JP2010520313A - 銀含有発泡体 - Google Patents
銀含有発泡体 Download PDFInfo
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- JP2010520313A JP2010520313A JP2009551113A JP2009551113A JP2010520313A JP 2010520313 A JP2010520313 A JP 2010520313A JP 2009551113 A JP2009551113 A JP 2009551113A JP 2009551113 A JP2009551113 A JP 2009551113A JP 2010520313 A JP2010520313 A JP 2010520313A
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- foam
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- 239000006260 foam Substances 0.000 title claims abstract description 61
- 229910052709 silver Inorganic materials 0.000 title claims description 35
- 239000004332 silver Substances 0.000 title claims description 35
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims description 32
- 239000000203 mixture Substances 0.000 claims abstract description 40
- 238000000034 method Methods 0.000 claims abstract description 25
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229920005830 Polyurethane Foam Polymers 0.000 claims abstract description 18
- 239000011496 polyurethane foam Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229920000570 polyether Polymers 0.000 claims abstract description 10
- 239000004094 surface-active agent Substances 0.000 claims abstract description 10
- 239000004721 Polyphenylene oxide Substances 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 5
- 229920001296 polysiloxane Polymers 0.000 claims description 36
- 230000000844 anti-bacterial effect Effects 0.000 claims description 19
- 239000008346 aqueous phase Substances 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 10
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical group [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 9
- YPNVIBVEFVRZPJ-UHFFFAOYSA-L silver sulfate Chemical compound [Ag+].[Ag+].[O-]S([O-])(=O)=O YPNVIBVEFVRZPJ-UHFFFAOYSA-L 0.000 claims description 9
- 229910000367 silver sulfate Inorganic materials 0.000 claims description 9
- 239000003054 catalyst Substances 0.000 claims description 8
- 239000001888 Peptone Substances 0.000 claims description 6
- 108010080698 Peptones Proteins 0.000 claims description 6
- 235000019319 peptone Nutrition 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 5
- 241000191967 Staphylococcus aureus Species 0.000 claims description 5
- 229910052697 platinum Inorganic materials 0.000 claims description 5
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- ZXSQEZNORDWBGZ-UHFFFAOYSA-N 1,3-dihydropyrrolo[2,3-b]pyridin-2-one Chemical compound C1=CN=C2NC(=O)CC2=C1 ZXSQEZNORDWBGZ-UHFFFAOYSA-N 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 claims description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 230000001186 cumulative effect Effects 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 125000000524 functional group Chemical group 0.000 claims description 3
- CQLFBEKRDQMJLZ-UHFFFAOYSA-M silver acetate Chemical compound [Ag+].CC([O-])=O CQLFBEKRDQMJLZ-UHFFFAOYSA-M 0.000 claims description 3
- 229940071536 silver acetate Drugs 0.000 claims description 3
- 229910001958 silver carbonate Inorganic materials 0.000 claims description 3
- LKZMBDSASOBTPN-UHFFFAOYSA-L silver carbonate Substances [Ag].[O-]C([O-])=O LKZMBDSASOBTPN-UHFFFAOYSA-L 0.000 claims description 3
- 229940071575 silver citrate Drugs 0.000 claims description 3
- FJOLTQXXWSRAIX-UHFFFAOYSA-K silver phosphate Chemical compound [Ag+].[Ag+].[Ag+].[O-]P([O-])([O-])=O FJOLTQXXWSRAIX-UHFFFAOYSA-K 0.000 claims description 3
- 229940019931 silver phosphate Drugs 0.000 claims description 3
- 229910000161 silver phosphate Inorganic materials 0.000 claims description 3
- LMEWRZSPCQHBOB-UHFFFAOYSA-M silver;2-hydroxypropanoate Chemical compound [Ag+].CC(O)C([O-])=O LMEWRZSPCQHBOB-UHFFFAOYSA-M 0.000 claims description 3
- 238000010561 standard procedure Methods 0.000 claims description 3
- QUTYHQJYVDNJJA-UHFFFAOYSA-K trisilver;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Ag+].[Ag+].[Ag+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QUTYHQJYVDNJJA-UHFFFAOYSA-K 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 2
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- 208000006820 Arthralgia Diseases 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 229920002023 Pluronic® F 87 Polymers 0.000 description 2
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 2
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- 230000000903 blocking effect Effects 0.000 description 2
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- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000004831 Hot glue Substances 0.000 description 1
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- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical group O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 208000024764 elbow pain Diseases 0.000 description 1
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- 238000011417 postcuring Methods 0.000 description 1
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- 229920002631 room-temperature vulcanizate silicone Polymers 0.000 description 1
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- 229940100890 silver compound Drugs 0.000 description 1
- 150000003379 silver compounds Chemical class 0.000 description 1
- 229960003600 silver sulfadiazine Drugs 0.000 description 1
- VYNIYUVRASGDDE-UHFFFAOYSA-N silver zirconium Chemical compound [Zr].[Ag] VYNIYUVRASGDDE-UHFFFAOYSA-N 0.000 description 1
- UEJSSZHHYBHCEL-UHFFFAOYSA-N silver(1+) sulfadiazinate Chemical compound [Ag+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CC=N1 UEJSSZHHYBHCEL-UHFFFAOYSA-N 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
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- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
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- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
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- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Polyurethanes Or Polyureas (AREA)
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- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
(a)界面活性剤を含む水相を提供する段階;
(b)二つ以上の官能基を有するイソシアネート末端ポリエーテルを提供する段階;
(c)前記水相と前記イソシアネート末端ポリエーテルとを混合し、得られる混合物を発泡体が得られる型又は連続ウェブに直ちに移動する段階;
(d)水分含有量が最大10重量%になるまで、好ましくは最大8重量%になるまで、さらに好ましくは最大5重量%になるまで、前記発泡体を乾燥する段階。
発泡体製造プロセスのための水相は、非イオン性界面活性剤Pluronic F87、硫酸銀、及び活性炭素を溶解/分散することによって調製された。水相内のこれらの構成成分の最終的な濃度は、Pluronic F87が0.5重量%、及び硫酸銀が2.2重量%であった。溶解された硫酸銀の濃度は0.8重量%であり、残りの硫酸銀は水相に分散された。
例1において製造された発泡体製品のサンプル、サンプルA、及び二つの商業的に入手可能な製品、国際公開2002/062403号に記載されるもの(サンプルB)、及び米国特許第5,681,575号明細書及び米国特許第5,837,275号明細書に記載されるもの(サンプルC)、は6×6cmの試験片に切断され、重量が測定された。その後、試験片は過剰量の水道水に浸漬された。3時間後試験片は再度重量が測定された。得られた結果は表1に示される。
直径20mmの円形サンプルは、例1により製造されたサンプルAで示される材料、及び二つの商業的に入手可能な製品、国際公開2002/062403号に記載されるもの(サンプルB)、及び米国特許第5,681,575号明細書及び米国特許第5,837,275号明細書に記載されるもの(サンプルC)、から打ち抜かれた。図3は銀の放出を測定する装置、すなわちどちらもBecton Dickinson Labwareの、FalconTM6ウェルMultiwellユニット(2)及び対応する細胞培養インサート(4)、を開示する。細胞培養インサート(4)の底部の拡散膜は取り除かれ、防水ポリアミドフィルムで置き換えられた。直径12mmの開口(6)は底部フィルムから打ち抜かれた。乾燥サンプル(10)は開口(6)上の細胞培養インサート(4)内に配置された。前記サンプルを圧縮し、かつ底部フィルムに固定するために、ステンレス鋼でできた重り(12)、重さ15g及び直径20mm、がサンプル(10)上に準備された。
抗菌活性はASTM E 2149基準法に基づく方法を用いて測定された。例1において得られた銀発泡体のサンプル(直径20mm)及び参照材料(国際公開2002/062403号に記載されるもの(サンプルB)、米国特許第5,681,575号明細書及び米国特許第5,837,275号明細書に記載されるもの(サンプルC)、及びコントロールサンプル;例1に記載されるような発泡体であるが銀を全く含有しない)は、バクテリア(Staphylococcus aureus、又はPseudomonas aeruginosa)、模擬創傷液体(simulated wound fluid:SWF)、すなわち(ウシ胎仔血清とペプトン水(0.9%NaClと0.5%ペプトン)との1:1溶液)、10mlと共にフラスコ中に配置された。フラスコは約10秒間振とうされ、その後フラスコは35±2℃で培養された。製品の抗菌効果を測定するため、サンプルは最大8日間24時間毎に取り出された。サンプル中の生存細胞の数は標準的な平板法算定を用いて決定された。
3 ゲル層
5 液体不浸透性層
Claims (10)
- (a)界面活性剤を含む水相を提供する段階;
(b)二つ以上の官能基を有するイソシアネート末端ポリエーテルを提供する段階;
(c)前記水相と前記イソシアネート末端ポリエーテルとを混合し、得られる混合物を発泡体が得られる型に直ちに移動する段階;
(d)水分含有量が最大10重量%になるまで、好ましくは最大8重量%になるまで、さらに好ましくは最大5重量%になるまで、前記発泡体を乾燥する段階;を含み、
前記段階(a)における水相が硫酸銀、クエン酸銀、酢酸銀、炭酸銀、乳酸銀、及びリン酸銀、又はこれらの塩の混合物からなる群から選択される銀塩を含み、前記銀塩の一部は前記水相に分散されることを特徴とする、抗菌性かつ親水性のポリウレタン発泡体の製造方法。 - 段階(c)において混合物が加えられる前に前記型が工程紙で裏打ちされ、前記工程紙は乾燥段階(d)の前に取り除かれる、請求項1に記載の方法。
- 一つ以上のゲル形成シリコーン成分が触媒の存在下で段階(d)の後得られる発泡体の一つの表面に加えられ、その後前記ゲル形成成分が硬化によって架橋シリコーンゲルを形成する、請求項1又は2に記載の方法。
- 前記触媒が白金錯体である、請求項3に記載の方法。
- 30から1000μmの間の微細孔サイズを有し、少なくとも一つの銀塩を含み、発泡体が請求項1から4の何れか一項に記載の方法によって製造される、抗菌性かつ親水性ポリウレタン発泡体。
- 48時間後の発泡体の1cm2あたりの累積された銀放出量は少なくとも0.2mg/cm2であり、好ましくは少なくとも0.25mg/cm2であり、最も好ましくは少なくとも0.30mg/cm2である、請求項5に記載の発泡体。
- 72時間後の発泡体の1cm2あたりの累積された銀放出量は少なくとも0.3mg/cm2であり、好ましくは少なくとも0.35mg/cm2であり、最も好ましくは少なくとも0.40mg/cm2である、請求項6に記載の発泡体。
- 48時間後、好ましくは96時間後、最も好ましくは120時間後の累積された銀放出量は最大0.80mg/cm2である、請求項6又は7に記載の発泡体。
- 直径20mm及び厚さ5mmの前記発泡体の円形サンプルが、ASTM E 2149基準法に従って35℃±2℃の温度において、10mlのバクテリア含有模擬創傷液体(ウシ胎仔血清とペプトン水(0.9重量%NaClと0.5重量%ペプトンとを含む水溶液)との1:1溶液)に曝されたとき、Pseudomonas aeruginosaの生存細胞数を72時間で106から102未満に低減することができ、及びStaphylococcus aureusの生存細胞数を120時間で106から102未満に低減することができる、請求項5に記載の発泡体。
- 請求項5から9の何れか一項に記載の発泡体を含む創傷ドレッシング。
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