JP2010512146A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010512146A5 JP2010512146A5 JP2009540294A JP2009540294A JP2010512146A5 JP 2010512146 A5 JP2010512146 A5 JP 2010512146A5 JP 2009540294 A JP2009540294 A JP 2009540294A JP 2009540294 A JP2009540294 A JP 2009540294A JP 2010512146 A5 JP2010512146 A5 JP 2010512146A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- desaturase
- yeast
- isolated polynucleotide
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 24
- 229920001184 polypeptide Polymers 0.000 claims description 24
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 24
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 24
- 108091033319 polynucleotide Proteins 0.000 claims description 21
- 102000040430 polynucleotide Human genes 0.000 claims description 21
- 239000002157 polynucleotide Substances 0.000 claims description 21
- 108010022240 delta-8 fatty acid desaturase Proteins 0.000 claims description 20
- 239000002773 nucleotide Substances 0.000 claims description 17
- 125000003729 nucleotide group Chemical group 0.000 claims description 17
- 210000004027 cell Anatomy 0.000 claims description 14
- 210000005253 yeast cell Anatomy 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 11
- 230000000295 complement effect Effects 0.000 claims description 10
- 229940098330 gamma linoleic acid Drugs 0.000 claims description 10
- 108020004511 Recombinant DNA Proteins 0.000 claims description 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 9
- 230000001105 regulatory effect Effects 0.000 claims description 9
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims description 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
- 241000223252 Rhodotorula Species 0.000 claims description 6
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 claims description 6
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 claims description 5
- 235000021297 Eicosadienoic acid Nutrition 0.000 claims description 5
- 241001149698 Lipomyces Species 0.000 claims description 5
- 241000235013 Yarrowia Species 0.000 claims description 5
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 4
- AHANXAKGNAKFSK-PDBXOOCHSA-N all-cis-icosa-11,14,17-trienoic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCCC(O)=O AHANXAKGNAKFSK-PDBXOOCHSA-N 0.000 claims description 4
- PRHHYVQTPBEDFE-UHFFFAOYSA-N eicosatrienoic acid Natural products CCCCCC=CCC=CCCCCC=CCCCC(O)=O PRHHYVQTPBEDFE-UHFFFAOYSA-N 0.000 claims description 4
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims description 3
- 241001527609 Cryptococcus Species 0.000 claims description 3
- 241000223230 Trichosporon Species 0.000 claims description 3
- 230000000813 microbial effect Effects 0.000 claims description 3
- BBWMTEYXFFWPIF-CJBMEHDJSA-N (2e,4e,6e)-icosa-2,4,6-trienoic acid Chemical compound CCCCCCCCCCCCC\C=C\C=C\C=C\C(O)=O BBWMTEYXFFWPIF-CJBMEHDJSA-N 0.000 claims description 2
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims description 2
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 claims description 2
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 claims description 2
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims description 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 2
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims description 2
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims description 2
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 2
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 2
- 229960004488 linolenic acid Drugs 0.000 claims description 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 1
- 241000195619 Euglena gracilis Species 0.000 description 3
- 241001501885 Isochrysis Species 0.000 description 3
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 102100034542 Acyl-CoA (8-3)-desaturase Human genes 0.000 description 1
- 102100034544 Acyl-CoA 6-desaturase Human genes 0.000 description 1
- 108010073542 Delta-5 Fatty Acid Desaturase Proteins 0.000 description 1
- 108010087894 Fatty acid desaturases Proteins 0.000 description 1
- 108010037138 Linoleoyl-CoA Desaturase Proteins 0.000 description 1
- 101000912235 Rebecca salina Acyl-lipid (7-3)-desaturase Proteins 0.000 description 1
- 101000877236 Siganus canaliculatus Acyl-CoA Delta-4 desaturase Proteins 0.000 description 1
- 102000016553 Stearoyl-CoA Desaturase Human genes 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 108010011713 delta-15 desaturase Proteins 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 150000007523 nucleic acids Chemical group 0.000 description 1
- -1 Δ12 desaturase Proteins 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/635,258 US7709239B2 (en) | 2006-12-07 | 2006-12-07 | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| US11/635,258 | 2006-12-07 | ||
| PCT/US2007/025001 WO2008073271A1 (en) | 2006-12-07 | 2007-12-05 | Mutant delta8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010512146A JP2010512146A (ja) | 2010-04-22 |
| JP2010512146A5 true JP2010512146A5 (enExample) | 2011-01-27 |
| JP5769374B2 JP5769374B2 (ja) | 2015-08-26 |
Family
ID=39269299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540294A Expired - Fee Related JP5769374B2 (ja) | 2006-12-07 | 2007-12-05 | 標的を定めた変異誘発によって改変された変異δ８デサチュラーゼ遺伝子及び多価不飽和脂肪酸の製造におけるそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7709239B2 (enExample) |
| EP (1) | EP2087106B1 (enExample) |
| JP (1) | JP5769374B2 (enExample) |
| CN (1) | CN101627118B (enExample) |
| AU (1) | AU2007332918B2 (enExample) |
| CA (1) | CA2669217C (enExample) |
| DK (1) | DK2087106T3 (enExample) |
| WO (1) | WO2008073271A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2529572T3 (es) | 2004-04-22 | 2015-02-23 | Commonwealth Scientific And Industrial Research Organisation | Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes |
| CA3056110C (en) | 2004-04-22 | 2020-07-14 | Surinder Pal Singh | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| RU2009111266A (ru) | 2006-08-29 | 2010-10-10 | Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) | Синтез жирных кислот |
| US7790156B2 (en) * | 2007-04-10 | 2010-09-07 | E. I. Du Pont De Nemours And Company | Δ-8 desaturases and their use in making polyunsaturated fatty acids |
| US8323935B2 (en) | 2007-10-03 | 2012-12-04 | E I Du Pont De Nemours And Company | Optimized strains of Yarrowia lipolytica for high eicosapentaenoic acid production |
| WO2010042510A1 (en) * | 2008-10-06 | 2010-04-15 | Abbott Laboratires | Delta-8 desaturase genes, enzymes encoded thereby and uses thereof |
| DK2358882T3 (da) | 2008-11-18 | 2017-11-06 | Commw Scient Ind Res Org | Enzymer og fremgangsmåder til fremstilling af omega-3 fedtsyrer |
| EP2358862B1 (en) | 2008-12-18 | 2017-08-02 | E. I. du Pont de Nemours and Company | Reducing byproduction of malonates in a fermentation process |
| JP5931721B2 (ja) | 2009-06-16 | 2016-06-08 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | アシルＣｏＡリゾリン脂質アシルトランスフェラーゼの発現による長鎖オメガ−３及びオメガ−６多価不飽和脂肪酸生合成の改良 |
| BRPI1009649A2 (pt) | 2009-06-16 | 2016-03-15 | Du Pont | célula hospedeira yarrowia sp, recombinante, método para fabricar um óleo microbiano e célula hospedeira recombinante para produção de um óleo |
| DK2442666T3 (da) | 2009-06-16 | 2015-07-13 | Du Pont | Olier med højt indhold af eicosapentaensyre fra forbedrede og optimerede stammer af yarrowia lipolytica |
| WO2011087981A2 (en) | 2010-01-15 | 2011-07-21 | E. I. Du Pont De Nemours And Company | Clinical benefits of eicosapentaenoic acid in humans |
| EP2561050A1 (en) | 2010-04-22 | 2013-02-27 | E.I. Du Pont De Nemours And Company | Method for obtaining polyunsaturated fatty acid-containing compositions from microbial biomass |
| US20120040076A1 (en) | 2010-08-11 | 2012-02-16 | E. I. Du Pont De Nemours And Company | Aquaculture feed compositions |
| AU2011289384A1 (en) | 2010-08-11 | 2013-01-24 | E. I. Du Pont De Nemours And Company | A sustainable aquaculture feeding strategy |
| WO2012021686A1 (en) | 2010-08-11 | 2012-02-16 | E. I. Du Pont De Nemours And Company | Improved aquaculture meat products |
| CA2807834C (en) | 2010-08-26 | 2019-06-25 | E. I. Du Pont De Nemours And Company | Recombinant microbial host cells for high eicosapentaenoic acid production |
| JP5963749B2 (ja) | 2010-08-26 | 2016-08-03 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ | 変異δ９エロンガーゼおよび多価不飽和脂肪酸の製造におけるそれらの使用 |
| JP2013535988A (ja) | 2010-08-26 | 2013-09-19 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 変異ｈｐｇｇモチーフおよびｈｄａｓｈモチーフδ５デサチュラーゼおよび多価不飽和脂肪酸の製造におけるそれらの使用 |
| CA2815341A1 (en) * | 2010-11-05 | 2012-05-10 | Basf Plant Science Company Gmbh | Methods for increasing yield and fine chemical production in plants |
| AU2011353002A1 (en) | 2010-12-30 | 2013-05-30 | E. I. Du Pont De Nemours And Company | Use of Saccharomyces cerevisiae SUC2 gene in Yarrowia lipolytica for sucrose utilization |
| US20130040340A1 (en) | 2011-02-07 | 2013-02-14 | E. I. Du Pont De Nemours And Company | Production of alcohol esters in situ using alcohols and fatty acids produced by microorganisms |
| US8969049B2 (en) | 2011-03-31 | 2015-03-03 | E I Du Pont De Nemours And Company | Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast |
| US20120247066A1 (en) | 2011-04-01 | 2012-10-04 | Ice House America, Llc | Ice bagging apparatus and methods |
| EP2694665A1 (en) | 2011-04-01 | 2014-02-12 | E. I. Du Pont de Nemours and Company | Yarrowia esterase/lipase promoter regions for gene expression in yeast |
| EP2694657A1 (en) | 2011-04-05 | 2014-02-12 | E. I. Du Pont de Nemours and Company | Yarrowia n-alkane-hydroxylating cytochrome p450 promoter regions for gene expression in yeast |
| US8609369B2 (en) | 2011-04-07 | 2013-12-17 | E I Du Pont De Nemours And Company | Yarrowia peroxisomal 2,4-dienoyl-CoA reductase promoter regions for gene expression in yeast |
| US8946460B2 (en) | 2012-06-15 | 2015-02-03 | Commonwealth Scientific And Industrial Research Organisation | Process for producing polyunsaturated fatty acids in an esterified form |
| WO2014100061A1 (en) | 2012-12-21 | 2014-06-26 | E. I. Du Pont De Nemours And Company | Down-regulation of a polynucleotide encoding a sou2 sorbitol utilization protein to modify lipid production in microbial cells |
| KR102386838B1 (ko) | 2013-12-18 | 2022-04-15 | 커먼웰쓰 사이언티픽 앤 인더스트리알 리서치 오거니제이션 | 장쇄 다중불포화 지방산을 포함하는 지질 |
| WO2015196250A1 (en) | 2014-06-27 | 2015-12-30 | Commonwealth Scientific And Industrial Research Organisation | Lipid comprising docosapentaenoic acid |
| CN104293769B (zh) * | 2014-10-27 | 2016-06-01 | 徐毅 | 一种来源于绿色巴夫藻的delta8去饱和酶新基因 |
| CN114207140A (zh) * | 2019-05-28 | 2022-03-18 | Dna斯克瑞普特公司 | 末端脱氧核苷酸转移酶变体及其用途 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6825017B1 (en) * | 1998-12-07 | 2004-11-30 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
| ATE353952T1 (de) | 1998-12-07 | 2007-03-15 | Univ Washington | Desaturasen und verfahren ihrer anwendung zur synthese von mehrfach ungesättigten fettsäuren |
| EP1576166B1 (en) * | 2002-12-19 | 2014-10-15 | University Of Bristol | Novel method for the production of polyunsaturated fatty acids |
| US7129089B2 (en) | 2003-02-12 | 2006-10-31 | E. I. Du Pont De Nemours And Company | Annexin and P34 promoters and use in expression of transgenic genes in plants |
| US20040172682A1 (en) | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
| US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| US7214491B2 (en) | 2003-05-07 | 2007-05-08 | E. I. Du Pont De Nemours And Company | Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7259255B2 (en) | 2003-06-25 | 2007-08-21 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| US7459546B2 (en) | 2003-06-25 | 2008-12-02 | E.I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase regulatory sequences for gene expression in oleaginous yeast |
| US7267976B2 (en) | 2003-07-02 | 2007-09-11 | E.I. Du Pont De Nemours And Company | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts |
| FR2857322B1 (fr) * | 2003-07-10 | 2006-08-11 | Nacam | Dispositif d'absorption d'energie infiniment modulable d'une colonne de direction de vehicule automobile |
| NO347177B1 (no) | 2003-08-01 | 2023-06-19 | Basf Plant Science Gmbh | Fremgangsmåte for fremstilling av flerumettede fettsyrer i transgene organismer |
| KR20050036190A (ko) * | 2003-10-15 | 2005-04-20 | 삼성전자주식회사 | 플립플롭 |
| CA2542574C (en) | 2003-11-12 | 2014-03-18 | E. I. Du Pont De Nemours And Company | Delta-15 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous plants and yeast |
| US7504259B2 (en) | 2003-11-12 | 2009-03-17 | E. I. Du Pont De Nemours And Company | Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast |
| WO2005049805A2 (en) | 2003-11-14 | 2005-06-02 | E.I. Dupont De Nemours And Company | Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast |
| CA2559360A1 (en) | 2004-02-27 | 2005-09-09 | Basf Plant Science Gmbh | Method for producing c18, c20 and c22 polyunsaturated fatty acids in transgenic plants |
| ES2529572T3 (es) * | 2004-04-22 | 2015-02-23 | Commonwealth Scientific And Industrial Research Organisation | Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes |
| CA3056110C (en) | 2004-04-22 | 2020-07-14 | Surinder Pal Singh | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| WO2005118814A2 (en) * | 2004-06-04 | 2005-12-15 | Fluxome Sciences A/S | Metabolically engineered cells for the production of polyunsaturated fatty acids |
| EP1758991B1 (en) * | 2004-06-25 | 2013-01-16 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7465564B2 (en) | 2004-08-10 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Production of γ-linolenic acid in oleaginous yeast |
| US7264949B2 (en) | 2004-09-15 | 2007-09-04 | E.I. Du Pont De Nemours And Company | Glycerol-3-phosphate o-acyltransferase promoter for gene expression in oleaginous yeast |
| US7189559B2 (en) | 2004-11-04 | 2007-03-13 | E. I. Du Pont De Nemours And Company | Mortierella alpina lysophosphatidic acid acyltransferase homolog for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US8685679B2 (en) | 2004-11-04 | 2014-04-01 | E I Du Pont De Nemours And Company | Acyltransferase regulation to increase the percent of polyunsaturated fatty acids in total lipids and oils of oleaginous organisms |
| US7273746B2 (en) | 2004-11-04 | 2007-09-25 | E.I. Dupont De Nemours And Company | Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7550286B2 (en) * | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| US7192762B2 (en) | 2004-11-04 | 2007-03-20 | E. I. Du Pont De Nemours And Company | Mortierella alpina glycerol-3-phosphate o-acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7198937B2 (en) | 2004-11-04 | 2007-04-03 | E. I. Du Pont De Nemours And Company | Mortierella alpina diacylglycerol acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US20060094102A1 (en) | 2004-11-04 | 2006-05-04 | Zhixiong Xue | Ammonium transporter promoter for gene expression in oleaginous yeast |
| US7470532B2 (en) | 2005-10-19 | 2008-12-30 | E.I. Du Pont De Nemours And Company | Mortierella alpina C16/18 fatty acid elongase |
| CA2624661C (en) | 2005-11-23 | 2015-06-30 | E.I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| US7465793B2 (en) | 2006-04-20 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids |
| US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| EP2013335A2 (en) | 2006-05-01 | 2009-01-14 | E.I. Du Pont De Nemours And Company | Fungal delta12 desaturase and delta15 desaturase motifs |
| US7678560B2 (en) | 2006-05-17 | 2010-03-16 | E.I. Du Pont De Nemours And Company | Δ 5 desaturase and its use in making polyunsaturated fatty acids |
| US7695950B2 (en) | 2006-05-17 | 2010-04-13 | E. I. Du Pont De Nemours And Company | Δ5 desaturase and its use in making polyunsaturated fatty acids |
-
2006
- 2006-12-07 US US11/635,258 patent/US7709239B2/en not_active Expired - Fee Related
-
2007
- 2007-12-05 EP EP07862593.6A patent/EP2087106B1/en not_active Not-in-force
- 2007-12-05 CN CN2007800452327A patent/CN101627118B/zh not_active Expired - Fee Related
- 2007-12-05 AU AU2007332918A patent/AU2007332918B2/en not_active Ceased
- 2007-12-05 DK DK07862593.6T patent/DK2087106T3/en active
- 2007-12-05 CA CA2669217A patent/CA2669217C/en not_active Expired - Fee Related
- 2007-12-05 JP JP2009540294A patent/JP5769374B2/ja not_active Expired - Fee Related
- 2007-12-05 WO PCT/US2007/025001 patent/WO2008073271A1/en not_active Ceased
-
2010
- 2010-03-18 US US12/726,390 patent/US8026089B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1878785B (zh) | 适于改变油质酵母中多不饱和脂肪酸水平的△12去饱和酶 | |
| US7678560B2 (en) | Δ 5 desaturase and its use in making polyunsaturated fatty acids | |
| CN101980595B (zh) | △4去饱和酶及其在制备多不饱和脂肪酸中的用途 | |
| JP2012502659A5 (enExample) | ||
| US7790156B2 (en) | Δ-8 desaturases and their use in making polyunsaturated fatty acids | |
| JP5762291B2 (ja) | 変異δ５デサチュラーゼと、多価不飽和脂肪酸の製造におけるそれらの使用 | |
| US7943365B2 (en) | Δ-5 desaturases and their use in making polyunsaturated fatty acids | |
| JP2010523147A5 (enExample) | ||
| WO2005047485A3 (en) | Delta12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast | |
| US20080125326A1 (en) | Delta 17 desaturase and its use in making polyunsaturated fatty acids | |
| AU2007240741B2 (en) | Delta17 desaturases and their use in making polyunsaturated fatty acids | |
| WO2008073271A1 (en) | Mutant delta8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids | |
| WO2004104167A3 (en) | A δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts | |
| JP2012529912A5 (enExample) | ||
| JP2009534032A5 (enExample) | ||
| US8609369B2 (en) | Yarrowia peroxisomal 2,4-dienoyl-CoA reductase promoter regions for gene expression in yeast | |
| EP2691518A1 (en) | Yarrowia diacylglycerol acyltransferase promoter regions for gene expression in yeast | |
| JP6351582B2 (ja) | アシルＣｏＡ：リゾホスファチジルコリンアシルトランスフェラーゼおよびリン脂質：ジアシルグリセロールアシルトランスフェラーゼの同時発現による多価不飽和脂肪酸の産生の改善 | |
| Kajikawa et al. | Isolation and functional characterization of fatty acid Δ5‐elongase gene from the liverwort Marchantia polymorpha L | |
| JP2013535988A (ja) | 変異ｈｐｇｇモチーフおよびｈｄａｓｈモチーフδ５デサチュラーゼおよび多価不飽和脂肪酸の製造におけるそれらの使用 | |
| US7923223B2 (en) | Δ-9 desaturase and its use in making polyunsaturated fatty acids | |
| Lee et al. | Identification of Δ9-elongation activity from Thraustochytrium aureum by heterologous expression in Pichia pastoris | |
| Kishore et al. | Isolation and characterization of microsomal omega-6-desaturase gene (fad2-1) from soybean | |
| CN1922311A (zh) | 去饱和酶 |