWJIOJBDA-QHCPKHFHSA-N 0.000 claims description 2
PSOLKLRBLRVLFN-SFHVURJKSA-N (2s)-2-[[8-(n'-ethylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C(=N)NCC)=CC=C3OC2=C1 PSOLKLRBLRVLFN-SFHVURJKSA-N 0.000 claims description 2
ZJFKXLGVJBITKP-KRWDZBQOSA-N (2s)-2-[[8-(n'-methoxycarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C(=N)NOC)=CC=C3OC2=C1 ZJFKXLGVJBITKP-KRWDZBQOSA-N 0.000 claims description 2
NIEGMRTVJZQPGZ-FQEVSTJZSA-N (2s)-2-[[8-(n,n'-diethylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C(=NCC)NCC)=CC=C3OC2=C1 NIEGMRTVJZQPGZ-FQEVSTJZSA-N 0.000 claims description 2
APDUOXKFPGXFIM-FQEVSTJZSA-N (2s)-2-[[8-(n,n-diethylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C(=N)N(CC)CC)=CC=C3OC2=C1 APDUOXKFPGXFIM-FQEVSTJZSA-N 0.000 claims description 2
YNABNFAGPHVTNV-KDLSMAQYSA-N (2s)-2-[[8-[(e)-2-cyclohexylethenyl]dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3\C=C\C1CCCCC1 YNABNFAGPHVTNV-KDLSMAQYSA-N 0.000 claims description 2
FRKIGRJTOJVSGZ-INIZCTEOSA-N (2s)-2-[[8-[(z)-n'-hydroxycarbamimidoyl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C(C(=N)NO)C=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 FRKIGRJTOJVSGZ-INIZCTEOSA-N 0.000 claims description 2
RZSNFCGMNARFLE-QFIPXVFZSA-N (2s)-2-[[8-[2-(diethylamino)ethynyl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C#CN(CC)CC)=CC=C3OC2=C1 RZSNFCGMNARFLE-QFIPXVFZSA-N 0.000 claims description 2
COUODDQJDFSUID-NRFANRHFSA-N (2s)-2-[[8-[3-(dimethylamino)prop-1-ynyl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C(C#CCN(C)C)C=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 COUODDQJDFSUID-NRFANRHFSA-N 0.000 claims description 2
DJPNFAACWDIEMT-QFIPXVFZSA-N (2s)-2-[[8-[3-[(dimethylamino)methyl]furan-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1OC=CC=1CN(C)C DJPNFAACWDIEMT-QFIPXVFZSA-N 0.000 claims description 2
FJVDHTCWQBQCMB-QFIPXVFZSA-N (2s)-2-[[8-[3-[(dimethylamino)methyl]thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1SC=CC=1CN(C)C FJVDHTCWQBQCMB-QFIPXVFZSA-N 0.000 claims description 2
MZRNJIRXVYICOL-DEOSSOPVSA-N (2s)-2-[[8-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(SC=1)=NC=1C1=CC=C(F)C=C1 MZRNJIRXVYICOL-DEOSSOPVSA-N 0.000 claims description 2
TXCNVCLRHGGHCQ-NRFANRHFSA-N (2s)-2-[[8-[5-(2,2-dimethylpropyl)-1,2,4-oxadiazol-3-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(CC(C)(C)C)=N1 TXCNVCLRHGGHCQ-NRFANRHFSA-N 0.000 claims description 2
VVGXPIQQGGSWEQ-QFIPXVFZSA-N (2s)-2-[[8-[5-(2,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1=CC=C(Cl)C=C1Cl VVGXPIQQGGSWEQ-QFIPXVFZSA-N 0.000 claims description 2
QQOQLIBMJSJQGL-IBGZPJMESA-N (2s)-2-[[8-[5-(hydroxymethyl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC=C(CO)S1 QQOQLIBMJSJQGL-IBGZPJMESA-N 0.000 claims description 2
NRYNGPSRPGKXBU-IBGZPJMESA-N (2s)-2-[[8-[5-(methoxymethyl)-1,2,4-oxadiazol-3-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound O1C(COC)=NC(C=2C=C3C4=CC=C(C=C4OC3=CC=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=N1 NRYNGPSRPGKXBU-IBGZPJMESA-N 0.000 claims description 2
MSXFYDXQBXRMKE-YKHFMZSMSA-N (2s)-2-[[8-[5-[1-(dimethylamino)ethyl]thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(C)N(C)C)S1 MSXFYDXQBXRMKE-YKHFMZSMSA-N 0.000 claims description 2
BZCITXZTWSOTSF-SANMLTNESA-N (2s)-2-[[8-[5-[[cyclopropylmethyl(propyl)amino]methyl]-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1N=C(C=2C=C3C4=CC=C(C=C4OC3=CC=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)SC=1CN(CCC)CC1CC1 BZCITXZTWSOTSF-SANMLTNESA-N 0.000 claims description 2
MFPGSWVSKFTKST-INIZCTEOSA-N (2s)-2-[[8-[5-chloro-4-(trifluoromethyl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC(C(F)(F)F)=C(Cl)S1 MFPGSWVSKFTKST-INIZCTEOSA-N 0.000 claims description 2
OPJXGBRQCUDJPA-SANMLTNESA-N (2s)-2-[[8-[6-(6-chloropyridin-3-yl)pyridin-3-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(C=N1)=CC=C1C1=CC=C(Cl)N=C1 OPJXGBRQCUDJPA-SANMLTNESA-N 0.000 claims description 2
FWTKURCQSPYGNL-SANMLTNESA-N (2s)-2-[[8-[6-(6-chloropyridin-3-yl)pyridin-3-yl]dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C(C=N1)=CC=C1C1=CC=C(Cl)N=C1 FWTKURCQSPYGNL-SANMLTNESA-N 0.000 claims description 2
DIIWHMJWAZUROJ-QFIPXVFZSA-N (2s)-3-methyl-2-[(7-phenyldibenzothiophen-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1SC2=CC=3C1=CC=CC=C1 DIIWHMJWAZUROJ-QFIPXVFZSA-N 0.000 claims description 2
MGAFKHLUTWEZTH-FQEVSTJZSA-N (2s)-3-methyl-2-[(7-thiophen-2-yldibenzofuran-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=CS1 MGAFKHLUTWEZTH-FQEVSTJZSA-N 0.000 claims description 2
RWTYONUBVSWBOZ-QFIPXVFZSA-N (2s)-3-methyl-2-[(8-phenyldibenzofuran-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=CC=C1 RWTYONUBVSWBOZ-QFIPXVFZSA-N 0.000 claims description 2
OZBOSNKACBKPLE-NRFANRHFSA-N (2s)-3-methyl-2-[(8-pyridin-3-yldibenzofuran-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=CN=C1 OZBOSNKACBKPLE-NRFANRHFSA-N 0.000 claims description 2
YKBPFINIIFIXCW-NRFANRHFSA-N (2s)-3-methyl-2-[(8-pyridin-3-yldibenzothiophen-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC=CN=C1 YKBPFINIIFIXCW-NRFANRHFSA-N 0.000 claims description 2
QDVROGSVRQKQIV-NRFANRHFSA-N (2s)-3-methyl-2-[(8-pyridin-4-yldibenzofuran-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=NC=C1 QDVROGSVRQKQIV-NRFANRHFSA-N 0.000 claims description 2
VAYIABKLBMFUTM-NRFANRHFSA-N (2s)-3-methyl-2-[(8-pyridin-4-yldibenzothiophen-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC=NC=C1 VAYIABKLBMFUTM-NRFANRHFSA-N 0.000 claims description 2
FCFSTYCXOYGMHI-FQEVSTJZSA-N (2s)-3-methyl-2-[(8-pyrimidin-5-yldibenzofuran-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CN=CN=C1 FCFSTYCXOYGMHI-FQEVSTJZSA-N 0.000 claims description 2
JOPVKXACSHJTNX-VWLOTQADSA-N (2s)-3-methyl-2-[(8-quinolin-6-yldibenzofuran-3-yl)sulfonylamino]butanoic acid Chemical compound N1=CC=CC2=CC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C21 JOPVKXACSHJTNX-VWLOTQADSA-N 0.000 claims description 2
HXBSTHBOPZEQHI-FQEVSTJZSA-N (2s)-3-methyl-2-[(8-thiophen-3-yldibenzothiophen-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C=CSC=1 HXBSTHBOPZEQHI-FQEVSTJZSA-N 0.000 claims description 2
FMQWYBXXWWRQHI-SFHVURJKSA-N (2s)-3-methyl-2-[[7-(1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NC=CS1 FMQWYBXXWWRQHI-SFHVURJKSA-N 0.000 claims description 2
WJWHXPLMCBRPBO-INIZCTEOSA-N (2s)-3-methyl-2-[[7-(2h-tetrazol-5-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NN=NN1 WJWHXPLMCBRPBO-INIZCTEOSA-N 0.000 claims description 2
IEBNQNLKLFSSFL-SFHVURJKSA-N (2s)-3-methyl-2-[[7-(3,4,5-trichlorothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C=1SC(Cl)=C(Cl)C=1Cl IEBNQNLKLFSSFL-SFHVURJKSA-N 0.000 claims description 2
IYAHXQXQRODEOQ-SFHVURJKSA-N (2s)-3-methyl-2-[[7-(5-methyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NOC(C)=N1 IYAHXQXQRODEOQ-SFHVURJKSA-N 0.000 claims description 2
UXTSZHSETJDRJJ-IBGZPJMESA-N (2s)-3-methyl-2-[[7-(5-methyl-1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NC=C(C)S1 UXTSZHSETJDRJJ-IBGZPJMESA-N 0.000 claims description 2
TXODJXONKWWETJ-NRFANRHFSA-N (2s)-3-methyl-2-[[7-(5-methylfuran-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=C(C)O1 TXODJXONKWWETJ-NRFANRHFSA-N 0.000 claims description 2
NIMXNQNNCDAXSM-NRFANRHFSA-N (2s)-3-methyl-2-[[7-(5-methylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=C(C)S1 NIMXNQNNCDAXSM-NRFANRHFSA-N 0.000 claims description 2
RFEPBTJIXMHPKQ-IBGZPJMESA-N (2s)-3-methyl-2-[[7-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NOC(C(C)C)=N1 RFEPBTJIXMHPKQ-IBGZPJMESA-N 0.000 claims description 2
FRLIEOABZAZATR-QHCPKHFHSA-N (2s)-3-methyl-2-[[7-(5-propylthiophen-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound S1C(CCC)=CC=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C3OC2=C1 FRLIEOABZAZATR-QHCPKHFHSA-N 0.000 claims description 2
CICZGMKIYTYHEP-QHCPKHFHSA-N (2s)-3-methyl-2-[[7-(5-propylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound S1C(CCC)=CC=C1C1=CC=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 CICZGMKIYTYHEP-QHCPKHFHSA-N 0.000 claims description 2
DATZVNVKDASYKB-QHCPKHFHSA-N (2s)-3-methyl-2-[[7-[2-(2-methylpropyl)-1,3-thiazol-5-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound S1C(CC(C)C)=NC=C1C1=CC=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 DATZVNVKDASYKB-QHCPKHFHSA-N 0.000 claims description 2
XKAJYASQFPOFFO-QHCPKHFHSA-N (2s)-3-methyl-2-[[7-[4-methyl-2-(2-methylpropyl)-1,3-thiazol-5-yl]dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound S1C(CC(C)C)=NC(C)=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C3OC2=C1 XKAJYASQFPOFFO-QHCPKHFHSA-N 0.000 claims description 2
KXGDPQKNMCYZMZ-QHCPKHFHSA-N (2s)-3-methyl-2-[[7-[4-methyl-2-(2-methylpropyl)-1,3-thiazol-5-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound S1C(CC(C)C)=NC(C)=C1C1=CC=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 KXGDPQKNMCYZMZ-QHCPKHFHSA-N 0.000 claims description 2
LZKRIOVDRZGISP-FQEVSTJZSA-N (2s)-3-methyl-2-[[7-[5-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C(S1)=NC=C1C1=NOC(C)=N1 LZKRIOVDRZGISP-FQEVSTJZSA-N 0.000 claims description 2
HFULTWXLGBAVDR-QFIPXVFZSA-N (2s)-3-methyl-2-[[7-[6-(trifluoromethyl)-1,3-benzothiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=C(C(F)(F)F)C=C2SC(C=3C=C4OC=5C(C4=CC=3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 HFULTWXLGBAVDR-QFIPXVFZSA-N 0.000 claims description 2
YXUCIMNKGIMIFY-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(1,2,3,6-tetrahydropyridin-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CCNCC1 YXUCIMNKGIMIFY-NRFANRHFSA-N 0.000 claims description 2
PCMJCNQXOIOQDQ-KRWDZBQOSA-N (2s)-3-methyl-2-[[8-(1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1N=CON=1 PCMJCNQXOIOQDQ-KRWDZBQOSA-N 0.000 claims description 2
LWSMVIRRZXEYRG-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-(1,3,5-trimethylpyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C(C)=NN(C)C=1C LWSMVIRRZXEYRG-QFIPXVFZSA-N 0.000 claims description 2
MUMVNZHARHFSLP-SFHVURJKSA-N (2s)-3-methyl-2-[[8-(1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC=CS1 MUMVNZHARHFSLP-SFHVURJKSA-N 0.000 claims description 2
AOMNNBZHSJHHSS-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(1-methylpyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=NN(C)C=1 AOMNNBZHSJHHSS-FQEVSTJZSA-N 0.000 claims description 2
FVOFKWFFJVGNEX-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(1-methylpyrazol-4-yl)dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C=NN(C)C=1 FVOFKWFFJVGNEX-FQEVSTJZSA-N 0.000 claims description 2
BUBKQIUPLIBUPE-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-(1-propylpyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CCC)C=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 BUBKQIUPLIBUPE-QFIPXVFZSA-N 0.000 claims description 2
AFRMNQLOQQIAAI-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-(1-propylpyrazol-4-yl)dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CCC)C=C1C1=CC=C(SC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 AFRMNQLOQQIAAI-QFIPXVFZSA-N 0.000 claims description 2
LAZBBXUXSNLDQA-IBGZPJMESA-N (2s)-3-methyl-2-[[8-(1h-pyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=NNC=1 LAZBBXUXSNLDQA-IBGZPJMESA-N 0.000 claims description 2
VNCWMXITGONGFT-IBGZPJMESA-N (2s)-3-methyl-2-[[8-(1h-pyrazol-4-yl)dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C=NNC=1 VNCWMXITGONGFT-IBGZPJMESA-N 0.000 claims description 2
URNSMGRITRSYDT-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(1h-pyrrol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=CN1 URNSMGRITRSYDT-FQEVSTJZSA-N 0.000 claims description 2
RTPOLIXDCQLFOR-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(1h-pyrrol-2-yl)dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC=CN1 RTPOLIXDCQLFOR-FQEVSTJZSA-N 0.000 claims description 2
UNZBPHBZHRKEGU-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(2-methyl-1,3-thiazol-5-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CN=C(C)S1 UNZBPHBZHRKEGU-FQEVSTJZSA-N 0.000 claims description 2
GUMXDFBZBYDOEC-KRWDZBQOSA-N (2s)-3-methyl-2-[[8-(2-methyltetrazol-5-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1N=NN(C)N=1 GUMXDFBZBYDOEC-KRWDZBQOSA-N 0.000 claims description 2
GQVCQMCAXYHISY-INIZCTEOSA-N (2s)-3-methyl-2-[[8-(2h-tetrazol-5-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1N=NNN=1 GQVCQMCAXYHISY-INIZCTEOSA-N 0.000 claims description 2
HPCSMWWPNIGQQV-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1CCCC(S2)=C1N=C2C1=CC=C2OC3=CC(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C3C2=C1 HPCSMWWPNIGQQV-QFIPXVFZSA-N 0.000 claims description 2
PNBZSCHMFRTSOZ-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(4,5,6-trifluoro-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound FC1=C(F)C=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1F PNBZSCHMFRTSOZ-NRFANRHFSA-N 0.000 claims description 2
HUZFQBCKLXLLLN-DEOSSOPVSA-N (2s)-3-methyl-2-[[8-(4-methyl-2-phenyl-1,3-thiazol-5-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=C(N=1)C)SC=1C1=CC=CC=C1 HUZFQBCKLXLLLN-DEOSSOPVSA-N 0.000 claims description 2
QZYSOPAEKFVZFU-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(4-methylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC(C)=CS1 QZYSOPAEKFVZFU-NRFANRHFSA-N 0.000 claims description 2
YZLPRCXRQYQCJO-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(4-methylthiophen-2-yl)dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC(C)=CS1 YZLPRCXRQYQCJO-NRFANRHFSA-N 0.000 claims description 2
JIZDPGRMHYGSRZ-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(4-methylthiophen-3-yl)dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CSC=C1C JIZDPGRMHYGSRZ-NRFANRHFSA-N 0.000 claims description 2
AJPXKPDDERRJRR-SFHVURJKSA-N (2s)-3-methyl-2-[[8-(5-methyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(C)=N1 AJPXKPDDERRJRR-SFHVURJKSA-N 0.000 claims description 2
AWRABTFLOWVDFY-SFHVURJKSA-N (2s)-3-methyl-2-[[8-(5-methyl-1,3,4-thiadiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NN=C(C)S1 AWRABTFLOWVDFY-SFHVURJKSA-N 0.000 claims description 2
FRPRECKGQMJJSQ-SANMLTNESA-N (2s)-3-methyl-2-[[8-(5-methyl-1-phenylpyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=C1C)C=NN1C1=CC=CC=C1 FRPRECKGQMJJSQ-SANMLTNESA-N 0.000 claims description 2
XJPPEFJWBKQLAY-VWLOTQADSA-N (2s)-3-methyl-2-[[8-(5-methyl-3-phenyl-1,2-oxazol-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=C(C)ON=C1C1=CC=CC=C1 XJPPEFJWBKQLAY-VWLOTQADSA-N 0.000 claims description 2
LLJREHOWNIBILL-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(5-methylfuran-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C)O1 LLJREHOWNIBILL-NRFANRHFSA-N 0.000 claims description 2
DKEROQXIMVSLEZ-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(5-methylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C)S1 DKEROQXIMVSLEZ-NRFANRHFSA-N 0.000 claims description 2
KEMDGKYEBOPVCD-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-(5-phenyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1=CC=CC=C1 KEMDGKYEBOPVCD-QFIPXVFZSA-N 0.000 claims description 2
CEMRGJBBNAXOEV-IBGZPJMESA-N (2s)-3-methyl-2-[[8-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(C(C)C)=N1 CEMRGJBBNAXOEV-IBGZPJMESA-N 0.000 claims description 2
XMYCBAYCRSNYQT-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-(5-propylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound S1C(CCC)=CC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 XMYCBAYCRSNYQT-QHCPKHFHSA-N 0.000 claims description 2
DRFNLDKUFPKTTB-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-(6-methyl-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=C(C)C=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 DRFNLDKUFPKTTB-QHCPKHFHSA-N 0.000 claims description 2
CFFBYKLEAXIDJJ-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-(n'-phenylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=N)NC1=CC=CC=C1 CFFBYKLEAXIDJJ-QFIPXVFZSA-N 0.000 claims description 2
CAGBUDBKEUNUQQ-IBGZPJMESA-N (2s)-3-methyl-2-[[8-(n'-propan-2-ylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C(=N)NC(C)C)=CC=C3OC2=C1 CAGBUDBKEUNUQQ-IBGZPJMESA-N 0.000 claims description 2
UFRHXRCTWNZPPB-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(n-methyl-n-propan-2-ylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=C(C(=N)N(C)C(C)C)C=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 UFRHXRCTWNZPPB-FQEVSTJZSA-N 0.000 claims description 2
WULPGZBIQUSVQT-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(pyrrolidine-1-carboximidoyl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=N)N1CCCC1 WULPGZBIQUSVQT-FQEVSTJZSA-N 0.000 claims description 2
AJHDDYUDTUXEFK-PXPVJAHISA-N (2s)-3-methyl-2-[[8-[(e)-prop-1-enyl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(/C=C/C)=CC=C3OC2=C1 AJHDDYUDTUXEFK-PXPVJAHISA-N 0.000 claims description 2
AJHDDYUDTUXEFK-HMECNJMJSA-N (2s)-3-methyl-2-[[8-[(z)-prop-1-enyl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(\C=C/C)=CC=C3OC2=C1 AJHDDYUDTUXEFK-HMECNJMJSA-N 0.000 claims description 2
JCAQNCWRWOJYTA-ODOSRFNGSA-N (2s)-3-methyl-2-[[8-[1-(2-methylbutyl)pyrazol-4-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CC(C)CC)C=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 JCAQNCWRWOJYTA-ODOSRFNGSA-N 0.000 claims description 2
HSWCQCWZHXVDDD-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-[1-(2-methylpropyl)pyrazol-4-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CC(C)C)C=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 HSWCQCWZHXVDDD-QHCPKHFHSA-N 0.000 claims description 2
VWGRHFFPSLVNAC-VWLOTQADSA-N (2s)-3-methyl-2-[[8-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=C1)C=NN1CCN1CCOCC1 VWGRHFFPSLVNAC-VWLOTQADSA-N 0.000 claims description 2
YCYRQEYFXGUFBW-DEOSSOPVSA-N (2s)-3-methyl-2-[[8-[1-(3-methylbutyl)pyrazol-4-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CCC(C)C)C=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 YCYRQEYFXGUFBW-DEOSSOPVSA-N 0.000 claims description 2
TYSZNFNQPFAONO-DEOSSOPVSA-N (2s)-3-methyl-2-[[8-[1-(3-methylbutyl)pyrazol-4-yl]dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CCC(C)C)C=C1C1=CC=C(SC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 TYSZNFNQPFAONO-DEOSSOPVSA-N 0.000 claims description 2
BSMYRYJBRSUDFE-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-[2-(2-methylpropyl)-1,3-thiazol-5-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound S1C(CC(C)C)=NC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 BSMYRYJBRSUDFE-QHCPKHFHSA-N 0.000 claims description 2
UBRBSALAOSNRPD-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[2-(3-methylimidazol-4-yl)ethynyl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C#CC1=CN=CN1C UBRBSALAOSNRPD-QFIPXVFZSA-N 0.000 claims description 2
JOMAZZXKNPJECX-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-[3-phenyl-5-(trifluoromethyl)-1h-pyrazol-4-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(C(=NN1)C(F)(F)F)=C1C1=CC=CC=C1 JOMAZZXKNPJECX-QHCPKHFHSA-N 0.000 claims description 2
FJFUENPXRBFIGU-SFHVURJKSA-N (2s)-3-methyl-2-[[8-[4-(trifluoromethyl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC(C(F)(F)F)=CS1 FJFUENPXRBFIGU-SFHVURJKSA-N 0.000 claims description 2
AXRNREJBUORIBT-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[4-(trifluoromethyl)phenyl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(F)(F)F)C=C1 AXRNREJBUORIBT-QFIPXVFZSA-N 0.000 claims description 2
SVNHHUPPVNMEMR-DEOSSOPVSA-N (2s)-3-methyl-2-[[8-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(SC=1)=NC=1C1=CC=C(C(F)(F)F)C=C1 SVNHHUPPVNMEMR-DEOSSOPVSA-N 0.000 claims description 2
ZTVNIISABDZIQG-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-[4-methyl-2-(2-methylpropyl)-1,3-thiazol-5-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound S1C(CC(C)C)=NC(C)=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 ZTVNIISABDZIQG-QHCPKHFHSA-N 0.000 claims description 2
XDAFLORZHFMNOG-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-[5-(1,2-oxazol-3-yl)thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(S1)=CC=C1C=1C=CON=1 XDAFLORZHFMNOG-QHCPKHFHSA-N 0.000 claims description 2
MPODMIXWHMXWEE-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-[5-(1,2-oxazol-5-yl)thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(S1)=CC=C1C1=CC=NO1 MPODMIXWHMXWEE-QHCPKHFHSA-N 0.000 claims description 2
PCISISKGZAHYFX-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-[5-(2h-tetrazol-5-yl)thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(S1)=CC=C1C1=NN=NN1 PCISISKGZAHYFX-FQEVSTJZSA-N 0.000 claims description 2
HFMYZOXOMAAVBC-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[5-(5-methyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(S1)=CC=C1C1=NOC(C)=N1 HFMYZOXOMAAVBC-QFIPXVFZSA-N 0.000 claims description 2
KYZDQEOFOIPKOE-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[5-(methylaminomethyl)furan-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound O1C(CNC)=CC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 KYZDQEOFOIPKOE-QFIPXVFZSA-N 0.000 claims description 2
MIMJOPWHYSLYIB-NRFANRHFSA-N (2s)-3-methyl-2-[[8-[5-(oxan-4-yl)-1,2,4-oxadiazol-3-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1CCOCC1 MIMJOPWHYSLYIB-NRFANRHFSA-N 0.000 claims description 2
XNJWMINHASIUCN-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[5-(pyrazol-1-ylmethyl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(S1)=NC=C1CN1C=CC=N1 XNJWMINHASIUCN-QFIPXVFZSA-N 0.000 claims description 2
NBNIONMVMBISNG-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-[5-(trifluoromethyl)thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(F)(F)F)S1 NBNIONMVMBISNG-FQEVSTJZSA-N 0.000 claims description 2
MHMALBKFABHZPZ-DEOSSOPVSA-N (2s)-3-methyl-2-[[8-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(S1)=NC=C1CN1CCN(C)CC1 MHMALBKFABHZPZ-DEOSSOPVSA-N 0.000 claims description 2
NKSBPSUCIBWVPQ-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[5-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1=CC=C(C(F)(F)F)C=C1 NKSBPSUCIBWVPQ-QFIPXVFZSA-N 0.000 claims description 2
GEGTWEYNSPBVQO-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=C(OC(F)(F)F)C=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 GEGTWEYNSPBVQO-QFIPXVFZSA-N 0.000 claims description 2
FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 claims description 2
NVUOFOKWDMEDLT-UHFFFAOYSA-N 2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-2-methylpropanoic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)NC(C)(C)C(O)=O)=CC=2)=N1 NVUOFOKWDMEDLT-UHFFFAOYSA-N 0.000 claims description 2
PUVCTLLJLXUYPY-UHFFFAOYSA-N 2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]acetic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)NCC(O)=O)=CC=2)=N1 PUVCTLLJLXUYPY-UHFFFAOYSA-N 0.000 claims description 2
UKKPHTGLZAQQCS-UHFFFAOYSA-N 2-[[8-(1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]acetic acid Chemical compound C=1C(S(=O)(=O)NCC(=O)O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC=CS1 UKKPHTGLZAQQCS-UHFFFAOYSA-N 0.000 claims description 2
GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 claims description 2
RHIGPZIDZSIXKU-FQEVSTJZSA-N 5-[7-[[(1s)-1-carboxy-2-methylpropyl]sulfamoyl]dibenzofuran-2-yl]thiophene-2-carboxylic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(O)=O)S1 RHIGPZIDZSIXKU-FQEVSTJZSA-N 0.000 claims description 2
YGJLDGIYMQYMJG-INIZCTEOSA-N 7-[[(1s)-1-carboxy-2-methylpropyl]sulfamoyl]dibenzofuran-2-carboxylic acid Chemical compound C1=C(C(O)=O)C=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 YGJLDGIYMQYMJG-INIZCTEOSA-N 0.000 claims description 2
YJKMJMMFQBCKRJ-MRXNPFEDSA-N CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)C3=CC4=C(C=C3)C5=C(O4)C=CC(=C5)S(=O)(=O)N[C@H](C)C(C)C Chemical compound CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)C3=CC4=C(C=C3)C5=C(O4)C=CC(=C5)S(=O)(=O)N[C@H](C)C(C)C YJKMJMMFQBCKRJ-MRXNPFEDSA-N 0.000 claims description 2
JLSKRMIJOXSIPB-INIZCTEOSA-N CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)C3=CC4=C(C=C3)OC5=C4C=CC(=C5)S(=O)(=O)N[C@@H](C)C(C)C Chemical compound CC1=C(SC(=N1)C2=CC=C(C=C2)C(F)(F)F)C3=CC4=C(C=C3)OC5=C4C=CC(=C5)S(=O)(=O)N[C@@H](C)C(C)C JLSKRMIJOXSIPB-INIZCTEOSA-N 0.000 claims description 2
MOBJWXWNZMVSHT-AWEZNQCLSA-N C[C@@H](C(C)(C)C)NS(=O)(=O)C1=CC2=C(C=C1)C3=C(O2)C=CC(=C3)C4=NOC(=N4)C(C)(C)C Chemical compound C[C@@H](C(C)(C)C)NS(=O)(=O)C1=CC2=C(C=C1)C3=C(O2)C=CC(=C3)C4=NOC(=N4)C(C)(C)C MOBJWXWNZMVSHT-AWEZNQCLSA-N 0.000 claims description 2
JDXQVKHFYFBLFL-AWEZNQCLSA-N C[C@@H](C(C)(C)C)NS(=O)(=O)C1=CC2=C(C=C1)OC3=C2C=CC(=C3)C4=NOC(=N4)C(C)(C)C Chemical compound C[C@@H](C(C)(C)C)NS(=O)(=O)C1=CC2=C(C=C1)OC3=C2C=CC(=C3)C4=NOC(=N4)C(C)(C)C JDXQVKHFYFBLFL-AWEZNQCLSA-N 0.000 claims description 2
QHYNVYTZRGNNSD-HNNXBMFYSA-N C[C@@H](C(C)C)NS(=O)(=O)C1=CC2=C(C=C1)C3=C(O2)C=C(C=C3)C4=NOC(=N4)C5=CC=C(C=C5)F Chemical compound C[C@@H](C(C)C)NS(=O)(=O)C1=CC2=C(C=C1)C3=C(O2)C=C(C=C3)C4=NOC(=N4)C5=CC=C(C=C5)F QHYNVYTZRGNNSD-HNNXBMFYSA-N 0.000 claims description 2
LEEMWMUSVNPSBS-NSHDSACASA-N C[C@@H](C(C)C)NS(=O)(=O)C1=CC2=C(C=C1)C3=C(O2)C=CC(=C3)C4=NOC(=N4)C(F)(F)F Chemical compound C[C@@H](C(C)C)NS(=O)(=O)C1=CC2=C(C=C1)C3=C(O2)C=CC(=C3)C4=NOC(=N4)C(F)(F)F LEEMWMUSVNPSBS-NSHDSACASA-N 0.000 claims description 2
SNRJPIOBWCROQT-HNNXBMFYSA-N C[C@@H](C(C)C)NS(=O)(=O)C1=CC2=C(C=C1)C3=C(O2)C=CC(=C3)C4=NOC(=N4)C5=CC=C(C=C5)F Chemical compound C[C@@H](C(C)C)NS(=O)(=O)C1=CC2=C(C=C1)C3=C(O2)C=CC(=C3)C4=NOC(=N4)C5=CC=C(C=C5)F SNRJPIOBWCROQT-HNNXBMFYSA-N 0.000 claims description 2
LEEMWMUSVNPSBS-LLVKDONJSA-N C[C@H](C(C)C)NS(=O)(=O)C1=CC2=C(C=C1)C3=C(O2)C=CC(=C3)C4=NOC(=N4)C(F)(F)F Chemical compound C[C@H](C(C)C)NS(=O)(=O)C1=CC2=C(C=C1)C3=C(O2)C=CC(=C3)C4=NOC(=N4)C(F)(F)F LEEMWMUSVNPSBS-LLVKDONJSA-N 0.000 claims description 2
MMNJGKRPTJYBEI-LLVKDONJSA-N C[C@H](C(C)C)NS(=O)(=O)C1=CC2=C(C=C1)OC3=C2C=C(C=C3)C4=NOC(=N4)C(F)(F)F Chemical compound C[C@H](C(C)C)NS(=O)(=O)C1=CC2=C(C=C1)OC3=C2C=C(C=C3)C4=NOC(=N4)C(F)(F)F MMNJGKRPTJYBEI-LLVKDONJSA-N 0.000 claims description 2
150000007650 D alpha amino acids Chemical class 0.000 claims description 2
150000007649 L alpha amino acids Chemical class 0.000 claims description 2
102100027998 Macrophage metalloelastase Human genes 0.000 claims description 2
101710187853 Macrophage metalloelastase Proteins 0.000 claims description 2
125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 2
125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 2
125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 2
125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims description 2
150000001576 beta-amino acids Chemical class 0.000 claims description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
UZVGSSNIUNSOFA-UHFFFAOYSA-N dibenzofuran-1-carboxylic acid Chemical compound O1C2=CC=CC=C2C2=C1C=CC=C2C(=O)O UZVGSSNIUNSOFA-UHFFFAOYSA-N 0.000 claims description 2
125000004988 dibenzothienyl group Chemical group C1(=CC=CC=2SC3=C(C21)C=CC=C3)* 0.000 claims description 2
239000003814 drug Substances 0.000 claims description 2
239000003937 drug carrier Substances 0.000 claims description 2
125000001041 indolyl group Chemical group 0.000 claims description 2
230000002401 inhibitory effect Effects 0.000 claims description 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 claims description 2
201000006417 multiple sclerosis Diseases 0.000 claims description 2
239000008194 pharmaceutical composition Substances 0.000 claims description 2
239000000546 pharmaceutical excipient Substances 0.000 claims description 2
125000005915 C6-C14 aryl group Chemical group 0.000 claims 13
239000000203 mixture Substances 0.000 claims 7
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
208000036487 Arthropathies Diseases 0.000 claims 1
208000012659 Joint disease Diseases 0.000 claims 1
102000002274 Matrix Metalloproteinases Human genes 0.000 claims 1
108010000684 Matrix Metalloproteinases Proteins 0.000 claims 1
201000009594 Systemic Scleroderma Diseases 0.000 claims 1
206010042953 Systemic sclerosis Diseases 0.000 claims 1
125000005870 benzindolyl group Chemical group 0.000 claims 1
125000004404 heteroalkyl group Chemical group 0.000 claims 1
125000006038 hexenyl group Chemical group 0.000 claims 1
125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
238000000034 method Methods 0.000 description 5
DIIWHMJWAZUROJ-JOCHJYFZSA-N (2r)-3-methyl-2-[(7-phenyldibenzothiophen-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1SC2=CC=3C1=CC=CC=C1 DIIWHMJWAZUROJ-JOCHJYFZSA-N 0.000 description 1
QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
0 I*Cc1cccc-2c1*c1ccccc-21 Chemical compound I*Cc1cccc-2c1*c1ccccc-21 0.000 description 1
208000034189 Sclerosis Diseases 0.000 description 1
150000007942 carboxylates Chemical class 0.000 description 1
125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 description 1

JP2010506709A 2007-05-04 2008-05-05 マトリックスメタロプロテアーゼインヒビターとしての三環式化合物 Withdrawn JP2010526106A (ja)