JP2020515248A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020515248A5 JP2020515248A5 JP2019552004A JP2019552004A JP2020515248A5 JP 2020515248 A5 JP2020515248 A5 JP 2020515248A5 JP 2019552004 A JP2019552004 A JP 2019552004A JP 2019552004 A JP2019552004 A JP 2019552004A JP 2020515248 A5 JP2020515248 A5 JP 2020515248A5
- Authority
- JP
- Japan
- Prior art keywords
- mouse
- trem2p
- apoe4p
- genetically modified
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023023328A JP2023056032A (ja) | 2017-03-21 | 2023-02-17 | ヒトＡＰＯＥ４およびマウスＴｒｅｍ２ ｐ．Ｒ４７Ｈを発現する遺伝子改変されたマウス、ならびにその使用の方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762474358P | 2017-03-21 | 2017-03-21 | |
| US62/474,358 | 2017-03-21 | ||
| PCT/US2018/023565 WO2018175581A1 (en) | 2017-03-21 | 2018-03-21 | A GENETICALLY MODIFIED MOUSE EXPRESSING HUMAN APOE4 MOUSE Trem2.p.R47H AND METHODS OF USE THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023023328A Division JP2023056032A (ja) | 2017-03-21 | 2023-02-17 | ヒトＡＰＯＥ４およびマウスＴｒｅｍ２ ｐ．Ｒ４７Ｈを発現する遺伝子改変されたマウス、ならびにその使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020515248A JP2020515248A (ja) | 2020-05-28 |
| JP2020515248A5 true JP2020515248A5 (https=) | 2021-04-22 |
| JP7623785B2 JP7623785B2 (ja) | 2025-01-29 |
Family
ID=63586166
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019552004A Active JP7623785B2 (ja) | 2017-03-21 | 2018-03-21 | ヒトＡＰＯＥ４およびマウスＴｒｅｍ２ ｐ．Ｒ４７Ｈを発現する遺伝子改変されたマウス、ならびにその使用の方法 |
| JP2023023328A Ceased JP2023056032A (ja) | 2017-03-21 | 2023-02-17 | ヒトＡＰＯＥ４およびマウスＴｒｅｍ２ ｐ．Ｒ４７Ｈを発現する遺伝子改変されたマウス、ならびにその使用の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023023328A Ceased JP2023056032A (ja) | 2017-03-21 | 2023-02-17 | ヒトＡＰＯＥ４およびマウスＴｒｅｍ２ ｐ．Ｒ４７Ｈを発現する遺伝子改変されたマウス、ならびにその使用の方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US11957115B2 (https=) |
| EP (1) | EP3599842B1 (https=) |
| JP (2) | JP7623785B2 (https=) |
| CN (1) | CN110891417B (https=) |
| AU (1) | AU2018239433B2 (https=) |
| CA (1) | CA3057289A1 (https=) |
| WO (1) | WO2018175581A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| US20210195879A1 (en) * | 2018-06-21 | 2021-07-01 | The Jackson Laboratory | Genetically modified mouse models of alzheimer's disease |
| WO2023015153A2 (en) * | 2021-08-02 | 2023-02-09 | President And Fellows Of Harvard College | ANTISENSE OLIGONUCLEOTIDE TARGETING APOE ε4 AND USES THEREOF |
| CN114731987B (zh) * | 2022-05-19 | 2023-06-23 | 华芯微鱼(苏州)生物科技有限公司 | 颅缝早闭症小鼠模型、其构建方法及应用 |
| CN115536734B (zh) * | 2022-11-24 | 2024-04-30 | 安徽农业大学 | 具有肝癌细胞毒性和α-葡萄糖苷酶抑制活性的环色-丙-缬-亮-亮肽及制备方法 |
| CN116103292B (zh) * | 2022-11-25 | 2024-01-30 | 首都医科大学宣武医院 | Zdhhc21基因突变动物模型的构建方法及其应用 |
| CN119234771A (zh) * | 2024-09-13 | 2025-01-03 | 广东省人民医院 | 一种帕金森病认知障碍小鼠模型的构建方法与应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356802A (en) | 1992-04-03 | 1994-10-18 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease |
| US5436150A (en) | 1992-04-03 | 1995-07-25 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease |
| US5487994A (en) | 1992-04-03 | 1996-01-30 | The Johns Hopkins University | Insertion and deletion mutants of FokI restriction endonuclease |
| EP0788546B9 (en) | 1994-10-18 | 2007-06-13 | Dendreon Corporation | Nematode-extracted serine protease inhibitors and anticoagulant proteins |
| CN1206421A (zh) * | 1995-11-01 | 1999-01-27 | 科斯药品公司 | 载脂蛋白e2和阿尔采默氏病的治疗 |
| US6175057B1 (en) * | 1997-10-08 | 2001-01-16 | The Regents Of The University Of California | Transgenic mouse model of alzheimer's disease and cerebral amyloid angiopathy |
| US6046381A (en) | 1998-04-30 | 2000-04-04 | The Regents Of The University Of California | Apolipoprotein E transgenic mice and assay methods |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| JP2001017028A (ja) * | 1999-05-06 | 2001-01-23 | Mitsubishi Chemicals Corp | アポｅヒト化哺乳動物 |
| EP1063298A3 (en) | 1999-06-04 | 2001-03-28 | Glaxo Group Limited | Transgenic Animal Model for Alzheimer Disease |
| US6830910B1 (en) | 1999-07-21 | 2004-12-14 | Albert Einstein College Of Medicine Of Yeshiva University | Drosophila recombination-associated protein and methods for use |
| IL147345A0 (en) | 1999-07-21 | 2002-08-14 | Einstein Coll Med | Drosphila recombination- associated protein and methods for use |
| US20060167227A1 (en) * | 2002-07-12 | 2006-07-27 | Axon Neuroscience Forschungs-Und Entwicklungs Gmbh | Truncated tau proteins |
| JP2005534710A (ja) | 2002-08-07 | 2005-11-17 | ノバルティス アクチエンゲゼルシャフト | Ａｐｏｅ遺伝子型を基準とした痴呆を処置するための方法 |
| US20070134796A1 (en) | 2005-07-26 | 2007-06-14 | Sangamo Biosciences, Inc. | Targeted integration and expression of exogenous nucleic acid sequences |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| ES2463476T3 (es) | 2004-10-19 | 2014-05-28 | Regeneron Pharmaceuticals, Inc. | Método para generar un ratón homocigótico para una modificación genética |
| EP1907566A4 (en) | 2005-05-27 | 2008-12-10 | Memory Pharm Corp | VECTORS FOR TRANSGENIC MORBUS ALZHEIMER MOUSE MODEL AND USES THEREOF |
| EP2027262B1 (en) | 2006-05-25 | 2010-03-31 | Sangamo Biosciences Inc. | Variant foki cleavage half-domains |
| JP4942081B2 (ja) | 2006-06-20 | 2012-05-30 | 独立行政法人理化学研究所 | アルツハイマー病モデル動物およびその用途 |
| WO2010002982A1 (en) * | 2008-07-01 | 2010-01-07 | Cognosci, Inc. | Methods of treating cancer with apoe peptides |
| CA2735578C (en) * | 2008-08-12 | 2018-10-23 | Zinfandel Pharmaceuticals, Inc. | Method of identifying risk factors for alzheimer's disease comprising tomm40 gene variants |
| EP2206723A1 (en) | 2009-01-12 | 2010-07-14 | Bonas, Ulla | Modular DNA-binding domains |
| WO2011072246A2 (en) | 2009-12-10 | 2011-06-16 | Regents Of The University Of Minnesota | Tal effector-mediated dna modification |
| US8450107B1 (en) | 2011-11-30 | 2013-05-28 | The Broad Institute Inc. | Nucleotide-specific recognition sequences for designer TAL effectors |
| WO2013181618A2 (en) * | 2012-05-31 | 2013-12-05 | The Trustees Of Columbia University In The City Of New York | Methods to treat alzheimer's disease using apoe inhibitors |
| WO2014074942A1 (en) | 2012-11-08 | 2014-05-15 | Illumina, Inc. | Risk variants of alzheimer's disease |
| CN109641961A (zh) * | 2016-07-22 | 2019-04-16 | 德国神经退行性疾病研究中心 | Trem2切割调节剂及其用途 |
| US20210195879A1 (en) | 2018-06-21 | 2021-07-01 | The Jackson Laboratory | Genetically modified mouse models of alzheimer's disease |
| US20220099659A1 (en) | 2019-01-23 | 2022-03-31 | The Regents Of The University Of California | Human Genomic Construct Reporter Cells and Mouse Models to Screen Therapeutics against Microglia-expressed Disease Associated Genes |
| EP4262372A4 (en) | 2020-12-16 | 2024-11-20 | The Jackson Laboratory | A genetically modified immunodeficient mouse expressing human or humanized app and mutated human psen1 |
-
2018
- 2018-03-21 CN CN201880031011.2A patent/CN110891417B/zh not_active Expired - Fee Related
- 2018-03-21 AU AU2018239433A patent/AU2018239433B2/en not_active Ceased
- 2018-03-21 EP EP18770741.9A patent/EP3599842B1/en active Active
- 2018-03-21 WO PCT/US2018/023565 patent/WO2018175581A1/en not_active Ceased
- 2018-03-21 CA CA3057289A patent/CA3057289A1/en active Pending
- 2018-03-21 US US16/496,261 patent/US11957115B2/en active Active
- 2018-03-21 JP JP2019552004A patent/JP7623785B2/ja active Active
-
2023
- 2023-02-17 JP JP2023023328A patent/JP2023056032A/ja not_active Ceased
-
2024
- 2024-03-14 US US18/605,786 patent/US20240315220A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020515248A5 (https=) | ||
| Dathe et al. | Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2 | |
| Logan et al. | Species specificity in major urinary proteins by parallel evolution | |
| JP2017514501A5 (https=) | ||
| JP2009148257A5 (https=) | ||
| JP2015523863A5 (https=) | ||
| Hughes et al. | Identification of novel alternative splicing events in the huntingtin gene and assessment of the functional consequences using structural protein homology modelling | |
| JP2017213006A5 (https=) | ||
| JP2011087580A5 (https=) | ||
| Guo et al. | Genome reference and sequence variation in the large repetitive central exon of human MUC5AC | |
| Grochowska et al. | Effects of intronic SNPs in the myostatin gene on growth and carcass traits in colored Polish merino sheep | |
| Bai et al. | A nucleotide substitution in the ovine KAP20-2 gene leads to a premature stop codon that affects wool fibre curvature | |
| Matuszek et al. | Base editing of trinucleotide repeats that cause Huntington’s disease and Friedreich’s ataxia reduces somatic repeat expansions in patient cells and in mice | |
| JP2019511918A5 (https=) | ||
| Fontanesi | Rabbit genetic resources can provide several animal models to explain at the genetic level the diversity of morphological and physiological relevant traits | |
| WO2018175581A8 (en) | A GENETICALLY MODIFIED MOUSE EXPRESSING HUMAN APOE4 AND MOUSE Trem2 p.R47H AND METHODS OF USE THEREOF | |
| IL319209A (en) | Non-human animals containing a humanized ASGR1 locus | |
| JP2019505216A5 (https=) | ||
| Arslan et al. | Analysis of structural variation among inbred mouse strains | |
| Duan et al. | Polymorphisms in ion transport genes are associated with eggshell mechanical property | |
| Sakamoto et al. | Delineation of genomic deletion in cardiomyopathic hamster | |
| Deshpande et al. | ZNF423 patient variants, truncations, and in-frame deletions in mice define an allele-dependent range of midline brain abnormalities | |
| JP2017500888A5 (https=) | ||
| JP2018512842A5 (https=) | ||
| JP2008505626A5 (https=) |