JP2010512320A5 - - Google Patents
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- JP2010512320A5 JP2010512320A5 JP2009540313A JP2009540313A JP2010512320A5 JP 2010512320 A5 JP2010512320 A5 JP 2010512320A5 JP 2009540313 A JP2009540313 A JP 2009540313A JP 2009540313 A JP2009540313 A JP 2009540313A JP 2010512320 A5 JP2010512320 A5 JP 2010512320A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- monoclonal antibody
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87383406P | 2006-12-08 | 2006-12-08 | |
| US60/873,834 | 2006-12-08 | ||
| PCT/US2007/025080 WO2008073300A2 (en) | 2006-12-08 | 2007-12-06 | Monoclonal antibodies against angptl3 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010512320A JP2010512320A (ja) | 2010-04-22 |
| JP2010512320A5 true JP2010512320A5 (https=) | 2011-01-27 |
| JP5484063B2 JP5484063B2 (ja) | 2014-05-07 |
Family
ID=39512267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540313A Expired - Fee Related JP5484063B2 (ja) | 2006-12-08 | 2007-12-06 | Ａｎｇｐｔｌ３に対するモノクローナル抗体 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7935796B2 (https=) |
| EP (1) | EP2121751B1 (https=) |
| JP (1) | JP5484063B2 (https=) |
| KR (1) | KR101503937B1 (https=) |
| CN (1) | CN101855241B (https=) |
| AR (1) | AR064205A1 (https=) |
| AU (1) | AU2007332855B2 (https=) |
| BR (1) | BRPI0720218A2 (https=) |
| CA (1) | CA2672049C (https=) |
| DK (1) | DK2121751T3 (https=) |
| EA (1) | EA019661B1 (https=) |
| ES (1) | ES2618830T3 (https=) |
| HU (1) | HUE033960T2 (https=) |
| IL (1) | IL199216A (https=) |
| MX (1) | MX2009006082A (https=) |
| NO (1) | NO20092215L (https=) |
| PL (1) | PL2121751T3 (https=) |
| PT (1) | PT2121751T (https=) |
| TW (1) | TW200846364A (https=) |
| WO (1) | WO2008073300A2 (https=) |
| ZA (1) | ZA200904022B (https=) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2121751T3 (pl) * | 2006-12-08 | 2017-07-31 | Lexicon Pharmaceuticals, Inc. | Przeciwciała monoklonalne przeciwko ANGPTL3 |
| US9388414B2 (en) | 2008-10-08 | 2016-07-12 | Trustees Of Dartmouth College | Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases |
| US9388413B2 (en) | 2008-10-08 | 2016-07-12 | Trustees Of Dartmouth College | Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases |
| US8802646B2 (en) | 2008-10-08 | 2014-08-12 | Trustees Of Dartmouth College | Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease |
| US9149492B2 (en) | 2008-10-08 | 2015-10-06 | Trustees Of Dartmouth College | Method for selectively inhibiting ACAT1 in the treatment of alzheimer's disease |
| WO2010042292A1 (en) * | 2008-10-08 | 2010-04-15 | Trustees Of Dartmouth College | Method for selectively inhibiting the activity of acat1 in the treatment of alzheimer's disease |
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| CN101852805B (zh) * | 2009-03-31 | 2015-04-01 | 浙江大学 | Angptl3作为卵巢癌的诊断标记物的用途 |
| US8653047B2 (en) * | 2010-01-08 | 2014-02-18 | Isis Pharmaceuticals, Inc. | Modulation of angiopoietin-like 3 expression |
| AU2015200969A1 (en) * | 2010-01-08 | 2015-03-19 | Ionis Pharmaceuticals, Inc. | Modulation of angiopoietin-like 3 expression |
| PH12012501751A1 (en) | 2010-03-04 | 2012-11-12 | Macrogenics Inc | Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof |
| JP5998060B2 (ja) * | 2010-03-04 | 2016-09-28 | マクロジェニクス，インコーポレーテッド | Ｂ７−ｈ３と反応性のある抗体、その免疫学的に活性なフラグメントおよびその使用 |
| US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| CA2826563C (en) | 2011-02-07 | 2020-10-20 | Paul Kussie | Methods and systems for treating eclampsia and pre-eclampsia |
| US8852592B2 (en) | 2011-05-10 | 2014-10-07 | Biocare Medical, Llc | Systems and methods for anti-PAX8 antibodies |
| AR087329A1 (es) | 2011-06-17 | 2014-03-19 | Regeneron Pharma | Anticuerpos humanos contra proteina 3 de tipo angiopoietina humana |
| ES2923573T3 (es) | 2011-06-21 | 2022-09-28 | Alnylam Pharmaceuticals Inc | Composiciones de ARNi de proteína 3 de tipo angiopoyetina (ANGPTL3) y métodos de uso de las mismas |
| DK2723769T4 (da) | 2011-06-23 | 2022-09-05 | Ablynx Nv | Teknikker til at forudsige, påvise og reducere uspecifik proteininterferens i assays, som involverer variable immunglobulin-enkeltdomæner |
| ES2992345T3 (es) | 2011-09-16 | 2024-12-11 | Regeneron Pharma | Métodos para reducir los niveles de lipoproteína(a) mediante la administración de un inhibidor de la proproteína convertasa subtilisina kexina-9 (PCSK9) |
| US10316103B1 (en) | 2012-03-30 | 2019-06-11 | Biocare Medical, Llc | Systems and methods for anti-Uroplakin III antibodies |
| LT3495387T (lt) | 2012-07-13 | 2021-11-25 | Roche Glycart Ag | Bispecifiniai anti-vegf / anti-ang-2 antikūnai ir jų panaudojimas akių kraujagyslių ligoms gydyti |
| TWI596115B (zh) | 2012-08-13 | 2017-08-21 | 再生元醫藥公司 | 具有ｐＨ－依賴性結合特性之抗－ＰＣＳＫ９抗體 |
| US9429577B2 (en) | 2012-09-27 | 2016-08-30 | Biocare Medical, Llc | Anti-uroplakin II antibodies systems and methods |
| GB201219487D0 (en) * | 2012-10-30 | 2012-12-12 | Cancer Rec Tech Ltd | Anti-S100A4 antibody molecules and their uses |
| US10429390B2 (en) | 2012-12-18 | 2019-10-01 | Biocare Medical, Llc | Antibody cocktail systems and methods for classification of histologic subtypes in lung cancer |
| EP2962113B1 (en) | 2013-02-28 | 2019-04-03 | Biocare Medical, LLC | Anti-p40 antibodies systems and methods |
| US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
| JO3564B1 (ar) | 2013-03-08 | 2020-07-05 | Novartis Ag | ببتيدات وتركيبات لعلاج ضرر المفاصل |
| US9301971B2 (en) | 2013-03-08 | 2016-04-05 | Novartis Ag | Peptides and compositions for treatment of joint damage |
| DK2991656T3 (da) | 2013-05-01 | 2020-03-23 | Ionis Pharmaceuticals Inc | Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression |
| US10111953B2 (en) | 2013-05-30 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| WO2015051320A2 (en) | 2013-10-03 | 2015-04-09 | Biocare Medical, Llc | Anti-sox10 antibody systems and methods |
| BR112016013514B1 (pt) | 2013-12-13 | 2022-04-19 | Stora Enso Oyj (Fi) | Papelão de múltiplas camadas |
| CN111394355A (zh) * | 2013-12-24 | 2020-07-10 | Ionis制药公司 | 促血管生成素样3表达的调节 |
| PT3137605T (pt) | 2014-05-01 | 2020-12-18 | Ionis Pharmaceuticals Inc | Composições e métodos para modulação da expressão de angiopoietina de tipo 3 |
| US10100308B2 (en) | 2014-05-29 | 2018-10-16 | Trustees Of Dartmouth College | Method for selectively inhibiting ACAT1 in the treatment of neurodegenerative diseases |
| US9527922B2 (en) * | 2014-12-31 | 2016-12-27 | Development Center For Biotechnology | Humanized alpha-enolase specific antibodies and methods of uses in cancer therapy |
| EA201792263A1 (ru) | 2015-04-13 | 2018-08-31 | Элнилэм Фармасьютикалз, Инк. | КОМПОЗИЦИИ НА ОСНОВЕ iRNA ПРОТИВ АНГИОПОЭТИН-ПОДОБНОГО БЕЛКА 3 (ANGPTL3) И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| AU2016349625B2 (en) | 2015-11-06 | 2022-07-07 | Ionis Pharmaceuticals, Inc. | Modulating apolipoprotein (a) expression |
| PL3416684T3 (pl) * | 2016-02-17 | 2023-11-06 | Regeneron Pharmaceuticals, Inc. | Sposoby leczenia lub profilaktyki miażdżycy tętnic przez podawanie inhibitora angptl3 |
| JP7541810B2 (ja) | 2016-03-03 | 2024-08-29 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ａｎｇｐｔｌ３阻害剤と組み合わせてｐｃｓｋ９阻害剤を投与することにより高脂血症を有する患者を処置するための方法 |
| TWI781098B (zh) | 2016-04-15 | 2022-10-21 | 美商宏觀基因股份有限公司 | 新穎的ｂ７-ｈ３-結合分子、其抗體藥物綴合物及其使用方法 |
| IL293308B2 (en) * | 2016-04-28 | 2024-12-01 | Regeneron Pharma | Methods for treating patients with familial hypercholesterolemia |
| EP3532034A4 (en) * | 2016-10-28 | 2020-12-02 | Washington University | ANTI-APOE ANTIBODY |
| CN107085112B (zh) * | 2017-05-10 | 2019-03-19 | 武汉圣润生物科技有限公司 | 一种用于检测白血病的试剂盒 |
| EP3774916A2 (en) * | 2018-04-06 | 2021-02-17 | Biolegend, Inc. | Anti-tetraspanin 33 agents and compositions and methods for making and using the same |
| EP3829595A4 (en) | 2018-08-02 | 2022-08-24 | Dyne Therapeutics, Inc. | MUSCLE-DIRECTED COMPLEXES AND USES THEREOF IN THE TREATMENT OF DYSTROPHINOPATHIES |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| AR116566A1 (es) | 2018-10-03 | 2021-05-19 | Novartis Ag | Administración sostenida de polipéptidos similares a la angiopoyetina 3 |
| EP3873519A1 (en) | 2018-10-29 | 2021-09-08 | F. Hoffmann-La Roche AG | Antibody formulation |
| TWI747098B (zh) | 2018-12-21 | 2021-11-21 | 美商美國禮來大藥廠 | 抗angptl3/8複合物抗體及其使用方法 |
| US12559551B2 (en) | 2019-05-24 | 2026-02-24 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-ANGPTL3 antibodies |
| CN112062845B (zh) * | 2019-06-10 | 2022-09-02 | 山东博安生物技术股份有限公司 | Angptl3结合片段及其用途 |
| EP3993820A4 (en) * | 2019-07-04 | 2023-08-16 | Cadila Healthcare Limited | VACCINE BASED ON ANGPTL3 FOR THE TREATMENT OF LIVER DISEASES |
| WO2021041300A2 (en) * | 2019-08-23 | 2021-03-04 | Ab Therapeutics, Inc. | Bispecific antibodies and uses thereof |
| CN110938144B (zh) * | 2019-11-27 | 2022-07-26 | 复旦大学附属儿科医院 | 一种抗angptl3单克隆抗体及其在制备治疗肾病综合征药物中的用途 |
| KR20220131935A (ko) * | 2020-01-22 | 2022-09-29 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | 항angptl3 항체 및 이의 용도 |
| US20240002479A1 (en) * | 2020-11-23 | 2024-01-04 | The Regents Of The University Of Michigan | Single-chain antibody against flavivirus ns1 protein |
| IL305442A (en) | 2021-03-04 | 2023-10-01 | Alnylam Pharmaceuticals Inc | Angiopoietin-like 3 (ANGPTL3) IRNA compositions and methods of using them |
| US20240141029A1 (en) * | 2021-03-05 | 2024-05-02 | Anji Pharmaceuticals Inc. | Methods and compositions for treating sepsis |
| JPWO2022244845A1 (https=) * | 2021-05-19 | 2022-11-24 | ||
| KR20240032945A (ko) * | 2021-07-09 | 2024-03-12 | 다인 세라퓨틱스, 인크. | 근육 표적화 복합체 및 디스트로핀병증을 치료하기 위한 그의 용도 |
| IL309936A (en) | 2021-07-09 | 2024-03-01 | Dyne Therapeutics Inc | Muscle targeting complexes and formulations for the treatment of dystrophinopathy |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| IL309912A (en) * | 2021-07-09 | 2024-03-01 | Dyne Therapeutics Inc | Muscle targeting complexes and their uses for the treatment of dystrophinopathy |
| TW202320847A (zh) * | 2021-07-21 | 2023-06-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種抗ａｎｇｐｔｌ３抗體或其抗原結合片段的醫藥組成物及其用途 |
| CN116284377A (zh) * | 2021-12-21 | 2023-06-23 | 复旦大学 | 抗人血管生成素3纳米抗体及其应用 |
| WO2023213779A1 (en) | 2022-05-02 | 2023-11-09 | Novo Nordisk A/S | Novel anti-angptl3 antibodies suitable for high concentration compositions and subcutaneous administration |
| CN117447593B (zh) * | 2022-07-26 | 2024-06-25 | 北京东方百泰生物科技股份有限公司 | 一种抗Siglec-15单克隆抗体 |
| CN116199779B (zh) * | 2022-12-08 | 2023-08-11 | 北京东方百泰生物科技股份有限公司 | 一种抗lilrb4单克隆抗体、其抗原结合片段及其应用 |
| WO2024130165A1 (en) | 2022-12-16 | 2024-06-20 | Regeneron Pharmaceuticals, Inc. | Angptl3 inhibitors for triglyceride reduction in multifactorial chylomicronemia syndrome |
| CN119192369A (zh) * | 2023-06-25 | 2024-12-27 | 百奥泰生物制药股份有限公司 | 抗angptl3抗体及其应用 |
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-
2007
- 2007-12-06 PL PL07862629T patent/PL2121751T3/pl unknown
- 2007-12-06 WO PCT/US2007/025080 patent/WO2008073300A2/en not_active Ceased
- 2007-12-06 CA CA2672049A patent/CA2672049C/en active Active
- 2007-12-06 DK DK07862629.8T patent/DK2121751T3/en active
- 2007-12-06 CN CN2007800511058A patent/CN101855241B/zh not_active Expired - Fee Related
- 2007-12-06 US US12/001,012 patent/US7935796B2/en active Active
- 2007-12-06 BR BRPI0720218-0A2A patent/BRPI0720218A2/pt not_active Application Discontinuation
- 2007-12-06 KR KR1020097013595A patent/KR101503937B1/ko not_active Expired - Fee Related
- 2007-12-06 JP JP2009540313A patent/JP5484063B2/ja not_active Expired - Fee Related
- 2007-12-06 MX MX2009006082A patent/MX2009006082A/es active IP Right Grant
- 2007-12-06 PT PT78626298T patent/PT2121751T/pt unknown
- 2007-12-06 ZA ZA200904022A patent/ZA200904022B/xx unknown
- 2007-12-06 EP EP07862629.8A patent/EP2121751B1/en active Active
- 2007-12-06 ES ES07862629.8T patent/ES2618830T3/es active Active
- 2007-12-06 AU AU2007332855A patent/AU2007332855B2/en not_active Ceased
- 2007-12-06 HU HUE07862629A patent/HUE033960T2/en unknown
- 2007-12-06 EA EA200970556A patent/EA019661B1/ru not_active IP Right Cessation
- 2007-12-07 TW TW096146844A patent/TW200846364A/zh unknown
- 2007-12-07 AR ARP070105505A patent/AR064205A1/es active IP Right Grant
-
2009
- 2009-06-07 IL IL199216A patent/IL199216A/en active IP Right Grant
- 2009-06-09 NO NO20092215A patent/NO20092215L/no not_active Application Discontinuation
-
2011
- 2011-03-28 US US13/073,617 patent/US8742075B2/en active Active
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