JP2010524958A - 改善された溶解度を有する両親媒性ペプチドおよびその使用方法 - Google Patents

改善された溶解度を有する両親媒性ペプチドおよびその使用方法 Download PDF

Info

Publication number
JP2010524958A
JP2010524958A JP2010504238A JP2010504238A JP2010524958A JP 2010524958 A JP2010524958 A JP 2010524958A JP 2010504238 A JP2010504238 A JP 2010504238A JP 2010504238 A JP2010504238 A JP 2010504238A JP 2010524958 A JP2010524958 A JP 2010524958A
Authority
JP
Japan
Prior art keywords
peptide
amphiphilic
amphiphilic peptide
growth
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010504238A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010524958A5 (https=
Inventor
ジェイムズ エフ． フルバット
ムスタファ オー． ギュレー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JP2010524958A publication Critical patent/JP2010524958A/ja
Publication of JP2010524958A5 publication Critical patent/JP2010524958A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2010504238A 2007-04-17 2008-04-17 改善された溶解度を有する両親媒性ペプチドおよびその使用方法 Pending JP2010524958A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91228907P 2007-04-17 2007-04-17
US12/104,407 US8076295B2 (en) 2007-04-17 2008-04-16 Peptide amphiphiles having improved solubility and methods of using same
PCT/US2008/060559 WO2008131052A2 (en) 2007-04-17 2008-04-17 Novel peptide amphiphiles having improved solubility and methods of using same

Publications (2)

Publication Number Publication Date
JP2010524958A true JP2010524958A (ja) 2010-07-22
JP2010524958A5 JP2010524958A5 (https=) 2011-05-19

Family

ID=39876156

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010504238A Pending JP2010524958A (ja) 2007-04-17 2008-04-17 改善された溶解度を有する両親媒性ペプチドおよびその使用方法

Country Status (8)

Country Link
US (1) US8076295B2 (https=)
EP (1) EP2146734A4 (https=)
JP (1) JP2010524958A (https=)
KR (1) KR20100021567A (https=)
CN (1) CN101848722A (https=)
AU (1) AU2008242940A1 (https=)
CA (1) CA2690772A1 (https=)
WO (1) WO2008131052A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022523299A (ja) * 2019-01-24 2022-04-22 ノースウエスタン ユニバーシティ 超分子ｉｋｖａｖマトリックス内の動力学は、ヒトｉｐｓｃ由来のニューロンの機能的成熟と再生を増強する

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003070749A2 (en) * 2002-02-15 2003-08-28 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
US7554021B2 (en) * 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
US7544661B2 (en) * 2003-12-05 2009-06-09 Northwestern University Self-assembling peptide amphiphiles and related methods for growth factor delivery
AU2006206194A1 (en) * 2005-01-21 2006-07-27 Northwestern University Methods and compositions for encapsulation of cells
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
MX2011010780A (es) * 2009-04-13 2011-10-28 Univ Northwestern Andamios novedosos basados en peptido para la regeneracion de cartilagos y metodos para su uso.
SG184345A1 (en) * 2010-03-31 2012-11-29 Agency Science Tech & Res Amphiphilic linear peptide/peptoid and hydrogel comprising the same
US8546338B2 (en) 2010-12-08 2013-10-01 Johnson & Johnson Consumer Companies, Inc. Self-assembling hydrogels based on dicephalic peptide amphiphiles
BR112014020103A2 (pt) * 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
KR101501436B1 (ko) * 2013-02-14 2015-03-18 주식회사 나이벡 생리활성 펩타이드가 자기회합된 젤 형태의 지지체 및 그 제조방법
EP3362079B1 (en) 2015-10-14 2022-04-06 Northwestern University Nanofiber paste for growth factor delivery and bone regeneration
CN105694030B (zh) * 2016-04-05 2018-01-26 中国科学院化学研究所 一种寡聚氨基酸与海藻酸钠复合的杂化抗菌水凝胶
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
WO2018075885A1 (en) 2016-10-21 2018-04-26 Northwestern University Anti-microbial supramolecular structures
WO2019036631A1 (en) 2017-08-18 2019-02-21 The Johns Hopkins University SUPRAMOLECULAR FILAMENT ASSEMBLIES FOR THE PURIFICATION OF PROTEINS
CN108070021B (zh) * 2017-12-27 2021-06-15 中南民族大学 可组装成高度有序纳米纤维的小分子肽及组装构建高度有序纳米纤维的方法
EP3921330A1 (en) * 2019-02-08 2021-12-15 Agency for Science, Technology and Research A self-assembling short amphiphilic peptide and related methods and uses
US12214076B2 (en) 2019-02-18 2025-02-04 Northwestern University Drug delivery vehicles for atherosclerosis nanomedicine
KR20220039725A (ko) * 2019-07-02 2022-03-29 트러스티즈 오브 터프츠 칼리지 작용제의 세포 및 조직으로의 전달을 위한 신규 펩티드, 조성물 및 방법
US12247063B2 (en) 2020-07-13 2025-03-11 Northwestern University Cell surface modification by coating with peptide amphiphiles (PAs)
US11998589B2 (en) 2020-07-13 2024-06-04 Northwestern University PEGylated peptide amphiphile nanofibers and methods of use
US12116461B2 (en) 2020-08-21 2024-10-15 Northwestern University Host-guest interactions for pa superstructure formation
WO2023010082A1 (en) 2021-07-29 2023-02-02 Northwestern University SELF-ASSEMBLING PEPTIDE AMPHIPHILES DISPLAYING A TRANSFORMING GROWTH FACTOR BETA 1 (TGF-β1) MIMETIC EPITOPE
EP4384532A4 (en) * 2021-08-09 2025-07-02 Gel4Med Inc SELF-ASSEMBLING AMPHIPHILIC PEPTIDE HYDROGELS FOR THE TREATMENT OF NERVE INJURY

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043686A1 (en) * 1997-04-03 1998-10-08 California Institute Of Technology Enzyme-mediated modification of fibrin for tissue engineering
US6855329B1 (en) * 1998-01-20 2005-02-15 Massachusetts Institute Of Technology Surface coating spatially controlled patterns
US20060247165A1 (en) * 2005-01-21 2006-11-02 Stupp Samuel I Methods and compositions for encapsulation of cells
WO2006117227A2 (en) * 2005-05-04 2006-11-09 Lonza Ag Solid phase bound thymosin alpha-1 and its synthesis
CN1915438A (zh) * 2006-07-27 2007-02-21 华中科技大学同济医学院附属协和医院 新型多肽神经组织工程支架材料及其制备方法和应用

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US5130123A (en) * 1981-03-04 1992-07-14 The University Of Melbourne Dentifrice
US4930077A (en) * 1987-04-06 1990-05-29 Fan David P Information processing expert system for text analysis and predicting public opinion based information available to the public
US5128319A (en) * 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
GB8812214D0 (en) * 1988-05-24 1988-06-29 Hoffmann La Roche Use of peptide from circumsporozoite protein of p falciparum as universally recognized t-cell epitope
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JPH0399096A (ja) 1989-09-11 1991-04-24 Agency Of Ind Science & Technol 短繊維型螺旋状分子会合体の長さ制御方法
DE4026978A1 (de) * 1990-08-25 1992-02-27 Bayer Ag Auf traegern angebrachte ein- oder mehrlagige schichtelemente und ihre herstellung
ATE156344T1 (de) * 1991-04-25 1997-08-15 Univ Brown Res Found Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte
WO1993022343A1 (en) 1992-05-01 1993-11-11 The Rockfeller University Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom
GB9215780D0 (en) 1992-07-24 1992-09-09 Univ London Pharmacy Peptide compounds
US5670483A (en) * 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5955343A (en) * 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
SE9402531L (sv) 1994-07-19 1996-01-20 Medicarb Ab Sårläkningsmedel
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6410690B1 (en) * 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
WO1997005185A2 (en) * 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
FR2739860B1 (fr) 1995-10-17 1998-01-02 Coletica Complexes amphiphiles, procede pour leur preparation et compositions en renfermant
SE9504347D0 (sv) 1995-12-01 1995-12-01 Boerje Sellergren Surface modification technique
US6051272A (en) * 1996-03-15 2000-04-18 The Board Of Trustees Of The University Of Illinois Method for synthesizing organoapatites on to surgical metal alloys
US5733868A (en) * 1996-04-16 1998-03-31 Depuy Orthopaedics, Inc. Poly(amino acid) adhesive tissue grafts
JP3862760B2 (ja) * 1996-06-12 2006-12-27 トレスパファン、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング 低い薄膜干渉を示す透明なバリヤコーティング
US6085206A (en) * 1996-06-20 2000-07-04 Microsoft Corporation Method and system for verifying accuracy of spelling and grammatical composition of a document
US5993541A (en) * 1996-07-31 1999-11-30 Geo Centers Inc Process for nucleation of ceramics and product thereof
US6096863A (en) * 1996-08-23 2000-08-01 Regents Of The University Of Minnesota Self-assembling amphiphiles for construction of peptide secondary structures
US6458924B2 (en) * 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
WO1998031394A2 (en) * 1997-01-22 1998-07-23 Board Of Regents, The University Of Texas System Tissue factor methods and compositions for coagulation and tumor treatment
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
US6181909B1 (en) * 1997-07-22 2001-01-30 Educational Testing Service System and method for computer-based automatic essay scoring
US6269368B1 (en) * 1997-10-17 2001-07-31 Textwise Llc Information retrieval using dynamic evidence combination
CN1166773C (zh) * 1997-12-02 2004-09-15 泽恩比奥公司 分离的人脂肪组织衍生的基质细胞
SE519827C2 (sv) * 1998-03-30 2003-04-15 Viranative Ab Näringsmedium innehållande metionin samt användning av detta
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
US6548048B1 (en) * 1998-04-28 2003-04-15 Amersham Health As Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents
US7601685B2 (en) * 1998-08-27 2009-10-13 Eidgenossische Technische Hochschule Zurich Growth factor modified protein matrices for tissue engineering
IL141688A0 (en) 1998-09-04 2002-03-10 Scios Inc Hydrogel compositions for the controlled release administration of growth factors
ATE235928T1 (de) * 1998-09-15 2003-04-15 Isotis Nv Beschichtungsverfahren von medizinischen implantaten
US6114038A (en) * 1998-11-10 2000-09-05 Biocrystal Ltd. Functionalized nanocrystals and their use in detection systems
DK1181323T3 (da) 1999-02-01 2011-10-17 Eidgenoess Tech Hochschule Biomaterialer dannet med nukleofil additionsreaktion med konjugerede uimættede grupper
EP1156816A4 (en) 1999-02-02 2004-12-29 Univ Jefferson MODULATION ACTIVITIES OF HEPARIN PEPTIDES, AND OTHER GLYCOSAMINOGLYCANS OR PROTEOGLYCANS
BR0008714A (pt) 1999-03-02 2002-01-02 Univ Massachusetts Public Inst Linhagens celulares embriÈnicas ou tipo tronco produzidas por transplante nuclear de espécies cruzadas
US6473730B1 (en) * 1999-04-12 2002-10-29 The Trustees Of Columbia University In The City Of New York Method and system for topical segmentation, segment significance and segment function
ES2255257T3 (es) 1999-04-22 2006-06-16 Eidgenossische Technische Hochschule (Eth) Liberacion controlada de factores de crecimiento a partir de matrices que contienen heparina.
US20090087878A9 (en) * 1999-05-06 2009-04-02 La Rosa Thomas J Nucleic acid molecules associated with plants
AU782286B2 (en) 1999-06-30 2005-07-14 Advanced Cell Technology, Inc. Cytoplasmic transfer to de-differentiate recipient cells
US6444723B1 (en) * 1999-11-10 2002-09-03 The United States Of America As Represented By The Secretary Of Commerce Crosslinked micellar gel composition
CA2395957A1 (en) 1999-12-28 2001-07-05 The Regents Of The University Of Michigan Process for ex vivo formation of mammalian bone and uses thereof
US20040018969A1 (en) * 2000-01-31 2004-01-29 Rosen Craig A. Nucleic acids, proteins, and antibodies
WO2001055301A2 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
ATE244027T1 (de) 2000-02-04 2003-07-15 Isotis Nv Proteinbeschichtung
US6689165B2 (en) * 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
BR0110679A (pt) * 2000-04-28 2004-04-20 Univ Dublin Derivados anfìfilos macrocìclicos e seus análogos
CA2408819C (en) * 2000-05-11 2006-11-07 University Of Southern California Machine translation techniques
EP2028187A1 (en) 2000-09-08 2009-02-25 Board Of Regents, The University Of Texas System Human and mouse targeting peptides identified by phage display
WO2002055185A2 (en) * 2000-10-19 2002-07-18 Eidgenoess Tech Hochschule Block copolymers for multifunctional self-assembled systems
WO2002039118A1 (en) 2000-11-06 2002-05-16 Thrasos, Inc. Screening methods for bone morphogenetic mimetics
US6796800B2 (en) * 2001-01-23 2004-09-28 Educational Testing Service Methods for automated essay analysis
DE60230593D1 (de) 2001-02-06 2009-02-12 Massachusetts Inst Technology Peptidgerüstverkapselung von gewebszellen und verwendungen davon
US7449180B2 (en) * 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
US7179784B2 (en) * 2001-07-10 2007-02-20 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
AU2002361601A1 (en) 2001-11-06 2003-05-19 Mark C. Fishman Stem and progenitor cell capture for tissue regeneration
US7491690B2 (en) * 2001-11-14 2009-02-17 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
WO2003070749A2 (en) * 2002-02-15 2003-08-28 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
AU2003222167A1 (en) 2002-04-02 2003-10-20 Northwestern University Peptide amphiphile solutions and self assembled peptide nanofiber networks
AU2003226428A1 (en) * 2002-04-18 2003-11-03 Northwestern University Encapsulation of nanotubes via self-assembled nanostructures
JP2005185101A (ja) * 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長ｃＤＮＡおよびその利用
WO2004003561A1 (en) 2002-06-27 2004-01-08 Northwestern University Peptide rod amphiphiles and self-assembly of same
AU2003285853A1 (en) 2002-07-23 2004-04-30 Northwestern University Self-assembled hybrid compositions and method of making, using and ordering same
AU2003262760A1 (en) * 2002-08-21 2004-03-11 Northwestern University Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom
US20050272662A1 (en) * 2002-09-23 2005-12-08 Stupp Samuel I Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals
US7135027B2 (en) * 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
US7554021B2 (en) * 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003304280A1 (en) 2002-11-12 2005-01-21 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
AU2003298647A1 (en) 2002-11-14 2004-06-15 Claussen, Randal, C. Synthesis and self-assembly of abc triblock bola peptide
EP1606065A4 (en) * 2003-02-11 2010-09-29 Univ Northwestern METHOD AND MATERIALS FOR NANOCRYSTALLINE SURFACE COATINGS AND ATTACHMENT OF AMPHIPHILENE PEPTIDE NANO FIBERS THEREOF
WO2005014619A2 (en) 2003-03-28 2005-02-17 Thomas Jefferson University Heparin-binding peptides and uses thereof
US20070141101A1 (en) 2003-04-10 2007-06-21 The Trustees Of Boston University Method for stimulating angiogenesis and wound healing
EP1696944A4 (en) 2003-12-05 2008-11-05 Univ Northwestern BRANCHED PEPTIDE AMPHIPHILES, RELATED EPITOPES COMPOUNDS AND SELF-ASSOCIATED STRUCTURES THEREOF
US7544661B2 (en) 2003-12-05 2009-06-09 Northwestern University Self-assembling peptide amphiphiles and related methods for growth factor delivery
US20050214257A1 (en) * 2003-12-23 2005-09-29 Northwestern University Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation
EP2266586A1 (en) * 2004-03-23 2010-12-29 Lifeline Nutraceuticals Corporation Compositions and method for alleviating inflammation and oxidative stress in a mammal
CA2593112A1 (en) * 2005-01-21 2006-07-27 Alza Corporation Therapeutic peptide formulations for coating microneedles with improved stability containing at least one counterion
WO2006096614A2 (en) 2005-03-04 2006-09-14 Northwestern University Angiogenic heparin binding peptide amphiphiles
US8114835B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles for tissue engineering
US8114834B2 (en) * 2006-11-09 2012-02-14 Northwestern University Self-assembling peptide amphiphiles
US8772228B2 (en) * 2007-02-14 2014-07-08 Northwestern University Aligned nanofibers and related methods of use
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
WO2009026233A2 (en) * 2007-08-17 2009-02-26 Northwestern University Self assembling peptide systems and methods

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043686A1 (en) * 1997-04-03 1998-10-08 California Institute Of Technology Enzyme-mediated modification of fibrin for tissue engineering
US6855329B1 (en) * 1998-01-20 2005-02-15 Massachusetts Institute Of Technology Surface coating spatially controlled patterns
US20060247165A1 (en) * 2005-01-21 2006-11-02 Stupp Samuel I Methods and compositions for encapsulation of cells
WO2006117227A2 (en) * 2005-05-04 2006-11-09 Lonza Ag Solid phase bound thymosin alpha-1 and its synthesis
CN1915438A (zh) * 2006-07-27 2007-02-21 华中科技大学同济医学院附属协和医院 新型多肽神经组织工程支架材料及其制备方法和应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6013016308; Ｂｉｏｍａｃｒｏｍｏｌｅｃｕｌｅｓ，　２００６，　Ｖｏｌ．７，　Ｖｏｌ．１８５５-１８６３ *
JPN6013016311; Ｊ．　Ａｍ．　Ｃｈｅｍ．　Ｓｏｃ．，　２００３，　Ｖｏｌ．１２５，　ｐ．７１４６-７１４７ *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022523299A (ja) * 2019-01-24 2022-04-22 ノースウエスタン ユニバーシティ 超分子ｉｋｖａｖマトリックス内の動力学は、ヒトｉｐｓｃ由来のニューロンの機能的成熟と再生を増強する
JP7560884B2 (ja) 2019-01-24 2024-10-03 ノースウエスタン ユニバーシティ 超分子ｉｋｖａｖマトリックス内の動力学は、ヒトｉｐｓｃ由来のニューロンの機能的成熟と再生を増強する
JP2024138368A (ja) * 2019-01-24 2024-10-08 ノースウエスタン ユニバーシティ 超分子ｉｋｖａｖマトリックス内の動力学は、ヒトｉｐｓｃ由来のニューロンの機能的成熟と再生を増強する

Also Published As

Publication number Publication date
WO2008131052A2 (en) 2008-10-30
US20090042804A1 (en) 2009-02-12
AU2008242940A1 (en) 2008-10-30
US8076295B2 (en) 2011-12-13
CA2690772A1 (en) 2008-10-30
CN101848722A (zh) 2010-09-29
EP2146734A2 (en) 2010-01-27
WO2008131052A9 (en) 2010-02-25
KR20100021567A (ko) 2010-02-25
EP2146734A4 (en) 2010-12-15

Similar Documents

Publication Publication Date Title
JP2010524958A (ja) 改善された溶解度を有する両親媒性ペプチドおよびその使用方法
US8748569B2 (en) Peptide amphiphiles and methods to electrostatically control bioactivity of the ikvav peptide epitope
Webber et al. Emerging peptide nanomedicine to regenerate tissues and organs
JP4741510B2 (ja) 分岐ペプチド両親媒性物質、関連するエピトープ化合物およびその自己集合構造物
JP5255274B2 (ja) 精製両親媒性ペプチド組成物およびその使用
Gelain et al. BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications
EP2560689B1 (en) Novel self-assembling peptides and their use in the formation of hydrogels
KR20140015149A (ko) Ｒｇｄ 바인딩 부위에 대한 세포 부착의 저해 또는 진단제 또는 치료제의 유도를 위한 조성물 및 방법
US8575311B2 (en) Collagen peptide conjugates and uses therefor
Sasselli et al. Modeling interactions within and between peptide amphiphile supramolecular filaments
US20180030093A1 (en) Self-assembling ultrashort aliphatic cyclic peptides for biomedical applications
Kumar et al. Self-assembling peptides: implications for patenting in drug delivery and tissue engineering
Yang et al. Mechanism of peptide self-assembly and its study in biomedicine
WO2014059384A2 (en) ICAM-1 TARGETING ELPs
Subramani et al. Self-assembly of proteins and peptides and their applications in bionanotechnology and dentistry
Ghosh et al. Supramolecular self-assembled peptide-based nanostructures and their applications in biomedicine
JP6823231B2 (ja) 自己組織化ペプチドおよびそれから形成されるゲル
WO2007094570A1 (en) Self-assembly nano-composites comprising hydrophilic bioactive peptides and hydrophobic materials
Budama-Kilinc et al. Peptide-based nanobiomaterials
Guler Presentation and recognition of functional groups on self-assembled nanostructures
Loo et al. Applications in bionanotechnology of Self-Assembled peptide nanostructures
Marletta et al. 3D Synthetic Peptide-based Architectures for the Engineering of the Enteric Nervous System

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110404

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110404

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130408

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130909