JP2010515081A5 - - Google Patents

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JP2010515081A5
JP2010515081A5 JP2009544971A JP2009544971A JP2010515081A5 JP 2010515081 A5 JP2010515081 A5 JP 2010515081A5 JP 2009544971 A JP2009544971 A JP 2009544971A JP 2009544971 A JP2009544971 A JP 2009544971A JP 2010515081 A5 JP2010515081 A5 JP 2010515081A5
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JP
Japan
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administered
composition
receptor agonist
adenosine receptor
partial
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JP2009544971A
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JP2010515081A (ja
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Priority claimed from PCT/US2008/050117 external-priority patent/WO2008086096A2/en
Publication of JP2010515081A publication Critical patent/JP2010515081A/ja
Publication of JP2010515081A5 publication Critical patent/JP2010515081A5/ja
Pending legal-status Critical Current

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Claims (20)

  1. ヒト患者において血管拡張薬誘発性心筋ストレスの灌流画像化の間に心筋機能不全を診断するための組成物であって、該組成物は、少なくとも１つの部分Ａ２Ａアデノシン受容体アゴニストを含み、該患者が最大下運動をしている間に該患者に投与され、そして少なくとも１０μｇの該部分Ａ ２Ａ アデノシン受容体アゴニストが投与されるような量で投与されるものであることを特徴とする、組成物。
  2. 前記組成物は、前記患者に約１０００μｇ以下の前記部分Ａ２Ａアデノシン受容体アゴニストが投与されるように投与されるものであることを特徴とする、請求項１に記載の組成物。
  3. 前記組成物は、前記投与される部分Ａ２Ａアデノシン受容体アゴニストの量が約６００μｇを超えるように投与されるものであることを特徴とする、請求項１に記載の組成物。
  4. 前記組成物は、前記投与される部分Ａ２Ａアデノシン受容体アゴニストの量が約１００μｇを超えるように投与されるものであることを特徴とする、請求項１に記載の組成物。
  5. 前記組成物は、前記投与される部分Ａ２Ａアデノシン受容体アゴニストの量が約１０μｇ〜約６００μｇの範囲にあるように投与されるものであることを特徴とする、請求項１に記載の組成物。
  6. 単一用量で投与されるものであることを特徴とする、請求項５に記載の組成物。
  7. 静脈内ボーラスによって投与されるものであることを特徴とする、請求項６に記載の組成物。
  8. 約１０秒未満で投与されるものであることを特徴とする、請求項６に記載の組成物。
  9. 前記組成物は、前記投与される部分Ａ２Ａアデノシン受容体アゴニストの量が約５００μｇを超えるように投与されるものであることを特徴とする、請求項６に記載の組成物。
  10. 前記組成物は、前記部分Ａ２Ａアデノシン受容体アゴニストが約１００μｇ〜約５００μｇの範囲の量で投与されるように投与されるものであることを特徴とする、請求項６に記載の組成物。
  11. 前記部分Ａ２Ａアデノシン受容体アゴニストが、ＣＶＴ−３０３３、リガデノソンおよびそれらの組合せからなる群から選択される、請求項１に記載の組成物。
  12. ヒト患者において血管拡張薬誘発性心筋ストレスの灌流画像化の間に心筋機能不全を診断するための組み合わせ物であって、該組み合わせ物は、放射性核種および部分Ａ２Ａ受容体アゴニストを含み、該患者が最大下運動をしている間に投与されるものであり、該部分Ａ ２Ａ 受容体アゴニストは、約１０μｇ〜約６００μｇの範囲の量で投与されるものであることを特徴とする、組み合わせ物。
  13. 前記部分Ａ２Ａアデノシン受容体アゴニストの前記投与が冠動脈血流の少なくとも２．５倍の増加を引き起こす、請求項１２に記載の組み合わせ物。
  14. 冠動脈血流の前記少なくとも２．５倍の増加が、前記部分Ａ２Ａアデノシン受容体アゴニストの前記投与から約１分以内に達成される、請求項１３に記載の組み合わせ物。
  15. 前記放射性核種および前記部分Ａ２Ａアデノシン受容体アゴニストが別々に投与されることを特徴とする、請求項１２に記載の組み合わせ物。
  16. 前記放射性核種および前記部分Ａ２Ａアデノシン受容体アゴニストが同時に投与されることを特徴とする、請求項１２に記載の組み合わせ物。
  17. 冠動脈血流の前記少なくとも２．５倍の増加の持続期間が約５分未満である、請求項１３に記載の組み合わせ物。
  18. 冠動脈血流の前記少なくとも２．５倍の増加の持続期間が約３分未満である、請求項１７に記載の組み合わせ物。
  19. ヒト患者において血管拡張薬誘発性心筋ストレスの灌流画像化の間に心筋機能不全を診断するための組成物であって、該組成物は、リガデノソンを含み、該患者が最大下運動をしている間に投与され、リガデノソンが約１０〜約６００μｇの範囲の量で投与されるように単一の静脈内ボーラスによって投与されるものであることを特徴とする、組成物。
  20. ヒト患者において血管拡張薬誘発性心筋ストレスの灌流画像化の間に心筋機能不全を診断するための組成物であって、該組成物は、リガデノソンを含み、該患者が最大下運動をしている間に投与され、リガデノソンが約１００〜約５００μｇの範囲の量で投与されるように単一の静脈内ボーラスによって投与されるものであることを特徴とする、組成物。
JP2009544971A 2007-01-03 2008-01-03 心筋灌流画像化 Pending JP2010515081A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87852907P 2007-01-03 2007-01-03
PCT/US2008/050117 WO2008086096A2 (en) 2007-01-03 2008-01-03 Myocardial perfusion imaging

Publications (2)

Publication Number Publication Date
JP2010515081A JP2010515081A (ja) 2010-05-06
JP2010515081A5 true JP2010515081A5 (ja) 2011-02-24

Family

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Application Number Title Priority Date Filing Date
JP2009544971A Pending JP2010515081A (ja) 2007-01-03 2008-01-03 心筋灌流画像化

Country Status (6)

Country Link
US (1) US20080267861A1 (ja)
EP (1) EP2099360A2 (ja)
JP (1) JP2010515081A (ja)
CA (1) CA2673653A1 (ja)
MX (1) MX2009007071A (ja)
WO (1) WO2008086096A2 (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
AU2001238665A1 (en) * 2000-02-23 2001-09-03 Cv Therapeutics, Inc. Method of identifying partial agonists of the a2a receptor
CN1671399A (zh) * 2002-07-29 2005-09-21 Cv医药有限公司 利用a2a受体激动剂的心肌灌注显像
US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
CA2583185A1 (en) * 2004-10-20 2006-04-27 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists
EP2581381A3 (en) * 2006-02-03 2013-10-30 Gilead Sciences, Inc. Process for preparing an A2A-adenosine receptor agonist and its polymorphs
JP2009541354A (ja) * 2006-06-22 2009-11-26 シーブイ・セラピューティクス・インコーポレイテッド 虚血の治療におけるａ２ａアデノシン受容体アゴニストの使用
WO2008028140A1 (en) * 2006-09-01 2008-03-06 Cv Therapeutics, Inc. Methods and compositions for increasing patient tolerability during myocardial imaging methods
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
CA2663361A1 (en) * 2006-09-29 2008-04-10 Cv Therapeutics, Inc. Methods for myocardial imaging in patients having a history of pulmonary disease
WO2010004365A1 (en) 2008-07-10 2010-01-14 Ecole Polytechnique Federale De Lausanne (Epfl) Functional optical coherent imaging
JP2012504147A (ja) * 2008-09-29 2012-02-16 ギリアード サイエンシーズ， インコーポレイテッド 多検出器型コンピュータ断層撮影法において使用するための心拍数コントロール薬およびＡ−２−α受容体作動薬の組み合わせ
US8880457B2 (en) * 2010-11-05 2014-11-04 Allegheny-Singer Research Institute Method and system for recommending a decision based on combined entity modeling
US9072490B2 (en) * 2010-12-20 2015-07-07 Toshiba Medical Systems Corporation Image processing apparatus and image processing method
EP2840957B1 (en) * 2012-04-27 2024-01-03 Stryker European Operations Limited Optical coherent imaging medical device and method
WO2017059302A1 (en) * 2015-09-30 2017-04-06 Cedars-Sinai Medical Center Robust myocardial blood oxygen level dependent magnetic resonance imaging with long-acting coronary vasodilators

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4120947A (en) * 1976-03-31 1978-10-17 Cooper Laboratories, Inc. Xanthine compounds and method of treating bronchospastic and allergic diseases
US4089959A (en) * 1976-03-31 1978-05-16 Cooper Laboratories, Inc. Long-acting xanthine bronchodilators and antiallergy agents
SE7810946L (sv) * 1978-10-20 1980-04-21 Draco Ab Metod att behandla kronisk obstruktiv luftvegssjukdom
US4326525A (en) * 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
US4593095A (en) * 1983-02-18 1986-06-03 The Johns Hopkins University Xanthine derivatives
US5364620A (en) * 1983-12-22 1994-11-15 Elan Corporation, Plc Controlled absorption diltiazem formulation for once daily administration
US4696932A (en) * 1984-10-26 1987-09-29 The United States Of America As Represented By The Department Of Health And Human Services Biologically-active xanthine derivatives
JPS6299395A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
US4968697A (en) * 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
US5001139A (en) * 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US4992445A (en) * 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
US4902514A (en) * 1988-07-21 1990-02-20 Alza Corporation Dosage form for administering nilvadipine for treating cardiovascular symptoms
US5070877A (en) * 1988-08-11 1991-12-10 Medco Research, Inc. Novel method of myocardial imaging
DE3831430A1 (de) * 1988-09-15 1990-03-22 Bayer Ag Substituierte 4-heterocyclyloximino-pyrazolin-5-one, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
KR0137786B1 (ko) * 1988-11-15 1998-05-15 하마구찌 미찌오 심장 또는 뇌의 허혈성 질환의 치료, 예방제
DE69022176T2 (de) * 1989-06-20 1996-02-15 Toa Eiyo Ltd., Tokio/Tokyo Zwischenverbindung für 2-alkynyladenosinherstellung, herstellung dieser zwischenverbindung, herstellung von 2-alkynyladenosin aus diesem zwischenprodukt sowie stabiles 2-alkynyladenosinderivat.
US5032252A (en) * 1990-04-27 1991-07-16 Mobil Oil Corporation Process and apparatus for hot catalyst stripping in a bubbling bed catalyst regenerator
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
US5189027A (en) * 1990-11-30 1993-02-23 Yamasa Shoyu Kabushiki Kaisha 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases
JP2740362B2 (ja) * 1991-02-12 1998-04-15 ヤマサ醤油株式会社 安定な固体状２‐オクチニルアデノシンおよびその製造法
US5516894A (en) * 1992-03-11 1996-05-14 The General Hospital Corporation A2b -adenosine receptors
IT1254915B (it) * 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
US5705491A (en) * 1992-10-27 1998-01-06 Nippon Zoki Pharmaceutical Co., Ltd. Adenosine deaminase inhibitor
CA2112031A1 (en) * 1992-12-24 1994-06-25 Fumio Suzuki Xanthine derivatives
US5477857A (en) * 1993-09-10 1995-12-26 Discovery Therapeutics, Inc. Diagnostic uses of hydrazinoadenosines
DE69526822T2 (de) * 1994-02-23 2003-01-23 Kyowa Hakko Kogyo Kk Xanthin-derivate
US5704491A (en) * 1995-07-21 1998-01-06 Cummins-Allison Corp. Method and apparatus for discriminating and counting documents
US5646156A (en) * 1994-04-25 1997-07-08 Merck & Co., Inc. Inhibition of eosinophil activation through A3 adenosine receptor antagonism
US5877180A (en) * 1994-07-11 1999-03-02 University Of Virginia Patent Foundation Method for treating inflammatory diseases with A2a adenosine receptor agonists
US6514949B1 (en) * 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US6448235B1 (en) * 1994-07-11 2002-09-10 University Of Virginia Patent Foundation Method for treating restenosis with A2A adenosine receptor agonists
US5854081A (en) * 1996-06-20 1998-12-29 The University Of Patent Foundation Stable expression of human A2B adenosine receptors, and assays employing the same
US5780481A (en) * 1996-08-08 1998-07-14 Merck & Co., Inc. Method for inhibiting activation of the human A3 adenosine receptor to treat asthma
US5776960A (en) * 1996-10-16 1998-07-07 Buckman Laboratories International, Inc. Synergistic antimicrobial compositions containing an ionene polymer and a pyrithione salt and methods of using the same
US5770716A (en) * 1997-04-10 1998-06-23 The Perkin-Elmer Corporation Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same
US6026317A (en) * 1998-02-06 2000-02-15 Baylor College Of Medicine Myocardial perfusion imaging during coronary vasodilation with selective adenosine A2 receptor agonists
US6117878A (en) * 1998-02-24 2000-09-12 University Of Virginia 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors
US6322771B1 (en) * 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
US6403567B1 (en) * 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
US6368573B1 (en) * 1999-11-15 2002-04-09 King Pharmaceuticals Research And Development, Inc. Diagnostic uses of 2-substituted adenosine carboxamides
US6605597B1 (en) * 1999-12-03 2003-08-12 Cv Therapeutics, Inc. Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives
US6294522B1 (en) * 1999-12-03 2001-09-25 Cv Therapeutics, Inc. N6 heterocyclic 8-modified adenosine derivatives
US6552023B2 (en) * 2000-02-22 2003-04-22 Cv Therapeutics, Inc. Aralkyl substituted piperazine compounds
US6677336B2 (en) * 2000-02-22 2004-01-13 Cv Therapeutics, Inc. Substituted piperazine compounds
AU2001238665A1 (en) * 2000-02-23 2001-09-03 Cv Therapeutics, Inc. Method of identifying partial agonists of the a2a receptor
US6387913B1 (en) * 2000-12-07 2002-05-14 S. Jamal Mustafa Method of treating airway diseases with combined administration of A2B and A3 adenosine receptor antagonists
US6670334B2 (en) * 2001-01-05 2003-12-30 University Of Virginia Patent Foundation Method and compositions for treating the inflammatory response
US6995148B2 (en) * 2001-04-05 2006-02-07 University Of Pittsburgh Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy
US6599283B1 (en) * 2001-05-04 2003-07-29 Cv Therapeutics, Inc. Method of preventing reperfusion injury
US6919804B1 (en) * 2001-05-08 2005-07-19 Vultron Incorporated Passenger detection system for vehicles
ES2340664T3 (es) * 2001-05-14 2010-06-08 Novartis Ag Derivados de sulfonamidas.
US20030235555A1 (en) * 2002-04-05 2003-12-25 David Shealey Asthma-related anti-IL-13 immunoglobulin derived proteins, compositions, methods and uses
US7125993B2 (en) * 2001-11-09 2006-10-24 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
EP1444233B1 (en) * 2001-11-09 2011-08-17 Gilead Palo Alto, Inc. A2b adenosine receptor antagonists
US6977300B2 (en) * 2001-11-09 2005-12-20 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
CN1671399A (zh) * 2002-07-29 2005-09-21 Cv医药有限公司 利用a2a受体激动剂的心肌灌注显像
CA2691611A1 (en) * 2004-01-27 2005-09-09 Gilead Palo Alto, Inc. Myocardial perfusion imaging using adenosine receptor agonists
WO2006044610A1 (en) * 2004-10-15 2006-04-27 Cv Therapeutics, Inc Method of preventing and treating airway remodeling and pulmonary inflammation using a2b adenosine receptor antagonists
CA2583185A1 (en) * 2004-10-20 2006-04-27 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists
AU2006204716A1 (en) * 2005-01-12 2006-07-20 King Pharmaceuticals Reserch & Development, Inc. Method of detecting myocardial dysfunction in patients having a history of asthma or bronchospasm
EP2581381A3 (en) * 2006-02-03 2013-10-30 Gilead Sciences, Inc. Process for preparing an A2A-adenosine receptor agonist and its polymorphs
JP2009541354A (ja) * 2006-06-22 2009-11-26 シーブイ・セラピューティクス・インコーポレイテッド 虚血の治療におけるａ２ａアデノシン受容体アゴニストの使用
WO2008028140A1 (en) * 2006-09-01 2008-03-06 Cv Therapeutics, Inc. Methods and compositions for increasing patient tolerability during myocardial imaging methods
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
CA2663361A1 (en) * 2006-09-29 2008-04-10 Cv Therapeutics, Inc. Methods for myocardial imaging in patients having a history of pulmonary disease

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