JP2010522541A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010522541A5 JP2010522541A5 JP2010500047A JP2010500047A JP2010522541A5 JP 2010522541 A5 JP2010522541 A5 JP 2010522541A5 JP 2010500047 A JP2010500047 A JP 2010500047A JP 2010500047 A JP2010500047 A JP 2010500047A JP 2010522541 A5 JP2010522541 A5 JP 2010522541A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sucralose
- terminus
- tas2r bitter
- tag
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000004376 Sucralose Substances 0.000 claims 9
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 9
- 235000019408 sucralose Nutrition 0.000 claims 9
- 101000633010 Rattus norvegicus Somatostatin Proteins 0.000 claims 6
- 235000019658 bitter taste Nutrition 0.000 claims 6
- 108091005708 gustatory receptors Proteins 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 235000019640 taste Nutrition 0.000 claims 3
- NCYCYZXNIZJOKI-IOUUIBBYSA-N 11-cis-retinal Chemical compound O=C/C=C(\C)/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-IOUUIBBYSA-N 0.000 claims 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 2
- 102000003939 Membrane transport proteins Human genes 0.000 claims 2
- 108090000301 Membrane transport proteins Proteins 0.000 claims 2
- 102000004330 Rhodopsin Human genes 0.000 claims 2
- 108090000820 Rhodopsin Proteins 0.000 claims 2
- 230000009061 membrane transport Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90914307P | 2007-03-30 | 2007-03-30 | |
| US60/909,143 | 2007-03-30 | ||
| US96254907P | 2007-07-30 | 2007-07-30 | |
| US60/962,549 | 2007-07-30 | ||
| PCT/CH2008/000134 WO2008119195A1 (en) | 2007-03-30 | 2008-03-27 | Methods to identify modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010522541A JP2010522541A (ja) | 2010-07-08 |
| JP2010522541A5 true JP2010522541A5 (cg-RX-API-DMAC7.html) | 2011-05-12 |
| JP5465656B2 JP5465656B2 (ja) | 2014-04-09 |
Family
ID=39709251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500047A Active JP5465656B2 (ja) | 2007-03-30 | 2008-03-27 | 調節物質を同定するための方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8187822B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2137322B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5465656B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100016044A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008119195A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8546085B2 (en) | 2008-06-13 | 2013-10-01 | Givaudan Sa | Methods of identifying modulators of the bitter taste receptor TAS2R44 |
| US8603762B2 (en) | 2008-08-07 | 2013-12-10 | Givaudan Sa | Methods to identify modulators of the interaction between dextromethorphan and the bitter taste receptor TAS2R46 |
| WO2010088633A2 (en) * | 2009-02-02 | 2010-08-05 | Chromocell Corporation | Novel cell lines and methods |
| SG11201401268RA (en) | 2011-10-20 | 2014-05-29 | Chromocell Corp | Assays for identifying compounds that modulate bitter taste |
| WO2013072332A1 (en) | 2011-11-14 | 2013-05-23 | Givaudan Sa | Methods of using antagonists of bitter taste receptors |
| US9169311B2 (en) | 2013-03-15 | 2015-10-27 | Applied Food Biotechnology, Inc. | Feline bitter taste receptors and methods |
| ES2797547T3 (es) | 2013-03-15 | 2020-12-02 | Applied Food Biotech Inc | Receptores del sabor amargo felino y métodos. |
| WO2014176336A1 (en) | 2013-04-24 | 2014-10-30 | Chromocell Corporation | Assays for identifying compounds that modulate bitter taste |
| PL2994482T3 (pl) * | 2013-05-10 | 2020-06-01 | Pepsico, Inc. | Test internalizacji receptora smaku |
| HK1218301A1 (zh) | 2013-05-10 | 2017-02-10 | 百事可乐公司 | 作為鑒別潛在味覺調節劑的模型的細胞 |
| CN104713927A (zh) * | 2015-03-16 | 2015-06-17 | 常州大学 | 一种检测食品中三氯蔗糖的电化学方法 |
| US20180372721A1 (en) * | 2015-07-28 | 2018-12-27 | Mars, Incorporated | Screening methods using canine t2r receptors and pet food products and compositions identified using the same |
| EP4493928A1 (en) * | 2022-04-19 | 2025-01-22 | Firmenich Incorporated | Reduction of bitter taste of active pharmaceutical ingredients and related assays and screening methods |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5825980B2 (ja) | 1976-02-12 | 1983-05-31 | ヤマサ醤油株式会社 | サイクリックヌクレオチドの定量法 |
| WO1990005745A1 (en) * | 1988-11-18 | 1990-05-31 | The General Hospital Corporation | A cAMP-RESPONSIVE TRANSCRIPTIONAL ENHANCER BINDING PROTEIN |
| US5462856A (en) | 1990-07-19 | 1995-10-31 | Bunsen Rush Laboratories, Inc. | Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins |
| IL148593A0 (en) | 1999-09-10 | 2002-09-12 | Univ California | T2r, a novel family of taste receptors |
| US6558910B2 (en) | 1999-09-10 | 2003-05-06 | The Regents Of The University Of California | SF, a novel family of taste receptors |
| JP2003530098A (ja) * | 2000-04-07 | 2003-10-14 | セノミックス、インコーポレイテッド | Ｔ２ｒ味覚受容体及びそれをコードする遺伝子 |
| TW201022287A (en) * | 2001-01-03 | 2010-06-16 | Senomyx Inc | T1R taste receptors and genes encoding same |
| US7022488B2 (en) | 2003-02-03 | 2006-04-04 | Senomyx, Inc. | Functional coupling of T1Rs and T2Rs by Gi proteins, and cells-based assays for the identification of T1R and T2R modulators |
| US7413535B2 (en) * | 2001-07-27 | 2008-08-19 | Illinois Tool Works Inc. | Method for manufacturing tamper evident reclosable plastic bags |
| EP2270154A3 (en) | 2002-09-25 | 2011-08-10 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke | Bitter taste receptors |
| AU2003286069A1 (en) * | 2002-12-18 | 2004-07-09 | Givaudan Sa | Chimeric alpha q-gustducin g-proteins |
| EP1644528A2 (en) | 2003-06-19 | 2006-04-12 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, | Variants of human taste receptor genes |
| KR20070053659A (ko) * | 2004-04-20 | 2007-05-25 | 도이체스 인스티튜트 퓌어 에른에룬그스포슝 | 쓴맛 수용체의 작용제 및 그의 용도 |
| US7829299B2 (en) | 2004-11-18 | 2010-11-09 | Deutsches Institut fur Ernahrungforschung Potsdam-Rehbrucke Stiftung des Offentlichen Rechts | Agonists of bitter taste receptors and uses thereof |
| JP4688517B2 (ja) * | 2005-02-15 | 2011-05-25 | 小川香料株式会社 | 高甘味度甘味料の呈味改善剤 |
-
2008
- 2008-03-27 WO PCT/CH2008/000134 patent/WO2008119195A1/en not_active Ceased
- 2008-03-27 US US12/593,155 patent/US8187822B2/en active Active
- 2008-03-27 EP EP08714784A patent/EP2137322B1/en active Active
- 2008-03-27 KR KR1020097022661A patent/KR20100016044A/ko not_active Ceased
- 2008-03-27 JP JP2010500047A patent/JP5465656B2/ja active Active
-
2012
- 2012-05-26 US US13/481,797 patent/US8597896B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010522541A5 (cg-RX-API-DMAC7.html) | ||
| Gillingham et al. | Long coiled-coil proteins and membrane traffic | |
| Elliott et al. | Conserved extracellular cysteine residues and cytoplasmic loop–loop interplay are required for functionality of the heptahelical MLO protein | |
| JP2015519344A5 (cg-RX-API-DMAC7.html) | ||
| JP2003510037A5 (cg-RX-API-DMAC7.html) | ||
| JP2014511698A5 (cg-RX-API-DMAC7.html) | ||
| JP2016519065A5 (cg-RX-API-DMAC7.html) | ||
| Perrone et al. | The thyroid transcription factor 2 (TTF-2) is a promoter-specific DNA-binding independent transcriptional repressor | |
| JP2010529860A5 (cg-RX-API-DMAC7.html) | ||
| JP2015524403A5 (cg-RX-API-DMAC7.html) | ||
| JP2009268467A5 (cg-RX-API-DMAC7.html) | ||
| JP2015525217A5 (cg-RX-API-DMAC7.html) | ||
| JP2015212284A5 (cg-RX-API-DMAC7.html) | ||
| JP2013502226A5 (cg-RX-API-DMAC7.html) | ||
| JP2013078329A5 (cg-RX-API-DMAC7.html) | ||
| Tanentzapf et al. | Multiple factors contribute to integrin-talin interactions in vivo | |
| JP2014525439A5 (cg-RX-API-DMAC7.html) | ||
| JP2017534851A5 (cg-RX-API-DMAC7.html) | ||
| JP2017536104A5 (cg-RX-API-DMAC7.html) | ||
| JP2012501165A5 (cg-RX-API-DMAC7.html) | ||
| RU2016152429A (ru) | Меченый антиген е гепаднавируса и его применение в скрининге противовирусных веществ | |
| Algrain et al. | In the footsteps of sea stars: Deciphering the catalogue of proteins involved in underwater temporary adhesion | |
| Kitada et al. | Hydrophobic tag-assisted liquid-phase synthesis of a growth hormone-inhibiting peptide somatostatin | |
| JP2008519592A5 (cg-RX-API-DMAC7.html) | ||
| Iyer et al. | Stapling monomeric GCN4 peptides allows for DNA binding and enhanced cellular uptake |