CN101636486A - 保存病毒颗粒的方法 - Google Patents

保存病毒颗粒的方法 Download PDF

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Publication number
CN101636486A
CN101636486A CN200880008926A CN200880008926A CN101636486A CN 101636486 A CN101636486 A CN 101636486A CN 200880008926 A CN200880008926 A CN 200880008926A CN 200880008926 A CN200880008926 A CN 200880008926A CN 101636486 A CN101636486 A CN 101636486A
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China
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virus
concentration
pei
sugar
polymine
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CN200880008926A
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Chinese (zh)
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杰弗里·德鲁
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Stabilitech Ltd
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Stabilitech Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32151—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Jellies, Jams, And Syrups (AREA)
CN200880008926A 2007-03-19 2008-03-19 保存病毒颗粒的方法 Pending CN101636486A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0705245.9 2007-03-19
GBGB0705245.9A GB0705245D0 (en) 2007-03-19 2007-03-19 Stable biological products
US60/917,220 2007-05-10

Publications (1)

Publication Number Publication Date
CN101636486A true CN101636486A (zh) 2010-01-27

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ID=38008686

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CN200880008926A Pending CN101636486A (zh) 2007-03-19 2008-03-19 保存病毒颗粒的方法

Country Status (18)

Country Link
US (1) US8313897B2 (cg-RX-API-DMAC7.html)
EP (1) EP2121898B8 (cg-RX-API-DMAC7.html)
JP (1) JP2010521961A (cg-RX-API-DMAC7.html)
KR (1) KR20100015613A (cg-RX-API-DMAC7.html)
CN (1) CN101636486A (cg-RX-API-DMAC7.html)
AT (1) ATE525455T1 (cg-RX-API-DMAC7.html)
AU (1) AU2008228086A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0808960A2 (cg-RX-API-DMAC7.html)
CA (1) CA2681182A1 (cg-RX-API-DMAC7.html)
DK (1) DK2121898T3 (cg-RX-API-DMAC7.html)
ES (1) ES2370675T3 (cg-RX-API-DMAC7.html)
GB (2) GB0705245D0 (cg-RX-API-DMAC7.html)
HR (1) HRP20110814T1 (cg-RX-API-DMAC7.html)
IL (1) IL200671A0 (cg-RX-API-DMAC7.html)
PL (1) PL2121898T3 (cg-RX-API-DMAC7.html)
RU (1) RU2009138344A (cg-RX-API-DMAC7.html)
SI (1) SI2121898T1 (cg-RX-API-DMAC7.html)
WO (1) WO2008114021A1 (cg-RX-API-DMAC7.html)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102892427A (zh) * 2010-03-31 2013-01-23 稳定性科技有限公司 用于稳定病毒颗粒、多肽或生物材料的赋形剂
CN102892424A (zh) * 2010-03-31 2013-01-23 稳定性科技有限公司 病毒颗粒的稳定
TWI732298B (zh) * 2018-09-28 2021-07-01 日商大塚製藥工場股份有限公司 包含阿卡波糖或水蘇糖之哺乳動物細胞保存用液
CN113655057A (zh) * 2021-08-24 2021-11-16 威世药业（如皋）有限公司 一种检测冷冻干燥处理对痘苗病毒毒力影响的设备
CN114392237A (zh) * 2021-12-28 2022-04-26 上海允英生物医药科技有限公司 一种冻干病毒制剂及其制备方法

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US8097245B2 (en) 2005-12-28 2012-01-17 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
US8968721B2 (en) 2005-12-28 2015-03-03 Advanced Bionutrition Corporation Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
US8460726B2 (en) 2006-12-18 2013-06-11 Advanced Bionutrition Corporation Dry food product containing live probiotic
KR20110079670A (ko) * 2008-09-24 2011-07-07 스타빌리테크 리미티드 슈가 및 폴리에틸렌이민을 사용하여 폴리펩티드를 보존하는 방법
CA2986751A1 (en) 2009-03-27 2010-09-30 Intervet International B.V. Microparticulated vaccines for the oral or nasal vaccination and boostering of animals including fish
JP5804453B2 (ja) * 2009-05-14 2015-11-04 国立大学法人 東京大学 結晶性ポリオール微粒子及びその調製方法
EP2435554B1 (en) 2009-05-26 2017-07-26 Advanced Bionutrition Corporation Stable dry powder composition comprising biologically active microorganisms and/or bioactive materials and methods of making
US9504750B2 (en) 2010-01-28 2016-11-29 Advanced Bionutrition Corporation Stabilizing composition for biological materials
CA2785815C (en) * 2010-01-28 2018-04-24 Advanced Bionutrition Corporation Dry glassy composition comprising a bioactive material
GB201002419D0 (en) * 2010-02-12 2010-03-31 Isis Innovation Stable live vaccine formulations
WO2011121305A2 (en) 2010-03-31 2011-10-06 Stabilitech Ltd. Method for preserving alum adjuvants and alum-adjuvanted vaccines
NZ607226A (en) 2010-08-13 2015-03-27 Advanced Bionutrition Corp Dry storage stabilizing composition for biological materials
CN103269716B (zh) 2010-12-02 2015-05-27 昂科利蒂克斯生物科技公司 冻干病毒制剂
CA2819246C (en) 2010-12-02 2023-04-25 Oncolytics Biotech Inc. Liquid viral formulations
GB201117233D0 (en) 2011-10-05 2011-11-16 Stabilitech Ltd Stabilisation of polypeptides
TWI690322B (zh) 2012-10-02 2020-04-11 法商傳斯堅公司 含病毒的調配物及其使用
GB201406569D0 (en) 2014-04-11 2014-05-28 Stabilitech Ltd Vaccine compositions
CA3190510A1 (en) 2014-07-16 2016-01-21 Transgene Sa Oncolytic virus for expression of immune checkpoint modulators
US20180028626A1 (en) 2015-02-13 2018-02-01 Transgene Sa Immunotherapeutic vaccine and antibody combination therapy
WO2016131945A1 (en) 2015-02-20 2016-08-25 Transgene Sa Combination product with autophagy modulator
CN108347982A (zh) 2015-07-29 2018-07-31 高级生物营养公司 用于特殊饮食用途的稳定的干燥益生菌组合物
WO2017035664A1 (en) 2015-09-02 2017-03-09 Mcmaster University Enhanced thermal stability for adenoviral vectors through spray drying
CA3023022A1 (en) 2016-05-04 2017-11-09 Transgene Sa Combination therapy with cpg tlr9 ligand
TW201825674A (zh) 2016-09-09 2018-07-16 美商艾斯合顧問有限公司 表現雙特異性接合分子的溶瘤病毒
US20190328869A1 (en) 2016-10-10 2019-10-31 Transgene Sa Immunotherapeutic product and mdsc modulator combination therapy
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US11626228B2 (en) * 2016-12-22 2023-04-11 Rogers Corporation Multi-layer magneto-dielectric material
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US10617756B2 (en) 2017-01-05 2020-04-14 Shimojani, LLC Drug regimen for treatment of cerebral ischemia
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US12263197B2 (en) 2018-10-30 2025-04-01 The University Of Tokyo Oncolytic virus for cancer therapy
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EP3996732A4 (en) * 2020-04-14 2022-08-24 Spectrum Solutions, LLC ASSAYS AND METHODS FOR DETECTION OF VIRAL NUCLEIC ACIDS
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KR20230152035A (ko) 2021-02-01 2023-11-02 에쓰티 피에이치아이 테라퓨틱스 컴퍼니 리미티드 표적 단백질 분해 시스템 및 이의 응용
WO2022246323A1 (en) * 2021-05-21 2022-11-24 Takeda Vaccines, Inc. Solid composition, freeze-drying method and glass vial
WO2023025899A2 (en) 2021-08-26 2023-03-02 Transgene Delivery system for targeting genes of the interferon pathway
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JP2025523573A (ja) 2022-07-01 2025-07-23 トランジェーヌ サーファクタントタンパク質－ｄとｔｎｆｓｆのメンバーを含んでなる融合タンパク質
KR20250052416A (ko) 2022-08-18 2025-04-18 트랜스진 키메라 폭스바이러스

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102892427A (zh) * 2010-03-31 2013-01-23 稳定性科技有限公司 用于稳定病毒颗粒、多肽或生物材料的赋形剂
CN102892424A (zh) * 2010-03-31 2013-01-23 稳定性科技有限公司 病毒颗粒的稳定
CN102892424B (zh) * 2010-03-31 2015-04-01 稳定性科技有限公司 病毒颗粒的稳定
TWI732298B (zh) * 2018-09-28 2021-07-01 日商大塚製藥工場股份有限公司 包含阿卡波糖或水蘇糖之哺乳動物細胞保存用液
CN113655057A (zh) * 2021-08-24 2021-11-16 威世药业（如皋）有限公司 一种检测冷冻干燥处理对痘苗病毒毒力影响的设备
CN114392237A (zh) * 2021-12-28 2022-04-26 上海允英生物医药科技有限公司 一种冻干病毒制剂及其制备方法
CN114392237B (zh) * 2021-12-28 2024-02-02 上海允英生物医药科技有限公司 一种冻干病毒制剂及其制备方法

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Publication number Publication date
SI2121898T1 (sl) 2012-02-29
PL2121898T3 (pl) 2012-02-29
RU2009138344A (ru) 2011-04-27
ATE525455T1 (de) 2011-10-15
GB0915291D0 (en) 2009-10-07
IL200671A0 (en) 2011-08-01
GB2459611A (en) 2009-11-04
US20100015177A1 (en) 2010-01-21
US8313897B2 (en) 2012-11-20
WO2008114021A1 (en) 2008-09-25
GB0705245D0 (en) 2007-04-25
JP2010521961A (ja) 2010-07-01
HRP20110814T1 (hr) 2012-01-31
GB2459611B (en) 2011-02-16
KR20100015613A (ko) 2010-02-12
CA2681182A1 (en) 2008-09-25
AU2008228086A1 (en) 2008-09-25
DK2121898T3 (da) 2012-01-09
EP2121898B1 (en) 2011-09-21
BRPI0808960A2 (pt) 2014-08-26
EP2121898B8 (en) 2012-02-15
EP2121898A1 (en) 2009-11-25
ES2370675T3 (es) 2011-12-21

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Application publication date: 20100127