JP2010512230A5 - - Google Patents
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- JP2010512230A5 JP2010512230A5 JP2009541532A JP2009541532A JP2010512230A5 JP 2010512230 A5 JP2010512230 A5 JP 2010512230A5 JP 2009541532 A JP2009541532 A JP 2009541532A JP 2009541532 A JP2009541532 A JP 2009541532A JP 2010512230 A5 JP2010512230 A5 JP 2010512230A5
- Authority
- JP
- Japan
- Prior art keywords
- transient gel
- agent according
- transient
- agent
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000499 gel Substances 0.000 claims 44
- 239000003814 drug Substances 0.000 claims 42
- 230000001052 transient effect Effects 0.000 claims 37
- 239000003795 chemical substances by application Substances 0.000 claims 33
- 229940079593 drug Drugs 0.000 claims 25
- 229920000642 polymer Polymers 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 14
- 230000007704 transition Effects 0.000 claims 13
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 12
- 210000000056 organ Anatomy 0.000 claims 10
- 229920001983 poloxamer Polymers 0.000 claims 8
- 229920002148 Gellan gum Polymers 0.000 claims 6
- 229960000502 poloxamer Drugs 0.000 claims 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 4
- 229920002359 Tetronic® Polymers 0.000 claims 4
- 235000010443 alginic acid Nutrition 0.000 claims 4
- 229920000615 alginic acid Polymers 0.000 claims 4
- 229910052791 calcium Inorganic materials 0.000 claims 4
- 239000011575 calcium Substances 0.000 claims 4
- 229920001992 poloxamer 407 Polymers 0.000 claims 4
- 229940044476 poloxamer 407 Drugs 0.000 claims 4
- 229920001987 poloxamine Polymers 0.000 claims 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 3
- 239000000783 alginic acid Substances 0.000 claims 3
- 229960001126 alginic acid Drugs 0.000 claims 3
- 150000004781 alginic acids Chemical class 0.000 claims 3
- 229920002674 hyaluronan Polymers 0.000 claims 3
- 229960003160 hyaluronic acid Drugs 0.000 claims 3
- 210000003734 kidney Anatomy 0.000 claims 3
- 229910052749 magnesium Inorganic materials 0.000 claims 3
- 239000011777 magnesium Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 239000011591 potassium Substances 0.000 claims 3
- 229910052700 potassium Inorganic materials 0.000 claims 3
- 235000010408 potassium alginate Nutrition 0.000 claims 3
- 239000000737 potassium alginate Substances 0.000 claims 3
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims 3
- 239000011734 sodium Substances 0.000 claims 3
- 229910052708 sodium Inorganic materials 0.000 claims 3
- 235000010413 sodium alginate Nutrition 0.000 claims 3
- 239000000661 sodium alginate Substances 0.000 claims 3
- 229940005550 sodium alginate Drugs 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 229920002517 Poloxamer 338 Polymers 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 229910052788 barium Inorganic materials 0.000 claims 2
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims 2
- 229920001400 block copolymer Polymers 0.000 claims 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229920001993 poloxamer 188 Polymers 0.000 claims 2
- 229940044519 poloxamer 188 Drugs 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
- 235000015424 sodium Nutrition 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000011632 Caseins Human genes 0.000 claims 1
- 108010076119 Caseins Proteins 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000016942 Elastin Human genes 0.000 claims 1
- 108010014258 Elastin Proteins 0.000 claims 1
- 102000009123 Fibrin Human genes 0.000 claims 1
- 108010073385 Fibrin Proteins 0.000 claims 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 claims 1
- 102000008946 Fibrinogen Human genes 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 108010076876 Keratins Proteins 0.000 claims 1
- 102000011782 Keratins Human genes 0.000 claims 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 102000007327 Protamines Human genes 0.000 claims 1
- 108010007568 Protamines Proteins 0.000 claims 1
- 102000043322 Reelin Human genes 0.000 claims 1
- 108700038365 Reelin Proteins 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 claims 1
- 229910052768 actinide Inorganic materials 0.000 claims 1
- 150000001255 actinides Chemical class 0.000 claims 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims 1
- 229940050528 albumin Drugs 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 229920006318 anionic polymer Polymers 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 229940124350 antibacterial drug Drugs 0.000 claims 1
- -1 antibacterial drugs Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 229920005605 branched copolymer Polymers 0.000 claims 1
- 239000005018 casein Substances 0.000 claims 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
- 235000021240 caseins Nutrition 0.000 claims 1
- 229920006317 cationic polymer Polymers 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 229920002549 elastin Polymers 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 229950003499 fibrin Drugs 0.000 claims 1
- 229940012952 fibrinogen Drugs 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 229920000578 graft copolymer Polymers 0.000 claims 1
- 230000023597 hemostasis Effects 0.000 claims 1
- 229910052747 lanthanoid Inorganic materials 0.000 claims 1
- 150000002602 lanthanoids Chemical class 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 239000002907 paramagnetic material Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229940048914 protamine Drugs 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229920005604 random copolymer Polymers 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical group [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 claims 1
- 229940082004 sodium laurate Drugs 0.000 claims 1
- FIWQZURFGYXCEO-UHFFFAOYSA-M sodium;decanoate Chemical compound [Na+].CCCCCCCCCC([O-])=O FIWQZURFGYXCEO-UHFFFAOYSA-M 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 229910052712 strontium Inorganic materials 0.000 claims 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
- 230000006459 vascular development Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87406206P | 2006-12-11 | 2006-12-11 | |
| US89399307P | 2007-03-09 | 2007-03-09 | |
| PCT/US2007/087079 WO2008073938A2 (en) | 2006-12-11 | 2007-12-11 | Perfusive organ hemostasis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014048739A Division JP5931943B2 (ja) | 2006-12-11 | 2014-03-12 | 灌流臓器止血法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010512230A JP2010512230A (ja) | 2010-04-22 |
| JP2010512230A5 true JP2010512230A5 (https=) | 2011-02-10 |
Family
ID=39512452
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541532A Pending JP2010512230A (ja) | 2006-12-11 | 2007-12-11 | 灌流臓器止血法 |
| JP2014048739A Expired - Fee Related JP5931943B2 (ja) | 2006-12-11 | 2014-03-12 | 灌流臓器止血法 |
| JP2016089234A Pending JP2016135365A (ja) | 2006-12-11 | 2016-04-27 | 灌流臓器止血法 |
| JP2017187859A Pending JP2018000996A (ja) | 2006-12-11 | 2017-09-28 | 灌流臓器止血法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014048739A Expired - Fee Related JP5931943B2 (ja) | 2006-12-11 | 2014-03-12 | 灌流臓器止血法 |
| JP2016089234A Pending JP2016135365A (ja) | 2006-12-11 | 2016-04-27 | 灌流臓器止血法 |
| JP2017187859A Pending JP2018000996A (ja) | 2006-12-11 | 2017-09-28 | 灌流臓器止血法 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US20080181952A1 (https=) |
| EP (1) | EP2094169A4 (https=) |
| JP (4) | JP2010512230A (https=) |
| CN (2) | CN105251035A (https=) |
| WO (1) | WO2008073938A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2866133B2 (ja) | 1989-07-25 | 1999-03-08 | 株式会社リコー | 液体噴射記録装置及び方法 |
| JP2989243B2 (ja) | 1990-10-16 | 1999-12-13 | 株式会社リコー | 液体噴射記録方法及び装置 |
| JP2989242B2 (ja) | 1990-10-16 | 1999-12-13 | 株式会社リコー | 液体噴射記録方法及び装置 |
| JP2957676B2 (ja) | 1990-10-16 | 1999-10-06 | 株式会社リコー | 液体噴射記録装置及び方法 |
| US20080031847A1 (en) * | 2005-12-22 | 2008-02-07 | Pluromed, Inc. | Methods and kits for treating lacerations and puncture wounds using inverse thermosensitive polymers |
| US8608760B2 (en) | 2006-06-21 | 2013-12-17 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for joining non-conjoined lumens |
| JP2009540965A (ja) | 2006-06-21 | 2009-11-26 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 非結合管腔を接合するための組成物および方法 |
| US8197499B2 (en) * | 2006-06-21 | 2012-06-12 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for joining non-conjoined lumens |
| CN101854960B (zh) | 2006-12-15 | 2014-06-25 | 生命连结有限公司 | 明胶-转谷氨酰胺酶止血敷料和密封材料 |
| BRPI0807558A2 (pt) * | 2007-02-22 | 2014-07-01 | Pluromed Inc | Uso de polímeros termosensíveis reversos para controlar o fluxo de fluido biológico subsequente a um procedimento médico |
| US8172861B2 (en) | 2007-12-20 | 2012-05-08 | Tautona Group, L.P. | Compositions and methods for joining non-conjoined lumens |
| JP2011513331A (ja) * | 2008-02-29 | 2011-04-28 | アレイ バイオファーマ、インコーポレイテッド | ピラゾール［３，４−ｂ］ピリジンＲＡＦ阻害剤 |
| EP2254652A4 (en) * | 2008-02-29 | 2017-05-03 | Genzyme Corporation | Local embolization via heating of thermosensitive polymers |
| KR101534422B1 (ko) | 2008-05-14 | 2015-07-09 | 오토노미, 인코포레이티드 | 귀 질환 치료를 위한 제어 방출형 코르티코스테로이드 조성물 및 방법 |
| EP2487206A3 (en) | 2008-06-18 | 2012-11-28 | Lifebond Ltd | Cross-linkable gelatin-based compositions |
| US8318817B2 (en) | 2008-07-21 | 2012-11-27 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
| US8563037B2 (en) * | 2009-02-06 | 2013-10-22 | Tautona Group, L.P. | Compositions and methods for joining non-conjoined lumens |
| JP5558573B2 (ja) * | 2009-09-22 | 2014-07-23 | ヴイライフ サイエンシズ テクノロジーズ プライベート リミテッド | 糖尿病性足潰瘍用の局所用製剤 |
| WO2011049958A2 (en) * | 2009-10-21 | 2011-04-28 | Otonomy, Inc. | Modulation of gel temperature of poloxamer-containing formulations |
| US9066991B2 (en) | 2009-12-22 | 2015-06-30 | Lifebond Ltd. | Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices |
| DK2600910T3 (en) | 2010-08-05 | 2016-04-04 | Lifebond Ltd | Wound dressings and adhesives COMPREHENSIVE DRYING FORMATIONS |
| WO2013025436A1 (en) * | 2011-08-12 | 2013-02-21 | Boston Scientific Scimed, Inc. | Anastomosis kit for radical prostatectomy procedure |
| JP5805882B2 (ja) | 2011-11-21 | 2015-11-10 | イノ セラピー インコーポレイテッド | カテコール基が結合したキトサンまたはポリアミン及び末端にチオール基が結合したポロキサマーを含むヒドロゲル及びこれの製造方法及びこれを利用した止血剤 |
| DE102013211316A1 (de) * | 2013-06-17 | 2014-12-18 | Aesculap Ag | Hämostyptikum |
| US9486405B2 (en) | 2013-08-27 | 2016-11-08 | Otonomy, Inc. | Methods for the treatment of pediatric otic disorders |
| ITMI20131927A1 (it) * | 2013-11-20 | 2015-05-21 | Cosmo Technologies Ltd | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection. emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica |
| ITMI20131924A1 (it) * | 2013-11-20 | 2015-05-21 | Cosmo Technologies Ltd | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica |
| WO2015145860A1 (ja) | 2014-03-28 | 2015-10-01 | テルモ株式会社 | 生体血管内血液置換用液体、生体血管内血液置換用液体製剤およびプレフィルドシリンジ |
| CA2961660A1 (en) * | 2014-10-01 | 2016-04-07 | Als Mountain Llc | Pharmaceutical composition comprising aspirin, metformin, and serotonin with non-ionic surfactant |
| US20170274189A1 (en) * | 2016-03-24 | 2017-09-28 | Ethicon, Inc. | Single lumen balloon delivery catheter with lumen bypass at balloon |
| CN108714243A (zh) * | 2017-06-08 | 2018-10-30 | 重庆大学 | 用于脑出血术后止血的植入剂及其制备方法 |
| WO2019163012A1 (ja) * | 2018-02-21 | 2019-08-29 | 国立大学法人信州大学 | 液体塞栓剤組成物 |
| EP3539571B1 (en) | 2018-03-16 | 2023-05-31 | Critical Innovations, LLC | Systems and methods relating to medical applications of synthetic polymer formulations |
| US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
| CN112138204A (zh) * | 2019-06-26 | 2020-12-29 | 广东博与再生医学有限公司 | 骨止血材料 |
| JP7546265B2 (ja) * | 2020-05-22 | 2024-09-06 | ウェトラブホールディング株式会社 | 生体組織用二液型バインダーおよび生体組織用二液型充填材 |
| CN111632189B (zh) * | 2020-05-27 | 2021-12-14 | 深圳先进技术研究院 | 基于海洋源明胶的可注射水凝胶止血剂及应用和应用方法 |
| US12410293B2 (en) | 2022-11-07 | 2025-09-09 | Critical Innovations Llc | Systems and methods relating to medical applications of inverse thermosensitive polymer foam formulations |
| CN121891589A (zh) * | 2025-11-25 | 2026-04-21 | 江苏申命医疗科技有限公司 | 用于制备栓塞剂的预混剂、试剂盒及应用 |
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| US3889685A (en) * | 1973-11-02 | 1975-06-17 | Cutter Lab | Tubular unit with vessel engaging cuff structure |
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| US4168708A (en) * | 1977-04-20 | 1979-09-25 | Medical Engineering Corp. | Blood vessel occlusion means suitable for use in anastomosis |
| US4474751A (en) * | 1983-05-16 | 1984-10-02 | Merck & Co., Inc. | Ophthalmic drug delivery system utilizing thermosetting gels |
| US4478822A (en) * | 1983-05-16 | 1984-10-23 | Merck & Co., Inc. | Drug delivery system utilizing thermosetting gels |
| US5567859A (en) * | 1991-03-19 | 1996-10-22 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US5843156A (en) * | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
| US4946463A (en) * | 1989-04-10 | 1990-08-07 | Pioneering Technologies, Inc. | Vessel occluder |
| ATE130517T1 (de) * | 1990-08-08 | 1995-12-15 | Takeda Chemical Industries Ltd | Intravaskulär embolisierendes mittel mit gehalt an einem die angiogenesis hemmenden stoff. |
| ATE187154T1 (de) * | 1991-03-19 | 1999-12-15 | Cytrx Corp | Polyoxypropylen/polyoxyethylen copolymere mit verbesserter biologischer aktivität |
| US5696298A (en) * | 1991-03-19 | 1997-12-09 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US5939485A (en) * | 1995-06-19 | 1999-08-17 | Medlogic Global Corporation | Responsive polymer networks and methods of their use |
| US5800711A (en) * | 1996-10-18 | 1998-09-01 | Mdv Technologies, Inc. | Process for the fractionation of polyoxyalkylene block copolymers |
| US6120751A (en) * | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| WO2000045868A1 (en) * | 1999-02-05 | 2000-08-10 | The Regents Of The University Of California | Thermo-reversible polymer for intralumenal implant |
| KR100872884B1 (ko) * | 2000-03-24 | 2008-12-10 | 바이오스피어 메디칼 인코포레이티드 | 능동 색전화용 미소구 |
| US6761824B2 (en) * | 2000-08-17 | 2004-07-13 | Reeve Lorraine E | Process for the fractionation of polymers |
| US7838699B2 (en) * | 2002-05-08 | 2010-11-23 | Biosphere Medical | Embolization using degradable crosslinked hydrogels |
| JP4909071B2 (ja) * | 2003-03-24 | 2012-04-04 | プルーローメッド， インコーポレイテッド | 逆感熱性ポリマーを使用する一時的な塞栓形成 |
| WO2005037062A2 (en) * | 2003-10-14 | 2005-04-28 | Pluromed, Inc. | Confinement of kidney-stone fragments during lithotripsy |
| WO2005046438A2 (en) * | 2003-11-06 | 2005-05-26 | Pluromed, Inc. | Internal clamp for surgical procedures |
| US20060253099A1 (en) * | 2005-04-21 | 2006-11-09 | Medtronic Vascular, Inc. | Guiding catheter with resiliently compressible occluder |
| WO2006119009A1 (en) * | 2005-05-02 | 2006-11-09 | Pluromed, Inc. | Non-lithotripsic kidney-stone therapy |
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2007
- 2007-12-11 JP JP2009541532A patent/JP2010512230A/ja active Pending
- 2007-12-11 CN CN201510386368.0A patent/CN105251035A/zh active Pending
- 2007-12-11 WO PCT/US2007/087079 patent/WO2008073938A2/en not_active Ceased
- 2007-12-11 CN CN200780051223A patent/CN101677822A/zh active Pending
- 2007-12-11 US US11/954,109 patent/US20080181952A1/en not_active Abandoned
- 2007-12-11 EP EP07865497.7A patent/EP2094169A4/en not_active Withdrawn
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2014
- 2014-03-12 JP JP2014048739A patent/JP5931943B2/ja not_active Expired - Fee Related
- 2014-03-25 US US14/225,299 patent/US20140205542A1/en not_active Abandoned
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2016
- 2016-03-18 US US15/074,432 patent/US20170043050A1/en not_active Abandoned
- 2016-04-27 JP JP2016089234A patent/JP2016135365A/ja active Pending
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2017
- 2017-06-13 US US15/621,704 patent/US20180117211A1/en not_active Abandoned
- 2017-09-28 JP JP2017187859A patent/JP2018000996A/ja active Pending
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