JP2010522240A5 - - Google Patents

Info

Publication number

JP2010522240A5

JP2010522240A5 JP2010501103A JP2010501103A JP2010522240A5 JP 2010522240 A5 JP2010522240 A5 JP 2010522240A5 JP 2010501103 A JP2010501103 A JP 2010501103A JP 2010501103 A JP2010501103 A JP 2010501103A JP 2010522240 A5 JP2010522240 A5 JP 2010522240A5

Authority

JP

Japan

Prior art keywords

tetracycline

compound

composition

inhibitor

tetracycline compound

Prior art date

2008-03-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000004098 Tetracycline Substances 0.000 claims 20
• 235000019364 tetracycline Nutrition 0.000 claims 20
• 229960002180 tetracycline Drugs 0.000 claims 18
• 229930101283 tetracycline Natural products 0.000 claims 18
• -1 tetracycline compounds Chemical class 0.000 claims 11
• 150000003522 tetracyclines Chemical class 0.000 claims 9
• 239000000203 mixture Substances 0.000 claims 7
• 229910052751 metal Inorganic materials 0.000 claims 6
• 239000002184 metal Substances 0.000 claims 6
• 238000010521 absorption reaction Methods 0.000 claims 5
• 239000003112 inhibitor Substances 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 150000003839 salts Chemical class 0.000 claims 5
• 150000001875 compounds Chemical class 0.000 claims 4
• 210000000936 intestine Anatomy 0.000 claims 4
• 210000002784 stomach Anatomy 0.000 claims 4
• 230000003110 anti-inflammatory effect Effects 0.000 claims 3
• 231100000252 nontoxic Toxicity 0.000 claims 3
• 230000003000 nontoxic effect Effects 0.000 claims 3
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
• 208000027866 inflammatory disease Diseases 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 230000003637 steroidlike Effects 0.000 claims 2
• 229940040944 tetracyclines Drugs 0.000 claims 2
• NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
• SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 claims 1
• 208000002874 Acne Vulgaris Diseases 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000030767 Autoimmune encephalitis Diseases 0.000 claims 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
• 208000002177 Cataract Diseases 0.000 claims 1
• 239000004099 Chlortetracycline Substances 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
• 201000009906 Meningitis Diseases 0.000 claims 1
• 206010028372 Muscular weakness Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 239000004100 Oxytetracycline Substances 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 206010063837 Reperfusion injury Diseases 0.000 claims 1
• 208000006011 Stroke Diseases 0.000 claims 1
• 206010046851 Uveitis Diseases 0.000 claims 1
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
• 206010000496 acne Diseases 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 239000003242 anti bacterial agent Substances 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 239000011230 binding agent Substances 0.000 claims 1
• 208000029028 brain injury Diseases 0.000 claims 1
• 229910052791 calcium Inorganic materials 0.000 claims 1
• 239000011575 calcium Substances 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims 1
• 229960004475 chlortetracycline Drugs 0.000 claims 1
• CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims 1
• 235000019365 chlortetracycline Nutrition 0.000 claims 1
• 206010009887 colitis Diseases 0.000 claims 1
• 230000001419 dependent effect Effects 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 235000015872 dietary supplement Nutrition 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000007884 disintegrant Substances 0.000 claims 1
• 229960003722 doxycycline Drugs 0.000 claims 1
• 206010015037 epilepsy Diseases 0.000 claims 1
• 230000003054 hormonal effect Effects 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 229910052742 iron Inorganic materials 0.000 claims 1
• 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
• 239000000314 lubricant Substances 0.000 claims 1
• 229910052749 magnesium Inorganic materials 0.000 claims 1
• 239000011777 magnesium Substances 0.000 claims 1
• 229940041616 menthol Drugs 0.000 claims 1
• 150000002739 metals Chemical class 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 230000036473 myasthenia Effects 0.000 claims 1
• 235000020824 obesity Nutrition 0.000 claims 1
• 229960000625 oxytetracycline Drugs 0.000 claims 1
• IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims 1
• 235000019366 oxytetracycline Nutrition 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 201000003068 rheumatic fever Diseases 0.000 claims 1
• 201000004700 rosacea Diseases 0.000 claims 1
• 239000000758 substrate Substances 0.000 claims 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
• IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims 1
• 206010043778 thyroiditis Diseases 0.000 claims 1
• 239000011782 vitamin Substances 0.000 claims 1
• 229940088594 vitamin Drugs 0.000 claims 1
• 229930003231 vitamin Natural products 0.000 claims 1
• 235000013343 vitamin Nutrition 0.000 claims 1
• 150000003722 vitamin derivatives Chemical class 0.000 claims 1
• 229910052725 zinc Inorganic materials 0.000 claims 1
• 239000011701 zinc Substances 0.000 claims 1