JP2010520308A5 - - Google Patents
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- JP2010520308A5 JP2010520308A5 JP2009552887A JP2009552887A JP2010520308A5 JP 2010520308 A5 JP2010520308 A5 JP 2010520308A5 JP 2009552887 A JP2009552887 A JP 2009552887A JP 2009552887 A JP2009552887 A JP 2009552887A JP 2010520308 A5 JP2010520308 A5 JP 2010520308A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical formulation
- alkyl
- compound according
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 27
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 208000035475 disorder Diseases 0.000 claims 7
- 102100036832 Steroid hormone receptor ERR1 Human genes 0.000 claims 6
- 101710205336 Steroid hormone receptor ERR1 Proteins 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 238000006467 substitution reaction Methods 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 4
- 230000003287 optical effect Effects 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 206010003246 arthritis Diseases 0.000 claims 3
- 210000000845 cartilage Anatomy 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 239000000883 anti-obesity agent Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229940125425 inverse agonist Drugs 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000025940 Back injury Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010006458 Bronchitis chronic Diseases 0.000 claims 1
- 229940124802 CB1 antagonist Drugs 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010007710 Cartilage injury Diseases 0.000 claims 1
- 206010008690 Chondrocalcinosis pyrophosphate Diseases 0.000 claims 1
- 208000005243 Chondrosarcoma Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 229940123900 Direct thrombin inhibitor Drugs 0.000 claims 1
- 206010058314 Dysplasia Diseases 0.000 claims 1
- 102000030595 Glucokinase Human genes 0.000 claims 1
- 108010021582 Glucokinase Proteins 0.000 claims 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
- 201000005569 Gout Diseases 0.000 claims 1
- 208000004575 Infectious Arthritis Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 229940127470 Lipase Inhibitors Drugs 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000010191 Osteitis Deformans Diseases 0.000 claims 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000027868 Paget disease Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000007048 Polymyalgia Rheumatica Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 208000033464 Reiter syndrome Diseases 0.000 claims 1
- 208000013200 Stress disease Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 239000003524 antilipemic agent Substances 0.000 claims 1
- 229940125710 antiobesity agent Drugs 0.000 claims 1
- 229960004676 antithrombotic agent Drugs 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 230000022159 cartilage development Effects 0.000 claims 1
- 208000002849 chondrocalcinosis Diseases 0.000 claims 1
- 208000007451 chronic bronchitis Diseases 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000019439 energy homeostasis Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 208000027202 mammary Paget disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000000407 monoamine reuptake Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 claims 1
- 229960001243 orlistat Drugs 0.000 claims 1
- 230000011164 ossification Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 230000000010 osteolytic effect Effects 0.000 claims 1
- 208000005368 osteomalacia Diseases 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000002574 reactive arthritis Diseases 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- JZCPYUJPEARBJL-UHFFFAOYSA-N rimonabant Chemical compound CC=1C(C(=O)NN2CCCCC2)=NN(C=2C(=CC(Cl)=CC=2)Cl)C=1C1=CC=C(Cl)C=C1 JZCPYUJPEARBJL-UHFFFAOYSA-N 0.000 claims 1
- 229960003015 rimonabant Drugs 0.000 claims 1
- 201000001223 septic arthritis Diseases 0.000 claims 1
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 claims 1
- 229960004425 sibutramine Drugs 0.000 claims 1
- 239000003868 thrombin inhibitor Substances 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- FZKBWHATZXQBRD-UKWGHVSLSA-N CCOc(cc(/C=C1\SC(N(C2)CC2C(O)=O)=NC1=O)cc1)c1Oc(c(C(F)(F)F)c1)ccc1C#N Chemical compound CCOc(cc(/C=C1\SC(N(C2)CC2C(O)=O)=NC1=O)cc1)c1Oc(c(C(F)(F)F)c1)ccc1C#N FZKBWHATZXQBRD-UKWGHVSLSA-N 0.000 description 4
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89346407P | 2007-03-07 | 2007-03-07 | |
| PCT/US2008/056029 WO2008109737A1 (en) | 2007-03-07 | 2008-03-06 | Substituted phenoxy aminothiazolones as estrogen related receptor-alpha modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010520308A JP2010520308A (ja) | 2010-06-10 |
| JP2010520308A5 true JP2010520308A5 (OSRAM) | 2011-03-24 |
Family
ID=39530136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009552887A Pending JP2010520308A (ja) | 2007-03-07 | 2008-03-06 | エストロゲン関連受容体−アルファモジュレーターとしての置換フェノキシアミノチアゾロン |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8580832B2 (OSRAM) |
| EP (1) | EP2134698A1 (OSRAM) |
| JP (1) | JP2010520308A (OSRAM) |
| KR (1) | KR20090128454A (OSRAM) |
| CN (1) | CN101679327A (OSRAM) |
| AR (1) | AR065657A1 (OSRAM) |
| AU (1) | AU2008222755B2 (OSRAM) |
| BR (1) | BRPI0808776A2 (OSRAM) |
| CA (1) | CA2680212A1 (OSRAM) |
| CL (1) | CL2008000667A1 (OSRAM) |
| EA (1) | EA016887B1 (OSRAM) |
| IL (1) | IL200759A0 (OSRAM) |
| MX (1) | MX2009009520A (OSRAM) |
| NZ (1) | NZ579417A (OSRAM) |
| TW (1) | TW200902506A (OSRAM) |
| UA (1) | UA98484C2 (OSRAM) |
| WO (1) | WO2008109737A1 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| AU2008297877C1 (en) | 2007-09-14 | 2013-11-07 | Addex Pharma S.A. | 1,3-disubstituted-4-phenyl-1 H-pyridin-2-ones |
| EP2203439B1 (en) | 2007-09-14 | 2011-01-26 | Ortho-McNeil-Janssen Pharmaceuticals, Inc. | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-ý1, 4'¨bipyridinyl-2'-ones |
| CN101848893B (zh) | 2007-09-14 | 2012-06-06 | 奥梅-杨森制药有限公司 | 1,3-二取代的4-(芳基-x-苯基)-1h-吡啶-2-酮 |
| CN101861316B (zh) | 2007-11-14 | 2013-08-21 | 奥梅-杨森制药有限公司 | 咪唑并[1,2-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途 |
| MX2011002042A (es) | 2008-09-02 | 2011-06-20 | Ortho Mcneil Janssen Pharm | Derivados de 3-azabiciclo[3.1.o]hexilo como moduladores de los receptores del glutamato metabotropico. |
| ES2466341T3 (es) | 2008-10-16 | 2014-06-10 | Janssen Pharmaceuticals, Inc. | Derivados de indol y benzomorfolina como moduladores de receptores de glutamato metabotrópicos |
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| US5037842A (en) | 1990-06-05 | 1991-08-06 | Pfizer Inc. | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents |
| JP2001072592A (ja) * | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
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| DE10131899A1 (de) | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
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| WO2006004555A1 (en) | 2004-06-30 | 2006-01-12 | Paysetter Pte Ltd | System and method for facilitating transfer of physical money and/or credit |
| AU2005275279A1 (en) * | 2004-07-14 | 2006-02-23 | Janssen Pharmaceutica N.V. | Arylidenes for the treatment of estrogen related receptor-alpha mediated diseases |
| CA2583271C (en) | 2004-10-22 | 2014-05-20 | Exelixis, Inc. | Benzylthiazolone inhibitors of estrogen-related receptors (err) |
-
2008
- 2008-03-06 JP JP2009552887A patent/JP2010520308A/ja active Pending
- 2008-03-06 AU AU2008222755A patent/AU2008222755B2/en not_active Expired - Fee Related
- 2008-03-06 US US12/043,311 patent/US8580832B2/en not_active Expired - Fee Related
- 2008-03-06 UA UAA200910122A patent/UA98484C2/ru unknown
- 2008-03-06 WO PCT/US2008/056029 patent/WO2008109737A1/en not_active Ceased
- 2008-03-06 TW TW097107931A patent/TW200902506A/zh unknown
- 2008-03-06 BR BRPI0808776-8A patent/BRPI0808776A2/pt not_active IP Right Cessation
- 2008-03-06 EA EA200970839A patent/EA016887B1/ru not_active IP Right Cessation
- 2008-03-06 EP EP08731528A patent/EP2134698A1/en not_active Ceased
- 2008-03-06 CN CN200880015410A patent/CN101679327A/zh active Pending
- 2008-03-06 KR KR1020097020836A patent/KR20090128454A/ko not_active Withdrawn
- 2008-03-06 MX MX2009009520A patent/MX2009009520A/es unknown
- 2008-03-06 NZ NZ579417A patent/NZ579417A/en not_active IP Right Cessation
- 2008-03-06 CA CA002680212A patent/CA2680212A1/en not_active Abandoned
- 2008-03-06 CL CL2008000667A patent/CL2008000667A1/es unknown
- 2008-03-07 AR ARP080100964A patent/AR065657A1/es not_active Application Discontinuation
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2009
- 2009-09-06 IL IL200759A patent/IL200759A0/en unknown
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