JP2010524937A5 - - Google Patents
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- Publication number
- JP2010524937A5 JP2010524937A5 JP2010504069A JP2010504069A JP2010524937A5 JP 2010524937 A5 JP2010524937 A5 JP 2010524937A5 JP 2010504069 A JP2010504069 A JP 2010504069A JP 2010504069 A JP2010504069 A JP 2010504069A JP 2010524937 A5 JP2010524937 A5 JP 2010524937A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- methyl
- composition
- pharmaceutically acceptable
- triazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92501807P | 2007-04-18 | 2007-04-18 | |
| US60/925,018 | 2007-04-18 | ||
| PCT/US2008/004862 WO2008130552A1 (en) | 2007-04-18 | 2008-04-15 | Triazole derivatives which are smo antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010524937A JP2010524937A (ja) | 2010-07-22 |
| JP2010524937A5 true JP2010524937A5 (https=) | 2011-05-19 |
| JP5498936B2 JP5498936B2 (ja) | 2014-05-21 |
Family
ID=39433852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010504069A Active JP5498936B2 (ja) | 2007-04-18 | 2008-04-15 | Ｓｍｏアンタゴニストであるトリアゾール誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7691887B2 (https=) |
| EP (1) | EP2136803B1 (https=) |
| JP (1) | JP5498936B2 (https=) |
| CN (1) | CN101663033B (https=) |
| AR (1) | AR066063A1 (https=) |
| AT (1) | ATE555785T1 (https=) |
| AU (1) | AU2008241527B2 (https=) |
| CA (1) | CA2683946C (https=) |
| CL (1) | CL2008001074A1 (https=) |
| PE (1) | PE20090806A1 (https=) |
| TW (1) | TW200901987A (https=) |
| WO (1) | WO2008130552A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
| PE20091180A1 (es) * | 2007-12-27 | 2009-08-26 | Infinity Pharmaceuticals Inc | Tratamientos terapeuticos contra el cancer |
| CA2710858A1 (en) | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
| GB0813740D0 (en) * | 2008-07-28 | 2008-09-03 | Angeletti P Ist Richerche Biologica | Therapeutic compounds |
| AU2009286528B2 (en) * | 2008-08-29 | 2014-07-17 | Msd Italia S.R.L. | Saturated bicyclic heterocyclic derivatives as Smo antagonists |
| AU2010279325B2 (en) | 2009-08-05 | 2016-10-20 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
| EP2502078A1 (en) * | 2009-11-20 | 2012-09-26 | Infinity Pharmaceuticals, Inc. | Methods and compositions for treating hedgehog-associated cancers |
| US9394313B2 (en) | 2010-09-14 | 2016-07-19 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| KR20160061911A (ko) | 2013-04-08 | 2016-06-01 | 데니스 엠. 브라운 | 최적하 투여된 화학 화합물의 치료 효과 |
| CN104324039A (zh) * | 2014-10-20 | 2015-02-04 | 付茜 | 一种治疗人身体表面脂肪瘤的药剂及使用方法 |
| PL3302428T3 (pl) | 2015-06-04 | 2026-04-13 | Sol-Gel Technologies Ltd. | Preparaty do zastosowania miejscowego do dostarczania związków inhibitora hedgehog i ich zastosowanie |
| CN108623446A (zh) * | 2017-03-24 | 2018-10-09 | 北京艾德旺科技发展有限公司 | 一种合成3，3-二氟环丁烷甲酸的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| AU2003207717B9 (en) | 2002-02-01 | 2009-05-07 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
| JO2397B1 (en) | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
| CN1795181A (zh) | 2003-05-29 | 2006-06-28 | 麦克公司 | 用作11β－羟基类固醇脱氢酶－1抑制剂的三唑衍生物 |
| WO2005033288A2 (en) | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Hedgehog pathway antagonists |
| PL1745041T3 (pl) | 2004-04-30 | 2012-11-30 | Genentech Inc | Inhibitory chinoksalinowe szlaku sygnałowego hedgehog |
| JP2008509146A (ja) | 2004-08-06 | 2008-03-27 | メルク エンド カムパニー インコーポレーテッド | １１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ−１の阻害剤としてのスルホニル化合物 |
| AU2005280112B2 (en) | 2004-08-27 | 2012-07-19 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogues and methods of use thereof |
| ES2377430T3 (es) | 2004-09-02 | 2012-03-27 | Genentech, Inc. | Inhibidores piridílicos de la señalización de hedgehog |
| CA2583812A1 (en) | 2004-10-28 | 2006-05-11 | Irm Llc | Compounds and compositions as hedgehog pathway modulators |
| EP1807074B1 (en) | 2004-11-03 | 2013-10-23 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| US7981910B2 (en) * | 2005-10-20 | 2011-07-19 | Merck Sharp & Dohme Corp. | Triazole derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase-1 |
-
2008
- 2008-04-15 AU AU2008241527A patent/AU2008241527B2/en active Active
- 2008-04-15 PE PE2008000654A patent/PE20090806A1/es not_active Application Discontinuation
- 2008-04-15 CL CL2008001074A patent/CL2008001074A1/es unknown
- 2008-04-15 AT AT08742913T patent/ATE555785T1/de active
- 2008-04-15 US US12/082,933 patent/US7691887B2/en active Active
- 2008-04-15 TW TW097113665A patent/TW200901987A/zh unknown
- 2008-04-15 WO PCT/US2008/004862 patent/WO2008130552A1/en not_active Ceased
- 2008-04-15 CA CA2683946A patent/CA2683946C/en active Active
- 2008-04-15 AR ARP080101540A patent/AR066063A1/es unknown
- 2008-04-15 CN CN2008800127274A patent/CN101663033B/zh active Active
- 2008-04-15 EP EP08742913A patent/EP2136803B1/en active Active
- 2008-04-15 JP JP2010504069A patent/JP5498936B2/ja active Active
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