JP2010516235A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010516235A5 JP2010516235A5 JP2009545932A JP2009545932A JP2010516235A5 JP 2010516235 A5 JP2010516235 A5 JP 2010516235A5 JP 2009545932 A JP2009545932 A JP 2009545932A JP 2009545932 A JP2009545932 A JP 2009545932A JP 2010516235 A5 JP2010516235 A5 JP 2010516235A5
- Authority
- JP
- Japan
- Prior art keywords
- qpct
- mouse
- transgene
- human animal
- transgenic non
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88564907P | 2007-01-19 | 2007-01-19 | |
| PCT/EP2008/050532 WO2008087197A1 (en) | 2007-01-19 | 2008-01-18 | In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010516235A JP2010516235A (ja) | 2010-05-20 |
| JP2010516235A5 true JP2010516235A5 (https=) | 2011-03-03 |
Family
ID=39271322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009545932A Pending JP2010516235A (ja) | 2007-01-19 | 2008-01-18 | アルツハイマー病及び他のｑｐｃｔ関連障害の治療のためのインビボスクリーニングモデル |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080200567A1 (https=) |
| EP (2) | EP2395095A1 (https=) |
| JP (1) | JP2010516235A (https=) |
| AT (1) | ATE521711T1 (https=) |
| AU (1) | AU2008206936B2 (https=) |
| CA (1) | CA2675192A1 (https=) |
| DK (1) | DK2121944T3 (https=) |
| ES (1) | ES2372229T3 (https=) |
| HR (1) | HRP20110651T1 (https=) |
| NZ (1) | NZ578513A (https=) |
| SI (1) | SI2121944T1 (https=) |
| WO (1) | WO2008087197A1 (https=) |
| ZA (1) | ZA200904353B (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9277737B2 (en) | 2006-09-21 | 2016-03-08 | Probiodrug Ag | Mouse models carrying a knock-out mutation of the QPCTL-gene |
| US7803810B2 (en) * | 2007-03-09 | 2010-09-28 | Probiodrug Ag | Inhibitors |
| DK2142515T3 (da) * | 2007-04-18 | 2014-06-23 | Probiodrug Ag | Nitrovinyl-diaminderivater som glutaminyl-cyclase-inhibitorer |
| JP5667440B2 (ja) * | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
| WO2008128982A1 (en) * | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thioxoquinazolinone derivatives as glutaminyl cyclase inhibitors |
| JP5675340B2 (ja) * | 2007-04-18 | 2015-02-25 | プロビオドルグ エージー | 新規阻害剤 |
| JP5675343B2 (ja) * | 2007-04-18 | 2015-02-25 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としての尿素誘導体 |
| WO2008128983A1 (en) * | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Cyano-guanidine derivatives as glutaminyl cyclase inhibitors |
| JP5676249B2 (ja) * | 2007-04-20 | 2015-02-25 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体 |
| CA2696934A1 (en) * | 2007-09-12 | 2010-02-16 | Probiodrug Ag | Transgenic mice |
| NZ586665A (en) | 2008-01-14 | 2011-12-22 | Probiodrug Ag | MOUSE MODELS CARRYING A KNOCK-OUT MUTATION OF THE GLUTAMINYL CYCLASE GENE (Qpct) |
| CN103983787A (zh) * | 2008-07-31 | 2014-08-13 | 前体生物药物股份公司 | 作为神经退行性疾病诊断/预后指示物的谷氨酰胺酰环化酶 |
| US11219696B2 (en) * | 2008-12-19 | 2022-01-11 | Nationwide Children's Hospital | Delivery of polynucleotides using recombinant AAV9 |
| US8409837B2 (en) | 2010-08-19 | 2013-04-02 | Probiodrug Ag | Crystal structure of glutaminyl cyclase |
| WO2012028706A1 (en) | 2010-09-02 | 2012-03-08 | Probiodrug Ag | IN VIVO SCREENING MODELS FOR TREATMENT OF isoQC-RELATED DISORDERS |
| EP2635675B1 (en) | 2010-11-02 | 2016-01-06 | Probiodrug AG | Crystal structure of isoglutaminyl cyclase |
| US20130052203A1 (en) | 2011-08-12 | 2013-02-28 | Probiodrug Ag | In vivo screening models for treatment of qc-related disorders |
| AU2013296425B2 (en) | 2012-08-01 | 2018-06-07 | Nationwide Children's Hospital | Intrathecal delivery of recombinant adeno-associated virus 9 |
| US20180318260A1 (en) * | 2015-11-04 | 2018-11-08 | The Scripps Research Institute | Compositions and methods for treating cystic fibrosis |
| MC200185B1 (fr) | 2016-09-16 | 2017-10-04 | Coronal Audio | Dispositif et procédé de captation et traitement d'un champ acoustique tridimensionnel |
| MC200186B1 (fr) | 2016-09-30 | 2017-10-18 | Coronal Encoding | Procédé de conversion, d'encodage stéréophonique, de décodage et de transcodage d'un signal audio tridimensionnel |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| DE122007000007I1 (de) | 1986-04-09 | 2007-05-16 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| GB8901778D0 (en) | 1989-01-27 | 1989-03-15 | Univ Court Of The University O | Manipulatory technique |
| US5602299A (en) | 1992-09-23 | 1997-02-11 | Mount Sinai School Of Medicine Of The City University Of New York | Transgenic animal models for neurodegenerative disease |
| JPH07132033A (ja) | 1993-11-12 | 1995-05-23 | Hoechst Japan Ltd | アルツハイマー病モデルトランスジェニック動物 |
| US6066778A (en) | 1996-11-06 | 2000-05-23 | The Regents Of The University Of Michigan | Transgenic mice expressing APC resistant factor V |
| US5981830A (en) | 1997-05-30 | 1999-11-09 | Schering Aktiengesellschaft | Knockout mice and their progeny with a disrupted hepsin gene |
| US6948038B2 (en) * | 2001-07-24 | 2005-09-20 | Microsoft Corporation | System and method for backing up and restoring data |
| JP4806628B2 (ja) * | 2003-05-05 | 2011-11-02 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤 |
| KR20110059664A (ko) * | 2003-05-05 | 2011-06-02 | 프로비오드룩 아게 | 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도 |
| JP5690463B2 (ja) | 2003-05-05 | 2015-03-25 | プロビオドルグ エージー | グルタミニル、及びグルタミン酸シクラーゼのエフェクターの使用 |
| EP2338490A3 (en) * | 2003-11-03 | 2012-06-06 | Probiodrug AG | Combinations useful for the treatment of neuronal disorders |
| US7304086B2 (en) * | 2004-02-05 | 2007-12-04 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| GB0704100D0 (en) | 2006-03-17 | 2007-04-11 | Vodafone Plc | Improvements in an ehspa architecture |
| BRPI0718507A2 (pt) * | 2006-09-21 | 2013-11-12 | Probiodrug Ag | Genes relacionados à glutaminil ciclase |
-
2008
- 2008-01-18 JP JP2009545932A patent/JP2010516235A/ja active Pending
- 2008-01-18 EP EP11178419A patent/EP2395095A1/en not_active Withdrawn
- 2008-01-18 SI SI200830434T patent/SI2121944T1/sl unknown
- 2008-01-18 AU AU2008206936A patent/AU2008206936B2/en not_active Ceased
- 2008-01-18 EP EP08707977A patent/EP2121944B1/en not_active Not-in-force
- 2008-01-18 ZA ZA200904353A patent/ZA200904353B/xx unknown
- 2008-01-18 WO PCT/EP2008/050532 patent/WO2008087197A1/en not_active Ceased
- 2008-01-18 HR HR20110651T patent/HRP20110651T1/hr unknown
- 2008-01-18 ES ES08707977T patent/ES2372229T3/es active Active
- 2008-01-18 AT AT08707977T patent/ATE521711T1/de active
- 2008-01-18 NZ NZ578513A patent/NZ578513A/en not_active IP Right Cessation
- 2008-01-18 CA CA002675192A patent/CA2675192A1/en not_active Abandoned
- 2008-01-18 US US12/016,266 patent/US20080200567A1/en not_active Abandoned
- 2008-01-18 DK DK08707977.8T patent/DK2121944T3/da active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010516235A5 (https=) | ||
| JP7755699B2 (ja) | ヒト化ＩＬ－４およびＩＬ－４Ｒα動物 | |
| JP2011501652A5 (https=) | ||
| ES2715949T3 (es) | Animales con IL-15 humanizada | |
| HRP20110651T1 (hr) | Modeli pretraživanja in vivo radi liječenja alzheimerove bolesti i drugih poremećaja povezanih s qpct | |
| FI3823443T3 (fi) | Ditra-taudin jyrsijämallit ja niiden käyttö | |
| TW200536859A (en) | Gastrointestinal proliferative factor and uses thereof | |
| Santander et al. | Lack of Flvcr2 impairs brain angiogenesis without affecting the blood-brain barrier | |
| JP2011509093A5 (https=) | ||
| JP2020515248A5 (https=) | ||
| Okunomiya et al. | Generation of a MOR‐CreER knock‐in mouse line to study cells and neural circuits involved in mu opioid receptor signaling | |
| JP2019505216A5 (https=) | ||
| EP3188600B1 (en) | Animal model of longevity and related methods for increasing longevity and inhibiting tumorigenesis | |
| CN103251958B (zh) | Men1基因及其编码蛋白的应用 | |
| CN114835798B (zh) | Cd36基因人源化非人动物的构建方法及应用 | |
| US7312079B1 (en) | Variants of FAM3C | |
| JPWO2009013794A1 (ja) | インスリン分泌誘導剤及び膵臓β細胞増加促進剤 | |
| EP2241628B1 (en) | Double knockout GABAA alpha 1-/-; CaV3.1 and GABAA alpha 1-/-; Emx1-cre mouse models with enhanced essential tremor | |
| JP2013541938A (ja) | アイソｑｃ関連障害の治療のためのインビボスクリーニングモデル | |
| Yan et al. | 3.077 Novel PLA2G6 gene mutation is associated with autosomal recessive early-onset parkinsonism | |
| JP2025508063A (ja) | アルツハイマー病の野生由来マウスモデル | |
| Laffita et al. | 3.075 UNEXPANDED AND INTERMEDIATE POLYMORPHISMS AT SCA2 LOCUS (ATXN2) IN THE CUBAN POPULATION: EVIDENCES ABOUT THE ORIGIN OF EXPANDED ALLELES | |
| Vishwanathan et al. | 3.076 AN EARLY ONSET SOUTH INDIAN PARKINSON'S DISEASE PATIENT WITH NOVEL C. 798_799INSA MUTATION-A CASE VIGNETTE | |
| Koziorowski et al. | 3.078 THE NOVEL THAP1 GENE MUTATION, CHARACTERIZED BY PHENOTYPICAL HETEROGENEITY | |
| JP2011511622A5 (https=) |