JP2010526091A - 癌の処置のための生物学的な標的基の改変 - Google Patents
癌の処置のための生物学的な標的基の改変 Download PDFInfo
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- JP2010526091A JP2010526091A JP2010506622A JP2010506622A JP2010526091A JP 2010526091 A JP2010526091 A JP 2010526091A JP 2010506622 A JP2010506622 A JP 2010506622A JP 2010506622 A JP2010506622 A JP 2010506622A JP 2010526091 A JP2010526091 A JP 2010526091A
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91507007P | 2007-04-30 | 2007-04-30 | |
PCT/US2008/062113 WO2008134761A2 (en) | 2007-04-30 | 2008-04-30 | Modification of biological targeting groups for the treatment of cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010526091A true JP2010526091A (ja) | 2010-07-29 |
JP2010526091A5 JP2010526091A5 (US07638558-20091229-C00200.png) | 2012-03-15 |
Family
ID=39820986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010506622A Pending JP2010526091A (ja) | 2007-04-30 | 2008-04-30 | 癌の処置のための生物学的な標的基の改変 |
Country Status (4)
Cited By (4)
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---|---|---|---|---|
JP2020502051A (ja) * | 2016-11-09 | 2020-01-23 | オハイオ・ステイト・イノベーション・ファウンデーション | ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法 |
US11352394B2 (en) | 2016-11-22 | 2022-06-07 | Ohio State Innovation Foundation | Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof |
US11859019B2 (en) | 2016-11-22 | 2024-01-02 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha |
US11987647B2 (en) | 2018-05-09 | 2024-05-21 | Ohio State Innovation Foundation | Cyclic cell-penetrating peptides with one or more hydrophobic residues |
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EP2010477A4 (en) | 2006-04-27 | 2012-05-30 | Intezyne Technologies Inc | POLY (ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDOGROUP |
EP2502628B1 (en) * | 2006-06-23 | 2016-12-14 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in cancer |
US8258190B2 (en) | 2007-04-30 | 2012-09-04 | Intezyne Technologies, Inc. | Encapsulated contrast agents |
GB0803076D0 (en) | 2008-02-20 | 2008-03-26 | Univ Ghent | Mucosal Membrane Receptor and uses thereof |
EP2279011B1 (en) | 2008-04-30 | 2017-10-25 | Siemens Medical Solutions USA, Inc. | Substrate based pet imaging agents |
MX336869B (es) | 2008-11-03 | 2016-02-04 | Alethia Biotherapeutics Inc | Anticuerpos que bloquean espicificamente la actividad biologica de un antigeno de tumor. |
EP2424359A4 (en) | 2009-04-30 | 2014-01-15 | Intezyne Technologies Inc | POLYMIC MICELLES WITH ANTHRACYCLINES FOR THE TREATMENT OF CANCER |
US8524784B2 (en) | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
CA2760771A1 (en) * | 2009-05-04 | 2010-11-11 | Intezyne Technologies, Incorporated | Polymer micelles containing sn-38 for the treatment of cancer |
GB2470770A (en) | 2009-06-04 | 2010-12-08 | Medical Res Council | Incorporation of unnatural amino acids having an orthogonal functional group into polypeptides using orthogonal tRNA/tRNA synthetase pairs |
US11673914B2 (en) | 2009-11-10 | 2023-06-13 | Allegro Pharmaceuticals, LLC | Peptide therapies for reduction of macular thickening |
MX346362B (es) | 2009-11-10 | 2017-03-15 | Allegro Pharmaceuticals Inc * | Composiciones y metodos para inhibir la adhesion celular o dirigir agentes de diagnostico o terapeuticos a sitios de enlace rgd. |
CA2785410A1 (en) * | 2009-12-23 | 2011-06-30 | Carlos F. Barbas, Iii | Tyrosine bioconjugation through aqueous ene-like reactions |
KR101993259B1 (ko) | 2011-03-31 | 2019-06-27 | 에이디씨 테라퓨틱스 에스에이 | 신장 결합 항원 1에 대한 항체 및 이의 항원 결합 단편 |
WO2012142659A1 (en) * | 2011-04-19 | 2012-10-26 | Baker Idi Heart And Diabetes Institute Holdings Limited | Site-selective modification of proteins |
ES2820855T3 (es) | 2011-05-09 | 2021-04-22 | Allegro Pharmaceuticals Llc | Antagonistas del receptor de integrina y sus métodos de uso |
CN102335190B (zh) * | 2011-07-18 | 2013-01-23 | 华东师范大学 | 还原降解释药可控的巯嘌呤纳米胶束前药及其应用 |
DK2802351T3 (da) | 2012-01-09 | 2019-05-13 | Adc Therapeutics Sa | Midler til behandling af triple-negativ brystkræft |
JP5927338B2 (ja) | 2012-04-11 | 2016-06-01 | インテザイン テクノロジーズ, インコーポレイテッド | 安定なミセルのためのブロックコポリマー |
US20150148525A1 (en) | 2012-05-18 | 2015-05-28 | Medical Research Council | Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase |
JP6498600B2 (ja) | 2012-06-08 | 2019-04-10 | ストロ バイオファーマ インコーポレーテッド | 部位特異的な非天然アミノ酸残基を含む抗体、その調製方法、及びその使用方法 |
US9732161B2 (en) | 2012-06-26 | 2017-08-15 | Sutro Biopharma, Inc. | Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use |
WO2014007632A1 (en) * | 2012-07-06 | 2014-01-09 | Stichting Het Nederlands Kanker Instituut | Cysteine protease capturing agents |
CN104981254B (zh) | 2012-08-31 | 2018-05-22 | 苏特罗生物制药公司 | 含有叠氮基的经修饰的氨基酸 |
SG11201504974PA (en) | 2012-12-24 | 2015-07-30 | Agency Science Tech & Res | Self-assembling ultrashort peptides modified with bioactive agents by click chemistry |
WO2014165842A2 (en) * | 2013-04-05 | 2014-10-09 | Igdrasol | Nanoparticle formulations in biomarker detection |
EP3019522B1 (en) | 2013-07-10 | 2017-12-13 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
US20170080093A1 (en) * | 2013-10-22 | 2017-03-23 | Tyme, Inc. | Tyrosine Derivatives And Compositions Comprising Them |
CN106102835B (zh) | 2014-01-13 | 2020-11-03 | 博格有限责任公司 | 烯醇酶1(eno1)组合物及其用途 |
GB2528227A (en) | 2014-03-14 | 2016-01-20 | Medical Res Council | Cyclopropene amino acids and methods |
US9303069B2 (en) * | 2014-05-05 | 2016-04-05 | University Of Mississippi Medical Center | Peptides for treating cancer |
CN104177476B (zh) * | 2014-08-29 | 2016-10-05 | 国家纳米科学中心 | 一种靶向人癌细胞的多肽及其应用 |
MX2018009085A (es) | 2016-01-27 | 2019-05-09 | Sutro Biopharma Inc | Conjugados de anticuerpos anti-cd74, composiciones que comprenden conjugados de anticuerpos anti-cd74 y metodos de uso de congujados de anticuerpos anti-cd74. |
CN105859834B (zh) * | 2016-04-12 | 2019-07-19 | 北京大学 | 一种用于靶向治疗的多肽和核酸偶联化合物 |
JP7289029B2 (ja) * | 2017-07-10 | 2023-06-09 | エスアールアイ インターナショナル | 分子誘導システムペプチド及びその使用 |
CA3075650A1 (en) * | 2017-10-17 | 2019-04-25 | University Of Wollongong | Anti-cancer agent |
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CN113876784B (zh) * | 2021-09-27 | 2023-07-21 | 潍坊博创国际生物医药研究院 | 硼代亮氨酸类化合物的新用途 |
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Citations (1)
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WO2007016542A2 (en) * | 2005-08-01 | 2007-02-08 | President And Fellows Of Harvard College | Her-2 blocking bifunctional targeted peptides |
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US20030008819A1 (en) * | 1995-09-08 | 2003-01-09 | Schnitzer Jan E. | Targeting endothelium for tissue-specific delivery of agents |
US5622699A (en) * | 1995-09-11 | 1997-04-22 | La Jolla Cancer Research Foundation | Method of identifying molecules that home to a selected organ in vivo |
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US6174687B1 (en) * | 1999-02-26 | 2001-01-16 | The Burnham Institute | Methods of identifying lung homing molecules using membrane dipeptidase |
US6303573B1 (en) * | 1999-06-07 | 2001-10-16 | The Burnham Institute | Heart homing peptides and methods of using same |
US20020041898A1 (en) * | 2000-01-05 | 2002-04-11 | Unger Evan C. | Novel targeted delivery systems for bioactive agents |
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US20030077826A1 (en) * | 2001-02-02 | 2003-04-24 | Lena Edelman | Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC) |
WO2004055160A2 (en) * | 2002-12-13 | 2004-07-01 | The Trustees Of Columbia University In The City Of New York | Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry |
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2008
- 2008-04-30 WO PCT/US2008/062113 patent/WO2008134761A2/en active Application Filing
- 2008-04-30 EP EP08747259A patent/EP2155177A2/en not_active Withdrawn
- 2008-04-30 US US12/113,101 patent/US20090110662A1/en not_active Abandoned
- 2008-04-30 JP JP2010506622A patent/JP2010526091A/ja active Pending
Patent Citations (1)
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WO2007016542A2 (en) * | 2005-08-01 | 2007-02-08 | President And Fellows Of Harvard College | Her-2 blocking bifunctional targeted peptides |
Non-Patent Citations (2)
Title |
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JPN6013014238; 新村出 編: 広辞苑 第五版 第五版, 19981111, p.622(き【基】の項), 岩波書店 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020502051A (ja) * | 2016-11-09 | 2020-01-23 | オハイオ・ステイト・イノベーション・ファウンデーション | ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法 |
JP7175887B2 (ja) | 2016-11-09 | 2022-11-21 | オハイオ・ステイト・イノベーション・ファウンデーション | ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法 |
US11878046B2 (en) | 2016-11-09 | 2024-01-23 | Ohio State Innovation Foundation | Di-sulfide containing cell penetrating peptides and methods of making and using thereof |
JP7490735B2 (ja) | 2016-11-09 | 2024-05-27 | オハイオ・ステイト・イノベーション・ファウンデーション | ジスルフィド含有細胞膜透過ペプチド並びにその製造方法及び使用方法 |
US11352394B2 (en) | 2016-11-22 | 2022-06-07 | Ohio State Innovation Foundation | Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof |
US11859019B2 (en) | 2016-11-22 | 2024-01-02 | Ohio State Innovation Foundation | Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha |
US11987647B2 (en) | 2018-05-09 | 2024-05-21 | Ohio State Innovation Foundation | Cyclic cell-penetrating peptides with one or more hydrophobic residues |
Also Published As
Publication number | Publication date |
---|---|
EP2155177A2 (en) | 2010-02-24 |
WO2008134761A2 (en) | 2008-11-06 |
US20090110662A1 (en) | 2009-04-30 |
WO2008134761A3 (en) | 2009-03-05 |
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