JP2010521961A - ウイルス粒子を保存するための方法 - Google Patents

ウイルス粒子を保存するための方法 Download PDF

Info

Publication number
JP2010521961A
JP2010521961A JP2009554082A JP2009554082A JP2010521961A JP 2010521961 A JP2010521961 A JP 2010521961A JP 2009554082 A JP2009554082 A JP 2009554082A JP 2009554082 A JP2009554082 A JP 2009554082A JP 2010521961 A JP2010521961 A JP 2010521961A
Authority
JP
Japan
Prior art keywords
virus
concentration
polyethyleneimine
pei
viral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2009554082A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010521961A5 (cg-RX-API-DMAC7.html
Inventor
ドリュー,ジェフリー
Original Assignee
スタビリテック リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by スタビリテック リミテッド filed Critical スタビリテック リミテッド
Publication of JP2010521961A publication Critical patent/JP2010521961A/ja
Publication of JP2010521961A5 publication Critical patent/JP2010521961A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/295Polyvalent viral antigens; Mixtures of viral and bacterial antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04Preserving or maintaining viable microorganisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04Inactivation or attenuation; Producing viral sub-units
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32111Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32151Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Jellies, Jams, And Syrups (AREA)
JP2009554082A 2007-03-19 2008-03-19 ウイルス粒子を保存するための方法 Withdrawn JP2010521961A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0705245.9A GB0705245D0 (en) 2007-03-19 2007-03-19 Stable biological products
US91722007P 2007-05-10 2007-05-10
PCT/GB2008/000987 WO2008114021A1 (en) 2007-03-19 2008-03-19 Method for preserving viral particles

Publications (2)

Publication Number Publication Date
JP2010521961A true JP2010521961A (ja) 2010-07-01
JP2010521961A5 JP2010521961A5 (cg-RX-API-DMAC7.html) 2011-05-06

Family

ID=38008686

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009554082A Withdrawn JP2010521961A (ja) 2007-03-19 2008-03-19 ウイルス粒子を保存するための方法

Country Status (18)

Country Link
US (1) US8313897B2 (cg-RX-API-DMAC7.html)
EP (1) EP2121898B8 (cg-RX-API-DMAC7.html)
JP (1) JP2010521961A (cg-RX-API-DMAC7.html)
KR (1) KR20100015613A (cg-RX-API-DMAC7.html)
CN (1) CN101636486A (cg-RX-API-DMAC7.html)
AT (1) ATE525455T1 (cg-RX-API-DMAC7.html)
AU (1) AU2008228086A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0808960A2 (cg-RX-API-DMAC7.html)
CA (1) CA2681182A1 (cg-RX-API-DMAC7.html)
DK (1) DK2121898T3 (cg-RX-API-DMAC7.html)
ES (1) ES2370675T3 (cg-RX-API-DMAC7.html)
GB (2) GB0705245D0 (cg-RX-API-DMAC7.html)
HR (1) HRP20110814T1 (cg-RX-API-DMAC7.html)
IL (1) IL200671A0 (cg-RX-API-DMAC7.html)
PL (1) PL2121898T3 (cg-RX-API-DMAC7.html)
RU (1) RU2009138344A (cg-RX-API-DMAC7.html)
SI (1) SI2121898T1 (cg-RX-API-DMAC7.html)
WO (1) WO2008114021A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020066991A1 (ja) * 2018-09-28 2020-04-02 株式会社大塚製薬工場 アカルボース又はスタキオースを含む哺乳動物細胞保存用液

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8097245B2 (en) 2005-12-28 2012-01-17 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
US8460726B2 (en) 2006-12-18 2013-06-11 Advanced Bionutrition Corporation Dry food product containing live probiotic
KR20110079670A (ko) * 2008-09-24 2011-07-07 스타빌리테크 리미티드 슈가 및 폴리에틸렌이민을 사용하여 폴리펩티드를 보존하는 방법
CA2986751A1 (en) 2009-03-27 2010-09-30 Intervet International B.V. Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish
JP5804453B2 (ja) * 2009-05-14 2015-11-04 国立大学法人 東京大学 結晶性ポリオール微粒子及びその調製方法
EP2435554B1 (en) 2009-05-26 2017-07-26 Advanced Bionutrition Corporation Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
CA2785815C (en) * 2010-01-28 2018-04-24 Advanced Bionutrition Corporation Dry glassy composition comprising a bioactive material
GB201002419D0 (en) * 2010-02-12 2010-03-31 Isis Innovation Stable live vaccine formulations
ES2543795T3 (es) 2010-03-31 2015-08-21 Stabilitech Ltd. Estabilización de partículas virales
WO2011121305A2 (en) 2010-03-31 2011-10-06 Stabilitech Ltd. Method for preserving alum adjuvants and alum-adjuvanted vaccines
DK2552478T3 (en) * 2010-03-31 2017-03-27 Stabilitech Ltd EXCIPIENTS FOR STABILIZING VIRUS PARTICLES
NZ607226A (en) 2010-08-13 2015-03-27 Advanced Bionutrition Corp Dry storage stabilizing composition for biological materials
CN103269716B (zh) 2010-12-02 2015-05-27 昂科利蒂克斯生物科技公司 冻干病毒制剂
CA2819246C (en) 2010-12-02 2023-04-25 Oncolytics Biotech Inc. Liquid viral formulations
GB201117233D0 (en) 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
TWI690322B (zh) 2012-10-02 2020-04-11 法商傳斯堅公司 含病毒的調配物及其使用
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
CA3190510A1 (en) 2014-07-16 2016-01-21 Transgene Sa Oncolytic virus for expression of immune checkpoint modulators
US20180028626A1 (en) 2015-02-13 2018-02-01 Transgene Sa Immunotherapeutic vaccine and antibody combination therapy
WO2016131945A1 (en) 2015-02-20 2016-08-25 Transgene Sa Combination product with autophagy modulator
CN108347982A (zh) 2015-07-29 2018-07-31 高级生物营养公司 用于特殊饮食用途的稳定的干燥益生菌组合物
WO2017035664A1 (en) 2015-09-02 2017-03-09 Mcmaster University Enhanced thermal stability for adenoviral vectors through spray drying
CA3023022A1 (en) 2016-05-04 2017-11-09 Transgene Sa Combination therapy with cpg tlr9 ligand
TW201825674A (zh) 2016-09-09 2018-07-16 美商艾斯合顧問有限公司 表現雙特異性接合分子的溶瘤病毒
US20190328869A1 (en) 2016-10-10 2019-10-31 Transgene Sa Immunotherapeutic product and mdsc modulator combination therapy
WO2018091680A1 (en) 2016-11-18 2018-05-24 Transgene Sa Cowpox-based oncolytic vectors
US11626228B2 (en) * 2016-12-22 2023-04-11 Rogers Corporation Multi-layer magneto-dielectric material
WO2018122088A1 (en) 2016-12-28 2018-07-05 Transgene Sa Oncolytic viruses and therapeutic molecules
US10617756B2 (en) 2017-01-05 2020-04-14 Shimojani, LLC Drug regimen for treatment of cerebral ischemia
GB2562241B (en) 2017-05-08 2022-04-06 Stabilitech Biopharma Ltd Vaccine compositions
WO2018234506A2 (en) 2017-06-21 2018-12-27 Transgene Sa PERSONALIZED VACCINE
WO2019020543A1 (en) 2017-07-28 2019-01-31 Transgene Sa ONCOLYTIC VIRUSES EXPRESSING AGENTS TARGETING METABOLIC IMMUNE MODULATORS
US12377142B2 (en) 2018-03-07 2025-08-05 Transgene Recombinant pseudocowpoxvirus
WO2020011754A1 (en) 2018-07-09 2020-01-16 Transgene Chimeric vaccinia viruses
US12263197B2 (en) 2018-10-30 2025-04-01 The University Of Tokyo Oncolytic virus for cancer therapy
AU2019412516A1 (en) 2018-12-28 2021-07-15 Transgene M2-defective poxvirus
WO2020136232A1 (en) 2018-12-28 2020-07-02 Transgene Sa Immunosuppressive m2 protein
EP3996732A4 (en) * 2020-04-14 2022-08-24 Spectrum Solutions, LLC ASSAYS AND METHODS FOR DETECTION OF VIRAL NUCLEIC ACIDS
EP4178605A1 (en) 2020-07-13 2023-05-17 Transgene Treatment of immune depression
KR20230152035A (ko) 2021-02-01 2023-11-02 에쓰티 피에이치아이 테라퓨틱스 컴퍼니 리미티드 표적 단백질 분해 시스템 및 이의 응용
WO2022246323A1 (en) * 2021-05-21 2022-11-24 Takeda Vaccines, Inc. Solid composition, freeze-drying method and glass vial
CN113655057A (zh) * 2021-08-24 2021-11-16 威世药业(如皋)有限公司 一种检测冷冻干燥处理对痘苗病毒毒力影响的设备
WO2023025899A2 (en) 2021-08-26 2023-03-02 Transgene Delivery system for targeting genes of the interferon pathway
CN114392237B (zh) * 2021-12-28 2024-02-02 上海允英生物医药科技有限公司 一种冻干病毒制剂及其制备方法
WO2023213764A1 (en) 2022-05-02 2023-11-09 Transgene Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf
WO2023213763A1 (en) 2022-05-02 2023-11-09 Transgene Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab
JP2025523573A (ja) 2022-07-01 2025-07-23 トランジェーヌ サーファクタントタンパク質-dとtnfsfのメンバーを含んでなる融合タンパク質
KR20250052416A (ko) 2022-08-18 2025-04-18 트랜스진 키메라 폭스바이러스

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5459698A (en) * 1997-11-26 1999-06-15 Universal Preservation Technologies, Inc. Preservation of sensitive biological samples by vitrification
CA2400318C (en) 2000-02-08 2005-06-14 Allergan, Inc. Botulinum toxin pharmaceutical compositions
US20040110267A1 (en) * 2000-12-15 2004-06-10 Stratagene Room temperature stable competent cells
GB0502661D0 (en) * 2005-02-09 2005-03-16 Stabilitech Ltd A desiccated product
RS20080138A (sr) * 2005-10-07 2009-07-15 Pfizer Products Inc., Vakcine i metode lečenja influence kod canina

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020066991A1 (ja) * 2018-09-28 2020-04-02 株式会社大塚製薬工場 アカルボース又はスタキオースを含む哺乳動物細胞保存用液

Also Published As

Publication number Publication date
SI2121898T1 (sl) 2012-02-29
PL2121898T3 (pl) 2012-02-29
RU2009138344A (ru) 2011-04-27
ATE525455T1 (de) 2011-10-15
GB0915291D0 (en) 2009-10-07
IL200671A0 (en) 2011-08-01
GB2459611A (en) 2009-11-04
US20100015177A1 (en) 2010-01-21
CN101636486A (zh) 2010-01-27
US8313897B2 (en) 2012-11-20
WO2008114021A1 (en) 2008-09-25
GB0705245D0 (en) 2007-04-25
HRP20110814T1 (hr) 2012-01-31
GB2459611B (en) 2011-02-16
KR20100015613A (ko) 2010-02-12
CA2681182A1 (en) 2008-09-25
AU2008228086A1 (en) 2008-09-25
DK2121898T3 (da) 2012-01-09
EP2121898B1 (en) 2011-09-21
BRPI0808960A2 (pt) 2014-08-26
EP2121898B8 (en) 2012-02-15
EP2121898A1 (en) 2009-11-25
ES2370675T3 (es) 2011-12-21

Similar Documents

Publication Publication Date Title
US8313897B2 (en) Method for preserving viral particles
JP5960120B2 (ja) ウイルス粒子の安定化
DK2552478T3 (en) EXCIPIENTS FOR STABILIZING VIRUS PARTICLES
CN108025081B (zh) 包含腺病毒载体的药物组合物
JP7051132B2 (ja) ワクチン接種または遺伝子治療のための効率的なウイルスベクターベースの組成物を得るための新規方法
JP2019163271A (ja) 熱安定性ワクチン製剤及びマイクロニードル
JP2005517394A (ja) ウイルス保存のための組成物
JP7090089B2 (ja) 新規配合物
CN103841963B (zh) 用于生物产品特别是疫苗的真空辅助保存
BR112020008482A2 (pt) formulações estáveis de citomegalovírus
KR20150137085A (ko) 안정화된 fmdv 캡시드
US20200129610A1 (en) Compositions and methods for production of cold-chain vaccines
AU2024273927A1 (en) Formulations to stabilize virus-based therapeutics
JP2022141602A (ja) 組換え麻疹ウイルス

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110315

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20110315

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110830

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20120824