JP2010512421A5 - - Google Patents
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- JP2010512421A5 JP2010512421A5 JP2009541545A JP2009541545A JP2010512421A5 JP 2010512421 A5 JP2010512421 A5 JP 2010512421A5 JP 2009541545 A JP2009541545 A JP 2009541545A JP 2009541545 A JP2009541545 A JP 2009541545A JP 2010512421 A5 JP2010512421 A5 JP 2010512421A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- disease
- disorder
- motomeko
- effective amount
- Prior art date
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 201000010099 disease Diseases 0.000 claims 12
- 208000035475 disorder Diseases 0.000 claims 11
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 claims 2
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 206010068956 Respiratory tract inflammation Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 150000004713 phosphodiesters Chemical class 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86960406P | 2006-12-12 | 2006-12-12 | |
| PCT/US2007/087182 WO2008073959A2 (en) | 2006-12-12 | 2007-12-12 | Synthetic agonists of tlr9 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010512421A JP2010512421A (ja) | 2010-04-22 |
| JP2010512421A5 true JP2010512421A5 (enExample) | 2011-02-03 |
Family
ID=39512457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541545A Withdrawn JP2010512421A (ja) | 2006-12-12 | 2007-12-12 | Ｔｌｒ９の合成アゴニスト |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7884197B2 (enExample) |
| EP (1) | EP2079305A4 (enExample) |
| JP (1) | JP2010512421A (enExample) |
| CN (1) | CN101610671A (enExample) |
| AU (1) | AU2007333146A1 (enExample) |
| CA (1) | CA2671883A1 (enExample) |
| MX (1) | MX2009006230A (enExample) |
| WO (1) | WO2008073959A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7354907B2 (en) * | 2003-02-07 | 2008-04-08 | Idera Pharmaceuticals, Inc. | Short immunomodulatory oligonucleotides |
| KR101126030B1 (ko) * | 2003-07-15 | 2012-03-19 | 이데라 파마슈티칼즈, 인코포레이티드 | 사이토킨 및/또는 화학치료제 또는 방사선 치료와 연계하여면역자극 올리고누클레오티드 및/또는 이뮤노머 화합물을이용하여 면역계를 공동 상승 자극시키는 방법 |
| US7470674B2 (en) * | 2005-11-07 | 2008-12-30 | Idera Pharmaceuticals, Inc. | Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides |
| AU2014203624B2 (en) * | 2007-08-01 | 2016-05-05 | Idera Pharmaceuticals, Inc. | Novel synthetic agonists of TLR9 |
| CA2693266C (en) * | 2007-08-01 | 2015-06-30 | Idera Pharmaceuticals, Inc. | Novel synthetic agonists of tlr9 |
| RU2015151857A (ru) | 2008-12-02 | 2019-01-15 | Уэйв Лайф Сайенсес Джапан, Инк. | Способ синтеза модифицированных по атому фосфора нуклеиновых кислот |
| BRPI1008063A2 (pt) * | 2009-01-30 | 2015-08-25 | Idera Pharmaceuticals Inc | Agonistas sinteticas de tlr9 |
| MX2011010050A (es) | 2009-03-25 | 2011-12-14 | Univ Texas | Composiciones para estimulación de resistencia inmune innata de mamiferos a patógenos. |
| MX342945B (es) | 2009-07-06 | 2016-10-18 | Ontorii Inc * | Profármacos de ácido nucleico novedosos y métodos de uso de los mismos. |
| PL2949670T3 (pl) | 2009-12-10 | 2019-07-31 | F. Hoffmann-La Roche Ag | Przeciwciała wiążące się preferencyjnie z zewnątrzkomórkową domeną 4 ludzkiego CSF-1R i ich zastosowanie |
| US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
| EP3248982A1 (en) | 2011-07-19 | 2017-11-29 | Wave Life Sciences Ltd. | Thiosulfonate reagents for the synthesis of functionalized nucleic acids |
| CA2853889A1 (en) | 2011-12-15 | 2013-06-20 | F. Hoffmann-La Roche Ag | Antibodies against human csf-1r and uses thereof |
| CA2879023C (en) | 2012-07-13 | 2017-03-28 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| CN104661664B (zh) | 2012-07-13 | 2020-07-03 | 波涛生命科学有限公司 | 手性控制 |
| WO2014110081A1 (en) * | 2013-01-08 | 2014-07-17 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
| GB2514591A (en) * | 2013-05-30 | 2014-12-03 | Mologen Ag | Predictive biomarker for cancer therapy |
| AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
| US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| JPWO2015108048A1 (ja) * | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| US10322173B2 (en) | 2014-01-15 | 2019-06-18 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| MX2016009290A (es) | 2014-01-16 | 2017-02-28 | Wave Life Sciences Ltd | Diseño quiral. |
| US10434064B2 (en) | 2014-06-04 | 2019-10-08 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| WO2016044839A2 (en) | 2014-09-19 | 2016-03-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds |
| MX391478B (es) * | 2014-10-10 | 2025-03-21 | Idera Pharmaceuticals Inc | Composiciones de agonista de tlr9 e inhibidores de punto de control para usarse en la respuesta inmune contra el cáncer. |
| CA2968531A1 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| AU2016364431B2 (en) | 2015-12-04 | 2020-08-27 | Zenyaku Kogyo Co., Ltd. | Anti-IL-17 aptamer having improved retention in blood |
| US10781175B2 (en) | 2016-07-15 | 2020-09-22 | Am Chemicals Llc | Solid supports and phosphoramidite building blocks for oligonucleotide conjugates |
| WO2018036852A1 (en) | 2016-08-25 | 2018-03-01 | F. Hoffmann-La Roche Ag | Intermittent dosing of an anti-csf-1r antibody in combination with macrophage activating agent |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| WO2018053242A1 (en) | 2016-09-15 | 2018-03-22 | Idera Pharmaceuticals, Inc. | Immune modulation with tlr9 agonists for cancer treatment |
| EP3551047A1 (en) | 2016-12-07 | 2019-10-16 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
| CA3046019A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a tlr modulator |
| JP7304287B2 (ja) | 2016-12-22 | 2023-07-06 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 抗ｐｄ－ｌ１／ｐｄ１治療の不成功後の、抗ｐｄ－ｌ１抗体との組み合わせでの抗ｃｓｆ－１ｒ抗体を用いた腫瘍の治療 |
| US12460208B2 (en) | 2017-04-18 | 2025-11-04 | Parr Biotechnology Co., Ltd. | Immunomodulatory polynucleotides and uses thereof |
| CN108728444A (zh) * | 2017-04-18 | 2018-11-02 | 长春华普生物技术股份有限公司 | 免疫调节性多核苷酸及其应用 |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| EP3690030A4 (en) | 2017-09-28 | 2021-06-23 | Industry-Academic Cooperation Foundation, Yonsei University | PROCESS FOR THE PRODUCTION OF SUPPRESSIVE CELLS OF MYELOID ORIGIN, SUPPRESSIVE CELLS OF MYELOID ORIGIN THUS PRODUCED AND THEIR USES |
| WO2020127618A1 (en) | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Tumor-targeted agonistic cd28 antigen binding molecules |
| WO2021174024A1 (en) | 2020-02-28 | 2021-09-02 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| AU2021300632A1 (en) | 2020-07-02 | 2023-02-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Method of achieving HIV viral remission using long-acting antiretroviral agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200303759A (en) * | 2001-11-27 | 2003-09-16 | Schering Corp | Methods for treating cancer |
| EP2371834B1 (en) * | 2003-06-11 | 2016-02-17 | Idera Pharmaceuticals, Inc. | Stabilized immunomodulatory oligonucleotides |
| WO2006116458A2 (en) * | 2005-04-26 | 2006-11-02 | Coley Pharmaceutical Gmbh | Modified oligoribonucleotide analogs with enhances immunostimulatory activity |
-
2007
- 2007-12-12 WO PCT/US2007/087182 patent/WO2008073959A2/en not_active Ceased
- 2007-12-12 EP EP07865548A patent/EP2079305A4/en not_active Withdrawn
- 2007-12-12 CN CNA200780051260XA patent/CN101610671A/zh active Pending
- 2007-12-12 JP JP2009541545A patent/JP2010512421A/ja not_active Withdrawn
- 2007-12-12 CA CA002671883A patent/CA2671883A1/en not_active Abandoned
- 2007-12-12 AU AU2007333146A patent/AU2007333146A1/en not_active Abandoned
- 2007-12-12 MX MX2009006230A patent/MX2009006230A/es not_active Application Discontinuation
- 2007-12-12 US US11/954,726 patent/US7884197B2/en not_active Expired - Fee Related
-
2010
- 2010-12-03 US US12/960,030 patent/US20110135669A1/en not_active Abandoned
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