JP2010526106A - マトリックスメタロプロテアーゼインヒビターとしての三環式化合物 - Google Patents

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Publication number

JP2010526106A

JP2010526106A JP2010506709A JP2010506709A JP2010526106A JP 2010526106 A JP2010526106 A JP 2010526106A JP 2010506709 A JP2010506709 A JP 2010506709A JP 2010506709 A JP2010506709 A JP 2010506709A JP 2010526106 A JP2010526106 A JP 2010526106A

Authority

JP

Japan

Prior art keywords

sulfonamido

furan

dibenzo

methyl

acid

Prior art date

2007-05-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

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• 150000001875 compounds Chemical class 0.000 title claims abstract description 614
• 239000011159 matrix material Substances 0.000 title claims abstract description 15
• 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
• 238000000034 method Methods 0.000 claims abstract description 206
• 150000003839 salts Chemical class 0.000 claims abstract description 69
• 150000002148 esters Chemical class 0.000 claims abstract description 65
• 102100027998 Macrophage metalloelastase Human genes 0.000 claims abstract description 21
• 101710187853 Macrophage metalloelastase Proteins 0.000 claims abstract description 20
• 230000001575 pathological effect Effects 0.000 claims abstract description 19
• 241000124008 Mammalia Species 0.000 claims abstract description 18
• 102000005741 Metalloproteases Human genes 0.000 claims abstract description 14
• 108010006035 Metalloproteases Proteins 0.000 claims abstract description 14
• 239000003814 drug Substances 0.000 claims abstract description 6
• 230000002401 inhibitory effect Effects 0.000 claims abstract description 6
• 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 6
• -1 N-isopropylcarbamimidoyl Chemical group 0.000 claims description 234
• 125000000217 alkyl group Chemical group 0.000 claims description 225
• 238000002360 preparation method Methods 0.000 claims description 189
• 125000001072 heteroaryl group Chemical group 0.000 claims description 63
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 55
• 125000003118 aryl group Chemical group 0.000 claims description 41
• 125000001188 haloalkyl group Chemical group 0.000 claims description 39
• 125000000304 alkynyl group Chemical group 0.000 claims description 38
• 239000002253 acid Substances 0.000 claims description 37
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 36
• 229910052739 hydrogen Inorganic materials 0.000 claims description 36
• 125000001424 substituent group Chemical group 0.000 claims description 34
• 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 33
• 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims description 32
• 150000001413 amino acids Chemical class 0.000 claims description 31
• 229910052757 nitrogen Inorganic materials 0.000 claims description 31
• UZVGSSNIUNSOFA-UHFFFAOYSA-N dibenzofuran-1-carboxylic acid Chemical compound O1C2=CC=CC=C2C2=C1C=CC=C2C(=O)O UZVGSSNIUNSOFA-UHFFFAOYSA-N 0.000 claims description 28
• 208000035475 disorder Diseases 0.000 claims description 23
• 239000001257 hydrogen Substances 0.000 claims description 22
• 229910052799 carbon Inorganic materials 0.000 claims description 21
• 150000002367 halogens Chemical class 0.000 claims description 21
• 229910052736 halogen Inorganic materials 0.000 claims description 20
• 238000011282 treatment Methods 0.000 claims description 20
• 125000005915 C6-C14 aryl group Chemical group 0.000 claims description 19
• 229910052717 sulfur Inorganic materials 0.000 claims description 16
• FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 14
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 14
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 14
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
• 150000001721 carbon Chemical group 0.000 claims description 12
• 229910052760 oxygen Inorganic materials 0.000 claims description 12
• 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 claims description 11
• 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 10
• 125000002541 furyl group Chemical group 0.000 claims description 9
• 125000004076 pyridyl group Chemical group 0.000 claims description 9
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 9
• 201000001320 Atherosclerosis Diseases 0.000 claims description 8
• 208000006673 asthma Diseases 0.000 claims description 8
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 8
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 8
• 125000002883 imidazolyl group Chemical group 0.000 claims description 8
• 125000000842 isoxazolyl group Chemical group 0.000 claims description 8
• 239000008194 pharmaceutical composition Substances 0.000 claims description 8
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 8
• 125000003831 tetrazolyl group Chemical group 0.000 claims description 8
• 125000000335 thiazolyl group Chemical group 0.000 claims description 8
• 125000001544 thienyl group Chemical group 0.000 claims description 8
• MKJSIHKQOWNHRU-JOCHJYFZSA-N (2r)-2-[[7-(1,3-benzoxazol-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2OC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1 MKJSIHKQOWNHRU-JOCHJYFZSA-N 0.000 claims description 7
• 206010016654 Fibrosis Diseases 0.000 claims description 7
• 208000008589 Obesity Diseases 0.000 claims description 7
• 125000003342 alkenyl group Chemical group 0.000 claims description 7
• 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims description 7
• 206010012601 diabetes mellitus Diseases 0.000 claims description 7
• 230000004761 fibrosis Effects 0.000 claims description 7
• 230000001404 mediated effect Effects 0.000 claims description 7
• 201000006417 multiple sclerosis Diseases 0.000 claims description 7
• 235000020824 obesity Nutrition 0.000 claims description 7
• 201000008482 osteoarthritis Diseases 0.000 claims description 7
• 125000001715 oxadiazolyl group Chemical group 0.000 claims description 7
• 208000020431 spinal cord injury Diseases 0.000 claims description 7
• 125000001425 triazolyl group Chemical group 0.000 claims description 7
• JYGJKRYSCVUTOS-FQEVSTJZSA-N (2s)-2-[[8-(furan-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=COC=1 JYGJKRYSCVUTOS-FQEVSTJZSA-N 0.000 claims description 6
• MUMVNZHARHFSLP-SFHVURJKSA-N (2s)-3-methyl-2-[[8-(1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC=CS1 MUMVNZHARHFSLP-SFHVURJKSA-N 0.000 claims description 6
• CAGBUDBKEUNUQQ-IBGZPJMESA-N (2s)-3-methyl-2-[[8-(n'-propan-2-ylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C(=N)NC(C)C)=CC=C3OC2=C1 CAGBUDBKEUNUQQ-IBGZPJMESA-N 0.000 claims description 6
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 6
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
• 208000000453 Skin Neoplasms Diseases 0.000 claims description 6
• 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 6
• 239000003937 drug carrier Substances 0.000 claims description 6
• 201000005202 lung cancer Diseases 0.000 claims description 6
• 208000020816 lung neoplasm Diseases 0.000 claims description 6
• 125000003226 pyrazolyl group Chemical group 0.000 claims description 6
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 6
• 201000000849 skin cancer Diseases 0.000 claims description 6
• QBZDEMPIXFGTOR-HXUWFJFHSA-N (2r)-2-[[7-(furan-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=CO1 QBZDEMPIXFGTOR-HXUWFJFHSA-N 0.000 claims description 5
• MXFRFKFDNZFUHI-GOSISDBHSA-N (2r)-3-methyl-2-[[7-(1,3-thiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NC=CS1 MXFRFKFDNZFUHI-GOSISDBHSA-N 0.000 claims description 5
• CHYPSOLFNUJOFQ-GOSISDBHSA-N (2r)-3-methyl-2-[[7-(1,3-thiazol-2-yl)dibenzothiophen-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3SC2=CC=1C1=NC=CS1 CHYPSOLFNUJOFQ-GOSISDBHSA-N 0.000 claims description 5
• VNUZETQPGOVXGM-NRFANRHFSA-N (2s)-2-[(8-cyclopentyldibenzofuran-3-yl)sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1CCCC1 VNUZETQPGOVXGM-NRFANRHFSA-N 0.000 claims description 5
• KDDIUYUBOHAVIC-IBGZPJMESA-N (2s)-2-[[8-(2-methoxyethynyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C#COC)=CC=C3OC2=C1 KDDIUYUBOHAVIC-IBGZPJMESA-N 0.000 claims description 5
• FDXJBNPNRWLQES-FQEVSTJZSA-N (2s)-2-[[8-(5-chlorofuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(Cl)O1 FDXJBNPNRWLQES-FQEVSTJZSA-N 0.000 claims description 5
• FRKIGRJTOJVSGZ-INIZCTEOSA-N (2s)-2-[[8-[(z)-n'-hydroxycarbamimidoyl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C(C(=N)NO)C=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 FRKIGRJTOJVSGZ-INIZCTEOSA-N 0.000 claims description 5
• OZBOSNKACBKPLE-NRFANRHFSA-N (2s)-3-methyl-2-[(8-pyridin-3-yldibenzofuran-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=CN=C1 OZBOSNKACBKPLE-NRFANRHFSA-N 0.000 claims description 5
• YKBPFINIIFIXCW-NRFANRHFSA-N (2s)-3-methyl-2-[(8-pyridin-3-yldibenzothiophen-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC=CN=C1 YKBPFINIIFIXCW-NRFANRHFSA-N 0.000 claims description 5
• TXODJXONKWWETJ-NRFANRHFSA-N (2s)-3-methyl-2-[[7-(5-methylfuran-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=C(C)O1 TXODJXONKWWETJ-NRFANRHFSA-N 0.000 claims description 5
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 5
• 230000001684 chronic effect Effects 0.000 claims description 5
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 5
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 5
• 125000002971 oxazolyl group Chemical group 0.000 claims description 5
• 125000003373 pyrazinyl group Chemical group 0.000 claims description 5
• 125000001113 thiadiazolyl group Chemical group 0.000 claims description 5
• 239000004474 valine Substances 0.000 claims description 5
• XCFOXFAYZNPHOE-HXUWFJFHSA-N (2r)-2-[[7-(5-chlorofuran-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=C(Cl)O1 XCFOXFAYZNPHOE-HXUWFJFHSA-N 0.000 claims description 4
• MRWNMNBJFHVERG-HXUWFJFHSA-N (2r)-2-[[7-(5-chlorofuran-2-yl)dibenzothiophen-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3SC2=CC=1C1=CC=C(Cl)O1 MRWNMNBJFHVERG-HXUWFJFHSA-N 0.000 claims description 4
• RZGHJCLQXWPAOF-AREMUKBSSA-N (2r)-3-methyl-2-[[7-(5-phenylthiophen-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(S1)=CC=C1C1=CC=CC=C1 RZGHJCLQXWPAOF-AREMUKBSSA-N 0.000 claims description 4
• WOVGSJCBVOSLER-QFIPXVFZSA-N (2s)-2-[[7-(1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C=3C=C4OC=5C(C4=CC=3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 WOVGSJCBVOSLER-QFIPXVFZSA-N 0.000 claims description 4
• PILIUQSMALEBNG-QFIPXVFZSA-N (2s)-2-[[7-(4-bromo-5-ethylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound BrC1=C(CC)SC(C=2C=C3C(C4=CC=C(C=C4O3)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=2)=C1 PILIUQSMALEBNG-QFIPXVFZSA-N 0.000 claims description 4
• XGBAXQHABRASEY-FQEVSTJZSA-N (2s)-2-[[7-(5-chlorothiophen-2-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1SC2=CC=3C1=CC=C(Cl)S1 XGBAXQHABRASEY-FQEVSTJZSA-N 0.000 claims description 4
• STDDMDWNCQOCLW-FQEVSTJZSA-N (2s)-2-[[7-(furan-2-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1SC2=CC=3C1=CC=CO1 STDDMDWNCQOCLW-FQEVSTJZSA-N 0.000 claims description 4
• NDQORPRLFZIHQI-FQEVSTJZSA-N (2s)-2-[[7-(furan-3-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1SC2=CC=3C=1C=COC=1 NDQORPRLFZIHQI-FQEVSTJZSA-N 0.000 claims description 4
• DATQMPZLPDEELU-SFHVURJKSA-N (2s)-2-[[8-(4-bromo-1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC(Br)=CS1 DATQMPZLPDEELU-SFHVURJKSA-N 0.000 claims description 4
• RFEPBTJIXMHPKQ-IBGZPJMESA-N (2s)-3-methyl-2-[[7-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NOC(C(C)C)=N1 RFEPBTJIXMHPKQ-IBGZPJMESA-N 0.000 claims description 4
• GQVCQMCAXYHISY-INIZCTEOSA-N (2s)-3-methyl-2-[[8-(2h-tetrazol-5-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1N=NNN=1 GQVCQMCAXYHISY-INIZCTEOSA-N 0.000 claims description 4
• BSMYRYJBRSUDFE-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-[2-(2-methylpropyl)-1,3-thiazol-5-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound S1C(CC(C)C)=NC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 BSMYRYJBRSUDFE-QHCPKHFHSA-N 0.000 claims description 4
• PUVCTLLJLXUYPY-UHFFFAOYSA-N 2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]acetic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)NCC(O)=O)=CC=2)=N1 PUVCTLLJLXUYPY-UHFFFAOYSA-N 0.000 claims description 4
• UKKPHTGLZAQQCS-UHFFFAOYSA-N 2-[[8-(1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]acetic acid Chemical compound C=1C(S(=O)(=O)NCC(=O)O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC=CS1 UKKPHTGLZAQQCS-UHFFFAOYSA-N 0.000 claims description 4
• 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 4
• 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 4
• 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 4
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
• 125000001041 indolyl group Chemical group 0.000 claims description 4
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
• KRXKFJHIUJIOOE-HXUWFJFHSA-N (2r)-2-[[7-(3-methoxyprop-1-ynyl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC=C(C#CCOC)C=C3SC2=C1 KRXKFJHIUJIOOE-HXUWFJFHSA-N 0.000 claims description 3
• HXDMHQRPIGGVQJ-OAQYLSRUSA-N (2r)-2-[[7-(4-fluoro-1,3-benzothiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1F HXDMHQRPIGGVQJ-OAQYLSRUSA-N 0.000 claims description 3
• KRSVEDPTDZZKJQ-JOCHJYFZSA-N (2r)-2-[[7-(6-fluoro-1,3-benzothiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C(F)C=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1 KRSVEDPTDZZKJQ-JOCHJYFZSA-N 0.000 claims description 3
• UQHQWCNASJELDN-HSZRJFAPSA-N (2r)-2-[[7-(6-methoxy-1,3-benzothiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C2OC3=CC=C(S(=O)(=O)N[C@H](C(C)C)C(O)=O)C=C3C2=CC=C1C1=NC2=CC=C(OC)C=C2S1 UQHQWCNASJELDN-HSZRJFAPSA-N 0.000 claims description 3
• DIIWHMJWAZUROJ-JOCHJYFZSA-N (2r)-3-methyl-2-[(7-phenyldibenzothiophen-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1SC2=CC=3C1=CC=CC=C1 DIIWHMJWAZUROJ-JOCHJYFZSA-N 0.000 claims description 3
• RKJUJSCHEBSPPY-JOCHJYFZSA-N (2r)-3-methyl-2-[[7-(1-propylpyrazol-4-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CCC)C=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 RKJUJSCHEBSPPY-JOCHJYFZSA-N 0.000 claims description 3
• GVGQMSMAVJBAHP-HSZRJFAPSA-N (2r)-3-methyl-2-[[7-(6-methyl-1,3-benzothiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C1=C(C)C=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1 GVGQMSMAVJBAHP-HSZRJFAPSA-N 0.000 claims description 3
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• JUURCPDGRPIPJW-JOCHJYFZSA-N (2r)-3-methyl-2-[[7-[4-(trifluoromethyl)phenyl]dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=C(C(F)(F)F)C=C1 JUURCPDGRPIPJW-JOCHJYFZSA-N 0.000 claims description 3
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• YGRUDSYBWURNJC-QHCPKHFHSA-N (2s)-2-[[7-(5-tert-butylfuran-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=C(C(C)(C)C)O1 YGRUDSYBWURNJC-QHCPKHFHSA-N 0.000 claims description 2
• VZADBEJFSRCFHF-QHCPKHFHSA-N (2s)-2-[[7-(5-tert-butylfuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=C(C(C)(C)C)O1 VZADBEJFSRCFHF-QHCPKHFHSA-N 0.000 claims description 2
• HIKBWOJNMATYIY-INIZCTEOSA-N (2s)-2-[[7-[5-chloro-4-(trifluoromethyl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NC(C(F)(F)F)=C(Cl)S1 HIKBWOJNMATYIY-INIZCTEOSA-N 0.000 claims description 2
• MQYOBJHCSNBTGH-QHCPKHFHSA-N (2s)-2-[[8-(1,3-benzodioxol-5-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C2OCOC2=CC(C2=CC=C3OC=4C(C3=C2)=CC=C(C=4)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=C1 MQYOBJHCSNBTGH-QHCPKHFHSA-N 0.000 claims description 2
• TXLLLKGIRPOVKR-QFIPXVFZSA-N (2s)-2-[[8-(1,3-benzoxazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2OC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 TXLLLKGIRPOVKR-QFIPXVFZSA-N 0.000 claims description 2
• XCJBAALJKPVXHW-FQEVSTJZSA-N (2s)-2-[[8-(2,4-dimethyl-1,3-thiazol-5-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1SC(C)=NC=1C XCJBAALJKPVXHW-FQEVSTJZSA-N 0.000 claims description 2
• YLHPVVVVMXZTLV-SFHVURJKSA-N (2s)-2-[[8-(2-chloro-1,3-thiazol-4-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CSC(Cl)=N1 YLHPVVVVMXZTLV-SFHVURJKSA-N 0.000 claims description 2
• WZUUKLCANAQARJ-SFHVURJKSA-N (2s)-2-[[8-(2-chloro-1,3-thiazol-5-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CN=C(Cl)S1 WZUUKLCANAQARJ-SFHVURJKSA-N 0.000 claims description 2
• NWRZZVFLHDOFGA-QFIPXVFZSA-N (2s)-2-[[8-(5,6-difluoro-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound FC1=C(F)C=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 NWRZZVFLHDOFGA-QFIPXVFZSA-N 0.000 claims description 2
• IEZFHPMTZIBRIJ-DEOSSOPVSA-N (2s)-2-[[8-(5-benzyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1CC1=CC=CC=C1 IEZFHPMTZIBRIJ-DEOSSOPVSA-N 0.000 claims description 2
• HJRSZDGUJSABSN-SFHVURJKSA-N (2s)-2-[[8-(5-chloro-1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC=C(Cl)S1 HJRSZDGUJSABSN-SFHVURJKSA-N 0.000 claims description 2
• HFOQNWMRADMEPV-IBGZPJMESA-N (2s)-2-[[8-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1CC1 HFOQNWMRADMEPV-IBGZPJMESA-N 0.000 claims description 2
• CDLQIGGXSYPPQK-QFIPXVFZSA-N (2s)-2-[[8-(5-ethylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound S1C(CC)=CC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 CDLQIGGXSYPPQK-QFIPXVFZSA-N 0.000 claims description 2
• LAAHFEGDXUAJDE-QHCPKHFHSA-N (2s)-2-[[8-(5-methoxy-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C=4SC5=CC=C(C=C5N=4)OC)=CC=C3OC2=C1 LAAHFEGDXUAJDE-QHCPKHFHSA-N 0.000 claims description 2
• NLXLWXGTVAEMII-SFHVURJKSA-N (2s)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-4-methylpentanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](CC(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(C(C)(C)C)=N1 NLXLWXGTVAEMII-SFHVURJKSA-N 0.000 claims description 2
• UVPKGATURLQTFF-QHCPKHFHSA-N (2s)-2-[[8-(5-tert-butylfuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(C)(C)C)O1 UVPKGATURLQTFF-QHCPKHFHSA-N 0.000 claims description 2
• KXKFCHFIAHCBBI-QFIPXVFZSA-N (2s)-2-[[8-(6-chloro-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C(Cl)C=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 KXKFCHFIAHCBBI-QFIPXVFZSA-N 0.000 claims description 2
• JELIUEOCFQOAQJ-QFIPXVFZSA-N (2s)-2-[[8-(6-fluoro-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C(F)C=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 JELIUEOCFQOAQJ-QFIPXVFZSA-N 0.000 claims description 2
• DJPNFAACWDIEMT-QFIPXVFZSA-N (2s)-2-[[8-[3-[(dimethylamino)methyl]furan-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1OC=CC=1CN(C)C DJPNFAACWDIEMT-QFIPXVFZSA-N 0.000 claims description 2
• MZRNJIRXVYICOL-DEOSSOPVSA-N (2s)-2-[[8-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(SC=1)=NC=1C1=CC=C(F)C=C1 MZRNJIRXVYICOL-DEOSSOPVSA-N 0.000 claims description 2
• QQOQLIBMJSJQGL-IBGZPJMESA-N (2s)-2-[[8-[5-(hydroxymethyl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC=C(CO)S1 QQOQLIBMJSJQGL-IBGZPJMESA-N 0.000 claims description 2
• MFPGSWVSKFTKST-INIZCTEOSA-N (2s)-2-[[8-[5-chloro-4-(trifluoromethyl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC(C(F)(F)F)=C(Cl)S1 MFPGSWVSKFTKST-INIZCTEOSA-N 0.000 claims description 2
• DIIWHMJWAZUROJ-QFIPXVFZSA-N (2s)-3-methyl-2-[(7-phenyldibenzothiophen-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1SC2=CC=3C1=CC=CC=C1 DIIWHMJWAZUROJ-QFIPXVFZSA-N 0.000 claims description 2
• RWTYONUBVSWBOZ-QFIPXVFZSA-N (2s)-3-methyl-2-[(8-phenyldibenzofuran-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=CC=C1 RWTYONUBVSWBOZ-QFIPXVFZSA-N 0.000 claims description 2
• UXTSZHSETJDRJJ-IBGZPJMESA-N (2s)-3-methyl-2-[[7-(5-methyl-1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NC=C(C)S1 UXTSZHSETJDRJJ-IBGZPJMESA-N 0.000 claims description 2
• FRLIEOABZAZATR-QHCPKHFHSA-N (2s)-3-methyl-2-[[7-(5-propylthiophen-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound S1C(CCC)=CC=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C3OC2=C1 FRLIEOABZAZATR-QHCPKHFHSA-N 0.000 claims description 2
• CICZGMKIYTYHEP-QHCPKHFHSA-N (2s)-3-methyl-2-[[7-(5-propylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound S1C(CCC)=CC=C1C1=CC=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 CICZGMKIYTYHEP-QHCPKHFHSA-N 0.000 claims description 2
• DATZVNVKDASYKB-QHCPKHFHSA-N (2s)-3-methyl-2-[[7-[2-(2-methylpropyl)-1,3-thiazol-5-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound S1C(CC(C)C)=NC=C1C1=CC=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 DATZVNVKDASYKB-QHCPKHFHSA-N 0.000 claims description 2
• LZKRIOVDRZGISP-FQEVSTJZSA-N (2s)-3-methyl-2-[[7-[5-(5-methyl-1,2,4-oxadiazol-3-yl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C(S1)=NC=C1C1=NOC(C)=N1 LZKRIOVDRZGISP-FQEVSTJZSA-N 0.000 claims description 2
• LWSMVIRRZXEYRG-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-(1,3,5-trimethylpyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C(C)=NN(C)C=1C LWSMVIRRZXEYRG-QFIPXVFZSA-N 0.000 claims description 2
• UNZBPHBZHRKEGU-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(2-methyl-1,3-thiazol-5-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CN=C(C)S1 UNZBPHBZHRKEGU-FQEVSTJZSA-N 0.000 claims description 2
• HUZFQBCKLXLLLN-DEOSSOPVSA-N (2s)-3-methyl-2-[[8-(4-methyl-2-phenyl-1,3-thiazol-5-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=C(N=1)C)SC=1C1=CC=CC=C1 HUZFQBCKLXLLLN-DEOSSOPVSA-N 0.000 claims description 2
• AJPXKPDDERRJRR-SFHVURJKSA-N (2s)-3-methyl-2-[[8-(5-methyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(C)=N1 AJPXKPDDERRJRR-SFHVURJKSA-N 0.000 claims description 2
• FRPRECKGQMJJSQ-SANMLTNESA-N (2s)-3-methyl-2-[[8-(5-methyl-1-phenylpyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=C1C)C=NN1C1=CC=CC=C1 FRPRECKGQMJJSQ-SANMLTNESA-N 0.000 claims description 2
• XJPPEFJWBKQLAY-VWLOTQADSA-N (2s)-3-methyl-2-[[8-(5-methyl-3-phenyl-1,2-oxazol-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=C(C)ON=C1C1=CC=CC=C1 XJPPEFJWBKQLAY-VWLOTQADSA-N 0.000 claims description 2
• XMYCBAYCRSNYQT-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-(5-propylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound S1C(CCC)=CC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 XMYCBAYCRSNYQT-QHCPKHFHSA-N 0.000 claims description 2
• JCAQNCWRWOJYTA-ODOSRFNGSA-N (2s)-3-methyl-2-[[8-[1-(2-methylbutyl)pyrazol-4-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CC(C)CC)C=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 JCAQNCWRWOJYTA-ODOSRFNGSA-N 0.000 claims description 2
• HSWCQCWZHXVDDD-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-[1-(2-methylpropyl)pyrazol-4-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CC(C)C)C=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 HSWCQCWZHXVDDD-QHCPKHFHSA-N 0.000 claims description 2
• AXRNREJBUORIBT-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[4-(trifluoromethyl)phenyl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(F)(F)F)C=C1 AXRNREJBUORIBT-QFIPXVFZSA-N 0.000 claims description 2
• SVNHHUPPVNMEMR-DEOSSOPVSA-N (2s)-3-methyl-2-[[8-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(SC=1)=NC=1C1=CC=C(C(F)(F)F)C=C1 SVNHHUPPVNMEMR-DEOSSOPVSA-N 0.000 claims description 2
• XDAFLORZHFMNOG-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-[5-(1,2-oxazol-3-yl)thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(S1)=CC=C1C=1C=CON=1 XDAFLORZHFMNOG-QHCPKHFHSA-N 0.000 claims description 2
• PCISISKGZAHYFX-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-[5-(2h-tetrazol-5-yl)thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(S1)=CC=C1C1=NN=NN1 PCISISKGZAHYFX-FQEVSTJZSA-N 0.000 claims description 2
• HFMYZOXOMAAVBC-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[5-(5-methyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(S1)=CC=C1C1=NOC(C)=N1 HFMYZOXOMAAVBC-QFIPXVFZSA-N 0.000 claims description 2
• MIMJOPWHYSLYIB-NRFANRHFSA-N (2s)-3-methyl-2-[[8-[5-(oxan-4-yl)-1,2,4-oxadiazol-3-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1CCOCC1 MIMJOPWHYSLYIB-NRFANRHFSA-N 0.000 claims description 2
• NKSBPSUCIBWVPQ-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[5-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1=CC=C(C(F)(F)F)C=C1 NKSBPSUCIBWVPQ-QFIPXVFZSA-N 0.000 claims description 2
• FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 claims description 2
• NVUOFOKWDMEDLT-UHFFFAOYSA-N 2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-2-methylpropanoic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)NC(C)(C)C(O)=O)=CC=2)=N1 NVUOFOKWDMEDLT-UHFFFAOYSA-N 0.000 claims description 2
• 150000007650 D alpha amino acids Chemical class 0.000 claims description 2
• 150000001576 beta-amino acids Chemical class 0.000 claims description 2
• 125000006038 hexenyl group Chemical group 0.000 claims description 2
• VCRAHYVYNXLHJB-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(4-methylthiophen-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CSC=C1C VCRAHYVYNXLHJB-NRFANRHFSA-N 0.000 claims 3
• RVQOOWATMSVVAU-LJQANCHMSA-N (2r)-3-methyl-2-[[7-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(C(C)C)=N1 RVQOOWATMSVVAU-LJQANCHMSA-N 0.000 claims 2
• ZXWPYXYVPWIWTH-NRFANRHFSA-N (2s)-2-[[8-(3,5-dimethyl-1,2-oxazol-4-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C(C)=NOC=1C ZXWPYXYVPWIWTH-NRFANRHFSA-N 0.000 claims 2
• PJUQYKFYQBYODS-XMMPIXPASA-N (2r)-2-[[7-(1-benzofuran-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2OC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC2=C1 PJUQYKFYQBYODS-XMMPIXPASA-N 0.000 claims 1
• AKJDDMBFNPUTEP-XMMPIXPASA-N (2r)-2-[[7-(1-benzothiophen-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC2=C1 AKJDDMBFNPUTEP-XMMPIXPASA-N 0.000 claims 1
• BWEOSIAMIQLVAL-HXUWFJFHSA-N (2r)-2-[[7-(2,4-dimethoxypyrimidin-5-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound COC1=NC(OC)=NC=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 BWEOSIAMIQLVAL-HXUWFJFHSA-N 0.000 claims 1
• AYCCKJBANOVGCC-OAQYLSRUSA-N (2r)-2-[[7-(3,5-dimethyl-1,2-oxazol-4-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C=1C(C)=NOC=1C AYCCKJBANOVGCC-OAQYLSRUSA-N 0.000 claims 1
• LUSXBDHEIQBWKO-HXUWFJFHSA-N (2r)-2-[[7-(5-bromothiophen-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=C(Br)S1 LUSXBDHEIQBWKO-HXUWFJFHSA-N 0.000 claims 1
• JIEVWFMIUJBLKA-HXUWFJFHSA-N (2r)-2-[[7-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(N=1)=NOC=1C1CCC1 JIEVWFMIUJBLKA-HXUWFJFHSA-N 0.000 claims 1
• YZBILURNXZUFTN-LJQANCHMSA-N (2r)-2-[[7-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(N=1)=NOC=1C1CC1 YZBILURNXZUFTN-LJQANCHMSA-N 0.000 claims 1
• FAONYVNQBWVWQW-LJQANCHMSA-N (2r)-2-[[7-(5-ethyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound O1C(CC)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=2)=N1 FAONYVNQBWVWQW-LJQANCHMSA-N 0.000 claims 1
• DLFHTNBVSIENQW-XMMPIXPASA-N (2r)-2-[[7-(5-fluoro-1h-indol-2-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound FC1=CC=C2NC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC2=C1 DLFHTNBVSIENQW-XMMPIXPASA-N 0.000 claims 1
• DQBJMGHOWYXFJM-LJQANCHMSA-N (2r)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(C(C)(C)C)=N1 DQBJMGHOWYXFJM-LJQANCHMSA-N 0.000 claims 1
• AKBDDNKWXKZCAT-OAQYLSRUSA-N (2r)-2-[[7-(6-chloropyridin-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=C(Cl)N=C1 AKBDDNKWXKZCAT-OAQYLSRUSA-N 0.000 claims 1
• RZBHGWWIXZZDIE-JOCHJYFZSA-N (2r)-2-[[7-(6-methoxypyridin-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=NC(OC)=CC=C1C1=CC=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=C1 RZBHGWWIXZZDIE-JOCHJYFZSA-N 0.000 claims 1
• YMEUKWAUTAFCQF-HXUWFJFHSA-N (2r)-2-[[7-(furan-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C=1C=COC=1 YMEUKWAUTAFCQF-HXUWFJFHSA-N 0.000 claims 1
• ZIFKIRZKPQSHGA-HCXLOTKHSA-N (2r)-2-[[7-[(e)-2-cyclohexylethenyl]dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1\C=C\C1CCCCC1 ZIFKIRZKPQSHGA-HCXLOTKHSA-N 0.000 claims 1
• UJQXNVUNVWNKPL-OAQYLSRUSA-N (2r)-2-[[7-[5-(2,2-dimethylpropyl)-1,2,4-oxadiazol-3-yl]dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(CC(C)(C)C)=N1 UJQXNVUNVWNKPL-OAQYLSRUSA-N 0.000 claims 1
• GJRHLVFJATZVDQ-HSZRJFAPSA-N (2r)-2-[[7-[5-(cyclopentylmethyl)-1,2,4-oxadiazol-3-yl]dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(N=1)=NOC=1CC1CCCC1 GJRHLVFJATZVDQ-HSZRJFAPSA-N 0.000 claims 1
• CLALSIAHDUVZJV-XMMPIXPASA-N (2r)-2-[[8-(4,4-dimethyl-2-oxo-1h-3,1-benzoxazin-6-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound N1C(=O)OC(C)(C)C2=CC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C21 CLALSIAHDUVZJV-XMMPIXPASA-N 0.000 claims 1
• QODKHJZZECMWOS-JOCHJYFZSA-N (2r)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-2-phenylacetic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C4=CC=C(C=C4OC3=CC=2)S(=O)(=O)N[C@@H](C(O)=O)C=2C=CC=CC=2)=N1 QODKHJZZECMWOS-JOCHJYFZSA-N 0.000 claims 1
• XZGLXKXBYMBTRV-HSZRJFAPSA-N (2r)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-(1h-indol-3-yl)propanoic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C4=CC=C(C=C4OC3=CC=2)S(=O)(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(O)=O)=N1 XZGLXKXBYMBTRV-HSZRJFAPSA-N 0.000 claims 1
• NLXLWXGTVAEMII-GOSISDBHSA-N (2r)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-4-methylpentanoic acid Chemical compound C=1C(S(=O)(=O)N[C@H](CC(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(C(C)(C)C)=N1 NLXLWXGTVAEMII-GOSISDBHSA-N 0.000 claims 1
• MKUGBDHSVMEUDJ-HXUWFJFHSA-N (2r)-3-methyl-2-[(7-thiophen-2-yldibenzofuran-2-yl)sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=CS1 MKUGBDHSVMEUDJ-HXUWFJFHSA-N 0.000 claims 1
• ZMIQQVOEDLENOT-HXUWFJFHSA-N (2r)-3-methyl-2-[(7-thiophen-3-yldibenzofuran-2-yl)sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C=1C=CSC=1 ZMIQQVOEDLENOT-HXUWFJFHSA-N 0.000 claims 1
• GEHJYKSQSKVXEY-RUZDIDTESA-N (2r)-3-methyl-2-[[7-(1-methylindol-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C1=CC=C2N(C)C(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC2=C1 GEHJYKSQSKVXEY-RUZDIDTESA-N 0.000 claims 1
• KDQWONZILVAQAS-HXUWFJFHSA-N (2r)-3-methyl-2-[[7-(1-methylpyrazol-4-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C=1C=NN(C)C=1 KDQWONZILVAQAS-HXUWFJFHSA-N 0.000 claims 1
• VZSJLZLWFLWJJU-LJQANCHMSA-N (2r)-3-methyl-2-[[7-(1h-pyrazol-4-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C=1C=NNC=1 VZSJLZLWFLWJJU-LJQANCHMSA-N 0.000 claims 1
• ZTIBAZKSPAAWHI-HXUWFJFHSA-N (2r)-3-methyl-2-[[7-(1h-pyrrol-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CC=CN1 ZTIBAZKSPAAWHI-HXUWFJFHSA-N 0.000 claims 1
• SEMFDWYGUQJJMG-OAQYLSRUSA-N (2r)-3-methyl-2-[[7-(4,5,6-trifluoro-1,3-benzothiazol-2-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound FC1=C(F)C=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1F SEMFDWYGUQJJMG-OAQYLSRUSA-N 0.000 claims 1
• KICOEUHSPRWFBO-OAQYLSRUSA-N (2r)-3-methyl-2-[[7-(4-methylthiophen-3-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=CSC=C1C KICOEUHSPRWFBO-OAQYLSRUSA-N 0.000 claims 1
• PBXDHOYLSMWAAK-GOSISDBHSA-N (2r)-3-methyl-2-[[7-(5-methyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(C)=N1 PBXDHOYLSMWAAK-GOSISDBHSA-N 0.000 claims 1
• XRILZBPWMMUGAA-JOCHJYFZSA-N (2r)-3-methyl-2-[[7-(5-phenyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C(N=1)=NOC=1C1=CC=CC=C1 XRILZBPWMMUGAA-JOCHJYFZSA-N 0.000 claims 1
• AUFRHAGCCKGSIJ-OAQYLSRUSA-N (2r)-3-methyl-2-[[7-[5-(2-methylpropyl)-1,2,4-oxadiazol-3-yl]dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound O1C(CC(C)C)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=CC=2)=N1 AUFRHAGCCKGSIJ-OAQYLSRUSA-N 0.000 claims 1
• IUYRAAWKZQFZLN-JOCHJYFZSA-N (2r)-3-methyl-2-[[7-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]dibenzofuran-2-yl]sulfonylamino]butanoic acid Chemical compound C1=C(OC(F)(F)F)C=C2SC(C=3C=C4OC5=CC=C(C=C5C4=CC=3)S(=O)(=O)N[C@H](C(C)C)C(O)=O)=NC2=C1 IUYRAAWKZQFZLN-JOCHJYFZSA-N 0.000 claims 1
• PBWYHJCKZXXNOW-SFHVURJKSA-N (2s)-2-[[6-(2-chlorothiophen-3-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=C3)C=1SC2=C3C=1C=CSC=1Cl PBWYHJCKZXXNOW-SFHVURJKSA-N 0.000 claims 1
• WMKPFDBOJXFTPN-DEOSSOPVSA-N (2s)-2-[[7-(1-benzofuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2OC(C=3C=C4OC=5C(C4=CC=3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC2=C1 WMKPFDBOJXFTPN-DEOSSOPVSA-N 0.000 claims 1
• OJAOBEJFBWRHDW-DEOSSOPVSA-N (2s)-2-[[7-(1-benzothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C=3C=C4OC=5C(C4=CC=3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC2=C1 OJAOBEJFBWRHDW-DEOSSOPVSA-N 0.000 claims 1
• FCCHMTOYPPUUDK-IBGZPJMESA-N (2s)-2-[[7-(3,5-dichlorothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C=1SC(Cl)=CC=1Cl FCCHMTOYPPUUDK-IBGZPJMESA-N 0.000 claims 1
• LHWRWIOMMDIVJW-FQEVSTJZSA-N (2s)-2-[[7-(5-chlorofuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=C(Cl)O1 LHWRWIOMMDIVJW-FQEVSTJZSA-N 0.000 claims 1
• BNZYOSWYHWZZRX-FQEVSTJZSA-N (2s)-2-[[7-(5-chlorothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=C(Cl)S1 BNZYOSWYHWZZRX-FQEVSTJZSA-N 0.000 claims 1
• KCOHNRGUPUUTRS-DEOSSOPVSA-N (2s)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-2-(1h-indol-3-yl)acetic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)N[C@H](C(O)=O)C=3C4=CC=CC=C4NC=3)=CC=2)=N1 KCOHNRGUPUUTRS-DEOSSOPVSA-N 0.000 claims 1
• FMJDYTTZBKMCRA-QFIPXVFZSA-N (2s)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-2-phenylacetic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C(C4=CC(=CC=C4O3)S(=O)(=O)N[C@H](C(O)=O)C=3C=CC=CC=3)=CC=2)=N1 FMJDYTTZBKMCRA-QFIPXVFZSA-N 0.000 claims 1
• DQBJMGHOWYXFJM-IBGZPJMESA-N (2s)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(C(C)(C)C)=N1 DQBJMGHOWYXFJM-IBGZPJMESA-N 0.000 claims 1
• ROWXCVNCYGOSEU-SFHVURJKSA-N (2s)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-2-yl]sulfonylamino]-4-methylpentanoic acid Chemical compound C=1C=C2C3=CC(S(=O)(=O)N[C@@H](CC(C)C)C(O)=O)=CC=C3OC2=CC=1C1=NOC(C(C)(C)C)=N1 ROWXCVNCYGOSEU-SFHVURJKSA-N 0.000 claims 1
• LSSPNSOFGKOJFU-IBGZPJMESA-N (2s)-2-[[7-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NOC(C(C)(C)C)=N1 LSSPNSOFGKOJFU-IBGZPJMESA-N 0.000 claims 1
• XUFXYJYYGGYCJE-FQEVSTJZSA-N (2s)-2-[[7-(furan-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=CO1 XUFXYJYYGGYCJE-FQEVSTJZSA-N 0.000 claims 1
• DMRVVWUUWSUTPF-FQEVSTJZSA-N (2s)-2-[[7-(furan-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C=1C=COC=1 DMRVVWUUWSUTPF-FQEVSTJZSA-N 0.000 claims 1
• OJXHTCGCFFZMMJ-NDEPHWFRSA-N (2s)-2-[[7-[5-ethyl-4-(5-ethylthiophen-2-yl)thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound S1C(CC)=CC=C1C1=C(CC)SC(C=2C=C3C(C4=CC=C(C=C4O3)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=2)=C1 OJXHTCGCFFZMMJ-NDEPHWFRSA-N 0.000 claims 1
• TYGUOZCIQMKNFS-QFIPXVFZSA-N (2s)-2-[[8-(1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 TYGUOZCIQMKNFS-QFIPXVFZSA-N 0.000 claims 1
• JOMUWLSAFJIALC-DEOSSOPVSA-N (2s)-2-[[8-(1-benzothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC2=C1 JOMUWLSAFJIALC-DEOSSOPVSA-N 0.000 claims 1
• HZFQLPLBPOFFSZ-DEOSSOPVSA-N (2s)-2-[[8-(1-benzothiophen-2-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2SC(C3=CC=C4SC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC2=C1 HZFQLPLBPOFFSZ-DEOSSOPVSA-N 0.000 claims 1
• UXSXLDRSHNYGME-DEOSSOPVSA-N (2s)-2-[[8-(1-benzothiophen-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=CC=C2C(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CSC2=C1 UXSXLDRSHNYGME-DEOSSOPVSA-N 0.000 claims 1
• ZGGKMWOGTYCTRX-SANMLTNESA-N (2s)-2-[[8-(1-benzylpyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=C1)C=NN1CC1=CC=CC=C1 ZGGKMWOGTYCTRX-SANMLTNESA-N 0.000 claims 1
• SFQCDTKIHKVLDB-SANMLTNESA-N (2s)-2-[[8-(1-benzylpyrazol-4-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C(=C1)C=NN1CC1=CC=CC=C1 SFQCDTKIHKVLDB-SANMLTNESA-N 0.000 claims 1
• WLAWRGNQJIIOBM-IBGZPJMESA-N (2s)-2-[[8-(2,5-dichlorofuran-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=C(Cl)OC=1Cl WLAWRGNQJIIOBM-IBGZPJMESA-N 0.000 claims 1
• BUDWSABESDDLQC-QFIPXVFZSA-N (2s)-2-[[8-(2,5-dimethylthiophen-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=C(C)SC=1C BUDWSABESDDLQC-QFIPXVFZSA-N 0.000 claims 1
• KLOPRDLMVVENMD-IBGZPJMESA-N (2s)-2-[[8-(2-chlorofuran-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=COC=1Cl KLOPRDLMVVENMD-IBGZPJMESA-N 0.000 claims 1
• XALYSICFKQWTFF-IBGZPJMESA-N (2s)-2-[[8-(2-chlorothiophen-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=CSC=1Cl XALYSICFKQWTFF-IBGZPJMESA-N 0.000 claims 1
• MLNLCCJLLRXNKW-IBGZPJMESA-N (2s)-2-[[8-(2-chlorothiophen-3-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C=CSC=1Cl MLNLCCJLLRXNKW-IBGZPJMESA-N 0.000 claims 1
• ZKBWCHKYJOOXJS-FQEVSTJZSA-N (2s)-2-[[8-(2-methoxypyrimidin-5-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=NC(OC)=NC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 ZKBWCHKYJOOXJS-FQEVSTJZSA-N 0.000 claims 1
• AAOCOEXPVQOMFW-IBGZPJMESA-N (2s)-2-[[8-(3,5-dichlorofuran-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1OC(Cl)=CC=1Cl AAOCOEXPVQOMFW-IBGZPJMESA-N 0.000 claims 1
• XIRFRBMMYJUDLK-IBGZPJMESA-N (2s)-2-[[8-(3,5-dichlorothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1SC(Cl)=CC=1Cl XIRFRBMMYJUDLK-IBGZPJMESA-N 0.000 claims 1
• DOJXYCQGSYTEGR-NRFANRHFSA-N (2s)-2-[[8-(3,5-dimethyl-1,2-oxazol-4-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C(C)=NOC=1C DOJXYCQGSYTEGR-NRFANRHFSA-N 0.000 claims 1
• PUITVRKBXHHQIB-NRFANRHFSA-N (2s)-2-[[8-(3,5-dimethyl-1h-pyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C(C)=NNC=1C PUITVRKBXHHQIB-NRFANRHFSA-N 0.000 claims 1
• AVZAZXIJRWGXCY-NRFANRHFSA-N (2s)-2-[[8-(3,5-dimethyl-1h-pyrazol-4-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C(C)=NNC=1C AVZAZXIJRWGXCY-NRFANRHFSA-N 0.000 claims 1
• SDNRSJSFMMXKFU-FQEVSTJZSA-N (2s)-2-[[8-(3-formylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1SC=CC=1C=O SDNRSJSFMMXKFU-FQEVSTJZSA-N 0.000 claims 1
• CQMMTHJRTHXZSV-FQEVSTJZSA-N (2s)-2-[[8-(3-methoxy-3-oxoprop-1-ynyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C#CC(=O)OC)=CC=C3OC2=C1 CQMMTHJRTHXZSV-FQEVSTJZSA-N 0.000 claims 1
• CLALSIAHDUVZJV-DEOSSOPVSA-N (2s)-2-[[8-(4,4-dimethyl-2-oxo-1h-3,1-benzoxazin-6-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound N1C(=O)OC(C)(C)C2=CC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C21 CLALSIAHDUVZJV-DEOSSOPVSA-N 0.000 claims 1
• PHZLIBHAJXIHCW-SFHVURJKSA-N (2s)-2-[[8-(4,5-dihydro-1,3-oxazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NCCO1 PHZLIBHAJXIHCW-SFHVURJKSA-N 0.000 claims 1
• GYYAODRYWUYDQY-SFHVURJKSA-N (2s)-2-[[8-(4,5-dihydro-1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NCCS1 GYYAODRYWUYDQY-SFHVURJKSA-N 0.000 claims 1
• UHEVEGBMHFVIKN-SFHVURJKSA-N (2s)-2-[[8-(4,5-dihydro-1h-imidazol-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NCCN1 UHEVEGBMHFVIKN-SFHVURJKSA-N 0.000 claims 1
• NAMHJJLLTFDCNG-QFIPXVFZSA-N (2s)-2-[[8-(5-acetylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(C)=O)S1 NAMHJJLLTFDCNG-QFIPXVFZSA-N 0.000 claims 1
• YTGNAVJOYPJODX-QFIPXVFZSA-N (2s)-2-[[8-(5-acetylthiophen-2-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC=C(C(C)=O)S1 YTGNAVJOYPJODX-QFIPXVFZSA-N 0.000 claims 1
• LDGFBRWCTQMLJI-FQEVSTJZSA-N (2s)-2-[[8-(5-carbamoylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(N)=O)S1 LDGFBRWCTQMLJI-FQEVSTJZSA-N 0.000 claims 1
• VKWUUWBRHYYCCV-FQEVSTJZSA-N (2s)-2-[[8-(5-chlorothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(Cl)S1 VKWUUWBRHYYCCV-FQEVSTJZSA-N 0.000 claims 1
• WJMYDAMERKEXFF-FQEVSTJZSA-N (2s)-2-[[8-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1CCC1 WJMYDAMERKEXFF-FQEVSTJZSA-N 0.000 claims 1
• KGFSDLQCKJSBSH-NRFANRHFSA-N (2s)-2-[[8-(5-cyclopentyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1CCCC1 KGFSDLQCKJSBSH-NRFANRHFSA-N 0.000 claims 1
• YEALYCAODNUTLF-IBGZPJMESA-N (2s)-2-[[8-(5-ethyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound O1C(CC)=NC(C=2C=C3C4=CC=C(C=C4OC3=CC=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=N1 YEALYCAODNUTLF-IBGZPJMESA-N 0.000 claims 1
• KWFTYLQUVUNSGF-FQEVSTJZSA-N (2s)-2-[[8-(5-fluorothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(F)S1 KWFTYLQUVUNSGF-FQEVSTJZSA-N 0.000 claims 1
• QODKHJZZECMWOS-QFIPXVFZSA-N (2s)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-2-phenylacetic acid Chemical compound O1C(C(C)(C)C)=NC(C=2C=C3C4=CC=C(C=C4OC3=CC=2)S(=O)(=O)N[C@H](C(O)=O)C=2C=CC=CC=2)=N1 QODKHJZZECMWOS-QFIPXVFZSA-N 0.000 claims 1
• NZQAAPJCTUNRMX-IBGZPJMESA-N (2s)-2-[[8-(5-tert-butyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(C(C)(C)C)=N1 NZQAAPJCTUNRMX-IBGZPJMESA-N 0.000 claims 1
• VAFNGMYFSXTJRC-NRFANRHFSA-N (2s)-2-[[8-(6-chloropyridin-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(Cl)N=C1 VAFNGMYFSXTJRC-NRFANRHFSA-N 0.000 claims 1
• HZXKGDMQMNNCRD-NRFANRHFSA-N (2s)-2-[[8-(6-chloropyridin-3-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC=C(Cl)N=C1 HZXKGDMQMNNCRD-NRFANRHFSA-N 0.000 claims 1
• YDQDFVSPQFLHIE-QFIPXVFZSA-N (2s)-2-[[8-(6-methoxypyridin-3-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=NC(OC)=CC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 YDQDFVSPQFLHIE-QFIPXVFZSA-N 0.000 claims 1
• SFFGSFGAFZZEKS-QFIPXVFZSA-N (2s)-2-[[8-(6-methoxypyridin-3-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=NC(OC)=CC=C1C1=CC=C(SC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 SFFGSFGAFZZEKS-QFIPXVFZSA-N 0.000 claims 1
• PPNPGGFZGVVPAB-FQEVSTJZSA-N (2s)-2-[[8-(furan-2-yl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=CO1 PPNPGGFZGVVPAB-FQEVSTJZSA-N 0.000 claims 1
• CCYLJGZXXCVFGH-FQEVSTJZSA-N (2s)-2-[[8-(furan-2-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC=CO1 CCYLJGZXXCVFGH-FQEVSTJZSA-N 0.000 claims 1
• WYMLGTKWPSECSN-FQEVSTJZSA-N (2s)-2-[[8-(furan-3-yl)dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C=COC=1 WYMLGTKWPSECSN-FQEVSTJZSA-N 0.000 claims 1
• SBYYWMWJIOJBDA-QHCPKHFHSA-N (2s)-2-[[8-(n'-benzylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=N)NCC1=CC=CC=C1 SBYYWMWJIOJBDA-QHCPKHFHSA-N 0.000 claims 1
• PSOLKLRBLRVLFN-SFHVURJKSA-N (2s)-2-[[8-(n'-ethylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C(=N)NCC)=CC=C3OC2=C1 PSOLKLRBLRVLFN-SFHVURJKSA-N 0.000 claims 1
• ZJFKXLGVJBITKP-KRWDZBQOSA-N (2s)-2-[[8-(n'-methoxycarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C(=N)NOC)=CC=C3OC2=C1 ZJFKXLGVJBITKP-KRWDZBQOSA-N 0.000 claims 1
• NIEGMRTVJZQPGZ-FQEVSTJZSA-N (2s)-2-[[8-(n,n'-diethylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C(=NCC)NCC)=CC=C3OC2=C1 NIEGMRTVJZQPGZ-FQEVSTJZSA-N 0.000 claims 1
• APDUOXKFPGXFIM-FQEVSTJZSA-N (2s)-2-[[8-(n,n-diethylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C(=N)N(CC)CC)=CC=C3OC2=C1 APDUOXKFPGXFIM-FQEVSTJZSA-N 0.000 claims 1
• YNABNFAGPHVTNV-KDLSMAQYSA-N (2s)-2-[[8-[(e)-2-cyclohexylethenyl]dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3\C=C\C1CCCCC1 YNABNFAGPHVTNV-KDLSMAQYSA-N 0.000 claims 1
• RZSNFCGMNARFLE-QFIPXVFZSA-N (2s)-2-[[8-[2-(diethylamino)ethynyl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(C#CN(CC)CC)=CC=C3OC2=C1 RZSNFCGMNARFLE-QFIPXVFZSA-N 0.000 claims 1
• COUODDQJDFSUID-NRFANRHFSA-N (2s)-2-[[8-[3-(dimethylamino)prop-1-ynyl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C1=C(C#CCN(C)C)C=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 COUODDQJDFSUID-NRFANRHFSA-N 0.000 claims 1
• FJVDHTCWQBQCMB-QFIPXVFZSA-N (2s)-2-[[8-[3-[(dimethylamino)methyl]thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1SC=CC=1CN(C)C FJVDHTCWQBQCMB-QFIPXVFZSA-N 0.000 claims 1
• TXCNVCLRHGGHCQ-NRFANRHFSA-N (2s)-2-[[8-[5-(2,2-dimethylpropyl)-1,2,4-oxadiazol-3-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(CC(C)(C)C)=N1 TXCNVCLRHGGHCQ-NRFANRHFSA-N 0.000 claims 1
• VVGXPIQQGGSWEQ-QFIPXVFZSA-N (2s)-2-[[8-[5-(2,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1=CC=C(Cl)C=C1Cl VVGXPIQQGGSWEQ-QFIPXVFZSA-N 0.000 claims 1
• NRYNGPSRPGKXBU-IBGZPJMESA-N (2s)-2-[[8-[5-(methoxymethyl)-1,2,4-oxadiazol-3-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound O1C(COC)=NC(C=2C=C3C4=CC=C(C=C4OC3=CC=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=N1 NRYNGPSRPGKXBU-IBGZPJMESA-N 0.000 claims 1
• MSXFYDXQBXRMKE-YKHFMZSMSA-N (2s)-2-[[8-[5-[1-(dimethylamino)ethyl]thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(C)N(C)C)S1 MSXFYDXQBXRMKE-YKHFMZSMSA-N 0.000 claims 1
• BZCITXZTWSOTSF-SANMLTNESA-N (2s)-2-[[8-[5-[[cyclopropylmethyl(propyl)amino]methyl]-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1N=C(C=2C=C3C4=CC=C(C=C4OC3=CC=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)SC=1CN(CCC)CC1CC1 BZCITXZTWSOTSF-SANMLTNESA-N 0.000 claims 1
• OPJXGBRQCUDJPA-SANMLTNESA-N (2s)-2-[[8-[6-(6-chloropyridin-3-yl)pyridin-3-yl]dibenzofuran-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(C=N1)=CC=C1C1=CC=C(Cl)N=C1 OPJXGBRQCUDJPA-SANMLTNESA-N 0.000 claims 1
• FWTKURCQSPYGNL-SANMLTNESA-N (2s)-2-[[8-[6-(6-chloropyridin-3-yl)pyridin-3-yl]dibenzothiophen-3-yl]sulfonylamino]-3-methylbutanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C(C=N1)=CC=C1C1=CC=C(Cl)N=C1 FWTKURCQSPYGNL-SANMLTNESA-N 0.000 claims 1
• MGAFKHLUTWEZTH-FQEVSTJZSA-N (2s)-3-methyl-2-[(7-thiophen-2-yldibenzofuran-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=CS1 MGAFKHLUTWEZTH-FQEVSTJZSA-N 0.000 claims 1
• QDVROGSVRQKQIV-NRFANRHFSA-N (2s)-3-methyl-2-[(8-pyridin-4-yldibenzofuran-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=NC=C1 QDVROGSVRQKQIV-NRFANRHFSA-N 0.000 claims 1
• VAYIABKLBMFUTM-NRFANRHFSA-N (2s)-3-methyl-2-[(8-pyridin-4-yldibenzothiophen-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC=NC=C1 VAYIABKLBMFUTM-NRFANRHFSA-N 0.000 claims 1
• FCFSTYCXOYGMHI-FQEVSTJZSA-N (2s)-3-methyl-2-[(8-pyrimidin-5-yldibenzofuran-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CN=CN=C1 FCFSTYCXOYGMHI-FQEVSTJZSA-N 0.000 claims 1
• JOPVKXACSHJTNX-VWLOTQADSA-N (2s)-3-methyl-2-[(8-quinolin-6-yldibenzofuran-3-yl)sulfonylamino]butanoic acid Chemical compound N1=CC=CC2=CC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C21 JOPVKXACSHJTNX-VWLOTQADSA-N 0.000 claims 1
• HXBSTHBOPZEQHI-FQEVSTJZSA-N (2s)-3-methyl-2-[(8-thiophen-3-yldibenzothiophen-3-yl)sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C=CSC=1 HXBSTHBOPZEQHI-FQEVSTJZSA-N 0.000 claims 1
• FMQWYBXXWWRQHI-SFHVURJKSA-N (2s)-3-methyl-2-[[7-(1,3-thiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NC=CS1 FMQWYBXXWWRQHI-SFHVURJKSA-N 0.000 claims 1
• IEBNQNLKLFSSFL-SFHVURJKSA-N (2s)-3-methyl-2-[[7-(3,4,5-trichlorothiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C=1SC(Cl)=C(Cl)C=1Cl IEBNQNLKLFSSFL-SFHVURJKSA-N 0.000 claims 1
• IYAHXQXQRODEOQ-SFHVURJKSA-N (2s)-3-methyl-2-[[7-(5-methyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=NOC(C)=N1 IYAHXQXQRODEOQ-SFHVURJKSA-N 0.000 claims 1
• NIMXNQNNCDAXSM-NRFANRHFSA-N (2s)-3-methyl-2-[[7-(5-methylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=CC=3)C=1OC2=CC=3C1=CC=C(C)S1 NIMXNQNNCDAXSM-NRFANRHFSA-N 0.000 claims 1
• HFULTWXLGBAVDR-QFIPXVFZSA-N (2s)-3-methyl-2-[[7-[6-(trifluoromethyl)-1,3-benzothiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=C(C(F)(F)F)C=C2SC(C=3C=C4OC=5C(C4=CC=3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 HFULTWXLGBAVDR-QFIPXVFZSA-N 0.000 claims 1
• YXUCIMNKGIMIFY-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(1,2,3,6-tetrahydropyridin-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CCNCC1 YXUCIMNKGIMIFY-NRFANRHFSA-N 0.000 claims 1
• PCMJCNQXOIOQDQ-KRWDZBQOSA-N (2s)-3-methyl-2-[[8-(1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1N=CON=1 PCMJCNQXOIOQDQ-KRWDZBQOSA-N 0.000 claims 1
• AOMNNBZHSJHHSS-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(1-methylpyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=NN(C)C=1 AOMNNBZHSJHHSS-FQEVSTJZSA-N 0.000 claims 1
• FVOFKWFFJVGNEX-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(1-methylpyrazol-4-yl)dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C=NN(C)C=1 FVOFKWFFJVGNEX-FQEVSTJZSA-N 0.000 claims 1
• BUBKQIUPLIBUPE-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-(1-propylpyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CCC)C=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 BUBKQIUPLIBUPE-QFIPXVFZSA-N 0.000 claims 1
• AFRMNQLOQQIAAI-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-(1-propylpyrazol-4-yl)dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CCC)C=C1C1=CC=C(SC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 AFRMNQLOQQIAAI-QFIPXVFZSA-N 0.000 claims 1
• LAZBBXUXSNLDQA-IBGZPJMESA-N (2s)-3-methyl-2-[[8-(1h-pyrazol-4-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C=1C=NNC=1 LAZBBXUXSNLDQA-IBGZPJMESA-N 0.000 claims 1
• VNCWMXITGONGFT-IBGZPJMESA-N (2s)-3-methyl-2-[[8-(1h-pyrazol-4-yl)dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C=1C=NNC=1 VNCWMXITGONGFT-IBGZPJMESA-N 0.000 claims 1
• URNSMGRITRSYDT-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(1h-pyrrol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=CN1 URNSMGRITRSYDT-FQEVSTJZSA-N 0.000 claims 1
• RTPOLIXDCQLFOR-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(1h-pyrrol-2-yl)dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC=CN1 RTPOLIXDCQLFOR-FQEVSTJZSA-N 0.000 claims 1
• HPCSMWWPNIGQQV-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1CCCC(S2)=C1N=C2C1=CC=C2OC3=CC(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C3C2=C1 HPCSMWWPNIGQQV-QFIPXVFZSA-N 0.000 claims 1
• PNBZSCHMFRTSOZ-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(4,5,6-trifluoro-1,3-benzothiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound FC1=C(F)C=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1F PNBZSCHMFRTSOZ-NRFANRHFSA-N 0.000 claims 1
• QZYSOPAEKFVZFU-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(4-methylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC(C)=CS1 QZYSOPAEKFVZFU-NRFANRHFSA-N 0.000 claims 1
• YZLPRCXRQYQCJO-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(4-methylthiophen-2-yl)dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CC(C)=CS1 YZLPRCXRQYQCJO-NRFANRHFSA-N 0.000 claims 1
• JIZDPGRMHYGSRZ-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(4-methylthiophen-3-yl)dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1SC2=CC=C3C1=CSC=C1C JIZDPGRMHYGSRZ-NRFANRHFSA-N 0.000 claims 1
• AWRABTFLOWVDFY-SFHVURJKSA-N (2s)-3-methyl-2-[[8-(5-methyl-1,3,4-thiadiazol-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NN=C(C)S1 AWRABTFLOWVDFY-SFHVURJKSA-N 0.000 claims 1
• LLJREHOWNIBILL-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(5-methylfuran-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C)O1 LLJREHOWNIBILL-NRFANRHFSA-N 0.000 claims 1
• DKEROQXIMVSLEZ-NRFANRHFSA-N (2s)-3-methyl-2-[[8-(5-methylthiophen-2-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C)S1 DKEROQXIMVSLEZ-NRFANRHFSA-N 0.000 claims 1
• KEMDGKYEBOPVCD-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-(5-phenyl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(N=1)=NOC=1C1=CC=CC=C1 KEMDGKYEBOPVCD-QFIPXVFZSA-N 0.000 claims 1
• CEMRGJBBNAXOEV-IBGZPJMESA-N (2s)-3-methyl-2-[[8-(5-propan-2-yl-1,2,4-oxadiazol-3-yl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NOC(C(C)C)=N1 CEMRGJBBNAXOEV-IBGZPJMESA-N 0.000 claims 1
• CFFBYKLEAXIDJJ-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-(n'-phenylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=N)NC1=CC=CC=C1 CFFBYKLEAXIDJJ-QFIPXVFZSA-N 0.000 claims 1
• UFRHXRCTWNZPPB-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(n-methyl-n-propan-2-ylcarbamimidoyl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=C(C(=N)N(C)C(C)C)C=C2C3=CC=C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C=C3OC2=C1 UFRHXRCTWNZPPB-FQEVSTJZSA-N 0.000 claims 1
• WULPGZBIQUSVQT-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-(pyrrolidine-1-carboximidoyl)dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=N)N1CCCC1 WULPGZBIQUSVQT-FQEVSTJZSA-N 0.000 claims 1
• AJHDDYUDTUXEFK-PXPVJAHISA-N (2s)-3-methyl-2-[[8-[(e)-prop-1-enyl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(/C=C/C)=CC=C3OC2=C1 AJHDDYUDTUXEFK-PXPVJAHISA-N 0.000 claims 1
• AJHDDYUDTUXEFK-HMECNJMJSA-N (2s)-3-methyl-2-[[8-[(z)-prop-1-enyl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NS(=O)(=O)C1=CC=C2C3=CC(\C=C/C)=CC=C3OC2=C1 AJHDDYUDTUXEFK-HMECNJMJSA-N 0.000 claims 1
• VWGRHFFPSLVNAC-VWLOTQADSA-N (2s)-3-methyl-2-[[8-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(=C1)C=NN1CCN1CCOCC1 VWGRHFFPSLVNAC-VWLOTQADSA-N 0.000 claims 1
• YCYRQEYFXGUFBW-DEOSSOPVSA-N (2s)-3-methyl-2-[[8-[1-(3-methylbutyl)pyrazol-4-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CCC(C)C)C=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 YCYRQEYFXGUFBW-DEOSSOPVSA-N 0.000 claims 1
• TYSZNFNQPFAONO-DEOSSOPVSA-N (2s)-3-methyl-2-[[8-[1-(3-methylbutyl)pyrazol-4-yl]dibenzothiophen-3-yl]sulfonylamino]butanoic acid Chemical compound C1=NN(CCC(C)C)C=C1C1=CC=C(SC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 TYSZNFNQPFAONO-DEOSSOPVSA-N 0.000 claims 1
• UBRBSALAOSNRPD-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[2-(3-methylimidazol-4-yl)ethynyl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C#CC1=CN=CN1C UBRBSALAOSNRPD-QFIPXVFZSA-N 0.000 claims 1
• JOMAZZXKNPJECX-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-[3-phenyl-5-(trifluoromethyl)-1h-pyrazol-4-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(C(=NN1)C(F)(F)F)=C1C1=CC=CC=C1 JOMAZZXKNPJECX-QHCPKHFHSA-N 0.000 claims 1
• FJFUENPXRBFIGU-SFHVURJKSA-N (2s)-3-methyl-2-[[8-[4-(trifluoromethyl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=NC(C(F)(F)F)=CS1 FJFUENPXRBFIGU-SFHVURJKSA-N 0.000 claims 1
• MPODMIXWHMXWEE-QHCPKHFHSA-N (2s)-3-methyl-2-[[8-[5-(1,2-oxazol-5-yl)thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(S1)=CC=C1C1=CC=NO1 MPODMIXWHMXWEE-QHCPKHFHSA-N 0.000 claims 1
• KYZDQEOFOIPKOE-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[5-(methylaminomethyl)furan-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound O1C(CNC)=CC=C1C1=CC=C(OC=2C3=CC=C(C=2)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)C3=C1 KYZDQEOFOIPKOE-QFIPXVFZSA-N 0.000 claims 1
• XNJWMINHASIUCN-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[5-(pyrazol-1-ylmethyl)-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(S1)=NC=C1CN1C=CC=N1 XNJWMINHASIUCN-QFIPXVFZSA-N 0.000 claims 1
• NBNIONMVMBISNG-FQEVSTJZSA-N (2s)-3-methyl-2-[[8-[5-(trifluoromethyl)thiophen-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(F)(F)F)S1 NBNIONMVMBISNG-FQEVSTJZSA-N 0.000 claims 1
• MHMALBKFABHZPZ-DEOSSOPVSA-N (2s)-3-methyl-2-[[8-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-thiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C(S1)=NC=C1CN1CCN(C)CC1 MHMALBKFABHZPZ-DEOSSOPVSA-N 0.000 claims 1
• GEGTWEYNSPBVQO-QFIPXVFZSA-N (2s)-3-methyl-2-[[8-[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]dibenzofuran-3-yl]sulfonylamino]butanoic acid Chemical compound C1=C(OC(F)(F)F)C=C2SC(C3=CC=C4OC=5C(C4=C3)=CC=C(C=5)S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=NC2=C1 GEGTWEYNSPBVQO-QFIPXVFZSA-N 0.000 claims 1
• GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 claims 1
• RHIGPZIDZSIXKU-FQEVSTJZSA-N 5-[7-[[(1s)-1-carboxy-2-methylpropyl]sulfamoyl]dibenzofuran-2-yl]thiophene-2-carboxylic acid Chemical compound C=1C(S(=O)(=O)N[C@@H](C(C)C)C(O)=O)=CC=C(C2=C3)C=1OC2=CC=C3C1=CC=C(C(O)=O)S1 RHIGPZIDZSIXKU-FQEVSTJZSA-N 0.000 claims 1
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