JP2010524486A - β−カテニンを調節するためのＲＮＡアンタゴニスト化合物 - Google Patents

β−カテニンを調節するためのＲＮＡアンタゴニスト化合物 Download PDF

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JP2010524486A
JP2010524486A JP2010504745A JP2010504745A JP2010524486A JP 2010524486 A JP2010524486 A JP 2010524486A JP 2010504745 A JP2010504745 A JP 2010504745A JP 2010504745 A JP2010504745 A JP 2010504745A JP 2010524486 A JP2010524486 A JP 2010524486A
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oligomer
catenin
seq
nucleotide
sequence
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JP2010524486A5 (enExample
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ヴォルム，イェスペル
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Roche Innovation Center Copenhagen AS
Viskase Holdings Inc
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Santaris Pharma AS
Enzon Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2010504745A 2007-05-01 2008-04-30 β−カテニンを調節するためのＲＮＡアンタゴニスト化合物 Pending JP2010524486A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91537107P 2007-05-01 2007-05-01
US2324408P 2008-01-24 2008-01-24
PCT/EP2008/055365 WO2008132234A2 (en) 2007-05-01 2008-04-30 Rna antagonist compounds for the modulation of beta-catenin

Related Child Applications (1)

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JP2014125205A Division JP2014209915A (ja) 2007-05-01 2014-06-18 β−カテニンを調節するためのＲＮＡアンタゴニスト化合物

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JP2010524486A true JP2010524486A (ja) 2010-07-22
JP2010524486A5 JP2010524486A5 (enExample) 2011-07-14

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JP2010504745A Pending JP2010524486A (ja) 2007-05-01 2008-04-30 β−カテニンを調節するためのＲＮＡアンタゴニスト化合物
JP2014125205A Abandoned JP2014209915A (ja) 2007-05-01 2014-06-18 β−カテニンを調節するためのＲＮＡアンタゴニスト化合物

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US (4) US20090005335A1 (enExample)
EP (1) EP2152879B1 (enExample)
JP (2) JP2010524486A (enExample)
KR (1) KR20100024399A (enExample)
CN (1) CN101842483A (enExample)
AU (1) AU2008244211B2 (enExample)
CA (1) CA2685444A1 (enExample)
DK (1) DK2152879T3 (enExample)
EA (1) EA018986B1 (enExample)
ES (1) ES2399371T3 (enExample)
IL (1) IL201865A0 (enExample)
MX (1) MX2009011878A (enExample)
NZ (1) NZ581200A (enExample)
TW (1) TW200848077A (enExample)
WO (1) WO2008132234A2 (enExample)

Cited By (1)

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JP2015503608A (ja) * 2012-01-09 2015-02-02 ノバルティス アーゲー ベータ−カテニン関連疾患を処置するための有機組成物

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DK2152879T3 (da) * 2007-05-01 2013-02-18 Santaris Pharma As RNA antagonistforbindelser til modulering af beta-catenin
EP2490767A4 (en) * 2009-07-15 2013-02-13 Santaris Pharma As OBJECTIVE RNA ANTAGONISTS FOR THE TREATMENT OF LEUKEMIA ON GLI2
DK2591105T3 (en) 2010-07-06 2017-07-31 Dicerna Pharmaceuticals Inc METHODS AND COMPOSITIONS FOR SPECIFIC INHIBITION OF BETA-CATENIN USING DOUBLE-STRENGTH RNA
EP3702460A1 (en) 2010-11-12 2020-09-02 The General Hospital Corporation Polycomb-associated non-coding rnas
US9920317B2 (en) 2010-11-12 2018-03-20 The General Hospital Corporation Polycomb-associated non-coding RNAs
US20140323557A1 (en) * 2011-11-11 2014-10-30 Santaris Pharma A/S Compounds for the modulation of beta-catenin expression and uses thereof
CN104583398A (zh) 2012-05-16 2015-04-29 Rana医疗有限公司 用于调节基因表达的组合物和方法
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
CN104583402A (zh) 2012-05-16 2015-04-29 Rana医疗有限公司 用于调节mecp2表达的组合物和方法
CA2889044A1 (en) 2012-11-15 2014-05-22 Roche Innovation Center Copenhagen A/S Anti apob antisense conjugate compounds
CA2893801A1 (en) * 2013-01-30 2014-08-07 F. Hoffmann-La Roche Ag Lna oligonucleotide carbohydrate conjugates
JP2016518842A (ja) 2013-05-01 2016-06-30 レグルス セラピューティクス インコーポレイテッド マイクロＲＮＡ化合物およびｍｉＲ−１２２をモジュレートする方法
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WO2015026346A1 (en) 2013-08-22 2015-02-26 Hewlett Packard Development Company, L.P. Projective computing system
TWI657755B (zh) * 2013-12-30 2019-05-01 Philip Morris Products S. A. 包含隔熱可燃熱源之煙品
JP2017506259A (ja) 2014-02-03 2017-03-02 イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム・リミテッドＹｉｓｓｕｍ Ｒｅｓｅａｒｃｈ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏｍｐａｎｙ Ｏｆ Ｔｈｅ Ｈｅｂｒｅｗ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｊｅｒｕｓａｌｅｍ Ｌｔｄ． 幹細胞を枯渇させるためのカゼインキナーゼｉ阻害剤の使用
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TWI854980B (zh) 2018-05-08 2024-09-11 美商雷格勒斯治療公司 用於調節mir-122之微小rna化合物及方法
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JP2015503608A (ja) * 2012-01-09 2015-02-02 ノバルティス アーゲー ベータ−カテニン関連疾患を処置するための有機組成物

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EP2152879B1 (en) 2012-11-14
US20120004288A1 (en) 2012-01-05
JP2014209915A (ja) 2014-11-13
WO2008132234A3 (en) 2009-05-07
MX2009011878A (es) 2010-01-25
DK2152879T3 (da) 2013-02-18
EA200971013A1 (ru) 2010-04-30
US20090005335A1 (en) 2009-01-01
US7915401B2 (en) 2011-03-29
US20090203137A1 (en) 2009-08-13
EP2152879A2 (en) 2010-02-17
AU2008244211B2 (en) 2014-08-21
CN101842483A (zh) 2010-09-22
US8039446B2 (en) 2011-10-18
CA2685444A1 (en) 2008-11-06
ES2399371T3 (es) 2013-03-27
KR20100024399A (ko) 2010-03-05
AU2008244211A1 (en) 2008-11-06
NZ581200A (en) 2012-04-27
EA018986B1 (ru) 2013-12-30
IL201865A0 (en) 2011-08-01
US20110086902A1 (en) 2011-04-14
WO2008132234A2 (en) 2008-11-06
WO2008132234A4 (en) 2009-07-09
TW200848077A (en) 2008-12-16

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