EA018986B1 - Соединения-антагонисты рнк для модуляции активности бета-катенина - Google Patents
Соединения-антагонисты рнк для модуляции активности бета-катенина Download PDFInfo
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- EA018986B1 EA018986B1 EA200971013A EA200971013A EA018986B1 EA 018986 B1 EA018986 B1 EA 018986B1 EA 200971013 A EA200971013 A EA 200971013A EA 200971013 A EA200971013 A EA 200971013A EA 018986 B1 EA018986 B1 EA 018986B1
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- Eurasian Patent Office
- Prior art keywords
- oligomer
- beta
- catenin
- nucleic
- sequence
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- MJIBOYFUEIDNPI-HBNMXAOGSA-L zinc 5-[2,3-dihydroxy-5-[(2R,3R,4S,5R,6S)-4,5,6-tris[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]-2-[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxymethyl]oxan-3-yl]oxycarbonylphenoxy]carbonyl-3-hydroxybenzene-1,2-diolate Chemical class [Zn++].Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c([O-])c([O-])c2)c1 MJIBOYFUEIDNPI-HBNMXAOGSA-L 0.000 description 1
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| EP2152879B1 (en) * | 2007-05-01 | 2012-11-14 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of beta-catenin |
| EP2490767A4 (en) | 2009-07-15 | 2013-02-13 | Santaris Pharma As | GLI2 TARGETING TARGET ANTAGONIST FOR THE TREATMENT OF LEUKEMIA |
| ES2873893T3 (es) | 2010-07-06 | 2021-11-04 | Dicerna Pharmaceuticals Inc | Métodos y composiciones para la inhibición específica de beta-catenina por RNA bicatenario |
| EP2638163B1 (en) | 2010-11-12 | 2017-05-17 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| JP2014533280A (ja) * | 2011-11-11 | 2014-12-11 | サンタリス ファーマ アー／エスＳａｎｔａｒｉｓ Ｐｈａｒｍａ Ａ／Ｓ | ベータ−カテニン発現の調節のための化合物およびその使用 |
| HK1205758A1 (en) * | 2012-01-09 | 2015-12-24 | Novartis Ag | Rnai agents to treat beta-catenin related diseases |
| AU2013262709A1 (en) | 2012-05-16 | 2015-01-22 | Rana Therapeutics, Inc. | Compositions and methods for modulating MECP2 expression |
| KR102028784B1 (ko) | 2012-05-16 | 2019-10-04 | 트랜슬레이트 바이오 인코포레이티드 | 유전자 발현을 조절하기 위한 조성물 및 방법 |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| BR112015010116A2 (pt) | 2012-11-15 | 2017-08-22 | Roche Innovation Ct Copenhagen As | COMPOSTOS CONJUGADOS ANTI-SENTIDO ANTI-ApoB |
| HK1215718A1 (zh) * | 2013-01-30 | 2016-09-09 | F. Hoffmann-La Roche Ag | Lna寡核苷酸碳水化合物缀合物 |
| SG10201803157XA (en) | 2013-05-01 | 2018-05-30 | Regulus Therapeutics Inc | Microrna compounds and methods for modulating mir-122 |
| US9506030B2 (en) | 2013-05-01 | 2016-11-29 | Regulus Therapeutics Inc. | Compounds and methods for enhanced cellular uptake |
| EP3036602A4 (en) | 2013-08-22 | 2017-04-12 | Hewlett-Packard Development Company, L.P. | Projective computing system |
| TWI657755B (zh) * | 2013-12-30 | 2019-05-01 | Philip Morris Products S. A. | 包含隔熱可燃熱源之煙品 |
| CN106470699A (zh) | 2014-02-03 | 2017-03-01 | 耶路撒冷希伯来大学的益生研究开发有限公司 | 使用酪蛋白激酶i抑制剂以消耗干细胞的用途 |
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| EP3790972A1 (en) | 2018-05-08 | 2021-03-17 | Regulus Therapeutics Inc. | Galnac conjugated modified oligonucleotide as mir-122 inhibitor having hcv antiviral activity with reduced hyperbilirubinemia side-effect |
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| WO2001000872A1 (en) * | 1999-06-25 | 2001-01-04 | Isis Pharmaceuticals, Inc. | Antisense modulation of beta catenin expression |
| US20030064384A1 (en) * | 2001-04-02 | 2003-04-03 | Mien-Chie Hung | Beta-catenin is a strong and independent prognostic factor for cancer |
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| US4962029A (en) | 1987-10-02 | 1990-10-09 | Cetus Corporation | Covalent oligonucleotide-horseradish peroxidase conjugate |
| US4914210A (en) | 1987-10-02 | 1990-04-03 | Cetus Corporation | Oligonucleotide functionalizing reagents |
| US6617442B1 (en) | 1999-09-30 | 2003-09-09 | Isis Pharmaceuticals, Inc. | Human Rnase H1 and oligonucleotide compositions thereof |
| US20030143586A1 (en) * | 2001-10-12 | 2003-07-31 | Qimin Chao | Genetic hypermutability of plants for gene discovery and diagnosis |
| US7087229B2 (en) | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| JP2006507841A (ja) | 2002-11-14 | 2006-03-09 | ダーマコン， インコーポレイテッド | 機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ |
| US9045518B2 (en) | 2002-11-18 | 2015-06-02 | Santaris Pharma A/S | Amino-LNA, thio-LNA and alpha-L-oxy-LN |
| RU2394041C2 (ru) * | 2003-04-13 | 2010-07-10 | Энзон Фармасьютикалз, Инк. | Полимерные олигонуклеотидные пролекарства |
| US20050136395A1 (en) * | 2003-05-08 | 2005-06-23 | Affymetrix, Inc | Methods for genetic analysis of SARS virus |
| US20070009899A1 (en) * | 2003-10-02 | 2007-01-11 | Mounts William M | Nucleic acid arrays for detecting gene expression in animal models of inflammatory diseases |
| WO2007031091A2 (en) | 2005-09-15 | 2007-03-22 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of p21 ras expression |
| EP1931778A2 (en) | 2005-09-15 | 2008-06-18 | Santaris Pharma A/S | RNA ANTAGONIST COMPOUNDS FOR THE INHIBITION OF APO-Bl00 EXPRESSION |
| JP5731115B2 (ja) | 2006-05-05 | 2015-06-10 | アイシス ファーマシューティカルズ， インコーポレーテッド | 遺伝子発現を調節するための化合物および方法 |
| AU2007296054B2 (en) | 2006-09-15 | 2013-03-28 | Enzon Pharmaceuticals, Inc. | Hindered ester-based biodegradable linkers for oligonucleotide delivery |
| MX2009002856A (es) | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Conjugados polimericos que contienen porciones cargadas positivamente. |
| WO2008053314A2 (en) | 2006-10-30 | 2008-05-08 | Nokia Corporation | Method, apparatus and system providing operator controlled mobility for user equipment |
| EP2152879B1 (en) * | 2007-05-01 | 2012-11-14 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of beta-catenin |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001000872A1 (en) * | 1999-06-25 | 2001-01-04 | Isis Pharmaceuticals, Inc. | Antisense modulation of beta catenin expression |
| US20030064384A1 (en) * | 2001-04-02 | 2003-04-03 | Mien-Chie Hung | Beta-catenin is a strong and independent prognostic factor for cancer |
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| Title |
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| CANTER R.J. ET AL.: "Suppression of beta-Catenin by antisense oligomers augments tumor response to isolated limb perfusion in a rodent model of adenomatous polyposis coli-mutant colon cancer". ANNALS OF SURGICAL ONCOLOGY, SPRINGER-VERLAG, NE, vol. 12, no. 9, 1 September, 2005 (2005-09-01), pages 733-742, XP019369730, ISSN: 1534-4681, the whole document * |
| EMANUELE S. ET AL.: "Sodium Butyrate induces apoptosis in human epatoma cells by a mitochondria/caspase pathway, associated with degradation of beta-catenin, pRb and Bcl-XL". EUROPEAN JOURNAL OF CANCER, vol. 40, 2004, pages 1441-1452, XP002512180, the whole document * |
| GREEN D.W. ET AL.: "Beta-Catenin antisense treatment decreases beta-Catenin expression and tumor growth rate in colon carcinoma xenografts". JOURNAL OF SURGICAL RESEARCH, vol. 101, 2001, pages 16-20, XP002512179, the whole document * |
| HEASMAN J. ET AL.: "Overexpression of Cadherins and underexpression of beta-Catenin inhibit dorsal mesoderm induction in early Xenopus embryos". CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 79, no. 5, 2 December, 1994 (1994-12-02), pages 791-803, XP024244579, ISSN: 0092-8674 [retrieved on 1994-12-02] * |
| KIM K. ET AL.: "Tissue-specific expression of beta-Catenin in normal mesenchyme and uveal melanomas and its effect on invasiveness". EXPERIMENTAL CELL RESEARCH, ACADEMIC PRESS, US, vol. 245, 1 January, 1998 (1998-01-01), pages 79-90, XP002930314, ISSN: 0014-4827, the whole document * |
| LI M. ET AL.: "Antitumor activity and chemosensitization effects of novel antisense oligonucleotides targeting beta-catenin". PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL MEETING, vol. 46, April 2005 (2005-04), page 137, XP001537058, 96th Annual Meeting of the American Association for Cancer Research; Anaheim, CA, USA; April 16-20, 2005 * |
| ROH H. ET AL.: "Suppression of beta-Catenin inhibits the neoplastic growth of APC-mutant colon cancer cells". CANCER RESEARCH, vol. 61, 1 September, 2001 (2001-09-01), pages 6563-6568, XP002512178, the whole document * |
| VEERAMACHANEMI N.K. ET AL.: "Down-regulation of beta catenin inhibits the growth of esophageal carcinoma cells". THE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, vol. 127, January 2004 (2004-01), pages 92-98, XP002512177, the whole document * |
Also Published As
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| MX2009011878A (es) | 2010-01-25 |
| US7915401B2 (en) | 2011-03-29 |
| JP2010524486A (ja) | 2010-07-22 |
| US20110086902A1 (en) | 2011-04-14 |
| US20090005335A1 (en) | 2009-01-01 |
| US20090203137A1 (en) | 2009-08-13 |
| CN101842483A (zh) | 2010-09-22 |
| NZ581200A (en) | 2012-04-27 |
| AU2008244211B2 (en) | 2014-08-21 |
| WO2008132234A3 (en) | 2009-05-07 |
| DK2152879T3 (da) | 2013-02-18 |
| US8039446B2 (en) | 2011-10-18 |
| IL201865A0 (en) | 2011-08-01 |
| WO2008132234A4 (en) | 2009-07-09 |
| ES2399371T3 (es) | 2013-03-27 |
| CA2685444A1 (en) | 2008-11-06 |
| KR20100024399A (ko) | 2010-03-05 |
| EP2152879A2 (en) | 2010-02-17 |
| WO2008132234A2 (en) | 2008-11-06 |
| EA200971013A1 (ru) | 2010-04-30 |
| EP2152879B1 (en) | 2012-11-14 |
| AU2008244211A1 (en) | 2008-11-06 |
| JP2014209915A (ja) | 2014-11-13 |
| TW200848077A (en) | 2008-12-16 |
| US20120004288A1 (en) | 2012-01-05 |
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